Click here to switch to the map view.

The map label for this gene is xseA

Identifier: 121637039

GI number: 121637039

Start: 1265628

End: 1266875

Strand: Reverse

Name: xseA

Synonym: BCG_1168c

Alternate gene names: 121637039

Gene position: 1266875-1265628 (Counterclockwise)

Preceding gene: 121637040

Following gene: 121637038

Centisome position: 28.96

GC content: 68.67

Gene sequence:

>1248_bases
GTGACCCAGAATTCGGCGGAGAATCCGTTCCCGGTTCGCGCGGTGGCAATCCGGGTCGCGGGCTGGATCGACAAGCTGGG
CGCGGTCTGGGTGGAGGGGCAATTGGCCCAGATCACAATGCGCCCAGACGCCAAGACGGTGTTCATGGTATTGCGCGATC
CTGCGGCCGACATGTCGCTGACCGTGACGTGTTCCCGCGACCTGGTGCTGTCCGCGCCGGTGAAGCTGGCCGAAGGCGTT
CAGGTAGTGGTCTGCGGCAAGCCCTCGTTCTACACCGGACGTGGCACATTCTCCTTGCGGCTCAGCGAGATTCGCGCTGT
CGGCATCGGCGAGCTGCTGGCACGCATCGACCGGCTGCGCCGGCTGCTGGACGCCGAGGGGCTCTTCGACCCCCGCCTCA
AGCGGCCGATCCCGTACCTGCCCAACATGATCGGTCTGATCACCGGCCGTGCGAGTGCCGCCGAACGTGACGTTACGACG
GTGGCCTCGGCGCGCTGGCCAGCGGCACGTTTCGCCGTCCGCAACGTCGCCGTGCAGGGCCCCAACGCCGTCGGCCAGAT
CGTCGAGGCGCTGCGCGAGCTCGATCGAGACCCGGACGTCGACGTGATCGTGCTGGCCCGGGGCGGCGGCTCCGTCGAGG
ACCTGCTGCCGTTTTCTGACGAGACGTTGTGCCGCGCGATCGCGGCCTGCCGTACGCCCGTGGTCAGCGCCGTCGGTCAC
GAACCCGACAATCCGCTGTGCGATCTGGTCGTCGACCTGCGCGCCGCCACCCCCACCGACGCCGCCAAGAAAGTGGTTCC
CGATACCGCAGCCGAGCAGCGGCTGATCGACGATCTGCGCCGGCGCAGCGCCCAGGCGTTGCGCAACTGGGTTTCCCGCG
AGCAACGGGCAGTCGCGCAGTTGCGTAGCCGCCCGGTGCTGGCCGATCCGATGACGATGGTCAGCGTGCGCGCCGAGGAG
GTCCACCGAGCCCGCTCGACGCTTCGTCGCAACCTCACCCTGATGGTCGCCGCCGAGACCGAACGCATCGGTCATCTGGC
CGCACGCCTGGCCACGCTGGGTCCGGCCGCCACGCTCGCCCGCGGCTATGCCATAGTGCAGACCGTTGCTCAGACGGGAC
CCGAGGGCGGATCCGAACCACAGGTGCTGCGGTCGGTCCACGACGCACCGGAAGGCACCAAGCTGCGCGTGCGGGTTGCC
GACGGAGCCCTAGCGGCGGTCAGTGAAGGACAAACCAATGGTCTGTGA

Upstream 100 bases:

>100_bases
TCCCCGAGCTCGAGGCCCTGCTGGCCTACGAGCAGGCCACCAAGGCCCGTGCCCCGTTCCAGACGCTGCTCGCCAACAGG
ATCACCCGCGCGACTGCGAA

Downstream 100 bases:

>100_bases
CCCCAACGGCGATGACACGGGCAGAACCCACGCAACTGTGCCTGTCAGTCAGCTTGGCTATGAAGCCTGCCGGGACGAGC
TGATGGAAGTCGTGCGGCTT

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MTQNSAENPFPVRAVAIRVAGWIDKLGAVWVEGQLAQITMRPDAKTVFMVLRDPAADMSLTVTCSRDLVLSAPVKLAEGV
QVVVCGKPSFYTGRGTFSLRLSEIRAVGIGELLARIDRLRRLLDAEGLFDPRLKRPIPYLPNMIGLITGRASAAERDVTT
VASARWPAARFAVRNVAVQGPNAVGQIVEALRELDRDPDVDVIVLARGGGSVEDLLPFSDETLCRAIAACRTPVVSAVGH
EPDNPLCDLVVDLRAATPTDAAKKVVPDTAAEQRLIDDLRRRSAQALRNWVSREQRAVAQLRSRPVLADPMTMVSVRAEE
VHRARSTLRRNLTLMVAAETERIGHLAARLATLGPAATLARGYAIVQTVAQTGPEGGSEPQVLRSVHDAPEGTKLRVRVA
DGALAAVSEGQTNGL

Sequences:

>Translated_415_residues
MTQNSAENPFPVRAVAIRVAGWIDKLGAVWVEGQLAQITMRPDAKTVFMVLRDPAADMSLTVTCSRDLVLSAPVKLAEGV
QVVVCGKPSFYTGRGTFSLRLSEIRAVGIGELLARIDRLRRLLDAEGLFDPRLKRPIPYLPNMIGLITGRASAAERDVTT
VASARWPAARFAVRNVAVQGPNAVGQIVEALRELDRDPDVDVIVLARGGGSVEDLLPFSDETLCRAIAACRTPVVSAVGH
EPDNPLCDLVVDLRAATPTDAAKKVVPDTAAEQRLIDDLRRRSAQALRNWVSREQRAVAQLRSRPVLADPMTMVSVRAEE
VHRARSTLRRNLTLMVAAETERIGHLAARLATLGPAATLARGYAIVQTVAQTGPEGGSEPQVLRSVHDAPEGTKLRVRVA
DGALAAVSEGQTNGL
>Mature_414_residues
TQNSAENPFPVRAVAIRVAGWIDKLGAVWVEGQLAQITMRPDAKTVFMVLRDPAADMSLTVTCSRDLVLSAPVKLAEGVQ
VVVCGKPSFYTGRGTFSLRLSEIRAVGIGELLARIDRLRRLLDAEGLFDPRLKRPIPYLPNMIGLITGRASAAERDVTTV
ASARWPAARFAVRNVAVQGPNAVGQIVEALRELDRDPDVDVIVLARGGGSVEDLLPFSDETLCRAIAACRTPVVSAVGHE
PDNPLCDLVVDLRAATPTDAAKKVVPDTAAEQRLIDDLRRRSAQALRNWVSREQRAVAQLRSRPVLADPMTMVSVRAEEV
HRARSTLRRNLTLMVAAETERIGHLAARLATLGPAATLARGYAIVQTVAQTGPEGGSEPQVLRSVHDAPEGTKLRVRVAD
GALAAVSEGQTNGL

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=430, Percent_Identity=29.5348837209302, Blast_Score=177, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_MYCBO (P67448)

Other databases:

- EMBL:   BX248337
- RefSeq:   NP_854794.1
- EnsemblBacteria:   EBMYCT00000017042
- GeneID:   1090443
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1138c
- GeneTree:   EBGT00050000016801
- HOGENOM:   HBG634411
- OMA:   PWPVRTV
- ProtClustDB:   PRK00286
- BioCyc:   MBOV233413:MB1138C-MONOMER
- BRENDA:   3.1.11.6
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L

EC number: =3.1.11.6

Molecular weight: Translated: 44629; Mature: 44498

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQNSAENPFPVRAVAIRVAGWIDKLGAVWVEGQLAQITMRPDAKTVFMVLRDPAADMSL
CCCCCCCCCCCHHHHHHHHHHHHHHHCCEEECCEEEEEEECCCCCEEEEEEECCCCCCEE
TVTCSRDLVLSAPVKLAEGVQVVVCGKPSFYTGRGTFSLRLSEIRAVGIGELLARIDRLR
EEEECCCEEEECCHHHHCCCEEEEECCCCEEECCCEEEEEHHHHHHCCHHHHHHHHHHHH
RLLDAEGLFDPRLKRPIPYLPNMIGLITGRASAAERDVTTVASARWPAARFAVRNVAVQG
HHHHCCCCCCCHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHEECC
PNAVGQIVEALRELDRDPDVDVIVLARGGGSVEDLLPFSDETLCRAIAACRTPVVSAVGH
CHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
EPDNPLCDLVVDLRAATPTDAAKKVVPDTAAEQRLIDDLRRRSAQALRNWVSREQRAVAQ
CCCCCHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRSRPVLADPMTMVSVRAEEVHRARSTLRRNLTLMVAAETERIGHLAARLATLGPAATLA
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHHHHCCHHHHHH
RGYAIVQTVAQTGPEGGSEPQVLRSVHDAPEGTKLRVRVADGALAAVSEGQTNGL
HHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCEEEECCCCCCCC
>Mature Secondary Structure 
TQNSAENPFPVRAVAIRVAGWIDKLGAVWVEGQLAQITMRPDAKTVFMVLRDPAADMSL
CCCCCCCCCCHHHHHHHHHHHHHHHCCEEECCEEEEEEECCCCCEEEEEEECCCCCCEE
TVTCSRDLVLSAPVKLAEGVQVVVCGKPSFYTGRGTFSLRLSEIRAVGIGELLARIDRLR
EEEECCCEEEECCHHHHCCCEEEEECCCCEEECCCEEEEEHHHHHHCCHHHHHHHHHHHH
RLLDAEGLFDPRLKRPIPYLPNMIGLITGRASAAERDVTTVASARWPAARFAVRNVAVQG
HHHHCCCCCCCHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHEECC
PNAVGQIVEALRELDRDPDVDVIVLARGGGSVEDLLPFSDETLCRAIAACRTPVVSAVGH
CHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
EPDNPLCDLVVDLRAATPTDAAKKVVPDTAAEQRLIDDLRRRSAQALRNWVSREQRAVAQ
CCCCCHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRSRPVLADPMTMVSVRAEEVHRARSTLRRNLTLMVAAETERIGHLAARLATLGPAATLA
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHHHHCCHHHHHH
RGYAIVQTVAQTGPEGGSEPQVLRSVHDAPEGTKLRVRVADGALAAVSEGQTNGL
HHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972