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The map label for this gene is coaE

Identifier: 121637538

GI number: 121637538

Start: 1840260

End: 1841483

Strand: Direct

Name: coaE

Synonym: BCG_1669

Alternate gene names: 121637538

Gene position: 1840260-1841483 (Clockwise)

Preceding gene: 121637537

Following gene: 121637540

Centisome position: 42.07

GC content: 67.16

Gene sequence:

>1224_bases
ATGCTGCGCATCGGGCTGACCGGCGGCATTGGCGCCGGGAAGTCGTTGCTGTCCACGACGTTCTCGCAATGCGGCGGAAT
CGTTGTCGACGGCGATGTGTTGGCGCGTGAAGTGGTCCAGCCGGGCACCGAGGGGCTGGCCTCGCTGGTCGACGCGTTCG
GTCGCGACATCCTGCTTGCAGACGGAGCGCTGGACCGGCAGGCGTTGGCGGCCAAGGCGTTTCGAGATGACGAGTCGCGC
GGTGTGCTCAACGGAATCGTGCACCCGCTGGTCGCCCGGCGCCGATCCGAGATCATCGCGGCGGTTTCGGGGGACGCGGT
TGTGGTCGAAGATATTCCACTGCTGGTGGAATCCGGGATGGCGCCATTGTTTCCGCTGGTGGTGGTGGTGCACGCCGACG
TCGAGCTACGGGTGCGACGGCTGGTCGAGCAACGCGGCATGGCCGAAGCCGACGCCCGGGCTAGGATCGCTGCGCAGGCC
AGCGACCAGCAGCGTCGTGCCGTCGCCGACGTCTGGCTGGACAACTCGGGCAGCCCAGAGGATTTGGTGCGGCGGGCCCG
CGACGTCTGGAACACGCGCGTCCAGCCCTTCGCGCACAACCTGGCCCAACGTCAGATTGCGCGCGCGCCGGCTAGGTTGG
TGCCGGCGGATCCAAGCTGGCCGGATCAGGCGCGGCGCATCGTCAACCGGCTAAAGATCGCGTGCGGGCATAAGGCCTTG
CGAGTTGACCACATTGGGTCAACCGCCGTGTCGGGCTTCCCCGATTTTCTAGCCAAGGATGTCATCGACATCCAGGTCAC
CGTCGAATCACTTGACGTGGCCGACGAGCTGGCCGAGCCCTTGCTGGCCGCCGGCTACCCACGCCTCGAGCACATCACCC
AGGACACCGAAAAGACCGACGCTCGCAGCACCGTCGGCCGCTACGACCACACCGACAGTGCCGCTCTGTGGCACAAGCGC
GTGCACGCCTCGGCGGATCCCGGTCGGCCGACCAACGTGCACCTGCGGGTGCACGGCTGGCCCAACCAACAGTTCGCCCT
GCTGTTCGTCGACTGGCTGGCGGCCAATCCCGGCGCGAGAGAAGACTATTTGACGGTCAAGTGTGACGCCGACAGGCGCG
CCGACGGTGAGCTCGCGCGCTACGTCACCGCCAAGGAGCCGTGGTTCCTGGATGCCTACCAGCGGGCATGGGAGTGGGCG
GATGCGGTGCACTGGCGTCCCTGA

Upstream 100 bases:

>100_bases
AAGACCGCGGGTGGATCACTGGCCAGCGACGCCCAGCTGGCGGCCCTGCGGGAAAAACTCGCCGGCAGCGCTTGATCTTG
CAGCTGATCGCGTTCACGTA

Downstream 100 bases:

>100_bases
ACGAGGGCCTGCCGCACTGGGCGATGACGCCATCGATCGAGCAGGCCGCCCAGCTGTCATCCCCGGCCAGCCTCATCTGA
GGCTTCCAGCTCGGGGGCGC

Product: dephospho-CoA kinase/protein folding accessory domain-containing protein

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MLRIGLTGGIGAGKSLLSTTFSQCGGIVVDGDVLAREVVQPGTEGLASLVDAFGRDILLADGALDRQALAAKAFRDDESR
GVLNGIVHPLVARRRSEIIAAVSGDAVVVEDIPLLVESGMAPLFPLVVVVHADVELRVRRLVEQRGMAEADARARIAAQA
SDQQRRAVADVWLDNSGSPEDLVRRARDVWNTRVQPFAHNLAQRQIARAPARLVPADPSWPDQARRIVNRLKIACGHKAL
RVDHIGSTAVSGFPDFLAKDVIDIQVTVESLDVADELAEPLLAAGYPRLEHITQDTEKTDARSTVGRYDHTDSAALWHKR
VHASADPGRPTNVHLRVHGWPNQQFALLFVDWLAANPGAREDYLTVKCDADRRADGELARYVTAKEPWFLDAYQRAWEWA
DAVHWRP

Sequences:

>Translated_407_residues
MLRIGLTGGIGAGKSLLSTTFSQCGGIVVDGDVLAREVVQPGTEGLASLVDAFGRDILLADGALDRQALAAKAFRDDESR
GVLNGIVHPLVARRRSEIIAAVSGDAVVVEDIPLLVESGMAPLFPLVVVVHADVELRVRRLVEQRGMAEADARARIAAQA
SDQQRRAVADVWLDNSGSPEDLVRRARDVWNTRVQPFAHNLAQRQIARAPARLVPADPSWPDQARRIVNRLKIACGHKAL
RVDHIGSTAVSGFPDFLAKDVIDIQVTVESLDVADELAEPLLAAGYPRLEHITQDTEKTDARSTVGRYDHTDSAALWHKR
VHASADPGRPTNVHLRVHGWPNQQFALLFVDWLAANPGAREDYLTVKCDADRRADGELARYVTAKEPWFLDAYQRAWEWA
DAVHWRP
>Mature_407_residues
MLRIGLTGGIGAGKSLLSTTFSQCGGIVVDGDVLAREVVQPGTEGLASLVDAFGRDILLADGALDRQALAAKAFRDDESR
GVLNGIVHPLVARRRSEIIAAVSGDAVVVEDIPLLVESGMAPLFPLVVVVHADVELRVRRLVEQRGMAEADARARIAAQA
SDQQRRAVADVWLDNSGSPEDLVRRARDVWNTRVQPFAHNLAQRQIARAPARLVPADPSWPDQARRIVNRLKIACGHKAL
RVDHIGSTAVSGFPDFLAKDVIDIQVTVESLDVADELAEPLLAAGYPRLEHITQDTEKTDARSTVGRYDHTDSAALWHKR
VHASADPGRPTNVHLRVHGWPNQQFALLFVDWLAANPGAREDYLTVKCDADRRADGELARYVTAKEPWFLDAYQRAWEWA
DAVHWRP

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=180, Percent_Identity=36.6666666666667, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI191252795, Length=180, Percent_Identity=36.6666666666667, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI110227607, Length=189, Percent_Identity=33.8624338624339, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI110227605, Length=190, Percent_Identity=34.7368421052632, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI110227603, Length=190, Percent_Identity=34.7368421052632, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI110227601, Length=190, Percent_Identity=34.7368421052632, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI205277394, Length=190, Percent_Identity=34.7368421052632, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI1786292, Length=177, Percent_Identity=35.5932203389831, Blast_Score=112, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17554944, Length=193, Percent_Identity=34.1968911917098, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320402, Length=203, Percent_Identity=34.4827586206897, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24644728, Length=194, Percent_Identity=32.9896907216495, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24658602, Length=192, Percent_Identity=30.7291666666667, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_MYCBO (P63827)

Other databases:

- EMBL:   BX248339
- RefSeq:   NP_855310.1
- ProteinModelPortal:   P63827
- SMR:   P63827
- EnsemblBacteria:   EBMYCT00000017852
- GeneID:   1092595
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1657
- GeneTree:   EBGT00050000016455
- HOGENOM:   HBG650290
- OMA:   RVDGWPG
- ProtClustDB:   PRK03333
- BioCyc:   MBOV233413:MB1657-MONOMER
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- InterPro:   IPR007344
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE; PF04229 UPF0157

EC number: =2.7.1.24

Molecular weight: Translated: 44669; Mature: 44669

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIGLTGGIGAGKSLLSTTFSQCGGIVVDGDVLAREVVQPGTEGLASLVDAFGRDILLA
CEEEEECCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHCCCHHHHHHHHHHCCCCEEEE
DGALDRQALAAKAFRDDESRGVLNGIVHPLVARRRSEIIAAVSGDAVVVEDIPLLVESGM
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCEEEEECCHHHHHCCC
APLFPLVVVVHADVELRVRRLVEQRGMAEADARARIAAQASDQQRRAVADVWLDNSGSPE
CHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHEECCCCCHH
DLVRRARDVWNTRVQPFAHNLAQRQIARAPARLVPADPSWPDQARRIVNRLKIACGHKAL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEE
RVDHIGSTAVSGFPDFLAKDVIDIQVTVESLDVADELAEPLLAAGYPRLEHITQDTEKTD
EEECCCCHHHCCCHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHH
ARSTVGRYDHTDSAALWHKRVHASADPGRPTNVHLRVHGWPNQQFALLFVDWLAANPGAR
HHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEEEEEEEHHHCCCCCC
EDYLTVKCDADRRADGELARYVTAKEPWFLDAYQRAWEWADAVHWRP
CCEEEEEECCCCCCCCHHHHHEECCCCEEHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLRIGLTGGIGAGKSLLSTTFSQCGGIVVDGDVLAREVVQPGTEGLASLVDAFGRDILLA
CEEEEECCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHCCCHHHHHHHHHHCCCCEEEE
DGALDRQALAAKAFRDDESRGVLNGIVHPLVARRRSEIIAAVSGDAVVVEDIPLLVESGM
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCEEEEECCHHHHHCCC
APLFPLVVVVHADVELRVRRLVEQRGMAEADARARIAAQASDQQRRAVADVWLDNSGSPE
CHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHEECCCCCHH
DLVRRARDVWNTRVQPFAHNLAQRQIARAPARLVPADPSWPDQARRIVNRLKIACGHKAL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEE
RVDHIGSTAVSGFPDFLAKDVIDIQVTVESLDVADELAEPLLAAGYPRLEHITQDTEKTD
EEECCCCHHHCCCHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHH
ARSTVGRYDHTDSAALWHKRVHASADPGRPTNVHLRVHGWPNQQFALLFVDWLAANPGAR
HHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEEEEEEEHHHCCCCCC
EDYLTVKCDADRRADGELARYVTAKEPWFLDAYQRAWEWADAVHWRP
CCEEEEEECCCCCCCCHHHHHEECCCCEEHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972