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The map label for this gene is frdBC [H]

Identifier: 121637474

GI number: 121637474

Start: 1771767

End: 1772897

Strand: Direct

Name: frdBC [H]

Synonym: BCG_1605

Alternate gene names: 121637474

Gene position: 1771767-1772897 (Clockwise)

Preceding gene: 121637473

Following gene: 121637475

Centisome position: 40.5

GC content: 62.69

Gene sequence:

>1131_bases
ATGATGGATCGAATTGTCATGGAGGTCTCCCGGTATCGGCCCGAGATCGAATCGGCCCCGACATTTCAGGCCTACGAGGT
TCCCCTCACCCGCGAATGGGCGGTGTTGGACGGCCTGACCTACATCAAGGATCACCTCGACGGAACACTCTCCTTCCGCT
GGTCGTGCCGGATGGGTATCTGCGGCAGTAGTGGTATGACGATCAACGGCGACCCAAAGCTGGCGTGCGCGACATTCCTT
GCCGATTACCTACCCGGGCCGGTGCGGGTGGAGCCGATGCGAAACTTCCCGGTGATCCGCGATCTCGTTGTCGACATCAG
TGACTTCATGGCCAAGCTGCCCAGTGTGAAGCCGTGGCTCGTCCGGCATGATGAACCGCCCGTCGAAGACGGCGAATACC
GGCAGACCCCGGCCGAACTCGATGCATTCAAGCAGTTCAGCATGTGTATCAACTGCATGTTGTGCTACTCGGCGTGCCCG
GTGTACGCGCTGGACCCCGACTTCCTCGGTCCGGCGGCGATCGCGCTGGGGCAGCGGTACAACCTGGACTCGCGCGACCA
AGGTGCGGCGGATCGCAGGGATGTCCTGGCCGCGGCCGACGGCGCTTGGGCGTGCACCCTGGTGGGCGAATGTTCGACGG
CTTGTCCGAAAGGCGTCGATCCTGCCGGCGCGATCCAGCGCTACAAGCTGACCGCGGCCACGCACGCGCTGAAGAAGTTG
CTGTTCCCTTGGGGGGGGGGGGGGGGGCGGATGAGCGCCTATCGCCAGCCGGTCGAAAGATACTGGTGGGCGAGGCGGCG
TTCTTACCTGCGATTCATGCTTCGCGAAATCAGTTGCATCTTCGTGGCCTGGTTTGTTCTCTATCTGGTGCTGGTATTGC
GCGCCGTTGGCGCGGGCGGGAATTCCTACCAGCGGTTTTTGGACTTCAGCGCCAATCCGGTTGTCGTAGTGCTGAACGTC
GTCGCGTTGAGTTTCCTGCTGCTGCATGCTGTTACCTGGTTCGGATCGGCACCGCGCGCGATGGTGATTCAGGTTCGCGG
CCGCCGGGTACCCGCTCGCGCGGTCCTTGCTGGGCACTACGCGGCATGGCTGGTGGTTTCGGTGATCGTTGCCTGGATGG
TGCTGTCATGA

Upstream 100 bases:

>100_bases
CCTTGGTTCATAGAGAAAGCGACGGAACGCTGCGGGTCGGCTACCTTCCGGTCACTATCACTCGCTGGCCACCGGGCGAA
CGCGTGTATGGGAGGTAAGG

Downstream 100 bases:

>100_bases
CTCCCTCGACATCGGATGCCAGGTCGCGCCGACGCTCGGCGGAGCCCTTCCTGTGGCTGCTGTTCAGCGCCGGGGGCATG
GTCACCGCCCTGGTTGCGCC

Product: fumarate reductase frdC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MMDRIVMEVSRYRPEIESAPTFQAYEVPLTREWAVLDGLTYIKDHLDGTLSFRWSCRMGICGSSGMTINGDPKLACATFL
ADYLPGPVRVEPMRNFPVIRDLVVDISDFMAKLPSVKPWLVRHDEPPVEDGEYRQTPAELDAFKQFSMCINCMLCYSACP
VYALDPDFLGPAAIALGQRYNLDSRDQGAADRRDVLAAADGAWACTLVGECSTACPKGVDPAGAIQRYKLTAATHALKKL
LFPWGGGGGRMSAYRQPVERYWWARRRSYLRFMLREISCIFVAWFVLYLVLVLRAVGAGGNSYQRFLDFSANPVVVVLNV
VALSFLLLHAVTWFGSAPRAMVIQVRGRRVPARAVLAGHYAAWLVVSVIVAWMVLS

Sequences:

>Translated_376_residues
MMDRIVMEVSRYRPEIESAPTFQAYEVPLTREWAVLDGLTYIKDHLDGTLSFRWSCRMGICGSSGMTINGDPKLACATFL
ADYLPGPVRVEPMRNFPVIRDLVVDISDFMAKLPSVKPWLVRHDEPPVEDGEYRQTPAELDAFKQFSMCINCMLCYSACP
VYALDPDFLGPAAIALGQRYNLDSRDQGAADRRDVLAAADGAWACTLVGECSTACPKGVDPAGAIQRYKLTAATHALKKL
LFPWGGGGGRMSAYRQPVERYWWARRRSYLRFMLREISCIFVAWFVLYLVLVLRAVGAGGNSYQRFLDFSANPVVVVLNV
VALSFLLLHAVTWFGSAPRAMVIQVRGRRVPARAVLAGHYAAWLVVSVIVAWMVLS
>Mature_376_residues
MMDRIVMEVSRYRPEIESAPTFQAYEVPLTREWAVLDGLTYIKDHLDGTLSFRWSCRMGICGSSGMTINGDPKLACATFL
ADYLPGPVRVEPMRNFPVIRDLVVDISDFMAKLPSVKPWLVRHDEPPVEDGEYRQTPAELDAFKQFSMCINCMLCYSACP
VYALDPDFLGPAAIALGQRYNLDSRDQGAADRRDVLAAADGAWACTLVGECSTACPKGVDPAGAIQRYKLTAATHALKKL
LFPWGGGGGRMSAYRQPVERYWWARRRSYLRFMLREISCIFVAWFVLYLVLVLRAVGAGGNSYQRFLDFSANPVVVVLNV
VALSFLLLHAVTWFGSAPRAMVIQVRGRRVPARAVLAGHYAAWLVVSVIVAWMVLS

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=222, Percent_Identity=37.8378378378378, Blast_Score=149, Evalue=3e-36,
Organism=Escherichia coli, GI1790596, Length=242, Percent_Identity=50, Blast_Score=254, Evalue=8e-69,
Organism=Escherichia coli, GI1786943, Length=232, Percent_Identity=37.5, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1790595, Length=122, Percent_Identity=31.1475409836066, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17533915, Length=227, Percent_Identity=34.8017621145374, Blast_Score=141, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6322987, Length=232, Percent_Identity=34.9137931034483, Blast_Score=136, Evalue=5e-33,
Organism=Drosophila melanogaster, GI17137106, Length=228, Percent_Identity=35.9649122807018, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24643156, Length=227, Percent_Identity=36.5638766519824, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 41904; Mature: 41904

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDRIVMEVSRYRPEIESAPTFQAYEVPLTREWAVLDGLTYIKDHLDGTLSFRWSCRMGI
CCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEEE
CGSSGMTINGDPKLACATFLADYLPGPVRVEPMRNFPVIRDLVVDISDFMAKLPSVKPWL
ECCCCCEECCCCCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEE
VRHDEPPVEDGEYRQTPAELDAFKQFSMCINCMLCYSACPVYALDPDFLGPAAIALGQRY
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHCCCC
NLDSRDQGAADRRDVLAAADGAWACTLVGECSTACPKGVDPAGAIQRYKLTAATHALKKL
CCCCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LFPWGGGGGRMSAYRQPVERYWWARRRSYLRFMLREISCIFVAWFVLYLVLVLRAVGAGG
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NSYQRFLDFSANPVVVVLNVVALSFLLLHAVTWFGSAPRAMVIQVRGRRVPARAVLAGHY
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHH
AAWLVVSVIVAWMVLS
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMDRIVMEVSRYRPEIESAPTFQAYEVPLTREWAVLDGLTYIKDHLDGTLSFRWSCRMGI
CCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEEE
CGSSGMTINGDPKLACATFLADYLPGPVRVEPMRNFPVIRDLVVDISDFMAKLPSVKPWL
ECCCCCEECCCCCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEE
VRHDEPPVEDGEYRQTPAELDAFKQFSMCINCMLCYSACPVYALDPDFLGPAAIALGQRY
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHCCCC
NLDSRDQGAADRRDVLAAADGAWACTLVGECSTACPKGVDPAGAIQRYKLTAATHALKKL
CCCCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LFPWGGGGGRMSAYRQPVERYWWARRRSYLRFMLREISCIFVAWFVLYLVLVLRAVGAGG
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NSYQRFLDFSANPVVVVLNVVALSFLLLHAVTWFGSAPRAMVIQVRGRRVPARAVLAGHY
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHH
AAWLVVSVIVAWMVLS
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]