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The map label for this gene is tcrA [H]

Identifier: 121636520

GI number: 121636520

Start: 729923

End: 730684

Strand: Reverse

Name: tcrA [H]

Synonym: BCG_0648c

Alternate gene names: 121636520

Gene position: 730684-729923 (Counterclockwise)

Preceding gene: 121636529

Following gene: 121636519

Centisome position: 16.7

GC content: 69.03

Gene sequence:

>762_bases
GTGGCAGATGAAACGACGATGAGAGCTGGTCGCGGCCCGGGCCGGGCATGCGGCAGGGTGTCGGGTGTGCGCATCCTGGT
GATCGAGGACGAGCCCAAGATGACGGCGCTGCTGGCGCGGGCGCTGACCGAGGAGGGCCACACGGTCGACACCGTTGCCG
ACGGCCGCCATGCGGTGGCGGCCGTCGACGGCGGTGACTACGACGCGGTGGTGCTGGATGTGATGCTGCCCGGTATCGAC
GGGTTCGAGGTATGCGCGCGGCTGCGACGGCAGCGGGTGTGGACACCGGTGCTGATGCTTACCGCCCGCGGCGCGGTCAC
CGACCGCATCGCGGGCCTAGACGGCGGCGCCGACGATTACCTCACCAAACCGTTCAACCTCGACGAACTGTTCGCCCGGT
TGCGCGCGCTGTCACGGCGCGGGCCCATCCCACGCCCACCGACGCTGGAGGCCGGCGATCTACGCCTGGACCCGAGCGAA
CACCGAGTCTGGCGTGCCGACACCGAAATCCGGCTCAGTCACAAGGAATTCACCCTGCTGGAAGCCCTGATCCGCCGTCC
CGGCATCGTCCACACCCGCGCCCAGCTGCTGGAACGCTGCTGGGACGCCGCCTACGAGGCCCGCTCCAACATCGTCGACG
TCTACATCCGCTACCTGCGCGACAAGATCGACCGGCCCTTCGGCGTCACCTCGCTGGAAACCATTCGCGGTGCCGGATAC
CGGCTGCGCAAGGACGGAGGACGGCATGCGCTCCCCCGCTGA

Upstream 100 bases:

>100_bases
GCCGCGGCCACGGCGGAAACTCCGAACTGCACGATGCGATTCATCGCTTTCTCCTGATCTGTCTACCTCGCTGTGACGGT
GTGCGGCTCCGACGGTAGGG

Downstream 100 bases:

>100_bases
GTGGCCCATCCGATGGCGACTCACCCTCGTCTTCAGCGCCGCCATGGCGCTCGTTCTGGCAGCAGCCGGTGCCGTCACCG
TCGTCCAGTTCCGCGACGCC

Product: putative two component DNA binding transcriptional regulatory protein tcrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MADETTMRAGRGPGRACGRVSGVRILVIEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGID
GFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSE
HRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGY
RLRKDGGRHALPR

Sequences:

>Translated_253_residues
MADETTMRAGRGPGRACGRVSGVRILVIEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGID
GFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSE
HRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGY
RLRKDGGRHALPR
>Mature_252_residues
ADETTMRAGRGPGRACGRVSGVRILVIEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDG
FEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEH
RVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYR
LRKDGGRHALPR

Specific function: Member of the three-protein two-component system HK1/HK2/tcrA [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=39.2070484581498, Blast_Score=171, Evalue=3e-44,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=41.8181818181818, Blast_Score=167, Evalue=4e-43,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=40.4545454545455, Blast_Score=151, Evalue=3e-38,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=36.9098712446352, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=37.3873873873874, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=39.5454545454545, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=36.322869955157, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=33.0275229357798, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=33.6244541484716, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=36.7256637168142, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=34.9775784753363, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=33.4782608695652, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=31.1688311688312, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=29.8701298701299, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=33.6448598130841, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1788713, Length=117, Percent_Identity=36.7521367521368, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790299, Length=127, Percent_Identity=28.3464566929134, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788905, Length=119, Percent_Identity=30.2521008403361, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI145693157, Length=116, Percent_Identity=31.8965517241379, Blast_Score=62, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=123, Percent_Identity=32.520325203252, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 28185; Mature: 28054

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADETTMRAGRGPGRACGRVSGVRILVIEDEPKMTALLARALTEEGHTVDTVADGRHAVA
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCEEEE
AVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDY
EECCCCCHHEEEEHHHCCCCHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHCCCCCCHHH
LTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLL
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCEEECCCEEEECHHHHHHH
EALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGY
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCE
RLRKDGGRHALPR
EEECCCCCCCCCC
>Mature Secondary Structure 
ADETTMRAGRGPGRACGRVSGVRILVIEDEPKMTALLARALTEEGHTVDTVADGRHAVA
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCEEEE
AVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDY
EECCCCCHHEEEEHHHCCCCHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHCCCCCCHHH
LTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLL
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCEEECCCEEEECHHHHHHH
EALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGY
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCE
RLRKDGGRHALPR
EEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]