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The map label for this gene is uvrB [H]

Identifier: 121637540

GI number: 121637540

Start: 1842322

End: 1844418

Strand: Direct

Name: uvrB [H]

Synonym: BCG_1671

Alternate gene names: 121637540

Gene position: 1842322-1844418 (Clockwise)

Preceding gene: 121637538

Following gene: 121637541

Centisome position: 42.11

GC content: 66.05

Gene sequence:

>2097_bases
GTGCGCGCCGGCGGTCACTTCGAGGTGGTCAGTCCGCATGCTCCGGCCGGCGACCAGCCGGCCGCAATCGACGAGCTGGA
GCGGCGGATCAACGCGGGGGAGCGTGACGTGGTGTTGCTCGGCGCCACCGGCACCGGGAAGTCGGCGACCACCGCGTGGC
TGATCGAACGCCTGCAGCGGCCCACCCTGGTGATGGCGCCCAACAAGACGTTGGCCGCCCAGCTGGCGAACGAACTGCGA
GAGATGTTGCCGCACAACGCCGTCGAGTACTTCGTCTCGTACTACGACTACTACCAGCCGGAGGCGTATATCGCGCAGAC
CGACACTTATATCGAAAAGGATAGCTCCATCAACGACGACGTGGAGCGGCTGCGGCACTCCGCGACCTCGGCGCTGCTGT
CGCGTCGTGACGTGGTGGTGGTGGCTTCGGTGTCCTGCATCTACGGCCTGGGCACACCGCAGTCCTACCTGGACCGCTCC
GTCGAGCTGAAGGTGGGCGAGGAAGTGCCGCGCGATGGGCTGCTGCGGCTGCTGGTCGACGTGCAATACACCCGAAACGA
CATGTCCTTTACTCGCGGCTCGTTTCGGGTGCGCGGCGACACCGTCGAGATCATCCCCTCCTACGAAGAGCTGGCGGTTC
GCATCGAGTTCTTCGGCGACGAGATCGAGGCGCTGTACTATCTGCACCCGCTGACCGGCGAGGTTATCCGCCAGGTCGAC
TCGCTGCGGATCTTTCCCGCTACCCATTACGTCGCCGGTCCGGAGCGGATGGCGCATGCCGTCTCGGCCATCGAGGAAGA
ACTCGCCGAGCGACTCGCCGAGCTTGAGAGCCAGGGCAAGCTGCTGGAGGCGCAGCGGCTGCGGATGCGCACCAACTACG
ACATCGAAATGATGCGGCAGGTCGGGTTCTGCTCGGGCATCGAGAACTACTCCCGCCACATCGACGGTAGGGGGCCCGGC
ACGCCGCCCGCGACCCTGCTCGACTATTTCCCCGAGGATTTCCTGCTCGTTATCGACGAGTCACATGTCACCGTGCCGCA
GATCGGCGGCATGTACGAGGGCGACATCTCCCGCAAGCGCAACCTGGTGGAGTACGGTTTCCGGCTGCCGTCGGCGTGCG
ACAACCGTCCGCTGACCTGGGAGGAGTTCGCTGACCGGATCGGGCAGACGGTGTATCTGTCTGCCACCCCGGGGCCCTAC
GAGCTCAGCCAGTCCGGCGGCGAGTTCGTCGAGCAGGTGATCCGGCCGACCGGTCTGGTGGACCCGAAAGTGGTAGTCAA
GCCGACCAAAGGGCAGATCGACGACCTGATCGGCGAGATCCGCACACGGGCAGACGCCGACCAGCGGGTGCTGGTGACGA
CGCTGACCAAGAAGATGGCCGAAGACCTCACCGACTACCTGCTGGAGATGGGCATTCGGGTGCGCTACCTGCATTCGGAG
GTCGACACGTTGCGCCGGGTCGAGTTGTTGCGCCAGCTGCGTCTGGGTGACTACGACGTGCTGGTCGGCATCAACCTGCT
CCGCGAGGGCCTAGACCTGCCCGAGGTGTCGCTGGTGGCGATCCTCGACGCCGACAAAGAAGGATTCCTGCGGTCAAGCC
GCAGCCTGATCCAGACCATCGGACGCGCCGCTCGCAACGTGTCCGGCGAGGTGCACATGTACGCCGACAAAATCACCGAC
TCGATGAGGGAAGCCATCGACGAGACCGAACGCCGGCGGGCCAAGCAGATCGCCTACAACGAGGCCAACGGAATCGACCC
ACAGCCGCTGCGCAAAAAGATCGCCGACATCCTCGATCAGGTCTATCGGGAGGCCGACGACACCGCCGTCGTCGAGGTCG
GCGGATCCGGGCGCAACGCATCCCGCGGCCGGCGGGCTCAGGGTGAGCCCGGCCGGGCGGTCAGCGCCGGCGTGTTCGAG
GGCCGCGACACCTCCGCCATGCCGCGCGCTGAGCTGGCCGACCTAATCAAAGACCTCACCGCACAGATGATGGCGGCCGC
GCGCGACCTGCAGTTCGAGCTGGCGGCCCGGTTCCGCGACGAGATCGCCGACCTCAAGCGGGAGCTGCGGGGGATGGACG
CGGCCGGCCTGAAGTGA

Upstream 100 bases:

>100_bases
GCACGGTGTGTCCGCGGGTGGCTCTAGGCTGGTTGGCGTGGCTTTCGCTACCGAGCATCCGGTGGTCGCGCATTCGGAGT
ATCGCGCGGTCGAGGAGATT

Downstream 100 bases:

>100_bases
CCGAAACAGCGAGCGAGACCGGCAGCTGGCGTCAGCTACTGAGCAGGTATCTGGGCACCTCCATAGTGCTGGCCGGTGGC
GTCGCGCTGTACGCCACCAA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 698; Mature: 698

Protein sequence:

>698_residues
MRAGGHFEVVSPHAPAGDQPAAIDELERRINAGERDVVLLGATGTGKSATTAWLIERLQRPTLVMAPNKTLAAQLANELR
EMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSALLSRRDVVVVASVSCIYGLGTPQSYLDRS
VELKVGEEVPRDGLLRLLVDVQYTRNDMSFTRGSFRVRGDTVEIIPSYEELAVRIEFFGDEIEALYYLHPLTGEVIRQVD
SLRIFPATHYVAGPERMAHAVSAIEEELAERLAELESQGKLLEAQRLRMRTNYDIEMMRQVGFCSGIENYSRHIDGRGPG
TPPATLLDYFPEDFLLVIDESHVTVPQIGGMYEGDISRKRNLVEYGFRLPSACDNRPLTWEEFADRIGQTVYLSATPGPY
ELSQSGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIGEIRTRADADQRVLVTTLTKKMAEDLTDYLLEMGIRVRYLHSE
VDTLRRVELLRQLRLGDYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSSRSLIQTIGRAARNVSGEVHMYADKITD
SMREAIDETERRRAKQIAYNEANGIDPQPLRKKIADILDQVYREADDTAVVEVGGSGRNASRGRRAQGEPGRAVSAGVFE
GRDTSAMPRAELADLIKDLTAQMMAAARDLQFELAARFRDEIADLKRELRGMDAAGLK

Sequences:

>Translated_698_residues
MRAGGHFEVVSPHAPAGDQPAAIDELERRINAGERDVVLLGATGTGKSATTAWLIERLQRPTLVMAPNKTLAAQLANELR
EMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSALLSRRDVVVVASVSCIYGLGTPQSYLDRS
VELKVGEEVPRDGLLRLLVDVQYTRNDMSFTRGSFRVRGDTVEIIPSYEELAVRIEFFGDEIEALYYLHPLTGEVIRQVD
SLRIFPATHYVAGPERMAHAVSAIEEELAERLAELESQGKLLEAQRLRMRTNYDIEMMRQVGFCSGIENYSRHIDGRGPG
TPPATLLDYFPEDFLLVIDESHVTVPQIGGMYEGDISRKRNLVEYGFRLPSACDNRPLTWEEFADRIGQTVYLSATPGPY
ELSQSGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIGEIRTRADADQRVLVTTLTKKMAEDLTDYLLEMGIRVRYLHSE
VDTLRRVELLRQLRLGDYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSSRSLIQTIGRAARNVSGEVHMYADKITD
SMREAIDETERRRAKQIAYNEANGIDPQPLRKKIADILDQVYREADDTAVVEVGGSGRNASRGRRAQGEPGRAVSAGVFE
GRDTSAMPRAELADLIKDLTAQMMAAARDLQFELAARFRDEIADLKRELRGMDAAGLK
>Mature_698_residues
MRAGGHFEVVSPHAPAGDQPAAIDELERRINAGERDVVLLGATGTGKSATTAWLIERLQRPTLVMAPNKTLAAQLANELR
EMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSALLSRRDVVVVASVSCIYGLGTPQSYLDRS
VELKVGEEVPRDGLLRLLVDVQYTRNDMSFTRGSFRVRGDTVEIIPSYEELAVRIEFFGDEIEALYYLHPLTGEVIRQVD
SLRIFPATHYVAGPERMAHAVSAIEEELAERLAELESQGKLLEAQRLRMRTNYDIEMMRQVGFCSGIENYSRHIDGRGPG
TPPATLLDYFPEDFLLVIDESHVTVPQIGGMYEGDISRKRNLVEYGFRLPSACDNRPLTWEEFADRIGQTVYLSATPGPY
ELSQSGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIGEIRTRADADQRVLVTTLTKKMAEDLTDYLLEMGIRVRYLHSE
VDTLRRVELLRQLRLGDYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSSRSLIQTIGRAARNVSGEVHMYADKITD
SMREAIDETERRRAKQIAYNEANGIDPQPLRKKIADILDQVYREADDTAVVEVGGSGRNASRGRRAQGEPGRAVSAGVFE
GRDTSAMPRAELADLIKDLTAQMMAAARDLQFELAARFRDEIADLKRELRGMDAAGLK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=682, Percent_Identity=56.4516129032258, Blast_Score=739, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=226, Percent_Identity=23.8938053097345, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 78057; Mature: 78057

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAGGHFEVVSPHAPAGDQPAAIDELERRINAGERDVVLLGATGTGKSATTAWLIERLQR
CCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHCC
PTLVMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDD
CEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCCCCHH
VERLRHSATSALLSRRDVVVVASVSCIYGLGTPQSYLDRSVELKVGEEVPRDGLLRLLVD
HHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHCCCEEEEECCCCCHHHHHHHHHH
VQYTRNDMSFTRGSFRVRGDTVEIIPSYEELAVRIEFFGDEIEALYYLHPLTGEVIRQVD
HHHHCCCCCCCCCCEEECCCEEEECCCHHHHEEEEEECCCCEEEEEEECCCHHHHHHHHH
SLRIFPATHYVAGPERMAHAVSAIEEELAERLAELESQGKLLEAQRLRMRTNYDIEMMRQ
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHH
VGFCSGIENYSRHIDGRGPGTPPATLLDYFPEDFLLVIDESHVTVPQIGGMYEGDISRKR
HHHHHCHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHHH
NLVEYGFRLPSACDNRPLTWEEFADRIGQTVYLSATPGPYELSQSGGEFVEQVIRPTGLV
HHHHHHCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCHHHCCHHHHHHHHHCCCCCC
DPKVVVKPTKGQIDDLIGEIRTRADADQRVLVTTLTKKMAEDLTDYLLEMGIRVRYLHSE
CCCEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHH
VDTLRRVELLRQLRLGDYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSSRSLIQTI
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHH
GRAARNVSGEVHMYADKITDSMREAIDETERRRAKQIAYNEANGIDPQPLRKKIADILDQ
HHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
VYREADDTAVVEVGGSGRNASRGRRAQGEPGRAVSAGVFEGRDTSAMPRAELADLIKDLT
HHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHH
AQMMAAARDLQFELAARFRDEIADLKRELRGMDAAGLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRAGGHFEVVSPHAPAGDQPAAIDELERRINAGERDVVLLGATGTGKSATTAWLIERLQR
CCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHCC
PTLVMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDD
CEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCCCCHH
VERLRHSATSALLSRRDVVVVASVSCIYGLGTPQSYLDRSVELKVGEEVPRDGLLRLLVD
HHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHCCCEEEEECCCCCHHHHHHHHHH
VQYTRNDMSFTRGSFRVRGDTVEIIPSYEELAVRIEFFGDEIEALYYLHPLTGEVIRQVD
HHHHCCCCCCCCCCEEECCCEEEECCCHHHHEEEEEECCCCEEEEEEECCCHHHHHHHHH
SLRIFPATHYVAGPERMAHAVSAIEEELAERLAELESQGKLLEAQRLRMRTNYDIEMMRQ
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHH
VGFCSGIENYSRHIDGRGPGTPPATLLDYFPEDFLLVIDESHVTVPQIGGMYEGDISRKR
HHHHHCHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHHH
NLVEYGFRLPSACDNRPLTWEEFADRIGQTVYLSATPGPYELSQSGGEFVEQVIRPTGLV
HHHHHHCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCHHHCCHHHHHHHHHCCCCCC
DPKVVVKPTKGQIDDLIGEIRTRADADQRVLVTTLTKKMAEDLTDYLLEMGIRVRYLHSE
CCCEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHH
VDTLRRVELLRQLRLGDYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSSRSLIQTI
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHH
GRAARNVSGEVHMYADKITDSMREAIDETERRRAKQIAYNEANGIDPQPLRKKIADILDQ
HHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
VYREADDTAVVEVGGSGRNASRGRRAQGEPGRAVSAGVFEGRDTSAMPRAELADLIKDLT
HHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHH
AQMMAAARDLQFELAARFRDEIADLKRELRGMDAAGLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA