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The map label for this gene is trcS [H]

Identifier: 121636962

GI number: 121636962

Start: 1186911

End: 1188440

Strand: Reverse

Name: trcS [H]

Synonym: BCG_1090c

Alternate gene names: 121636962

Gene position: 1188440-1186911 (Counterclockwise)

Preceding gene: 121636963

Following gene: 121636957

Centisome position: 27.17

GC content: 64.97

Gene sequence:

>1530_bases
ATGATCCCGGACCGAAACACTCGGTCCAGAAAAGCCCCCTGCTGGCGACCCCGCTCGTTACGCCAGCAATTGCTGCTCGG
CGTGTTGGCGGTCGTTACCGTTGTGCTGGTGGCCGTCGGTGTCGTCTCCGTGCTGAGCCTAAGCGGCTATGTCACCGCGA
TGAACGACGCCGAGCTAGTCGAATCCCTGCACGCGTTGAACCACTCTTACACCAGATACCGCGACAGTGCGCAAACATCC
ACGCCCACCGGCAACCTCCCGATGTCACAAGCGGTGCTGGAGTTCACCGGCCAGACGCCCGGAAACCTCATTGCCGTGCT
GCACGACGGCGTGGTGATCGGATCGGCCGTTTTCTCCGAAGACGGAGCACGACCCGCTCCGCCCGACGTCATCCGCGCGA
TCGAAGCGCAAGTGTGGGACGGCGGCCCGCCGCGTGTCGAAAGCCTGGGCAGCCTGGGCGCCTACCAGGTTGACAGCAGC
GCCGCTGGCGCCGATCGACTGTTCGTCGGCGTATCGCTAAGCCTGGCCAACCAGATCATCGCCCGCAAGAAAGTCACCAC
CGTCGCGCTTGTTGGGGCCGCACTGGTGGTTACCGCAGCACTGACGGTGTGGGTGGTGGGATATGCGCTACGCCCGCTGC
GCCGGGTCGCCGCGACCGCCGCCGAGGTCGCCACCATGCCACTTACCGATGACGACCACCAGATCAGCGTGCGAGTCCGT
CCGGGGGATACCGACCCGGATAACGAGGTCGGAATCGTCGGGCACACGCTGAATCGCTTGTTGGACAACGTCGATGGTGC
GCTGGCGCATCGCGTCGATTCCGATCTGCGGATGCGGCAGTTCATCACCGACGCCAGCCACGAGCTGCGTACTCCCCTGG
CGGCGATCCAGGGCTATGCCGAACTGACACGTCAGGATAGCTCGGACCTACCGCCCACCACCGAATACGCGCTGGCCCGC
ATCGAATCCGAGGCGCGGCGGATGACGCTGCTGGTCGACGAGCTGCTGCTGCTCTCCCGTCTCAGCGAGGGCGAAGATCT
AGAAACCGAGGACCTCGACCTGACCGACCTGGTCATCAACGCGGTGAATGACGCGGCGGTTGCGGCGCCCACCCACCGTT
GGGTGAAGAATCTGCCCGACGAGCCGGTCTGGGTCAACGGGGATCATGCCCGCTTGCATCAACTCGTCAGCAATCTACTC
ACCAATGCCTGGGTGCATACCCAGCCCGGCGTCACAGTGACCATCGGGATCACCTGCCACCGCACTGGTCCCAACGCGCC
GTGTGTTGAATTGTCGGTGACCGACGACGGCCCCGACATCGACCCGGAGATCCTGCCCCACCTCTTCGACCGGTTCGTGC
GGGCCAGCAAGTCTCGGTCCAATGGGTCCGGCCACGGCTTGGGCCTGGCCATCGTCAGCTCGATCGTCAAGGCGCATCGC
GGCTCGGTCACGGCCGAGTCGGGCAACGGCCAGACGGTGTTTCGGGTGCGGCTCCCGATGATCGAGCAGCAGATCGCCAC
TACCGCCTGA

Upstream 100 bases:

>100_bases
ATCTCCTATCTGAGGAAGAAGATCGACTCCGACCGGGAGCCAATGATCCATACGGTCCGCGGCATTGGATACATGCTGCG
TCCGCCGGAATGAGCCTGGC

Downstream 100 bases:

>100_bases
GAGTCAGAGGCGATCCAATGCGAGGTTCAGCCTGAGCACGTTCACCGCGCGCTCGCCCAGGAAGCCGAGACCACGCGCGT
CGGTGTGGTCCTCGATCAGA

Product: two component sensor histidine kinase trcS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MIPDRNTRSRKAPCWRPRSLRQQLLLGVLAVVTVVLVAVGVVSVLSLSGYVTAMNDAELVESLHALNHSYTRYRDSAQTS
TPTGNLPMSQAVLEFTGQTPGNLIAVLHDGVVIGSAVFSEDGARPAPPDVIRAIEAQVWDGGPPRVESLGSLGAYQVDSS
AAGADRLFVGVSLSLANQIIARKKVTTVALVGAALVVTAALTVWVVGYALRPLRRVAATAAEVATMPLTDDDHQISVRVR
PGDTDPDNEVGIVGHTLNRLLDNVDGALAHRVDSDLRMRQFITDASHELRTPLAAIQGYAELTRQDSSDLPPTTEYALAR
IESEARRMTLLVDELLLLSRLSEGEDLETEDLDLTDLVINAVNDAAVAAPTHRWVKNLPDEPVWVNGDHARLHQLVSNLL
TNAWVHTQPGVTVTIGITCHRTGPNAPCVELSVTDDGPDIDPEILPHLFDRFVRASKSRSNGSGHGLGLAIVSSIVKAHR
GSVTAESGNGQTVFRVRLPMIEQQIATTA

Sequences:

>Translated_509_residues
MIPDRNTRSRKAPCWRPRSLRQQLLLGVLAVVTVVLVAVGVVSVLSLSGYVTAMNDAELVESLHALNHSYTRYRDSAQTS
TPTGNLPMSQAVLEFTGQTPGNLIAVLHDGVVIGSAVFSEDGARPAPPDVIRAIEAQVWDGGPPRVESLGSLGAYQVDSS
AAGADRLFVGVSLSLANQIIARKKVTTVALVGAALVVTAALTVWVVGYALRPLRRVAATAAEVATMPLTDDDHQISVRVR
PGDTDPDNEVGIVGHTLNRLLDNVDGALAHRVDSDLRMRQFITDASHELRTPLAAIQGYAELTRQDSSDLPPTTEYALAR
IESEARRMTLLVDELLLLSRLSEGEDLETEDLDLTDLVINAVNDAAVAAPTHRWVKNLPDEPVWVNGDHARLHQLVSNLL
TNAWVHTQPGVTVTIGITCHRTGPNAPCVELSVTDDGPDIDPEILPHLFDRFVRASKSRSNGSGHGLGLAIVSSIVKAHR
GSVTAESGNGQTVFRVRLPMIEQQIATTA
>Mature_509_residues
MIPDRNTRSRKAPCWRPRSLRQQLLLGVLAVVTVVLVAVGVVSVLSLSGYVTAMNDAELVESLHALNHSYTRYRDSAQTS
TPTGNLPMSQAVLEFTGQTPGNLIAVLHDGVVIGSAVFSEDGARPAPPDVIRAIEAQVWDGGPPRVESLGSLGAYQVDSS
AAGADRLFVGVSLSLANQIIARKKVTTVALVGAALVVTAALTVWVVGYALRPLRRVAATAAEVATMPLTDDDHQISVRVR
PGDTDPDNEVGIVGHTLNRLLDNVDGALAHRVDSDLRMRQFITDASHELRTPLAAIQGYAELTRQDSSDLPPTTEYALAR
IESEARRMTLLVDELLLLSRLSEGEDLETEDLDLTDLVINAVNDAAVAAPTHRWVKNLPDEPVWVNGDHARLHQLVSNLL
TNAWVHTQPGVTVTIGITCHRTGPNAPCVELSVTDDGPDIDPEILPHLFDRFVRASKSRSNGSGHGLGLAIVSSIVKAHR
GSVTAESGNGQTVFRVRLPMIEQQIATTA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=284, Percent_Identity=33.0985915492958, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1786600, Length=234, Percent_Identity=34.1880341880342, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790346, Length=281, Percent_Identity=29.8932384341637, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1786783, Length=338, Percent_Identity=28.698224852071, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1786912, Length=219, Percent_Identity=34.703196347032, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788279, Length=381, Percent_Identity=23.0971128608924, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788713, Length=235, Percent_Identity=29.3617021276596, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI145693157, Length=231, Percent_Identity=28.1385281385281, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789403, Length=303, Percent_Identity=30.6930693069307, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787894, Length=255, Percent_Identity=31.7647058823529, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1788549, Length=223, Percent_Identity=29.1479820627803, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790861, Length=296, Percent_Identity=26.6891891891892, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789149, Length=235, Percent_Identity=29.7872340425532, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI87082128, Length=223, Percent_Identity=27.3542600896861, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI87081816, Length=226, Percent_Identity=30.5309734513274, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789808, Length=227, Percent_Identity=29.5154185022026, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790551, Length=302, Percent_Identity=26.158940397351, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=30.6666666666667, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54592; Mature: 54592

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPDRNTRSRKAPCWRPRSLRQQLLLGVLAVVTVVLVAVGVVSVLSLSGYVTAMNDAELV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHH
ESLHALNHSYTRYRDSAQTSTPTGNLPMSQAVLEFTGQTPGNLIAVLHDGVVIGSAVFSE
HHHHHHCCHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCEEEEHHHHCC
DGARPAPPDVIRAIEAQVWDGGPPRVESLGSLGAYQVDSSAAGADRLFVGVSLSLANQII
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCEEECCCCCCCCEEEEEEHHHHHHHHH
ARKKVTTVALVGAALVVTAALTVWVVGYALRPLRRVAATAAEVATMPLTDDDHQISVRVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
PGDTDPDNEVGIVGHTLNRLLDNVDGALAHRVDSDLRMRQFITDASHELRTPLAAIQGYA
CCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELTRQDSSDLPPTTEYALARIESEARRMTLLVDELLLLSRLSEGEDLETEDLDLTDLVIN
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
AVNDAAVAAPTHRWVKNLPDEPVWVNGDHARLHQLVSNLLTNAWVHTQPGVTVTIGITCH
HHCCHHHCCCHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHCCEEECCCCEEEEEEEEEE
RTGPNAPCVELSVTDDGPDIDPEILPHLFDRFVRASKSRSNGSGHGLGLAIVSSIVKAHR
CCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHC
GSVTAESGNGQTVFRVRLPMIEQQIATTA
CCEEEECCCCCEEEEEECHHHHHHHHCCC
>Mature Secondary Structure
MIPDRNTRSRKAPCWRPRSLRQQLLLGVLAVVTVVLVAVGVVSVLSLSGYVTAMNDAELV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHH
ESLHALNHSYTRYRDSAQTSTPTGNLPMSQAVLEFTGQTPGNLIAVLHDGVVIGSAVFSE
HHHHHHCCHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCEEEEHHHHCC
DGARPAPPDVIRAIEAQVWDGGPPRVESLGSLGAYQVDSSAAGADRLFVGVSLSLANQII
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCEEECCCCCCCCEEEEEEHHHHHHHHH
ARKKVTTVALVGAALVVTAALTVWVVGYALRPLRRVAATAAEVATMPLTDDDHQISVRVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
PGDTDPDNEVGIVGHTLNRLLDNVDGALAHRVDSDLRMRQFITDASHELRTPLAAIQGYA
CCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELTRQDSSDLPPTTEYALARIESEARRMTLLVDELLLLSRLSEGEDLETEDLDLTDLVIN
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
AVNDAAVAAPTHRWVKNLPDEPVWVNGDHARLHQLVSNLLTNAWVHTQPGVTVTIGITCH
HHCCHHHCCCHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHCCEEECCCCEEEEEEEEEE
RTGPNAPCVELSVTDDGPDIDPEILPHLFDRFVRASKSRSNGSGHGLGLAIVSSIVKAHR
CCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHC
GSVTAESGNGQTVFRVRLPMIEQQIATTA
CCEEEECCCCCEEEEEECHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]