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The map label for this gene is acoA [H]

Identifier: 121636766

GI number: 121636766

Start: 969894

End: 970898

Strand: Direct

Name: acoA [H]

Synonym: BCG_0895

Alternate gene names: 121636766

Gene position: 969894-970898 (Clockwise)

Preceding gene: 121636765

Following gene: 121636768

Centisome position: 22.17

GC content: 64.68

Gene sequence:

>1005_bases
GTGACTCGTACCAGTGAAGGGTTGGCTGCGTTCGTGGTCGATCAGCTGGAGGAGCTGTATCGCCGGATGTGGGTGTTGCG
ACTGCTCGATATGGCGTTGGAGCAGTTGCGCATCGAAGGCCTGATCAACGGGCCGCTGCAGGGTGGCTTCGGCCAGGAAG
CAGTAAGTGTCGGTGCCGCGGCGGCGCTGGGCGAAGGCGATGTCATCATCACCACCCATCGTCCGCATGCCCAACACGTT
GGTACTGACGCTCCGCTGGGCCCGGTGATCGCCGACATGCTGGGTGCGACCGCAGGCGATCTAGAAGGCGCTGACGAGGA
TGCGCACATTGCCGATCCTCGGGCCGGGCTACCGGCTGCAATACGCGTGGTCAAGCAATCGCCGCTGTTGGCTATCGGAC
ACGCCTACGCCCTGTGGCTGCGCGACACCGGACGGGTCACACTCTGCGTGACCCAAGACTGTGATGTTGATGCCGATGCC
TTCAACGAGGCCGCGGACCTAGCGGCCGTGTGGCAACTTCCGGTGGTGATTCTCGTCGAAAACATTCGTGGTGCCCTAAG
TGTGCACCTGGGCAGGTACACGCACGAGCCTCGGGTTTATCGCCGGGCTGTGGCCTACGGAATGCCGGGGGTATCGGTGG
ACGGCAACGACGTCGAAGCGGTCCGTGACTGTGTGGCCAACGCGGTGGTTCGGGCTCGCGCTGGTGGCGGCCCCACGCTG
GTCCAAGCCATCACCTACCGCACCACCGATTTCTCTGGATCTGACCGCGGCGGCTATCGCGACCTGGCCGGATCCGAGCA
GTTTCTGGATCCGCTGATCTTCGCGAGAAGGCGGCTGATTGCTGCTGGCACGACCCGCGGTCGGCTCGACGAGCAGGAGC
GGGCGGCATGCCAACAGGTGGCCGATGCCGTGGCGTTCGCCAAGGCCAGGGCGCGGCCCAACGGCGGTGGGCCAATCAGC
CGACCAACATCCGGCTGGCACCAACAACCAAAGACCCGGTTCTGA

Upstream 100 bases:

>100_bases
ACGGTGACGGTTGGTTTCTTCGGGGCCGCTTTGTGCTTGCCGCTGGCTCGTGTTCTGGCAGCTGCCAGTTGCGGTCCGTT
GAGCAGCAAGGAGCCGTCGC

Downstream 100 bases:

>100_bases
GGCCTAGATGTACGTTGGCCGCGGACAACGCGGTCGGTACATGCCGTCGCGCCGCGGCCCCAGCTAGTCGAGCAGCCTCT
GCCGCATCGCCTCGGCGACC

Product: putative dehydrogenase

Products: [dihydrolipoyllysine-residue acetyltransferase] ; $S-acetyldihydrolipoyllysine; CO2

Alternate protein names: Acetoin:DCPIP oxidoreductase-alpha; Ao:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 subunit alpha [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MTRTSEGLAAFVVDQLEELYRRMWVLRLLDMALEQLRIEGLINGPLQGGFGQEAVSVGAAAALGEGDVIITTHRPHAQHV
GTDAPLGPVIADMLGATAGDLEGADEDAHIADPRAGLPAAIRVVKQSPLLAIGHAYALWLRDTGRVTLCVTQDCDVDADA
FNEAADLAAVWQLPVVILVENIRGALSVHLGRYTHEPRVYRRAVAYGMPGVSVDGNDVEAVRDCVANAVVRARAGGGPTL
VQAITYRTTDFSGSDRGGYRDLAGSEQFLDPLIFARRRLIAAGTTRGRLDEQERAACQQVADAVAFAKARARPNGGGPIS
RPTSGWHQQPKTRF

Sequences:

>Translated_334_residues
MTRTSEGLAAFVVDQLEELYRRMWVLRLLDMALEQLRIEGLINGPLQGGFGQEAVSVGAAAALGEGDVIITTHRPHAQHV
GTDAPLGPVIADMLGATAGDLEGADEDAHIADPRAGLPAAIRVVKQSPLLAIGHAYALWLRDTGRVTLCVTQDCDVDADA
FNEAADLAAVWQLPVVILVENIRGALSVHLGRYTHEPRVYRRAVAYGMPGVSVDGNDVEAVRDCVANAVVRARAGGGPTL
VQAITYRTTDFSGSDRGGYRDLAGSEQFLDPLIFARRRLIAAGTTRGRLDEQERAACQQVADAVAFAKARARPNGGGPIS
RPTSGWHQQPKTRF
>Mature_333_residues
TRTSEGLAAFVVDQLEELYRRMWVLRLLDMALEQLRIEGLINGPLQGGFGQEAVSVGAAAALGEGDVIITTHRPHAQHVG
TDAPLGPVIADMLGATAGDLEGADEDAHIADPRAGLPAAIRVVKQSPLLAIGHAYALWLRDTGRVTLCVTQDCDVDADAF
NEAADLAAVWQLPVVILVENIRGALSVHLGRYTHEPRVYRRAVAYGMPGVSVDGNDVEAVRDCVANAVVRARAGGGPTLV
QAITYRTTDFSGSDRGGYRDLAGSEQFLDPLIFARRRLIAAGTTRGRLDEQERAACQQVADAVAFAKARARPNGGGPISR
PTSGWHQQPKTRF

Specific function: Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde. The alpha subunit is probably the catalytic subunit of the enzyme [H]

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=304, Percent_Identity=28.9473684210526, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4505685, Length=303, Percent_Identity=28.0528052805281, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI291084742, Length=303, Percent_Identity=28.0528052805281, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI291084744, Length=310, Percent_Identity=27.741935483871, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI11386135, Length=311, Percent_Identity=25.7234726688103, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI258645172, Length=316, Percent_Identity=26.2658227848101, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI291084757, Length=156, Percent_Identity=30.1282051282051, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32564172, Length=297, Percent_Identity=29.6296296296296, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17536047, Length=297, Percent_Identity=29.6296296296296, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321026, Length=304, Percent_Identity=26.6447368421053, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24639740, Length=303, Percent_Identity=29.7029702970297, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24639744, Length=303, Percent_Identity=29.7029702970297, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28571106, Length=303, Percent_Identity=29.7029702970297, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24639746, Length=295, Percent_Identity=29.4915254237288, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24639748, Length=268, Percent_Identity=29.8507462686567, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: 1.2.4.1

Molecular weight: Translated: 35700; Mature: 35569

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRTSEGLAAFVVDQLEELYRRMWVLRLLDMALEQLRIEGLINGPLQGGFGQEAVSVGAA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
AALGEGDVIITTHRPHAQHVGTDAPLGPVIADMLGATAGDLEGADEDAHIADPRAGLPAA
HCCCCCCEEEEECCCCHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHH
IRVVKQSPLLAIGHAYALWLRDTGRVTLCVTQDCDVDADAFNEAADLAAVWQLPVVILVE
HHHHHCCCCEEECCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
NIRGALSVHLGRYTHEPRVYRRAVAYGMPGVSVDGNDVEAVRDCVANAVVRARAGGGPTL
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHH
VQAITYRTTDFSGSDRGGYRDLAGSEQFLDPLIFARRRLIAAGTTRGRLDEQERAACQQV
HHHHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ADAVAFAKARARPNGGGPISRPTSGWHQQPKTRF
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TRTSEGLAAFVVDQLEELYRRMWVLRLLDMALEQLRIEGLINGPLQGGFGQEAVSVGAA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
AALGEGDVIITTHRPHAQHVGTDAPLGPVIADMLGATAGDLEGADEDAHIADPRAGLPAA
HCCCCCCEEEEECCCCHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHH
IRVVKQSPLLAIGHAYALWLRDTGRVTLCVTQDCDVDADAFNEAADLAAVWQLPVVILVE
HHHHHCCCCEEECCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
NIRGALSVHLGRYTHEPRVYRRAVAYGMPGVSVDGNDVEAVRDCVANAVVRARAGGGPTL
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHH
VQAITYRTTDFSGSDRGGYRDLAGSEQFLDPLIFARRRLIAAGTTRGRLDEQERAACQQV
HHHHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ADAVAFAKARARPNGGGPISRPTSGWHQQPKTRF
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pyruvate; [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine

Specific reaction: pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S- $acetyldihydrolipoyllysine + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969503; 10368162; 9384377 [H]