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The map label for this gene is betA [C]

Identifier: 121636408

GI number: 121636408

Start: 612287

End: 614176

Strand: Reverse

Name: betA [C]

Synonym: BCG_0533c

Alternate gene names: 121636408

Gene position: 614176-612287 (Counterclockwise)

Preceding gene: 121636409

Following gene: 121636400

Centisome position: 14.04

GC content: 71.9

Gene sequence:

>1890_bases
ATGAGCCGGCTCGCCGATCGGGCTAAGTCCTATCCGTTGGCCTCGTTCGGCGCCGCGCTGCTGCCGCCGGAGCTCGGCGG
CCCGTTGCCGGCTCAATTCGTGCAGCGCGTTGACCGCTACGTCACACGACTGCCGGCGACCTCACGATTCGCGGTGCGCG
CCGGGCTGGCTTCACTGGCGGCGGCCAGCTACCTCACCACCGGCCGGTCGCTACCGCGACTGCACCCGGACGAGCGGGCA
CGGGTGCTGCACCGGATCGCCGCACTGAGCCCGGAAGTCGCTGCGGCCGTGGAGGGGTTGAAGGCGATCGTGCTGTTGGC
CAACGGCGCCGACACCTACGCGCACGAATTGCTCGCCCGCGCCCAGGAACATGACGCGGCGCGCCCCGACGCGGAGTTGA
CCGTCATCTTGTCGGCGGACAGCCCATCCGTCACCAGGGCCGATGCGGTGGTCGTCGGCTCCGGGGCGGGCGGCGCGATG
GTCGCGCGCACGCTGGCCCGGGCCGGCCTTGACGTGGTCGTGCTCGAAGAGGGACGGCGCTGGACGGTCGAGGAGTTCCG
TAGCACCCACCCGGTCGACCGTTATGCCGGGTTGTACCGTGGCGCCGGGGCCACCGTCGCGCTCGGGCGACCGGCGGTGG
TGCTGCCGATGGGCCGGGCGGTGGGCGGCACCACCGTCGTCAACTCCGGCACCTGCTTTCGGCCTTCACTTGCCGTGCAG
CGGCGCTGGCGTGACGAGTTCGGTCTCGGCCTGGCCGACCCCGACCAGCTGGGACGTCGTCTTGACGATGCGGAGCAAAC
ACTGCGGGTTGCGCCGGTGCCGCTGGAGATCATGGGCCGCAACGGGCGCCTGTTGCTGCAGGCCGCCAAGTCGCTGGGCT
GGCGGGCGGCGCCCATCCCGCGCAATGCGCCGGGGTGCCGTGGCTGTTGCCAGTGCGCGATCGGCTGCCCCAGCAACGCC
AAGTTCGGCGTGCACCTCAACGCCCTGCCGCAAGCCTGCGCGGCCGGCGCGCGGATCATCTCCTGGGCGCGGGTCGAACG
GATCCTGCACCGCGCCGGGCGGGCCTATGGCGTGCGAGCCCGCCGGCCCGACGGCACCACACTCGACGTGCTGGCCGACG
CGGTCGTCGTCGCCGCCGGTGCGACGGAGACGCCAGGGCTGTTGCGGCGCAGCGGTCTTGGTGGGCACCCGCGACTGGGC
CACAACCTTGCGCTGCACCCGGCAACTATGCTGGCCGGGCTCTTCGACGACGACGTCTTCGCGTGGCGCGGGGTGCTGCA
GAGCGCGGCGGTTCACGAGTTTCACGAATCCGACGGCGTGCTGATCGAGGCCACCTCCACACCGCCGGGCATGGGGTCGA
TGGTCTTCCCCGGCTACGGGGCCGAGCTGCTCCGCTGGCTCGACCGGGCGCCGCAGATCGCAACATTCGGGGCGATGGTG
GCCGATCGGGGCGTCGGCACGGTGCGGTCGGTGCGCGGCGAGACGGTGGTGCGCTATGACATAGCTCCAGGTGAGATCGC
CAAGCTACGGGTCGCGCTGCAGGCCATTGGCCGGCTGTTCTTTGCCGCCGGCGCGGTGGAGGTGCTGACCGGTATCCCCG
GCGCCCCACCGATGCGGTCCCTGCCCGAGCTGCAGGATGTGCTGCGCCGAGCCAACCCCAGAAGCCTGCACCTGGCCGCC
TTCCATCCGACGGGCACCGCGGCCGCCGGCGCCGACGAGCAGCTTTGTCCGGTCGACGCGACGGGCCGGCTGCGCGGCGT
CGAGGGCGTGTGGGTTGCCGACGCCTCGATCCTGCCCAGCTGCCCGGAAGTGAACCCGCAGCTGTCCATCATGGCGATGG
CACTGGCCGTAGCCGACCAGACAGTCGCCAAGGTTGTCGGCGTCCGCTAG

Upstream 100 bases:

>100_bases
ATGTGGCCCGCGCGGAGTGGCCGCTGCACGCGATGGCCGCTGCCATCTTCGCAACGTATCCGTTCTTCATAAAGCTCGGC
CGCCGGCTCGGGCGCCGGAT

Downstream 100 bases:

>100_bases
CCCTCGAGTTTGTAGCCCAGCCCGCGCACCGTCACCAAGTGAACCGGGTTAGCCGGGTCGGCTTCGATCTTGGAGCGCAG
CCGCTTGACATGGACGTCGA

Product: putative oxidoreductase GMC-type

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: NA

Number of amino acids: Translated: 629; Mature: 628

Protein sequence:

>629_residues
MSRLADRAKSYPLASFGAALLPPELGGPLPAQFVQRVDRYVTRLPATSRFAVRAGLASLAAASYLTTGRSLPRLHPDERA
RVLHRIAALSPEVAAAVEGLKAIVLLANGADTYAHELLARAQEHDAARPDAELTVILSADSPSVTRADAVVVGSGAGGAM
VARTLARAGLDVVVLEEGRRWTVEEFRSTHPVDRYAGLYRGAGATVALGRPAVVLPMGRAVGGTTVVNSGTCFRPSLAVQ
RRWRDEFGLGLADPDQLGRRLDDAEQTLRVAPVPLEIMGRNGRLLLQAAKSLGWRAAPIPRNAPGCRGCCQCAIGCPSNA
KFGVHLNALPQACAAGARIISWARVERILHRAGRAYGVRARRPDGTTLDVLADAVVVAAGATETPGLLRRSGLGGHPRLG
HNLALHPATMLAGLFDDDVFAWRGVLQSAAVHEFHESDGVLIEATSTPPGMGSMVFPGYGAELLRWLDRAPQIATFGAMV
ADRGVGTVRSVRGETVVRYDIAPGEIAKLRVALQAIGRLFFAAGAVEVLTGIPGAPPMRSLPELQDVLRRANPRSLHLAA
FHPTGTAAAGADEQLCPVDATGRLRGVEGVWVADASILPSCPEVNPQLSIMAMALAVADQTVAKVVGVR

Sequences:

>Translated_629_residues
MSRLADRAKSYPLASFGAALLPPELGGPLPAQFVQRVDRYVTRLPATSRFAVRAGLASLAAASYLTTGRSLPRLHPDERA
RVLHRIAALSPEVAAAVEGLKAIVLLANGADTYAHELLARAQEHDAARPDAELTVILSADSPSVTRADAVVVGSGAGGAM
VARTLARAGLDVVVLEEGRRWTVEEFRSTHPVDRYAGLYRGAGATVALGRPAVVLPMGRAVGGTTVVNSGTCFRPSLAVQ
RRWRDEFGLGLADPDQLGRRLDDAEQTLRVAPVPLEIMGRNGRLLLQAAKSLGWRAAPIPRNAPGCRGCCQCAIGCPSNA
KFGVHLNALPQACAAGARIISWARVERILHRAGRAYGVRARRPDGTTLDVLADAVVVAAGATETPGLLRRSGLGGHPRLG
HNLALHPATMLAGLFDDDVFAWRGVLQSAAVHEFHESDGVLIEATSTPPGMGSMVFPGYGAELLRWLDRAPQIATFGAMV
ADRGVGTVRSVRGETVVRYDIAPGEIAKLRVALQAIGRLFFAAGAVEVLTGIPGAPPMRSLPELQDVLRRANPRSLHLAA
FHPTGTAAAGADEQLCPVDATGRLRGVEGVWVADASILPSCPEVNPQLSIMAMALAVADQTVAKVVGVR
>Mature_628_residues
SRLADRAKSYPLASFGAALLPPELGGPLPAQFVQRVDRYVTRLPATSRFAVRAGLASLAAASYLTTGRSLPRLHPDERAR
VLHRIAALSPEVAAAVEGLKAIVLLANGADTYAHELLARAQEHDAARPDAELTVILSADSPSVTRADAVVVGSGAGGAMV
ARTLARAGLDVVVLEEGRRWTVEEFRSTHPVDRYAGLYRGAGATVALGRPAVVLPMGRAVGGTTVVNSGTCFRPSLAVQR
RWRDEFGLGLADPDQLGRRLDDAEQTLRVAPVPLEIMGRNGRLLLQAAKSLGWRAAPIPRNAPGCRGCCQCAIGCPSNAK
FGVHLNALPQACAAGARIISWARVERILHRAGRAYGVRARRPDGTTLDVLADAVVVAAGATETPGLLRRSGLGGHPRLGH
NLALHPATMLAGLFDDDVFAWRGVLQSAAVHEFHESDGVLIEATSTPPGMGSMVFPGYGAELLRWLDRAPQIATFGAMVA
DRGVGTVRSVRGETVVRYDIAPGEIAKLRVALQAIGRLFFAAGAVEVLTGIPGAPPMRSLPELQDVLRRANPRSLHLAAF
HPTGTAAAGADEQLCPVDATGRLRGVEGVWVADASILPSCPEVNPQLSIMAMALAVADQTVAKVVGVR

Specific function: Can Catalyze The Oxidation Of Choline To Betaine Aldehyde And Betaine Aldehyde To Glycine Betaine At The Same Rate. [C]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 66189; Mature: 66058

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS00624 GMC_OXRED_2 ; PS00198 4FE4S_FERREDOXIN ; PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLADRAKSYPLASFGAALLPPELGGPLPAQFVQRVDRYVTRLPATSRFAVRAGLASLA
CCHHHHHHHCCCCHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
AASYLTTGRSLPRLHPDERARVLHRIAALSPEVAAAVEGLKAIVLLANGADTYAHELLAR
HHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCEEEEEEECCCHHHHHHHHHH
AQEHDAARPDAELTVILSADSPSVTRADAVVVGSGAGGAMVARTLARAGLDVVVLEEGRR
HHHHCCCCCCCEEEEEEECCCCCCEECCEEEEECCCCHHHHHHHHHHCCCEEEEECCCCE
WTVEEFRSTHPVDRYAGLYRGAGATVALGRPAVVLPMGRAVGGTTVVNSGTCFRPSLAVQ
ECHHHHHCCCCHHHHHHHHCCCCCEEEECCCEEEEECCCCCCCCEEECCCCCCCCHHHHH
RRWRDEFGLGLADPDQLGRRLDDAEQTLRVAPVPLEIMGRNGRLLLQAAKSLGWRAAPIP
HHHHHHHCCCCCCHHHHHHHHCHHHHHHEECCCCCEEECCCCHHHHHHHHHCCCCCCCCC
RNAPGCRGCCQCAIGCPSNAKFGVHLNALPQACAAGARIISWARVERILHRAGRAYGVRA
CCCCCCHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RRPDGTTLDVLADAVVVAAGATETPGLLRRSGLGGHPRLGHNLALHPATMLAGLFDDDVF
CCCCCCCHHHHHHHHHEECCCCCCCHHHHHCCCCCCCCCCCCEEECHHHHHHHHCCCHHH
AWRGVLQSAAVHEFHESDGVLIEATSTPPGMGSMVFPGYGAELLRWLDRAPQIATFGAMV
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHH
ADRGVGTVRSVRGETVVRYDIAPGEIAKLRVALQAIGRLFFAAGAVEVLTGIPGAPPMRS
HHCCCCHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LPELQDVLRRANPRSLHLAAFHPTGTAAAGADEQLCPVDATGRLRGVEGVWVADASILPS
CHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCC
CPEVNPQLSIMAMALAVADQTVAKVVGVR
CCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SRLADRAKSYPLASFGAALLPPELGGPLPAQFVQRVDRYVTRLPATSRFAVRAGLASLA
CHHHHHHHCCCCHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
AASYLTTGRSLPRLHPDERARVLHRIAALSPEVAAAVEGLKAIVLLANGADTYAHELLAR
HHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCEEEEEEECCCHHHHHHHHHH
AQEHDAARPDAELTVILSADSPSVTRADAVVVGSGAGGAMVARTLARAGLDVVVLEEGRR
HHHHCCCCCCCEEEEEEECCCCCCEECCEEEEECCCCHHHHHHHHHHCCCEEEEECCCCE
WTVEEFRSTHPVDRYAGLYRGAGATVALGRPAVVLPMGRAVGGTTVVNSGTCFRPSLAVQ
ECHHHHHCCCCHHHHHHHHCCCCCEEEECCCEEEEECCCCCCCCEEECCCCCCCCHHHHH
RRWRDEFGLGLADPDQLGRRLDDAEQTLRVAPVPLEIMGRNGRLLLQAAKSLGWRAAPIP
HHHHHHHCCCCCCHHHHHHHHCHHHHHHEECCCCCEEECCCCHHHHHHHHHCCCCCCCCC
RNAPGCRGCCQCAIGCPSNAKFGVHLNALPQACAAGARIISWARVERILHRAGRAYGVRA
CCCCCCHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RRPDGTTLDVLADAVVVAAGATETPGLLRRSGLGGHPRLGHNLALHPATMLAGLFDDDVF
CCCCCCCHHHHHHHHHEECCCCCCCHHHHHCCCCCCCCCCCCEEECHHHHHHHHCCCHHH
AWRGVLQSAAVHEFHESDGVLIEATSTPPGMGSMVFPGYGAELLRWLDRAPQIATFGAMV
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHH
ADRGVGTVRSVRGETVVRYDIAPGEIAKLRVALQAIGRLFFAAGAVEVLTGIPGAPPMRS
HHCCCCHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LPELQDVLRRANPRSLHLAAFHPTGTAAAGADEQLCPVDATGRLRGVEGVWVADASILPS
CHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCC
CPEVNPQLSIMAMALAVADQTVAKVVGVR
CCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]