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The map label for this gene is trpE

Identifier: 121637516

GI number: 121637516

Start: 1813150

End: 1814700

Strand: Direct

Name: trpE

Synonym: BCG_1647

Alternate gene names: 121637516

Gene position: 1813150-1814700 (Clockwise)

Preceding gene: 121637514

Following gene: 121637517

Centisome position: 41.45

GC content: 65.38

Gene sequence:

>1551_bases
GTGCACGCCGACCTCGCAGCCACCACCTCGCGTGAGGATTTCCGCCTCCTGGCGGCCGAGCACCGGGTGGTTCCGGTGAC
TCGCAAGGTCTTGGCCGACAGCGAGACGCCGCTGTCGGCCTACCGCAAGCTCGCCGCCAATCGCCCGGGTACGTTCCTGC
TGGAGTCGGCCGAGAACGGCCGGTCGTGGTCGCGATGGTCGTTTATCGGTGCGGGGGCGCCAACGGCGTTGACCGTGCGT
GAGGGGCAAGCGGTATGGCTGGGTGCCGTGCCCAAGGACGCTCCCACTGGCGGAGACCCGCTGCGGGCGCTGCAGGTGAC
CTTGGAGCTGCTGGCTACGGCGGATCGTCAGTCCGAGCCGGGTCTTCCGCCGCTGTCGGGTGGCATGGTCGGTTTCTTCG
CCTATGACATGGTGCGACGGCTGGAACGATTGCCGGAACGGGCCGTCGATGACCTCTGCCTGCCGGACATGCTGCTGTTG
CTGGCCACCGATGTGGCGGCGGTCGATCACCACGAGGGCACCATCACGTTGATCGCCAACGCCGTGAACTGGAACGGCAC
CGACGAGCGGGTCGACTGGGCCTACGACGACGCGGTCGCTCGGCTGGACGTGATGACCGCAGCGCTCGGCCAACCACTAC
CGTCAACCGTGGCCACCTTCAGCCGACCCGAGCCGCGCCACCGTGCGCAACGCACCGTCGAAGAATATGGTGCGATCGTC
GAATACTTGGTGGATCAGATTGCAGCCGGTGAAGCGTTCCAGGTGGTGCCCTCGCAGCGCTTCGAGATGGACACCGATGT
CGATCCCATCGACGTGTACCGAATTCTGCGGGTAACCAACCCAAGTCCCTACATGTATCTACTGCAGGTGCCGAATAGTG
ATGGTGCAGTGGACTTTTCGATTGTTGGATCCAGTCCGGAGGCGCTGGTAACGGTCCACGAAGGCTGGGCGACGACGCAT
CCGATCGCCGGAACCCGGTGGCGCGGAAGGACAGACGACGAGGACGTGCTTCTGGAAAAAGAGCTGCTGGCGGACGACAA
AGAACGTGCCGAGCATCTGATGCTGGTCGACCTCGGCCGAAACGACCTGGGTCGGGTCTGCACGCCGGGCACTGTTCGGG
TCGAGGATTACAGCCACATCGAGCGGTACAGCCACGTGATGCACCTGGTGTCCACGGTGACCGGGAAGCTCGGCGAAGGG
CGCACCGCGCTGGACGCGGTGACCGCCTGCTTTCCGGCCGGCACGCTGTCGGGCGCGCCGAAGGTGCGGGCGATGGAGCT
GATCGAAGAGGTGGAGAAGACACGCCGCGGCCTTTACGGCGGTGTCGTCGGTTACCTTGACTTCGCCGGCAACGCTGACT
TCGCCATCGCCATCCGCACCGCGCTGATGCGTAACGGCACGGCTTATGTCCAGGCAGGCGGTGGTGTGGTGGCCGACTCC
AACGGATCCTACGAATACAACGAGGCGAGGAACAAGGCTCGGGCTGTGCTCAACGCGATCGCTGCCGCCGAGACGCTGGC
CGCTCCGGGCGCGAACCGCAGTGGCTGCTAA

Upstream 100 bases:

>100_bases
CGCTTCGCGGCTGGGGGTGCCCCCATGCGCGCCGTTTGCGCGGCGTGCATCGTCGTCGGGCTACGCCCGGGCCGATCGGC
GTATCTGGGAAGATGGTTCG

Downstream 100 bases:

>100_bases
TGCCGGCAGTGTTCGGCCCAACCGCCGGGCCAGGCCGATGATCGGCATCGCCCAGTTGCTGTTGGTGGTTGCCGCCGGGG
CGCTGTGGATGGCCGCACGG

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MHADLAATTSREDFRLLAAEHRVVPVTRKVLADSETPLSAYRKLAANRPGTFLLESAENGRSWSRWSFIGAGAPTALTVR
EGQAVWLGAVPKDAPTGGDPLRALQVTLELLATADRQSEPGLPPLSGGMVGFFAYDMVRRLERLPERAVDDLCLPDMLLL
LATDVAAVDHHEGTITLIANAVNWNGTDERVDWAYDDAVARLDVMTAALGQPLPSTVATFSRPEPRHRAQRTVEEYGAIV
EYLVDQIAAGEAFQVVPSQRFEMDTDVDPIDVYRILRVTNPSPYMYLLQVPNSDGAVDFSIVGSSPEALVTVHEGWATTH
PIAGTRWRGRTDDEDVLLEKELLADDKERAEHLMLVDLGRNDLGRVCTPGTVRVEDYSHIERYSHVMHLVSTVTGKLGEG
RTALDAVTACFPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVVGYLDFAGNADFAIAIRTALMRNGTAYVQAGGGVVADS
NGSYEYNEARNKARAVLNAIAAAETLAAPGANRSGC

Sequences:

>Translated_516_residues
MHADLAATTSREDFRLLAAEHRVVPVTRKVLADSETPLSAYRKLAANRPGTFLLESAENGRSWSRWSFIGAGAPTALTVR
EGQAVWLGAVPKDAPTGGDPLRALQVTLELLATADRQSEPGLPPLSGGMVGFFAYDMVRRLERLPERAVDDLCLPDMLLL
LATDVAAVDHHEGTITLIANAVNWNGTDERVDWAYDDAVARLDVMTAALGQPLPSTVATFSRPEPRHRAQRTVEEYGAIV
EYLVDQIAAGEAFQVVPSQRFEMDTDVDPIDVYRILRVTNPSPYMYLLQVPNSDGAVDFSIVGSSPEALVTVHEGWATTH
PIAGTRWRGRTDDEDVLLEKELLADDKERAEHLMLVDLGRNDLGRVCTPGTVRVEDYSHIERYSHVMHLVSTVTGKLGEG
RTALDAVTACFPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVVGYLDFAGNADFAIAIRTALMRNGTAYVQAGGGVVADS
NGSYEYNEARNKARAVLNAIAAAETLAAPGANRSGC
>Mature_516_residues
MHADLAATTSREDFRLLAAEHRVVPVTRKVLADSETPLSAYRKLAANRPGTFLLESAENGRSWSRWSFIGAGAPTALTVR
EGQAVWLGAVPKDAPTGGDPLRALQVTLELLATADRQSEPGLPPLSGGMVGFFAYDMVRRLERLPERAVDDLCLPDMLLL
LATDVAAVDHHEGTITLIANAVNWNGTDERVDWAYDDAVARLDVMTAALGQPLPSTVATFSRPEPRHRAQRTVEEYGAIV
EYLVDQIAAGEAFQVVPSQRFEMDTDVDPIDVYRILRVTNPSPYMYLLQVPNSDGAVDFSIVGSSPEALVTVHEGWATTH
PIAGTRWRGRTDDEDVLLEKELLADDKERAEHLMLVDLGRNDLGRVCTPGTVRVEDYSHIERYSHVMHLVSTVTGKLGEG
RTALDAVTACFPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVVGYLDFAGNADFAIAIRTALMRNGTAYVQAGGGVVADS
NGSYEYNEARNKARAVLNAIAAAETLAAPGANRSGC

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family

Homologues:

Organism=Escherichia coli, GI1787518, Length=381, Percent_Identity=44.3569553805774, Blast_Score=285, Evalue=7e-78,
Organism=Escherichia coli, GI1788114, Length=461, Percent_Identity=33.1887201735358, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1786809, Length=309, Percent_Identity=29.4498381877023, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI87082077, Length=302, Percent_Identity=24.8344370860927, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320935, Length=486, Percent_Identity=39.5061728395062, Blast_Score=297, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6324361, Length=401, Percent_Identity=23.1920199501247, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPE_MYCBO (P67002)

Other databases:

- EMBL:   BX248339
- RefSeq:   NP_855288.1
- ProteinModelPortal:   P67002
- SMR:   P67002
- EnsemblBacteria:   EBMYCT00000016585
- GeneID:   1092566
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1635
- GeneTree:   EBGT00050000015088
- HOGENOM:   HBG507440
- OMA:   DRPGTFL
- ProtClustDB:   PRK13571
- BioCyc:   MBOV233413:MB1635-MONOMER
- BRENDA:   4.1.3.27
- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890
- Gene3D:   G3DSA:3.60.120.10
- PANTHER:   PTHR11236
- PRINTS:   PR00095
- TIGRFAMs:   TIGR00564

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind; SSF56322 TRPE_1_chor_bd

EC number: =4.1.3.27

Molecular weight: Translated: 55850; Mature: 55850

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHADLAATTSREDFRLLAAEHRVVPVTRKVLADSETPLSAYRKLAANRPGTFLLESAENG
CCCCCCCCCCCHHHHHHHHCCCEEHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEECCCCC
RSWSRWSFIGAGAPTALTVREGQAVWLGAVPKDAPTGGDPLRALQVTLELLATADRQSEP
CCCCCEEEEECCCCCEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
GLPPLSGGMVGFFAYDMVRRLERLPERAVDDLCLPDMLLLLATDVAAVDHHEGTITLIAN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEEE
AVNWNGTDERVDWAYDDAVARLDVMTAALGQPLPSTVATFSRPEPRHRAQRTVEEYGAIV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHH
EYLVDQIAAGEAFQVVPSQRFEMDTDVDPIDVYRILRVTNPSPYMYLLQVPNSDGAVDFS
HHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHEEEEEECCCCCEEEEEEECCCCCCEEEE
IVGSSPEALVTVHEGWATTHPIAGTRWRGRTDDEDVLLEKELLADDKERAEHLMLVDLGR
EECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHCCEEEEEECCC
NDLGRVCTPGTVRVEDYSHIERYSHVMHLVSTVTGKLGEGRTALDAVTACFPAGTLSGAP
CCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCC
KVRAMELIEEVEKTRRGLYGGVVGYLDFAGNADFAIAIRTALMRNGTAYVQAGGGVVADS
CHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHHHHCCCEEEEECCCEEECC
NGSYEYNEARNKARAVLNAIAAAETLAAPGANRSGC
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MHADLAATTSREDFRLLAAEHRVVPVTRKVLADSETPLSAYRKLAANRPGTFLLESAENG
CCCCCCCCCCCHHHHHHHHCCCEEHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEECCCCC
RSWSRWSFIGAGAPTALTVREGQAVWLGAVPKDAPTGGDPLRALQVTLELLATADRQSEP
CCCCCEEEEECCCCCEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
GLPPLSGGMVGFFAYDMVRRLERLPERAVDDLCLPDMLLLLATDVAAVDHHEGTITLIAN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEEE
AVNWNGTDERVDWAYDDAVARLDVMTAALGQPLPSTVATFSRPEPRHRAQRTVEEYGAIV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHH
EYLVDQIAAGEAFQVVPSQRFEMDTDVDPIDVYRILRVTNPSPYMYLLQVPNSDGAVDFS
HHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHEEEEEECCCCCEEEEEEECCCCCCEEEE
IVGSSPEALVTVHEGWATTHPIAGTRWRGRTDDEDVLLEKELLADDKERAEHLMLVDLGR
EECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHCCEEEEEECCC
NDLGRVCTPGTVRVEDYSHIERYSHVMHLVSTVTGKLGEGRTALDAVTACFPAGTLSGAP
CCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCC
KVRAMELIEEVEKTRRGLYGGVVGYLDFAGNADFAIAIRTALMRNGTAYVQAGGGVVADS
CHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHHHHCCCEEEEECCCEEECC
NGSYEYNEARNKARAVLNAIAAAETLAAPGANRSGC
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972