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The map label for this gene is ghrA [H]

Identifier: 120612986

GI number: 120612986

Start: 4831616

End: 4832542

Strand: Reverse

Name: ghrA [H]

Synonym: Aave_4350

Alternate gene names: 120612986

Gene position: 4832542-4831616 (Counterclockwise)

Preceding gene: 120612987

Following gene: 120612985

Centisome position: 90.28

GC content: 70.87

Gene sequence:

>927_bases
ATGACCGACATCCTCTTTTGCTGTACCGATATACCGCCCGCGCCCTGGCTGGAAGGCCTGCGCTCGGCCCTGCCCGATGC
CCGCATCACGGTCTGGGAGCCCGGCGCGCCCCAGGCCGATTACGCGGTGGTGTGGGCGCCGCCGCAGCAGTTCCTCGACG
AGCAGCCGCGGCTGCGGGCGCTGTTCAACATCGGCGCGGGCGTGGATGCGCTGCTGAAGCTGCGCGTGCCCGAAGGCTGC
CGCATCGTGCGGCTCGACGACGCGGGCATGGCCGTGCAGATGGCGGAATACGTCTGCCATGCCGTCATCCGCCATTTCCG
TGAGTTCGATGCCTACGAGGCCGCGGAGCGCGAAGGCCGCTGGGCTTTCCGCAAGCCGCGGCTGCGCCAGGATTTCCCGG
TGGGCGTCATGGGGCTGGGCGTGCTGGGCGAGCGCGTGGCGCGCGCCCTGGCGCATTTCGAGTTCCCCGTGCAGGGCTGG
AGCCGCTCGCCCAAGGCCCTTGACGGCGTGCGCACATTCCACGGGGCCGACGGGCTGCAGGATTTCCTGTCGGCGAGCCG
GGTGCTGGTGAACCTGCTGCCCCTCACGCCTGATACGACCGGCATCCTGCGCCGCGAGACGCTGTCGCGCCTGCTGCCGG
GAGGCTATGTGATCAACGTGGCGCGGGGAGCGCACCTCGTGGAGGAGGACCTGTTGCCCCTGCTGGACAGCGGCCATCTC
GCGGGCGCCACGCTGGACGTCTTCCGCACCGAGCCGCTGCCGGCGGACCATCCGTTCTGGGGCCATCCGCGCGTCACCGT
CACGCCCCACACCTCGGCGCGCACGCTGCGCGCGGAGAGCATCGCCCAGATCGCGCGCAAGATCGATGCGCTGCGCCAGG
GCGCACCCTCCGTGTCCGGCGAGGTCGATCCGTCGCGAGGGTATTGA

Upstream 100 bases:

>100_bases
ACCGAAGGGGCCGAACTGCTGCGCCTGGCTGCGGCGGCATGACGGCGCGGAAAGCCTGCGTGACAGCGCGGACCATGCCC
TCTGCGATAGGCTCCTGGGA

Downstream 100 bases:

>100_bases
GGCCGCCGCTTCCCACGAACCTTTTCAGGAACTTTCCATGTCTTCCCTTCCCACCCGCGCCAAGATCGTGGACGTCGGCC
CGCGCGACGGGCTGCAGAAC

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTDILFCCTDIPPAPWLEGLRSALPDARITVWEPGAPQADYAVVWAPPQQFLDEQPRLRALFNIGAGVDALLKLRVPEGC
RIVRLDDAGMAVQMAEYVCHAVIRHFREFDAYEAAEREGRWAFRKPRLRQDFPVGVMGLGVLGERVARALAHFEFPVQGW
SRSPKALDGVRTFHGADGLQDFLSASRVLVNLLPLTPDTTGILRRETLSRLLPGGYVINVARGAHLVEEDLLPLLDSGHL
AGATLDVFRTEPLPADHPFWGHPRVTVTPHTSARTLRAESIAQIARKIDALRQGAPSVSGEVDPSRGY

Sequences:

>Translated_308_residues
MTDILFCCTDIPPAPWLEGLRSALPDARITVWEPGAPQADYAVVWAPPQQFLDEQPRLRALFNIGAGVDALLKLRVPEGC
RIVRLDDAGMAVQMAEYVCHAVIRHFREFDAYEAAEREGRWAFRKPRLRQDFPVGVMGLGVLGERVARALAHFEFPVQGW
SRSPKALDGVRTFHGADGLQDFLSASRVLVNLLPLTPDTTGILRRETLSRLLPGGYVINVARGAHLVEEDLLPLLDSGHL
AGATLDVFRTEPLPADHPFWGHPRVTVTPHTSARTLRAESIAQIARKIDALRQGAPSVSGEVDPSRGY
>Mature_307_residues
TDILFCCTDIPPAPWLEGLRSALPDARITVWEPGAPQADYAVVWAPPQQFLDEQPRLRALFNIGAGVDALLKLRVPEGCR
IVRLDDAGMAVQMAEYVCHAVIRHFREFDAYEAAEREGRWAFRKPRLRQDFPVGVMGLGVLGERVARALAHFEFPVQGWS
RSPKALDGVRTFHGADGLQDFLSASRVLVNLLPLTPDTTGILRRETLSRLLPGGYVINVARGAHLVEEDLLPLLDSGHLA
GATLDVFRTEPLPADHPFWGHPRVTVTPHTSARTLRAESIAQIARKIDALRQGAPSVSGEVDPSRGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=239, Percent_Identity=30.1255230125523, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI6912396, Length=237, Percent_Identity=24.8945147679325, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI145580578, Length=235, Percent_Identity=26.3829787234043, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI4557499, Length=235, Percent_Identity=26.3829787234043, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI87081824, Length=313, Percent_Identity=45.6869009584665, Blast_Score=264, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI17532191, Length=200, Percent_Identity=31.5, Blast_Score=85, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=304, Percent_Identity=25.3289473684211, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324980, Length=174, Percent_Identity=29.3103448275862, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI19921140, Length=254, Percent_Identity=27.5590551181102, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28574286, Length=327, Percent_Identity=24.1590214067278, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 33954; Mature: 33823

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDILFCCTDIPPAPWLEGLRSALPDARITVWEPGAPQADYAVVWAPPQQFLDEQPRLRA
CCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCHHHHCCCCCHHHH
LFNIGAGVDALLKLRVPEGCRIVRLDDAGMAVQMAEYVCHAVIRHFREFDAYEAAEREGR
HHHCCCCHHHHEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WAFRKPRLRQDFPVGVMGLGVLGERVARALAHFEFPVQGWSRSPKALDGVRTFHGADGLQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHH
DFLSASRVLVNLLPLTPDTTGILRRETLSRLLPGGYVINVARGAHLVEEDLLPLLDSGHL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCC
AGATLDVFRTEPLPADHPFWGHPRVTVTPHTSARTLRAESIAQIARKIDALRQGAPSVSG
CCCEEEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EVDPSRGY
CCCCCCCC
>Mature Secondary Structure 
TDILFCCTDIPPAPWLEGLRSALPDARITVWEPGAPQADYAVVWAPPQQFLDEQPRLRA
CCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCHHHHCCCCCHHHH
LFNIGAGVDALLKLRVPEGCRIVRLDDAGMAVQMAEYVCHAVIRHFREFDAYEAAEREGR
HHHCCCCHHHHEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WAFRKPRLRQDFPVGVMGLGVLGERVARALAHFEFPVQGWSRSPKALDGVRTFHGADGLQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHH
DFLSASRVLVNLLPLTPDTTGILRRETLSRLLPGGYVINVARGAHLVEEDLLPLLDSGHL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCC
AGATLDVFRTEPLPADHPFWGHPRVTVTPHTSARTLRAESIAQIARKIDALRQGAPSVSG
CCCEEEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EVDPSRGY
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA