The gene/protein map for NC_008769 is currently unavailable.
Definition Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome.
Accession NC_008769
Length 4,374,522

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The map label for this gene is dfp

Identifier: 121637321

GI number: 121637321

Start: 1590601

End: 1591857

Strand: Direct

Name: dfp

Synonym: BCG_1452

Alternate gene names: 121637321

Gene position: 1590601-1591857 (Clockwise)

Preceding gene: 121637320

Following gene: 121637322

Centisome position: 36.36

GC content: 67.78

Gene sequence:

>1257_bases
GTGGTGGACCATAAACGGATCCCCAAGCAGGTAATAGTCGGTGTCTCCGGGGGCATCGCCGCCTACAAGGCGTGCACGGT
TGTTCGTCAACTCACCGAGGCCAGTCATCGCGTCCGAGTCATTCCCACCGAATCCGCCCTGCGCTTCGTCGGTGCCGCGA
CCTTCGAGGCGCTCTCCGGTGAGCCGGTGTGCACCGACGTTTTCGCCGACGTTCCGGCGGTCCCGCATGTTCACCTCGGC
CAGCAGGCCGATCTGGTCGTAGTGGCGCCGGCCACCGCCGACCTGCTGGCCCGCGCGGCGGCCGGTCGAGCCGACGATCT
GCTGACCGCGACGCTGCTGACGGCGCGGTGTCCGGTGCTGTTCGCGCCGGCGATGCACACCGAGATGTGGTTGCATCCGG
CCACCGTCGACAACGTGGCCACGCTGCGCCGCCGCGGCGCGGTGGTGCTCGAGCCCGCGACAGGACGGCTTACCGGCGCC
GACAGCGGGGCCGGCCGACTGCCCGAGGCGGAGGAGATCACCACCCTCGCCCAGCTGCTGCTGGAGCGGCACGACGCCCT
GCCCTACGATCTCGCGGGGCGAAAGCTGCTGGTTACCGCCGGTGGCACACGCGAGCCGATCGATCCGGTGCGCTTTATCG
GCAACCGCAGCTCCGGCAAGCAGGGCTATGCGGTGGCGCGGGTGGCCGCCCAGCGCGGCGCCGACGTTACTTTGATCGCT
GGGCATACCGCAGGGCTCGTCGATCCCGCCGGCGTCGAGGTGGTGCACGTCAGCTCGGCCCAGCAACTCGCCGACGCGGT
GTCCAAGCACGCTCCGACCGCCGACGTATTGGTGATGGCGGCGGCCGTCGCCGACTTCCGGCCCGCGCAGGTTGCCACCG
CCAAAATCAAGAAAGGCGTCGAAGGCCCACCGACCATCGAGCTGCTGCGCAACGACGACGTGCTGGCCGGGGTGGTGCGG
GCCCGAGCCCATGGACAACTGCCCAACATGCGGGCCATTGTGGGCTTCGCAGCCGAGACCGGCGACGCCAATGGCGACGT
GCTCTTTCATGCCCGAGCTAAACTGCGACGCAAAGGCTGCGATCTGTTAGTCGTCAATGCCGTCGGCGAAGGCAGGGCCT
TTGAGGTAGACAGCAACGACGGCTGGCTACTGGCGTCCGATGGTACCGAGTCGGCATTGCAGCACGGCTCCAAGACACTG
ATGGCGAGCCGTATCGTTGATGCAATCGTCACGTTCCTGGCAGGCTGTAGCAGCTAA

Upstream 100 bases:

>100_bases
TGAGCCGGGGTTGCAAGAGAAGCCGTTGTCCATCGCGTTGCGCGAGATCCACGCCGATCTGCTCGAGCACACCGAGGGCG
AGTAGCAGGGCAGGCCTGAG

Downstream 100 bases:

>100_bases
CGGGTCCGGCGGCCGGTTCTGTACGGGTCCTGGACAGGTGCTGGACGATCCCTTGCTCGATTGGACGAGCTGAGATTGAT
GCCTGAGGATATAATTCGGC

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MVDHKRIPKQVIVGVSGGIAAYKACTVVRQLTEASHRVRVIPTESALRFVGAATFEALSGEPVCTDVFADVPAVPHVHLG
QQADLVVVAPATADLLARAAAGRADDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGAVVLEPATGRLTGA
DSGAGRLPEAEEITTLAQLLLERHDALPYDLAGRKLLVTAGGTREPIDPVRFIGNRSSGKQGYAVARVAAQRGADVTLIA
GHTAGLVDPAGVEVVHVSSAQQLADAVSKHAPTADVLVMAAAVADFRPAQVATAKIKKGVEGPPTIELLRNDDVLAGVVR
ARAHGQLPNMRAIVGFAAETGDANGDVLFHARAKLRRKGCDLLVVNAVGEGRAFEVDSNDGWLLASDGTESALQHGSKTL
MASRIVDAIVTFLAGCSS

Sequences:

>Translated_418_residues
MVDHKRIPKQVIVGVSGGIAAYKACTVVRQLTEASHRVRVIPTESALRFVGAATFEALSGEPVCTDVFADVPAVPHVHLG
QQADLVVVAPATADLLARAAAGRADDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGAVVLEPATGRLTGA
DSGAGRLPEAEEITTLAQLLLERHDALPYDLAGRKLLVTAGGTREPIDPVRFIGNRSSGKQGYAVARVAAQRGADVTLIA
GHTAGLVDPAGVEVVHVSSAQQLADAVSKHAPTADVLVMAAAVADFRPAQVATAKIKKGVEGPPTIELLRNDDVLAGVVR
ARAHGQLPNMRAIVGFAAETGDANGDVLFHARAKLRRKGCDLLVVNAVGEGRAFEVDSNDGWLLASDGTESALQHGSKTL
MASRIVDAIVTFLAGCSS
>Mature_418_residues
MVDHKRIPKQVIVGVSGGIAAYKACTVVRQLTEASHRVRVIPTESALRFVGAATFEALSGEPVCTDVFADVPAVPHVHLG
QQADLVVVAPATADLLARAAAGRADDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGAVVLEPATGRLTGA
DSGAGRLPEAEEITTLAQLLLERHDALPYDLAGRKLLVTAGGTREPIDPVRFIGNRSSGKQGYAVARVAAQRGADVTLIA
GHTAGLVDPAGVEVVHVSSAQQLADAVSKHAPTADVLVMAAAVADFRPAQVATAKIKKGVEGPPTIELLRNDDVLAGVVR
ARAHGQLPNMRAIVGFAAETGDANGDVLFHARAKLRRKGCDLLVVNAVGEGRAFEVDSNDGWLLASDGTESALQHGSKTL
MASRIVDAIVTFLAGCSS

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family

Homologues:

Organism=Homo sapiens, GI71725351, Length=182, Percent_Identity=32.967032967033, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI87082301, Length=408, Percent_Identity=39.9509803921569, Blast_Score=227, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24657262, Length=181, Percent_Identity=27.6243093922652, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COABC_MYCBO (P67734)

Other databases:

- EMBL:   BX248338
- RefSeq:   NP_855078.1
- ProteinModelPortal:   P67734
- EnsemblBacteria:   EBMYCT00000016249
- GeneID:   1090715
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1426
- GeneTree:   EBGT00050000017596
- HOGENOM:   HBG523890
- OMA:   VTSGPTH
- ProtClustDB:   PRK05579
- BioCyc:   MBOV233413:MB1426-MONOMER
- BRENDA:   4.1.1.36
- BRENDA:   6.3.2.5
- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382
- Gene3D:   G3DSA:3.40.50.10300
- Gene3D:   G3DSA:3.40.50.1950
- TIGRFAMs:   TIGR00521

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein; SSF102645 DNA/pantothenate-metab_flavo_C; SSF52507 Flavoprotein

EC number: =4.1.1.36; =6.3.2.5

Molecular weight: Translated: 43577; Mature: 43577

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: BINDING 285-285 BINDING 295-295 BINDING 354-354 BINDING 358-358

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MVDHKRIPKQVIVGVSGGIAAYKACTVVRQLTEASHRVRVIPTESALRFVGAATFEALSG
CCCCHHCCHHHEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHCCC
EPVCTDVFADVPAVPHVHLGQQADLVVVAPATADLLARAAAGRADDLLTATLLTARCPVL
CCCHHHHHHCCCCCCCEECCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEE
FAPAMHTEMWLHPATVDNVATLRRRGAVVLEPATGRLTGADSGAGRLPEAEEITTLAQLL
ECCCHHHHHEECCCCHHHHHHHHHCCCEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHH
LERHDALPYDLAGRKLLVTAGGTREPIDPVRFIGNRSSGKQGYAVARVAAQRGADVTLIA
HHHHCCCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEE
GHTAGLVDPAGVEVVHVSSAQQLADAVSKHAPTADVLVMAAAVADFRPAQVATAKIKKGV
CCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCC
EGPPTIELLRNDDVLAGVVRARAHGQLPNMRAIVGFAAETGDANGDVLFHARAKLRRKGC
CCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCEEEEEHHHHHHCCC
DLLVVNAVGEGRAFEVDSNDGWLLASDGTESALQHGSKTLMASRIVDAIVTFLAGCSS
CEEEEEECCCCEEEEECCCCCEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVDHKRIPKQVIVGVSGGIAAYKACTVVRQLTEASHRVRVIPTESALRFVGAATFEALSG
CCCCHHCCHHHEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHCCC
EPVCTDVFADVPAVPHVHLGQQADLVVVAPATADLLARAAAGRADDLLTATLLTARCPVL
CCCHHHHHHCCCCCCCEECCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEE
FAPAMHTEMWLHPATVDNVATLRRRGAVVLEPATGRLTGADSGAGRLPEAEEITTLAQLL
ECCCHHHHHEECCCCHHHHHHHHHCCCEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHH
LERHDALPYDLAGRKLLVTAGGTREPIDPVRFIGNRSSGKQGYAVARVAAQRGADVTLIA
HHHHCCCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEE
GHTAGLVDPAGVEVVHVSSAQQLADAVSKHAPTADVLVMAAAVADFRPAQVATAKIKKGV
CCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCC
EGPPTIELLRNDDVLAGVVRARAHGQLPNMRAIVGFAAETGDANGDVLFHARAKLRRKGC
CCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCEEEEEHHHHHHCCC
DLLVVNAVGEGRAFEVDSNDGWLLASDGTESALQHGSKTLMASRIVDAIVTFLAGCSS
CEEEEEECCCCEEEEECCCCCEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972