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The map label for this gene is frdA

Identifier: 121637473

GI number: 121637473

Start: 1770013

End: 1771764

Strand: Direct

Name: frdA

Synonym: BCG_1604

Alternate gene names: 121637473

Gene position: 1770013-1771764 (Clockwise)

Preceding gene: 121637472

Following gene: 121637474

Centisome position: 40.46

GC content: 63.36

Gene sequence:

>1752_bases
ATGACCGCCCAACACAACATCGTGGTTATCGGCGGCGGTGGTGCGGGTCTGCGCGCCGCGATTGCGATAGCCGAAACCAA
TCCGCACCTGGATGTGGCGATCGTTTCCAAGGTGTACCCGATGCGCAGCCACACCGTCTCGGCTGAGGGCGGCGCCGCGG
CGGTGACCGGTGACGACGACAGCCTCGATGAACACGCGCACGACACGGTATCCGGTGGCGACTGGCTGTGTGACCAAGAT
GCGGTCGAGGCTTTCGTGGCCGAGGCGCCCAAAGAGTTGGTGCAGCTCGAGCATTGGGGCTGTCCGTGGAGCCGTAAACC
AGACGGGCGCGTTGCCGTTCGCCCGTTCGGCGGGATGAAGAAGCTGCGCACCTGGTTTGCCGCCGACAAGACGGGATTTC
ACCTCCTGCACACGTTGTTTCAACGGCTGCTCACCTATTCCGACGTCATGCGCTATGACGAGTGGTTCGCTACGACGCTG
CTGGTCGACGACGGCAGGGTATGTGGTCTGGTCGCTATCGAGTTGGCGACCGGGCGCATCGAGACGATCCTTGCCGACGC
GGTGATTCTGTGCACCGGCGGATGCGGGCGGGTATTTCCATTCACCACCAACGCGAACATCAAGACCGGCGACGGCATGG
CGCTCGCATTCCGCGCGGGCGCGCCCCTAAAAGACATGGAATTCGTCCAATACCACCCCACCGGACTGCCGTTCACCGGG
ATCTTGATCACCGAGGCCGCACGAGCTGAAGGCGGCTGGCTGCTCAACAAAGACGGCTACCGCTACCTCCAGGATTACGA
CCTCGGCAAGCCCACGCCCGAGCCCAGGCTGCGCAGTATGGAGCTCGGGCCCAGGGACCGACTGTCGCAGGCCTTCGTAC
ACGAGCACAACAAAGGAAGGACGGTCGACACCCCGTACGGCCCCGTCGTCTATCTAGACCTGCGGCACCTGGGGGCGGAC
CTGATCGATGCAAAGTTGCCGTTCGTACGTGAGCTGTGCCGCGACTACCAGCACATCGACCCCGTGGTCGAATTGGTCCC
GGTACGACCGGTAGTGCACTACATGATGGGTGGCGTTCACACCGATATCAACGGCGCCACAACGCTTCCCGGGCTATATG
CCGCAGGTGAAACAGCCTGCGTGAGCATTAATGGCGCCAACCGCCTGGGGTCGAACTCGCTGCCCGAGCTGCTGGTGTTC
GGGGCTCGAGCGGGCCGTGCCGCCGCGGATTACGCAGCGCGCCACCAAAAGTCGGACCGTGGCCCGTCGTCGGCAGTGCG
GGCTCAGGCCCGCACCGAGGCTCTACGGCTAGAGCGTGAGCTCAGCCGCCATGGCCAGGGAGGCGAACGAATCGCGGATA
TTCGGGCGGACATGCAGGCCACCTTGGAAAGCGCCGCGGGTATTTATCGTGACGGACCCACCCTCACCAAAGCGGTCGAG
GAGATTCGGGTGCTGCAGGAACGATTCGCCACGGCGGGCATCGACGATCACAGCCGCACATTCAACACCGAGCTGACTGC
GCTGCTCGAGTTGTCGGGGATGCTCGACGTTGCACTGGCGATCGTCGAATCTGGTTTGCGCCGAGAAGAATCCCGTGGCG
CACACCAGCGAACCGACTTTCCGAACCGGGACGACGAGCATTTCTTGGCGCACACCTTGGTTCATAGAGAAAGCGACGGA
ACGCTGCGGGTCGGCTACCTTCCGGTCACTATCACTCGCTGGCCACCGGGCGAACGCGTGTATGGGAGGTAA

Upstream 100 bases:

>100_bases
TTTCTACCACGACGGATCCATGCGGGTACGCACGATTCGACACGACGGCAAGGTGTTGAAGGACGAGCACAGCGGCGATC
ACGAAGCGTGAACCAGCGCG

Downstream 100 bases:

>100_bases
GGATGATGGATCGAATTGTCATGGAGGTCTCCCGGTATCGGCCCGAGATCGAATCGGCCCCGACATTTCAGGCCTACGAG
GTTCCCCTCACCCGCGAATG

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 583; Mature: 582

Protein sequence:

>583_residues
MTAQHNIVVIGGGGAGLRAAIAIAETNPHLDVAIVSKVYPMRSHTVSAEGGAAAVTGDDDSLDEHAHDTVSGGDWLCDQD
AVEAFVAEAPKELVQLEHWGCPWSRKPDGRVAVRPFGGMKKLRTWFAADKTGFHLLHTLFQRLLTYSDVMRYDEWFATTL
LVDDGRVCGLVAIELATGRIETILADAVILCTGGCGRVFPFTTNANIKTGDGMALAFRAGAPLKDMEFVQYHPTGLPFTG
ILITEAARAEGGWLLNKDGYRYLQDYDLGKPTPEPRLRSMELGPRDRLSQAFVHEHNKGRTVDTPYGPVVYLDLRHLGAD
LIDAKLPFVRELCRDYQHIDPVVELVPVRPVVHYMMGGVHTDINGATTLPGLYAAGETACVSINGANRLGSNSLPELLVF
GARAGRAAADYAARHQKSDRGPSSAVRAQARTEALRLERELSRHGQGGERIADIRADMQATLESAAGIYRDGPTLTKAVE
EIRVLQERFATAGIDDHSRTFNTELTALLELSGMLDVALAIVESGLRREESRGAHQRTDFPNRDDEHFLAHTLVHRESDG
TLRVGYLPVTITRWPPGERVYGR

Sequences:

>Translated_583_residues
MTAQHNIVVIGGGGAGLRAAIAIAETNPHLDVAIVSKVYPMRSHTVSAEGGAAAVTGDDDSLDEHAHDTVSGGDWLCDQD
AVEAFVAEAPKELVQLEHWGCPWSRKPDGRVAVRPFGGMKKLRTWFAADKTGFHLLHTLFQRLLTYSDVMRYDEWFATTL
LVDDGRVCGLVAIELATGRIETILADAVILCTGGCGRVFPFTTNANIKTGDGMALAFRAGAPLKDMEFVQYHPTGLPFTG
ILITEAARAEGGWLLNKDGYRYLQDYDLGKPTPEPRLRSMELGPRDRLSQAFVHEHNKGRTVDTPYGPVVYLDLRHLGAD
LIDAKLPFVRELCRDYQHIDPVVELVPVRPVVHYMMGGVHTDINGATTLPGLYAAGETACVSINGANRLGSNSLPELLVF
GARAGRAAADYAARHQKSDRGPSSAVRAQARTEALRLERELSRHGQGGERIADIRADMQATLESAAGIYRDGPTLTKAVE
EIRVLQERFATAGIDDHSRTFNTELTALLELSGMLDVALAIVESGLRREESRGAHQRTDFPNRDDEHFLAHTLVHRESDG
TLRVGYLPVTITRWPPGERVYGR
>Mature_582_residues
TAQHNIVVIGGGGAGLRAAIAIAETNPHLDVAIVSKVYPMRSHTVSAEGGAAAVTGDDDSLDEHAHDTVSGGDWLCDQDA
VEAFVAEAPKELVQLEHWGCPWSRKPDGRVAVRPFGGMKKLRTWFAADKTGFHLLHTLFQRLLTYSDVMRYDEWFATTLL
VDDGRVCGLVAIELATGRIETILADAVILCTGGCGRVFPFTTNANIKTGDGMALAFRAGAPLKDMEFVQYHPTGLPFTGI
LITEAARAEGGWLLNKDGYRYLQDYDLGKPTPEPRLRSMELGPRDRLSQAFVHEHNKGRTVDTPYGPVVYLDLRHLGADL
IDAKLPFVRELCRDYQHIDPVVELVPVRPVVHYMMGGVHTDINGATTLPGLYAAGETACVSINGANRLGSNSLPELLVFG
ARAGRAAADYAARHQKSDRGPSSAVRAQARTEALRLERELSRHGQGGERIADIRADMQATLESAAGIYRDGPTLTKAVEE
IRVLQERFATAGIDDHSRTFNTELTALLELSGMLDVALAIVESGLRREESRGAHQRTDFPNRDDEHFLAHTLVHRESDGT
LRVGYLPVTITRWPPGERVYGR

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily

Homologues:

Organism=Homo sapiens, GI156416003, Length=537, Percent_Identity=37.4301675977654, Blast_Score=332, Evalue=7e-91,
Organism=Escherichia coli, GI1790597, Length=555, Percent_Identity=54.7747747747748, Blast_Score=600, Evalue=1e-173,
Organism=Escherichia coli, GI1786942, Length=574, Percent_Identity=40.5923344947735, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1788928, Length=555, Percent_Identity=32.972972972973, Blast_Score=233, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17505833, Length=545, Percent_Identity=37.7981651376147, Blast_Score=339, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI17550100, Length=598, Percent_Identity=35.61872909699, Blast_Score=335, Evalue=5e-92,
Organism=Caenorhabditis elegans, GI71986328, Length=439, Percent_Identity=27.5626423690205, Blast_Score=102, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6322701, Length=576, Percent_Identity=39.4097222222222, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6322416, Length=559, Percent_Identity=37.7459749552773, Blast_Score=347, Evalue=2e-96,
Organism=Drosophila melanogaster, GI17137288, Length=541, Percent_Identity=38.6321626617375, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI24655642, Length=541, Percent_Identity=38.6321626617375, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI24655647, Length=541, Percent_Identity=38.6321626617375, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI24663005, Length=598, Percent_Identity=35.7859531772575, Blast_Score=334, Evalue=9e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FRDA_MYCBO (P64175)

Other databases:

- EMBL:   BX248339
- RefSeq:   NP_855230.1
- ProteinModelPortal:   P64175
- SMR:   P64175
- EnsemblBacteria:   EBMYCT00000017917
- GeneID:   1092446
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1578
- GeneTree:   EBGT00050000015552
- HOGENOM:   HBG293998
- OMA:   RFDEYFV
- ProtClustDB:   PRK09231
- BioCyc:   MBOV233413:MB1578-MONOMER
- BRENDA:   1.3.99.1
- GO:   GO:0006810
- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005884
- InterPro:   IPR014006
- Gene3D:   G3DSA:1.20.58.100
- PRINTS:   PR00368
- TIGRFAMs:   TIGR01176
- TIGRFAMs:   TIGR01812

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C; SSF46977 Succ_DH_flav_C

EC number: =1.3.99.1

Molecular weight: Translated: 63764; Mature: 63633

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: ACT_SITE 232-232 ACT_SITE 248-248

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQHNIVVIGGGGAGLRAAIAIAETNPHLDVAIVSKVYPMRSHTVSAEGGAAAVTGDDD
CCCCCCEEEEECCCCCCEEEEEEECCCCCEEEEEHHHHCCCCCCEECCCCCEEEEECCCC
SLDEHAHDTVSGGDWLCDQDAVEAFVAEAPKELVQLEHWGCPWSRKPDGRVAVRPFGGMK
CHHHHHCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCEEEECCCCHH
KLRTWFAADKTGFHLLHTLFQRLLTYSDVMRYDEWFATTLLVDDGRVCGLVAIELATGRI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEEEEEECCCHH
ETILADAVILCTGGCGRVFPFTTNANIKTGDGMALAFRAGAPLKDMEFVQYHPTGLPFTG
HHHHHCEEEEEECCCCCEEEEECCCCEECCCCEEEEEECCCCCCCCCEEEECCCCCCEEE
ILITEAARAEGGWLLNKDGYRYLQDYDLGKPTPEPRLRSMELGPRDRLSQAFVHEHNKGR
EEEEECCCCCCCEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
TVDTPYGPVVYLDLRHLGADLIDAKLPFVRELCRDYQHIDPVVELVPVRPVVHYMMGGVH
CCCCCCCCEEEEEHHHCCCHHHHCCCHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHCCEE
TDINGATTLPGLYAAGETACVSINGANRLGSNSLPELLVFGARAGRAAADYAARHQKSDR
ECCCCCCCCCCEEECCCEEEEEECCCCCCCCCCCCHHHEECCCCCCHHHHHHHHHCCCCC
GPSSAVRAQARTEALRLERELSRHGQGGERIADIRADMQATLESAAGIYRDGPTLTKAVE
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
EIRVLQERFATAGIDDHSRTFNTELTALLELSGMLDVALAIVESGLRREESRGAHQRTDF
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PNRDDEHFLAHTLVHRESDGTLRVGYLPVTITRWPPGERVYGR
CCCCCHHHHHHHHHEECCCCEEEEEEEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
TAQHNIVVIGGGGAGLRAAIAIAETNPHLDVAIVSKVYPMRSHTVSAEGGAAAVTGDDD
CCCCCEEEEECCCCCCEEEEEEECCCCCEEEEEHHHHCCCCCCEECCCCCEEEEECCCC
SLDEHAHDTVSGGDWLCDQDAVEAFVAEAPKELVQLEHWGCPWSRKPDGRVAVRPFGGMK
CHHHHHCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCEEEECCCCHH
KLRTWFAADKTGFHLLHTLFQRLLTYSDVMRYDEWFATTLLVDDGRVCGLVAIELATGRI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEEEEEECCCHH
ETILADAVILCTGGCGRVFPFTTNANIKTGDGMALAFRAGAPLKDMEFVQYHPTGLPFTG
HHHHHCEEEEEECCCCCEEEEECCCCEECCCCEEEEEECCCCCCCCCEEEECCCCCCEEE
ILITEAARAEGGWLLNKDGYRYLQDYDLGKPTPEPRLRSMELGPRDRLSQAFVHEHNKGR
EEEEECCCCCCCEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
TVDTPYGPVVYLDLRHLGADLIDAKLPFVRELCRDYQHIDPVVELVPVRPVVHYMMGGVH
CCCCCCCCEEEEEHHHCCCHHHHCCCHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHCCEE
TDINGATTLPGLYAAGETACVSINGANRLGSNSLPELLVFGARAGRAAADYAARHQKSDR
ECCCCCCCCCCEEECCCEEEEEECCCCCCCCCCCCHHHEECCCCCCHHHHHHHHHCCCCC
GPSSAVRAQARTEALRLERELSRHGQGGERIADIRADMQATLESAAGIYRDGPTLTKAVE
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
EIRVLQERFATAGIDDHSRTFNTELTALLELSGMLDVALAIVESGLRREESRGAHQRTDF
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PNRDDEHFLAHTLVHRESDGTLRVGYLPVTITRWPPGERVYGR
CCCCCHHHHHHHHHEECCCCEEEEEEEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972