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The map label for this gene is argK [C]

Identifier: 121637428

GI number: 121637428

Start: 1711957

End: 1712961

Strand: Direct

Name: argK [C]

Synonym: BCG_1559

Alternate gene names: 121637428

Gene position: 1711957-1712961 (Clockwise)

Preceding gene: 121637427

Following gene: 121637429

Centisome position: 39.13

GC content: 67.76

Gene sequence:

>1005_bases
ATGATGGCCGCATCCCACGACGACGACACCGTCGACGGGTTGGCGACGGCCGTGCGCGGCGGTGACCGTGCGGCGCTGCC
ACGGGCCATCACACTGGTCGAGTCGACCCGCCCCGACCATCGTGAGCAGGCGCAACAGCTGCTGCTGCGATTGCTGCCGG
ACTCCGGGAACGCCCATCGCGTCGGCATCACCGGGGTCCCGGGGGTGGGCAAGTCGACTGCCATCGAGGCGCTGGGCATG
CATCTGATCGAGCGCGGGCATCGGGTGGCGGTGCTGGCGGTCGACCCGTCGTCGACCCGCACGGGTGGATCGATTCTTGG
TGATAAAACCCGGATGGCGCGGCTGGCGGTGCACCCGAACGCCTACATCCGGCCGTCCCCGACGTCGGGAACGCTGGGTG
GGGTGACGAGGGCCACCCGGGAAACGGTGGTGCTGTTGGAGGCGGCCGGTTTTGATGTGATCCTGATCGAAACCGTCGGG
GTGGGCCAGTCCGAGGTCGCGGTGGCCAACATGGTCGACACGTTCGTGTTGCTGACCTTGGCCCGCACCGGTGATCAGTT
GCAGGGCATCAAGAAGGGCGTGCTGGAGCTCGCCGACATCGTGGTGGTGAACAAGGCCGACGGGGAGCACCACAAAGAGG
CCCGGCTGGCCGCCCGGGAGCTGTCGGCGGCGATCAGATTGATCTATCCTCGCGAAGCACTGTGGCGCCCACCGGTGCTC
ACCATGAGCGCGGTGGAGGGCAGGGGACTGGCCGAGCTGTGGGACACCGTCGAGCGTCATCGCCAGGTGCTCACCGGGGC
CGGCGAATTCGACGCCCGTCGGCGCGATCAGCAGGTCGACTGGACCTGGCAGCTGGTTCGCGACGCCGTCCTGGATCGGG
TGTGGTCCAATCCGACGGTGCGCAAGGTCCGCTCCGAGCTCGAGCGTCGGGTCCGCGCCGGCGAACTGACCCCGGCCCTG
GCGGCTCAGCAAATACTGGAGATAGCTAACCTAACGGATAGGTAA

Upstream 100 bases:

>100_bases
TCGGCAAAGACGAGCTCGGTGACTACCTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACC
GCGCTGGGGCTACCGTGGCC

Downstream 100 bases:

>100_bases
ATAAATCCGTGTTTGCCGATGGTCGCTGCGAAATCCACGTAAGTTCGACCGTGTGATGGTTGACACCGGAGTCGATCACC
GCGCGGTTTCGTCCCACGAC

Product: arginine/ornithine transport system ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MMAASHDDDTVDGLATAVRGGDRAALPRAITLVESTRPDHREQAQQLLLRLLPDSGNAHRVGITGVPGVGKSTAIEALGM
HLIERGHRVAVLAVDPSSTRTGGSILGDKTRMARLAVHPNAYIRPSPTSGTLGGVTRATRETVVLLEAAGFDVILIETVG
VGQSEVAVANMVDTFVLLTLARTGDQLQGIKKGVLELADIVVVNKADGEHHKEARLAARELSAAIRLIYPREALWRPPVL
TMSAVEGRGLAELWDTVERHRQVLTGAGEFDARRRDQQVDWTWQLVRDAVLDRVWSNPTVRKVRSELERRVRAGELTPAL
AAQQILEIANLTDR

Sequences:

>Translated_334_residues
MMAASHDDDTVDGLATAVRGGDRAALPRAITLVESTRPDHREQAQQLLLRLLPDSGNAHRVGITGVPGVGKSTAIEALGM
HLIERGHRVAVLAVDPSSTRTGGSILGDKTRMARLAVHPNAYIRPSPTSGTLGGVTRATRETVVLLEAAGFDVILIETVG
VGQSEVAVANMVDTFVLLTLARTGDQLQGIKKGVLELADIVVVNKADGEHHKEARLAARELSAAIRLIYPREALWRPPVL
TMSAVEGRGLAELWDTVERHRQVLTGAGEFDARRRDQQVDWTWQLVRDAVLDRVWSNPTVRKVRSELERRVRAGELTPAL
AAQQILEIANLTDR
>Mature_334_residues
MMAASHDDDTVDGLATAVRGGDRAALPRAITLVESTRPDHREQAQQLLLRLLPDSGNAHRVGITGVPGVGKSTAIEALGM
HLIERGHRVAVLAVDPSSTRTGGSILGDKTRMARLAVHPNAYIRPSPTSGTLGGVTRATRETVVLLEAAGFDVILIETVG
VGQSEVAVANMVDTFVLLTLARTGDQLQGIKKGVLELADIVVVNKADGEHHKEARLAARELSAAIRLIYPREALWRPPVL
TMSAVEGRGLAELWDTVERHRQVLTGAGEFDARRRDQQVDWTWQLVRDAVLDRVWSNPTVRKVRSELERRVRAGELTPAL
AAQQILEIANLTDR

Specific function: Probable GTPase. May also bind and hydrolyze ATP. May function as chaperone (Probable)

COG id: COG1703

COG function: function code E; Putative periplasmic protein kinase ArgK and related GTPases of G3E family

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ArgK family

Homologues:

Organism=Homo sapiens, GI26892295, Length=327, Percent_Identity=50.4587155963303, Blast_Score=313, Evalue=1e-85,
Organism=Escherichia coli, GI1789285, Length=311, Percent_Identity=45.6591639871383, Blast_Score=277, Evalue=7e-76,
Organism=Caenorhabditis elegans, GI71994271, Length=335, Percent_Identity=42.3880597014925, Blast_Score=283, Evalue=9e-77,
Organism=Caenorhabditis elegans, GI71994275, Length=269, Percent_Identity=44.6096654275093, Blast_Score=255, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1496_MYCTU (P63577)

Other databases:

- EMBL:   BX842576
- EMBL:   AE000516
- PIR:   C70712
- RefSeq:   NP_216012.1
- RefSeq:   NP_335996.1
- PDB:   3MD0
- PDB:   3P32
- PDBsum:   3MD0
- PDBsum:   3P32
- ProteinModelPortal:   P63577
- SMR:   P63577
- EnsemblBacteria:   EBMYCT00000003132
- EnsemblBacteria:   EBMYCT00000072207
- GeneID:   886496
- GeneID:   924431
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1543
- KEGG:   mtu:Rv1496
- TIGR:   MT1543
- TubercuList:   Rv1496
- GeneTree:   EBGT00050000017570
- HOGENOM:   HBG728764
- OMA:   ALKFMRP
- ProtClustDB:   PRK09435
- InterPro:   IPR005129
- TIGRFAMs:   TIGR00750

Pfam domain/function: PF03308 ArgK

EC number: 2.7.-.- [C]

Molecular weight: Translated: 36257; Mature: 36257

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: NA

Important sites: BINDING 207-207

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMAASHDDDTVDGLATAVRGGDRAALPRAITLVESTRPDHREQAQQLLLRLLPDSGNAHR
CCCCCCCCCHHHHHHHHHCCCCCHHCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEE
VGITGVPGVGKSTAIEALGMHLIERGHRVAVLAVDPSSTRTGGSILGDKTRMARLAVHPN
EEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHEEEEECCC
AYIRPSPTSGTLGGVTRATRETVVLLEAAGFDVILIETVGVGQSEVAVANMVDTFVLLTL
CEECCCCCCCCCCCHHHHCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHH
ARTGDQLQGIKKGVLELADIVVVNKADGEHHKEARLAARELSAAIRLIYPREALWRPPVL
HHCCHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHEEECHHHHCCCCCE
TMSAVEGRGLAELWDTVERHRQVLTGAGEFDARRRDQQVDWTWQLVRDAVLDRVWSNPTV
EEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHH
RKVRSELERRVRAGELTPALAAQQILEIANLTDR
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMAASHDDDTVDGLATAVRGGDRAALPRAITLVESTRPDHREQAQQLLLRLLPDSGNAHR
CCCCCCCCCHHHHHHHHHCCCCCHHCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEE
VGITGVPGVGKSTAIEALGMHLIERGHRVAVLAVDPSSTRTGGSILGDKTRMARLAVHPN
EEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHEEEEECCC
AYIRPSPTSGTLGGVTRATRETVVLLEAAGFDVILIETVGVGQSEVAVANMVDTFVLLTL
CEECCCCCCCCCCCHHHHCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHH
ARTGDQLQGIKKGVLELADIVVVNKADGEHHKEARLAARELSAAIRLIYPREALWRPPVL
HHCCHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHEEECHHHHCCCCCE
TMSAVEGRGLAELWDTVERHRQVLTGAGEFDARRRDQQVDWTWQLVRDAVLDRVWSNPTV
EEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHH
RKVRSELERRVRAGELTPALAAQQILEIANLTDR
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Arg [C]

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036