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The map label for this gene is acdA [H]

Identifier: 120613007

GI number: 120613007

Start: 4857335

End: 4858522

Strand: Reverse

Name: acdA [H]

Synonym: Aave_4371

Alternate gene names: 120613007

Gene position: 4858522-4857335 (Counterclockwise)

Preceding gene: 120613008

Following gene: 120613006

Centisome position: 90.77

GC content: 62.79

Gene sequence:

>1188_bases
ATGAGCATTTCCTCGTTGCCCGGACTGAACTTTCAATTGGGTGAAGACATCGACGCGCTGCGCGACGCCGTGCGGGAGTT
CGCACAGGCCGAGATCGCGCCCCGCGCCGGGGAGATCGATCGGGAAGATCAGTTTCCGATGGATCTCTGGCGCAAGATGG
GCGAGCTGGGAGTGCTGGGCATCACGGTTTCCGAAGCCTACGGCGGTGCGCAGATGGGCTACCTTGCCCATATGGTGGCG
ATGGAGGAGATTTCCCGCGCCAGCGCGTCGGTCGGGTTGTCCTACGGTGCGCACAGCAATCTGTGCGTGAACCAGATCCA
CCGCAACGGCTCGGAGGAGCAAAAGCGAAAGTATCTGCCAAAGCTGGTGTCCGGCGAGCATGTCGGAGCCCTGGCCATGA
GCGAGCCCGGTGCGGGTTCGGATGTCATCAGCATGAAGCTCCGGGCCGAAGACAAGGGTGGCTATTACCTGCTCAACGGC
AACAAGATGTGGATCACGAACGGCCCTGACGCCGATACGCTGGTGGTCTATGCCAAGACCGAGCCGGAACTTGGTGCGCG
CGGCGTCACCGCCTTCCTGATCGAGAAAGGCATGAAGGGCTTCAGCATTGCGCAGAAGCTCGACAAGCTGGGCATGCGGG
GTAGCCACACCGGGGAACTGGTGTTCGAGAATGTGGAGGTGCCTGCCTCCCAGGTGCTTGGCCAGGTGAACGGCGGGGCG
AAGGTGCTCATGAGCGGGCTGGACTACGAACGCGCGGTGCTGACGGGCGGTCCGTTGGGCATCATGCAGGCGGTGATGGA
CAACGTGGTGCCCTACATTCACGACCGCAGGCAGTTCGGCCAGAGCATCGGCGAGTTCCAGCTCATCCAGGGCAAGGTGG
CGGACATGTACACGGTGCTCCAGGCGGGGCGTTCCTTCGCATACACCGTGGCGAAGAATCTGGACATGCTCGGCACGGAA
CACGTCCGGCAGGTGCGCAAGGACTGCGCCTCTGTCATCCTGTGGTGTGCCGAGAAGGCGACGTGGATGGCCGGCGAGGG
CATCCAGATCTTCGGCGGCAACGGATACATCAACGAGTATCCGCTCGGCCGTCTGTGGCGGGATGCGAAACTCTACGAGA
TCGGCGCCGGCACCAGCGAGATCCGCCGCATGCTGATCGGTCGGGAACTGTTCGCCGAGACCACCTGA

Upstream 100 bases:

>100_bases
TGACGTTTACGTAAACGTAATGACGCCTGCCATGCTGCACGCCTAGGCCGTGTAGACACGCCGAAGGCAGTCTTGCCACC
CCTTCAAGGAGACAACCCCT

Downstream 100 bases:

>100_bases
CTTTGTACAACGCTCCAGAAAGAAGCCTGATGACCGCTCCCAGTATCGATGAATTGTTCGTCCACAACCGCGCATGGGCC
GCGCGGATGGAGCGGGAGCG

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MSISSLPGLNFQLGEDIDALRDAVREFAQAEIAPRAGEIDREDQFPMDLWRKMGELGVLGITVSEAYGGAQMGYLAHMVA
MEEISRASASVGLSYGAHSNLCVNQIHRNGSEEQKRKYLPKLVSGEHVGALAMSEPGAGSDVISMKLRAEDKGGYYLLNG
NKMWITNGPDADTLVVYAKTEPELGARGVTAFLIEKGMKGFSIAQKLDKLGMRGSHTGELVFENVEVPASQVLGQVNGGA
KVLMSGLDYERAVLTGGPLGIMQAVMDNVVPYIHDRRQFGQSIGEFQLIQGKVADMYTVLQAGRSFAYTVAKNLDMLGTE
HVRQVRKDCASVILWCAEKATWMAGEGIQIFGGNGYINEYPLGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETT

Sequences:

>Translated_395_residues
MSISSLPGLNFQLGEDIDALRDAVREFAQAEIAPRAGEIDREDQFPMDLWRKMGELGVLGITVSEAYGGAQMGYLAHMVA
MEEISRASASVGLSYGAHSNLCVNQIHRNGSEEQKRKYLPKLVSGEHVGALAMSEPGAGSDVISMKLRAEDKGGYYLLNG
NKMWITNGPDADTLVVYAKTEPELGARGVTAFLIEKGMKGFSIAQKLDKLGMRGSHTGELVFENVEVPASQVLGQVNGGA
KVLMSGLDYERAVLTGGPLGIMQAVMDNVVPYIHDRRQFGQSIGEFQLIQGKVADMYTVLQAGRSFAYTVAKNLDMLGTE
HVRQVRKDCASVILWCAEKATWMAGEGIQIFGGNGYINEYPLGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETT
>Mature_394_residues
SISSLPGLNFQLGEDIDALRDAVREFAQAEIAPRAGEIDREDQFPMDLWRKMGELGVLGITVSEAYGGAQMGYLAHMVAM
EEISRASASVGLSYGAHSNLCVNQIHRNGSEEQKRKYLPKLVSGEHVGALAMSEPGAGSDVISMKLRAEDKGGYYLLNGN
KMWITNGPDADTLVVYAKTEPELGARGVTAFLIEKGMKGFSIAQKLDKLGMRGSHTGELVFENVEVPASQVLGQVNGGAK
VLMSGLDYERAVLTGGPLGIMQAVMDNVVPYIHDRRQFGQSIGEFQLIQGKVADMYTVLQAGRSFAYTVAKNLDMLGTEH
VRQVRKDCASVILWCAEKATWMAGEGIQIFGGNGYINEYPLGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETT

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=385, Percent_Identity=61.8181818181818, Blast_Score=489, Evalue=1e-138,
Organism=Homo sapiens, GI226958414, Length=348, Percent_Identity=64.0804597701149, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI4557233, Length=382, Percent_Identity=38.7434554973822, Blast_Score=269, Evalue=4e-72,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=35.0267379679144, Blast_Score=245, Evalue=4e-65,
Organism=Homo sapiens, GI4501857, Length=378, Percent_Identity=33.3333333333333, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI21361497, Length=385, Percent_Identity=36.8831168831169, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI4557231, Length=386, Percent_Identity=33.9378238341969, Blast_Score=215, Evalue=7e-56,
Organism=Homo sapiens, GI187960098, Length=386, Percent_Identity=33.9378238341969, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI4557235, Length=349, Percent_Identity=35.8166189111748, Blast_Score=204, Evalue=9e-53,
Organism=Homo sapiens, GI76496475, Length=344, Percent_Identity=35.4651162790698, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI7656849, Length=396, Percent_Identity=29.2929292929293, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI4503943, Length=390, Percent_Identity=33.8461538461538, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI7669494, Length=364, Percent_Identity=34.8901098901099, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI48976061, Length=288, Percent_Identity=24.3055555555556, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI211971008, Length=288, Percent_Identity=24.3055555555556, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI38505218, Length=285, Percent_Identity=21.4035087719298, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI87081958, Length=388, Percent_Identity=29.3814432989691, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1786223, Length=386, Percent_Identity=26.4248704663212, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI87081702, Length=333, Percent_Identity=25.8258258258258, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87082384, Length=263, Percent_Identity=24.3346007604563, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538396, Length=387, Percent_Identity=60.2067183462532, Blast_Score=474, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17506239, Length=382, Percent_Identity=33.2460732984293, Blast_Score=234, Evalue=7e-62,
Organism=Caenorhabditis elegans, GI17569725, Length=388, Percent_Identity=34.2783505154639, Blast_Score=230, Evalue=9e-61,
Organism=Caenorhabditis elegans, GI17508101, Length=377, Percent_Identity=32.8912466843501, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17534899, Length=386, Percent_Identity=32.6424870466321, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17570075, Length=390, Percent_Identity=31.7948717948718, Blast_Score=214, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI17533517, Length=388, Percent_Identity=31.701030927835, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI71990804, Length=286, Percent_Identity=38.1118881118881, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71985184, Length=359, Percent_Identity=31.4763231197772, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=37.2294372294372, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17534353, Length=386, Percent_Identity=29.5336787564767, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=32.7272727272727, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI71985192, Length=288, Percent_Identity=33.3333333333333, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17505929, Length=372, Percent_Identity=29.3010752688172, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17551932, Length=373, Percent_Identity=28.4182305630027, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=26.6393442622951, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355753, Length=389, Percent_Identity=61.1825192802057, Blast_Score=463, Evalue=1e-131,
Organism=Drosophila melanogaster, GI21356377, Length=381, Percent_Identity=38.5826771653543, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI24646207, Length=381, Percent_Identity=38.3202099737533, Blast_Score=265, Evalue=5e-71,
Organism=Drosophila melanogaster, GI24666513, Length=382, Percent_Identity=32.1989528795811, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI24660351, Length=389, Percent_Identity=33.9331619537275, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI281363737, Length=380, Percent_Identity=32.6315789473684, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI19920834, Length=388, Percent_Identity=31.4432989690722, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 43054; Mature: 42923

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISSLPGLNFQLGEDIDALRDAVREFAQAEIAPRAGEIDREDQFPMDLWRKMGELGVLG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCEEE
ITVSEAYGGAQMGYLAHMVAMEEISRASASVGLSYGAHSNLCVNQIHRNGSEEQKRKYLP
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHH
KLVSGEHVGALAMSEPGAGSDVISMKLRAEDKGGYYLLNGNKMWITNGPDADTLVVYAKT
HHHCCCCCCEEEECCCCCCCCEEEEEEEECCCCCEEEECCCEEEEECCCCCCEEEEEEEC
EPELGARGVTAFLIEKGMKGFSIAQKLDKLGMRGSHTGELVFENVEVPASQVLGQVNGGA
CCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHCCCCH
KVLMSGLDYERAVLTGGPLGIMQAVMDNVVPYIHDRRQFGQSIGEFQLIQGKVADMYTVL
HHHHHCCCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHH
QAGRSFAYTVAKNLDMLGTEHVRQVRKDCASVILWCAEKATWMAGEGIQIFGGNGYINEY
HCCCCEEEHHHHCCHHCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEECCCCCCCCC
PLGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETT
CCHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SISSLPGLNFQLGEDIDALRDAVREFAQAEIAPRAGEIDREDQFPMDLWRKMGELGVLG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCEEE
ITVSEAYGGAQMGYLAHMVAMEEISRASASVGLSYGAHSNLCVNQIHRNGSEEQKRKYLP
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHH
KLVSGEHVGALAMSEPGAGSDVISMKLRAEDKGGYYLLNGNKMWITNGPDADTLVVYAKT
HHHCCCCCCEEEECCCCCCCCEEEEEEEECCCCCEEEECCCEEEEECCCCCCEEEEEEEC
EPELGARGVTAFLIEKGMKGFSIAQKLDKLGMRGSHTGELVFENVEVPASQVLGQVNGGA
CCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHCCCCH
KVLMSGLDYERAVLTGGPLGIMQAVMDNVVPYIHDRRQFGQSIGEFQLIQGKVADMYTVL
HHHHHCCCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHH
QAGRSFAYTVAKNLDMLGTEHVRQVRKDCASVILWCAEKATWMAGEGIQIFGGNGYINEY
HCCCCEEEHHHHCCHHCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEECCCCCCCCC
PLGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETT
CCHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]