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The map label for this gene is kdpD [H]

Identifier: 121636957

GI number: 121636957

Start: 1179589

End: 1182171

Strand: Reverse

Name: kdpD [H]

Synonym: BCG_1085c

Alternate gene names: 121636957

Gene position: 1182171-1179589 (Counterclockwise)

Preceding gene: 121636962

Following gene: 121636956

Centisome position: 27.02

GC content: 67.09

Gene sequence:

>2583_bases
GTGACGTTGCTCTTCGCCGATCTTTGCGCGATCTTTACGCCCTACCGGTGGATGATTGAGCATGTGACCACCAAGCGCGG
GCAGCTGCGGATCTATCTGGGCGCGGCCCCCGGCGTGGGCAAAACCTACGCCATGCTCGGCGAGGCGCACCGCAGGCTGG
AGCGCGGCACCGACGTGGTCGCCGCGGTCGTCGAGACACACGGACGCAACAAGACCGCGAAACTGCTCGAGGGCATCGAG
ATGATCTCGCCGCGCTACGTCGAATATCGGGGTGCCAGGTTTCCCGAACTCGATGTGGAGGCAGTACTGCGACGTCATCC
TCAGGTGGTGCTGGTGGACGAACTCGCCCACACCAACACACCTGGCAGCAAGAACCCCAAGCGCTGGCAGGACGTTCAGG
AAATCCTCGACGCCGGCATCACGGTGATCTCGACGGTCAACATCCAGCACTTGGAGGGCCTAAACGATGTCGTGGAGCAA
ATCACCGGCATCGAGCAGAAGGAGAAGATCCCCGACGAGATCGTCCGCGCGGCCGATCAGGTCGAGCTGGTCGACATCAC
ACCGGAAGCGTTGCGGCGCAGGCTTGCTCACGGCAACGTCTATGCAGCCGAACGGGTCGATGCCGCGCTGTCGAACTACT
TCCGCACGGGCAATCTGACCGCGCTGCGCGAGATCGCGTTGCTGTGGCTGGCCGACCAAGTTGATGCGGCCCTGGAGAAG
TACCGCGCAGACAAAAAGATCACCGCCACGTGGGAGGCGCGGGAACGCGTCGTCGTCGCCGTGACCGGCGGCCCGGAGTC
GGAGACGTTGGTGCGACGGGCATCGCGGATCGCGTCGAAGTCCAGCGCCGAGCTGATGGTGGTTCACGTTATCCGTGGCG
ACGACCTGGCGGGGGTGTCCGCGCCGCAGCTGGGCAGGGTCCGCGAGCTGGCGACAAGCCTCGGTGCGACCATGCACACC
GTGGTCGGCGACGACGTGCCCACCGCGCTGCTGGACTTCGCCCGCGAGATGAACGCCACGCAGCTCGTCGTCGGCACATC
GCGGCGATCGCGATGGGCACGCCTGTTTGACGAGGGGATCGGCGCCCGCACCGTCCAGGAGTCCGGCGGCATCGACGTTC
ACATGGTCACCCATCCCGCGGCCAGCCGGGCCTCCGGGTGGTCGCGGGTCTCCCCGCGCGAGCGGCATATCGCGTCGTGG
CTGGCCGCGCTGGTGGTGCCCTCGGTGATCTGCGCCATCACGGTGGCCTGGCTCGACCGATTCATGGGCATCGGCGGCGA
GAGCGCGTTGTTCTTCATCGGCGTGCTGATCGTGGCGTTGCTGGGCGGCGTCGCCCCCGCCGCATTGTCGGCCTTGCTGT
CGGGCATGCTGCTGAACTACTTTCTGACCGAGCCCCGCTACACCTGGACCATCGCCGAACCGGACGCCGCAGTAACCGAA
TTCGTGTTGTTGGCGATGGCCGTTGCGGTGGCGGTGTTGGTGGACGGCGCGGCTAGCCGAACCCGTGAGGCTCGGCGCGC
ATCCCAGGAGGCTGAGTTGCTGGCCCTGTTTGCCGGTTCGGTGTTGCGCGGCGCAGACCTTGCCACGCTGCTGCAGCGGG
TCCGCGAAACGTATTCCCAACGGGCCGTGACCATGCTGCGTGTCCGGCAGGGCGCATCGACAGGCGAAACCGTCGCGTGC
GTCGGGACAAACCCGTGTCGGGACGTCGACTCCGCCGACACCGCAATCGAAGTCGGCGACGACGAGTTTTGGATGCTGAT
GGCAGGCCGCAAGTTGGCCGCCCGCGACCGCCGAGTGCTGACCGCGGTCGCGACACAGGCCGCGGGTCTGGTGAAGCAGC
GCGAGCTGGCGGAAGAGGCCGGCCAGGCCGAGGCCATCGCTAGGGCCGATGAGCTGCGCCGGTCGCTGCTGTCGGCGGTC
AGCCACGACCTGCGCACCCCGCTGGCGGCGGCCAAGGTTGCGGTGTCCAGCTTGCGCACCGAAGACGTCGCTTTCTCCCC
CGAGGATACCGCCGAGCTGTTGGCCACCATCGAGGAGTCCATCGACCAACTCACCGCCCTGGTCGCAAACCTGCTCGATT
CGTCGCGGTTGGCTGCCGGCGTGATTCGCCCCCAGCTGCGCCGGGCATACCTGGAAGAAGCGGTGCAACGGGCCTTGGTC
AGCATCGGCAAGGGCGCCACCGGTTTTTACCGATCCGGCATCGACCGGGTCAAGGTCGACGTGGGAGACGCCGTGGCGAT
GGCCGACGCCGGGTTGCTGGAGCGGGTGCTAGCCAACCTGATCGACAACGCGCTGCGATATGCGCCCGACTGCGTGGTCC
GGGTCGACGCGGGACGGGTGCGTGAGCGGGTCCTGATTAATGTCATCGACGAGGGCCCAGGGGTCCCGCGCGGGACCGAG
GAGCAACTCTTTGCCCCGTTCCAGCGGCCGGGGGATCACGACAACACCACCGGTGTCGGTCTGGGGATGTCGGTGGCACG
CGGCTTCGTCGAGGCTATGGGCGGCACGATTTCGGCTACCGATACCCCGGGCGGCGGGCTCACAGTGGTGATCGATCTAG
CGGCTCCCGAGGACCGCCCATGA

Upstream 100 bases:

>100_bases
AGTCGGCCATGTGAGTCCTCTCGATTCTTGTGCACCGGCATCGCAGCGCATCAGATAGCCCAGCAGGATGGTAGTTGCCG
GGCCCCCCAGGAACACGACC

Downstream 100 bases:

>100_bases
CCCTCGTCTTGGTGATTGACGACGAACCCCAGATCCTGCGCGCGCTGCGTATCAACCTGACCGTGCGTGGCTACCAGGTC
ATCACCGCCTCGACGGGTGC

Product: putative sensor protein kdpD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 860; Mature: 859

Protein sequence:

>860_residues
MTLLFADLCAIFTPYRWMIEHVTTKRGQLRIYLGAAPGVGKTYAMLGEAHRRLERGTDVVAAVVETHGRNKTAKLLEGIE
MISPRYVEYRGARFPELDVEAVLRRHPQVVLVDELAHTNTPGSKNPKRWQDVQEILDAGITVISTVNIQHLEGLNDVVEQ
ITGIEQKEKIPDEIVRAADQVELVDITPEALRRRLAHGNVYAAERVDAALSNYFRTGNLTALREIALLWLADQVDAALEK
YRADKKITATWEARERVVVAVTGGPESETLVRRASRIASKSSAELMVVHVIRGDDLAGVSAPQLGRVRELATSLGATMHT
VVGDDVPTALLDFAREMNATQLVVGTSRRSRWARLFDEGIGARTVQESGGIDVHMVTHPAASRASGWSRVSPRERHIASW
LAALVVPSVICAITVAWLDRFMGIGGESALFFIGVLIVALLGGVAPAALSALLSGMLLNYFLTEPRYTWTIAEPDAAVTE
FVLLAMAVAVAVLVDGAASRTREARRASQEAELLALFAGSVLRGADLATLLQRVRETYSQRAVTMLRVRQGASTGETVAC
VGTNPCRDVDSADTAIEVGDDEFWMLMAGRKLAARDRRVLTAVATQAAGLVKQRELAEEAGQAEAIARADELRRSLLSAV
SHDLRTPLAAAKVAVSSLRTEDVAFSPEDTAELLATIEESIDQLTALVANLLDSSRLAAGVIRPQLRRAYLEEAVQRALV
SIGKGATGFYRSGIDRVKVDVGDAVAMADAGLLERVLANLIDNALRYAPDCVVRVDAGRVRERVLINVIDEGPGVPRGTE
EQLFAPFQRPGDHDNTTGVGLGMSVARGFVEAMGGTISATDTPGGGLTVVIDLAAPEDRP

Sequences:

>Translated_860_residues
MTLLFADLCAIFTPYRWMIEHVTTKRGQLRIYLGAAPGVGKTYAMLGEAHRRLERGTDVVAAVVETHGRNKTAKLLEGIE
MISPRYVEYRGARFPELDVEAVLRRHPQVVLVDELAHTNTPGSKNPKRWQDVQEILDAGITVISTVNIQHLEGLNDVVEQ
ITGIEQKEKIPDEIVRAADQVELVDITPEALRRRLAHGNVYAAERVDAALSNYFRTGNLTALREIALLWLADQVDAALEK
YRADKKITATWEARERVVVAVTGGPESETLVRRASRIASKSSAELMVVHVIRGDDLAGVSAPQLGRVRELATSLGATMHT
VVGDDVPTALLDFAREMNATQLVVGTSRRSRWARLFDEGIGARTVQESGGIDVHMVTHPAASRASGWSRVSPRERHIASW
LAALVVPSVICAITVAWLDRFMGIGGESALFFIGVLIVALLGGVAPAALSALLSGMLLNYFLTEPRYTWTIAEPDAAVTE
FVLLAMAVAVAVLVDGAASRTREARRASQEAELLALFAGSVLRGADLATLLQRVRETYSQRAVTMLRVRQGASTGETVAC
VGTNPCRDVDSADTAIEVGDDEFWMLMAGRKLAARDRRVLTAVATQAAGLVKQRELAEEAGQAEAIARADELRRSLLSAV
SHDLRTPLAAAKVAVSSLRTEDVAFSPEDTAELLATIEESIDQLTALVANLLDSSRLAAGVIRPQLRRAYLEEAVQRALV
SIGKGATGFYRSGIDRVKVDVGDAVAMADAGLLERVLANLIDNALRYAPDCVVRVDAGRVRERVLINVIDEGPGVPRGTE
EQLFAPFQRPGDHDNTTGVGLGMSVARGFVEAMGGTISATDTPGGGLTVVIDLAAPEDRP
>Mature_859_residues
TLLFADLCAIFTPYRWMIEHVTTKRGQLRIYLGAAPGVGKTYAMLGEAHRRLERGTDVVAAVVETHGRNKTAKLLEGIEM
ISPRYVEYRGARFPELDVEAVLRRHPQVVLVDELAHTNTPGSKNPKRWQDVQEILDAGITVISTVNIQHLEGLNDVVEQI
TGIEQKEKIPDEIVRAADQVELVDITPEALRRRLAHGNVYAAERVDAALSNYFRTGNLTALREIALLWLADQVDAALEKY
RADKKITATWEARERVVVAVTGGPESETLVRRASRIASKSSAELMVVHVIRGDDLAGVSAPQLGRVRELATSLGATMHTV
VGDDVPTALLDFAREMNATQLVVGTSRRSRWARLFDEGIGARTVQESGGIDVHMVTHPAASRASGWSRVSPRERHIASWL
AALVVPSVICAITVAWLDRFMGIGGESALFFIGVLIVALLGGVAPAALSALLSGMLLNYFLTEPRYTWTIAEPDAAVTEF
VLLAMAVAVAVLVDGAASRTREARRASQEAELLALFAGSVLRGADLATLLQRVRETYSQRAVTMLRVRQGASTGETVACV
GTNPCRDVDSADTAIEVGDDEFWMLMAGRKLAARDRRVLTAVATQAAGLVKQRELAEEAGQAEAIARADELRRSLLSAVS
HDLRTPLAAAKVAVSSLRTEDVAFSPEDTAELLATIEESIDQLTALVANLLDSSRLAAGVIRPQLRRAYLEEAVQRALVS
IGKGATGFYRSGIDRVKVDVGDAVAMADAGLLERVLANLIDNALRYAPDCVVRVDAGRVRERVLINVIDEGPGVPRGTEE
QLFAPFQRPGDHDNTTGVGLGMSVARGFVEAMGGTISATDTPGGGLTVVIDLAAPEDRP

Specific function: Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates kdpE in response to environmental signals [H]

COG id: COG2205

COG function: function code T; Osmosensitive K+ channel histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=896, Percent_Identity=31.4732142857143, Blast_Score=394, Evalue=1e-110,
Organism=Escherichia coli, GI1788393, Length=253, Percent_Identity=27.6679841897233, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1787894, Length=218, Percent_Identity=31.1926605504587, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI145693157, Length=271, Percent_Identity=27.3062730627306, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1790346, Length=236, Percent_Identity=29.6610169491525, Blast_Score=77, Evalue=6e-15,
Organism=Escherichia coli, GI87082128, Length=244, Percent_Identity=27.0491803278689, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789808, Length=227, Percent_Identity=25.9911894273128, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1789149, Length=254, Percent_Identity=28.740157480315, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI87081816, Length=264, Percent_Identity=29.1666666666667, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1787374, Length=269, Percent_Identity=25.2788104089219, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1788713, Length=242, Percent_Identity=22.7272727272727, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR014729
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR003852
- InterPro:   IPR006016 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF02702 KdpD; PF00582 Usp [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 92789; Mature: 92658

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLFADLCAIFTPYRWMIEHVTTKRGQLRIYLGAAPGVGKTYAMLGEAHRRLERGTDVV
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCHHHH
AAVVETHGRNKTAKLLEGIEMISPRYVEYRGARFPELDVEAVLRRHPQVVLVDELAHTNT
HHHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHCCCCEEEEEHHHCCCC
PGSKNPKRWQDVQEILDAGITVISTVNIQHLEGLNDVVEQITGIEQKEKIPDEIVRAADQ
CCCCCCHHHHHHHHHHHCCCHHEEECCHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHCC
VELVDITPEALRRRLAHGNVYAAERVDAALSNYFRTGNLTALREIALLWLADQVDAALEK
EEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
YRADKKITATWEARERVVVAVTGGPESETLVRRASRIASKSSAELMVVHVIRGDDLAGVS
HCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCC
APQLGRVRELATSLGATMHTVVGDDVPTALLDFAREMNATQLVVGTSRRSRWARLFDEGI
CCCHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCC
GARTVQESGGIDVHMVTHPAASRASGWSRVSPRERHIASWLAALVVPSVICAITVAWLDR
CCCEECCCCCCEEEEEECCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FMGIGGESALFFIGVLIVALLGGVAPAALSALLSGMLLNYFLTEPRYTWTIAEPDAAVTE
HHCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHH
FVLLAMAVAVAVLVDGAASRTREARRASQEAELLALFAGSVLRGADLATLLQRVRETYSQ
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RAVTMLRVRQGASTGETVACVGTNPCRDVDSADTAIEVGDDEFWMLMAGRKLAARDRRVL
HHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCEEEECCCCEEEEECCCHHHHHHHHHH
TAVATQAAGLVKQRELAEEAGQAEAIARADELRRSLLSAVSHDLRTPLAAAKVAVSSLRT
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
EDVAFSPEDTAELLATIEESIDQLTALVANLLDSSRLAAGVIRPQLRRAYLEEAVQRALV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIGKGATGFYRSGIDRVKVDVGDAVAMADAGLLERVLANLIDNALRYAPDCVVRVDAGRV
HHCCCCCHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHH
RERVLINVIDEGPGVPRGTEEQLFAPFQRPGDHDNTTGVGLGMSVARGFVEAMGGTISAT
HHHHHHEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEC
DTPGGGLTVVIDLAAPEDRP
CCCCCCEEEEEEECCCCCCC
>Mature Secondary Structure 
TLLFADLCAIFTPYRWMIEHVTTKRGQLRIYLGAAPGVGKTYAMLGEAHRRLERGTDVV
CCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCHHHH
AAVVETHGRNKTAKLLEGIEMISPRYVEYRGARFPELDVEAVLRRHPQVVLVDELAHTNT
HHHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHCCCCEEEEEHHHCCCC
PGSKNPKRWQDVQEILDAGITVISTVNIQHLEGLNDVVEQITGIEQKEKIPDEIVRAADQ
CCCCCCHHHHHHHHHHHCCCHHEEECCHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHCC
VELVDITPEALRRRLAHGNVYAAERVDAALSNYFRTGNLTALREIALLWLADQVDAALEK
EEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
YRADKKITATWEARERVVVAVTGGPESETLVRRASRIASKSSAELMVVHVIRGDDLAGVS
HCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCC
APQLGRVRELATSLGATMHTVVGDDVPTALLDFAREMNATQLVVGTSRRSRWARLFDEGI
CCCHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCC
GARTVQESGGIDVHMVTHPAASRASGWSRVSPRERHIASWLAALVVPSVICAITVAWLDR
CCCEECCCCCCEEEEEECCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FMGIGGESALFFIGVLIVALLGGVAPAALSALLSGMLLNYFLTEPRYTWTIAEPDAAVTE
HHCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHH
FVLLAMAVAVAVLVDGAASRTREARRASQEAELLALFAGSVLRGADLATLLQRVRETYSQ
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RAVTMLRVRQGASTGETVACVGTNPCRDVDSADTAIEVGDDEFWMLMAGRKLAARDRRVL
HHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCEEEECCCCEEEEECCCHHHHHHHHHH
TAVATQAAGLVKQRELAEEAGQAEAIARADELRRSLLSAVSHDLRTPLAAAKVAVSSLRT
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
EDVAFSPEDTAELLATIEESIDQLTALVANLLDSSRLAAGVIRPQLRRAYLEEAVQRALV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIGKGATGFYRSGIDRVKVDVGDAVAMADAGLLERVLANLIDNALRYAPDCVVRVDAGRV
HHCCCCCHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHH
RERVLINVIDEGPGVPRGTEEQLFAPFQRPGDHDNTTGVGLGMSVARGFVEAMGGTISAT
HHHHHHEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEC
DTPGGGLTVVIDLAAPEDRP
CCCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]