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The map label for this gene is fadE16 [H]

Identifier: 121637586

GI number: 121637586

Start: 1908573

End: 1909694

Strand: Direct

Name: fadE16 [H]

Synonym: BCG_1717

Alternate gene names: 121637586

Gene position: 1908573-1909694 (Clockwise)

Preceding gene: 121637585

Following gene: 121637587

Centisome position: 43.63

GC content: 67.47

Gene sequence:

>1122_bases
ATGGCCACACCGGGCGTTGTGCAGGAAGTCGTTTCCGTCGCTGCAGAACACGCCGAGCGGGTCGACACCGACTGTGCTTT
CCCGGCCGAGGCGGTCGACGCCCTCCGCAAGACCGGCCTGCTGGGTCTGGTGCTGCCCCGCGAGATCGGCGGAATGGGTT
CCGGACCAGTGGAATTCACCGAGGTGGTCGCCCAGCTGTCGGCTGCATGTGGATCAACGGCGATGATCTATTTGATGCAC
ATGGCGGCCGCTGTCACGGTAGCCGCGTCGCCTCCGCCGGGTCTGCCGGATCTGTTGGCGGACATGGCTTCCGGAAAACA
ACTTGGCACCTTGGCATTCAGTGAACCGGGTTCTCGTTCGCACTTCTGGGCGCCCGTGTCCACGGCGAGCGCCGACGGTG
ACGGCATCGCGGTGCGGGCCGACAAGAGCTGGGTGACCTCGGCGGGGTTCGCCGACGTCTATGTGGTGTCCGTCGGTTCG
GCCGACGGTGCCGCGGGCGACGTCGACCTCTACGCGGTTCCGGCGGACACACCGGGCCTGCGGGTAGCGGGCACCTTCAC
CGGGATGGGTCTGCGGGGGAATGCCTCCGCGCCAATGGCCGTCGACATTCGCATCCCGGATTCGTATCGTCTCGGGGAGG
CCGGCGGCGGATTCGGCATCATGATGCAAACGGTACTGCCCTGGTTCAATCTCGGAAATGCGGCTGTCTCACTGGGTTTG
GCGACCGCAGCCACCGGTGCCGCGGTCAAGCACGTCGGGACCGCCCGGTTGGAACACCTCGGTGGCAGCCTGGCCGAGCT
GCCCACGATCCGCGCCCAGATCGCTCGGATGGGCACCACGCTGGCCGCGCAAAAGGCGTACCTTGAGGTCGCCGCCAACA
GTGTCAGCTCGCCCGACGACACCACCTTGACCCACGTGCTGGGTGTGAAGGCCTCGGTCAACGACGCCGCGCTGACCATC
ACCGAATCGGCCATGCGGGTGTGCGGCGGGGCCGCGTTCTCCAAGCATCTGCCCATCGAACGCGCCTTCCGCGACGCCCG
GGCGGGGTCGGTGATGGCGCCAACCGCCGACGCGCTCTACGACTTCTACGGCAGGGCCGTCACCGGGCTGCCGCTGTTCT
AG

Upstream 100 bases:

>100_bases
TGTGGCTCGGCGGGACGAACACCACCGCAGCGGTTTTCGTGTGCGCGGCGGTGGTGAGTCTGGCAACCGAATTCCGGATC
GGACGGGTGGAAGGGGCGTG

Downstream 100 bases:

>100_bases
GAGGCGATATGTCAACCGAACCGCTCGTCGTGGGAGCAGTCGCATACACACCCAACGTGGTCCCGATTTGGGAAGGCATC
CGCGGCTACTTCCAAGACTC

Product: putative acyl-CoA dehydrogenase fadE16

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MATPGVVQEVVSVAAEHAERVDTDCAFPAEAVDALRKTGLLGLVLPREIGGMGSGPVEFTEVVAQLSAACGSTAMIYLMH
MAAAVTVAASPPPGLPDLLADMASGKQLGTLAFSEPGSRSHFWAPVSTASADGDGIAVRADKSWVTSAGFADVYVVSVGS
ADGAAGDVDLYAVPADTPGLRVAGTFTGMGLRGNASAPMAVDIRIPDSYRLGEAGGGFGIMMQTVLPWFNLGNAAVSLGL
ATAATGAAVKHVGTARLEHLGGSLAELPTIRAQIARMGTTLAAQKAYLEVAANSVSSPDDTTLTHVLGVKASVNDAALTI
TESAMRVCGGAAFSKHLPIERAFRDARAGSVMAPTADALYDFYGRAVTGLPLF

Sequences:

>Translated_373_residues
MATPGVVQEVVSVAAEHAERVDTDCAFPAEAVDALRKTGLLGLVLPREIGGMGSGPVEFTEVVAQLSAACGSTAMIYLMH
MAAAVTVAASPPPGLPDLLADMASGKQLGTLAFSEPGSRSHFWAPVSTASADGDGIAVRADKSWVTSAGFADVYVVSVGS
ADGAAGDVDLYAVPADTPGLRVAGTFTGMGLRGNASAPMAVDIRIPDSYRLGEAGGGFGIMMQTVLPWFNLGNAAVSLGL
ATAATGAAVKHVGTARLEHLGGSLAELPTIRAQIARMGTTLAAQKAYLEVAANSVSSPDDTTLTHVLGVKASVNDAALTI
TESAMRVCGGAAFSKHLPIERAFRDARAGSVMAPTADALYDFYGRAVTGLPLF
>Mature_372_residues
ATPGVVQEVVSVAAEHAERVDTDCAFPAEAVDALRKTGLLGLVLPREIGGMGSGPVEFTEVVAQLSAACGSTAMIYLMHM
AAAVTVAASPPPGLPDLLADMASGKQLGTLAFSEPGSRSHFWAPVSTASADGDGIAVRADKSWVTSAGFADVYVVSVGSA
DGAAGDVDLYAVPADTPGLRVAGTFTGMGLRGNASAPMAVDIRIPDSYRLGEAGGGFGIMMQTVLPWFNLGNAAVSLGLA
TAATGAAVKHVGTARLEHLGGSLAELPTIRAQIARMGTTLAAQKAYLEVAANSVSSPDDTTLTHVLGVKASVNDAALTIT
ESAMRVCGGAAFSKHLPIERAFRDARAGSVMAPTADALYDFYGRAVTGLPLF

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=355, Percent_Identity=29.5774647887324, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI21361497, Length=371, Percent_Identity=24.7978436657682, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI4501859, Length=340, Percent_Identity=23.8235294117647, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI226958412, Length=377, Percent_Identity=24.4031830238727, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI226958414, Length=349, Percent_Identity=24.6418338108883, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI7656849, Length=346, Percent_Identity=22.5433526011561, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI187960098, Length=359, Percent_Identity=23.6768802228412, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4557231, Length=361, Percent_Identity=24.0997229916898, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4501857, Length=339, Percent_Identity=22.1238938053097, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI76496475, Length=354, Percent_Identity=25.1412429378531, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI4557235, Length=352, Percent_Identity=25.2840909090909, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786223, Length=368, Percent_Identity=25.5434782608696, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=25.7294429708223, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17538396, Length=369, Percent_Identity=27.10027100271, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17508101, Length=326, Percent_Identity=24.2331288343558, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17534899, Length=367, Percent_Identity=25.3405994550409, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17505929, Length=340, Percent_Identity=27.0588235294118, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71985184, Length=375, Percent_Identity=25.0666666666667, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17506239, Length=333, Percent_Identity=24.3243243243243, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17569725, Length=352, Percent_Identity=23.8636363636364, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17570075, Length=369, Percent_Identity=25.7452574525745, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71990804, Length=275, Percent_Identity=23.2727272727273, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71985192, Length=361, Percent_Identity=23.2686980609418, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17551932, Length=335, Percent_Identity=22.9850746268657, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21356377, Length=345, Percent_Identity=24.0579710144928, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24646207, Length=356, Percent_Identity=26.685393258427, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21355753, Length=340, Percent_Identity=25, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24666513, Length=348, Percent_Identity=22.7011494252874, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281363737, Length=375, Percent_Identity=22.6666666666667, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 37876; Mature: 37745

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATPGVVQEVVSVAAEHAERVDTDCAFPAEAVDALRKTGLLGLVLPREIGGMGSGPVEFT
CCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEECHHHCCCCCCCHHHH
EVVAQLSAACGSTAMIYLMHMAAAVTVAASPPPGLPDLLADMASGKQLGTLAFSEPGSRS
HHHHHHHHHCCCHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHCCCEEEEEEECCCCCCC
HFWAPVSTASADGDGIAVRADKSWVTSAGFADVYVVSVGSADGAAGDVDLYAVPADTPGL
EEECCCCCCCCCCCEEEEEECCCHHCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCE
RVAGTFTGMGLRGNASAPMAVDIRIPDSYRLGEAGGGFGIMMQTVLPWFNLGNAAVSLGL
EEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
ATAATGAAVKHVGTARLEHLGGSLAELPTIRAQIARMGTTLAAQKAYLEVAANSVSSPDD
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TTLTHVLGVKASVNDAALTITESAMRVCGGAAFSKHLPIERAFRDARAGSVMAPTADALY
CHHHHHHCCCCCCCCEEEEEEHHHHHHHCCHHHHHCCCHHHHHHHHCCCCEECCCHHHHH
DFYGRAVTGLPLF
HHHCCHHCCCCCC
>Mature Secondary Structure 
ATPGVVQEVVSVAAEHAERVDTDCAFPAEAVDALRKTGLLGLVLPREIGGMGSGPVEFT
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEECHHHCCCCCCCHHHH
EVVAQLSAACGSTAMIYLMHMAAAVTVAASPPPGLPDLLADMASGKQLGTLAFSEPGSRS
HHHHHHHHHCCCHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHCCCEEEEEEECCCCCCC
HFWAPVSTASADGDGIAVRADKSWVTSAGFADVYVVSVGSADGAAGDVDLYAVPADTPGL
EEECCCCCCCCCCCEEEEEECCCHHCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCE
RVAGTFTGMGLRGNASAPMAVDIRIPDSYRLGEAGGGFGIMMQTVLPWFNLGNAAVSLGL
EEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
ATAATGAAVKHVGTARLEHLGGSLAELPTIRAQIARMGTTLAAQKAYLEVAANSVSSPDD
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TTLTHVLGVKASVNDAALTITESAMRVCGGAAFSKHLPIERAFRDARAGSVMAPTADALY
CHHHHHHCCCCCCCCEEEEEEHHHHHHHCCHHHHHCCCHHHHHHHHCCCCEECCCHHHHH
DFYGRAVTGLPLF
HHHCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]