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The map label for this gene is mvaB [H]

Identifier: 120612985

GI number: 120612985

Start: 4830667

End: 4831578

Strand: Reverse

Name: mvaB [H]

Synonym: Aave_4349

Alternate gene names: 120612985

Gene position: 4831578-4830667 (Counterclockwise)

Preceding gene: 120612986

Following gene: 120612984

Centisome position: 90.26

GC content: 68.64

Gene sequence:

>912_bases
ATGTCTTCCCTTCCCACCCGCGCCAAGATCGTGGACGTCGGCCCGCGCGACGGGCTGCAGAACGAGAAATCCCCCGTGCC
GGCCAGCGTCAAGATCGGTCTCGTGCACCGGCTGCAGGCGGCCGGGCTGACCGAGATCGAGGTCACGAGCTATGTCTCTC
CCAAATGGGTGCCGCAGATGGCGGACAACCATGAGGTGATGGCCGGCATCGAGCGGCTCCCGGGCGTCCGCTATTCGGTG
CTGACGCCCAACCTGAAGGGCTACGAGGCGGCCGTGCTGGACCGGCCCGACGAGATCGTTGTGTTCGGCTCCGCCAGCGA
GGCGTTCAGCCAGAAGAACATCAACTGCAGCATCGCCGAGAGCATCGAGCGCTTCGCCCCGGTGGTCGAGGCCGCGCGCG
CCGCGGGCATCCACGTGCGCGGCGCCATGAGCTGCACCGTGGGCTGCCCCTACGAGGGCGAAGTGGCGCCGGAGCGCGTG
GGTTACCTGGCCGGGCTCATGAAGGGCATCGGCGTGCAGCATATCGGCGTGGCGGACACCATCGGCGTGGGCACCCCGCG
CAAGGTGCAGCGTGCCATCGAGGCGACGCTCGCGCACTATGCCGTGGACGACGTTTCCGGGCACTTCCACGATACCTACG
GGCAGGCGCTCGCCAACACCCTGGCCGCGCTGGAGATGGGCATCTGGCAGTTCGACACGTCGGTGGCCGGCCTGGGCGGC
TGTCCCTATGCGAAGGGGGCCACGGGCAACGTGGCCACCGAGGACGTGGTGTACATGCTGCACGGCATGGGCATCGAGAC
GGGCATCGACCTGGATGCGCTGGTCGATGCCGGGGCCTACATCAGTGACTTCCTCGGCCGCAAGCCGAATTCGCGCGCCG
CCACCGCCCTGCTGAACAGGCGCGCCGGCTGA

Upstream 100 bases:

>100_bases
GATGCGCTGCGCCAGGGCGCACCCTCCGTGTCCGGCGAGGTCGATCCGTCGCGAGGGTATTGAGGCCGCCGCTTCCCACG
AACCTTTTCAGGAACTTTCC

Downstream 100 bases:

>100_bases
TGCGCCGCACGGCGGAGCGCGGCACAATCCGGCACTTCGTCCATCCCACGATTTTCCAGGAGGCCTTGAGCATGTGCGGT
GCTGAACTTCAATCCCTTCC

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MSSLPTRAKIVDVGPRDGLQNEKSPVPASVKIGLVHRLQAAGLTEIEVTSYVSPKWVPQMADNHEVMAGIERLPGVRYSV
LTPNLKGYEAAVLDRPDEIVVFGSASEAFSQKNINCSIAESIERFAPVVEAARAAGIHVRGAMSCTVGCPYEGEVAPERV
GYLAGLMKGIGVQHIGVADTIGVGTPRKVQRAIEATLAHYAVDDVSGHFHDTYGQALANTLAALEMGIWQFDTSVAGLGG
CPYAKGATGNVATEDVVYMLHGMGIETGIDLDALVDAGAYISDFLGRKPNSRAATALLNRRAG

Sequences:

>Translated_303_residues
MSSLPTRAKIVDVGPRDGLQNEKSPVPASVKIGLVHRLQAAGLTEIEVTSYVSPKWVPQMADNHEVMAGIERLPGVRYSV
LTPNLKGYEAAVLDRPDEIVVFGSASEAFSQKNINCSIAESIERFAPVVEAARAAGIHVRGAMSCTVGCPYEGEVAPERV
GYLAGLMKGIGVQHIGVADTIGVGTPRKVQRAIEATLAHYAVDDVSGHFHDTYGQALANTLAALEMGIWQFDTSVAGLGG
CPYAKGATGNVATEDVVYMLHGMGIETGIDLDALVDAGAYISDFLGRKPNSRAATALLNRRAG
>Mature_302_residues
SSLPTRAKIVDVGPRDGLQNEKSPVPASVKIGLVHRLQAAGLTEIEVTSYVSPKWVPQMADNHEVMAGIERLPGVRYSVL
TPNLKGYEAAVLDRPDEIVVFGSASEAFSQKNINCSIAESIERFAPVVEAARAAGIHVRGAMSCTVGCPYEGEVAPERVG
YLAGLMKGIGVQHIGVADTIGVGTPRKVQRAIEATLAHYAVDDVSGHFHDTYGQALANTLAALEMGIWQFDTSVAGLGGC
PYAKGATGNVATEDVVYMLHGMGIETGIDLDALVDAGAYISDFLGRKPNSRAATALLNRRAG

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=296, Percent_Identity=55.4054054054054, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI109150427, Length=299, Percent_Identity=53.8461538461538, Blast_Score=335, Evalue=2e-92,
Organism=Homo sapiens, GI109150422, Length=299, Percent_Identity=53.8461538461538, Blast_Score=335, Evalue=2e-92,
Organism=Homo sapiens, GI260654708, Length=145, Percent_Identity=49.6551724137931, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17510563, Length=302, Percent_Identity=45.0331125827815, Blast_Score=278, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6320019, Length=240, Percent_Identity=27.5, Blast_Score=63, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320071, Length=240, Percent_Identity=27.5, Blast_Score=63, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24582381, Length=292, Percent_Identity=53.4246575342466, Blast_Score=326, Evalue=2e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 31943; Mature: 31812

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS01062 HMG_COA_LYASE ; PS50991 PYR_CT ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLPTRAKIVDVGPRDGLQNEKSPVPASVKIGLVHRLQAAGLTEIEVTSYVSPKWVPQM
CCCCCCCEEEEECCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCCEEEEECCCCCCCCCCC
ADNHEVMAGIERLPGVRYSVLTPNLKGYEAAVLDRPDEIVVFGSASEAFSQKNINCSIAE
CCCHHHHHHHHHCCCCEEEEECCCCCCCEEHEECCCCCEEEECCCHHHHHHCCCCCHHHH
SIERFAPVVEAARAAGIHVRGAMSCTVGCPYEGEVAPERVGYLAGLMKGIGVQHIGVADT
HHHHHHHHHHHHHHCCEEEEECEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHH
IGVGTPRKVQRAIEATLAHYAVDDVSGHFHDTYGQALANTLAALEMGIWQFDTSVAGLGG
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
CPYAKGATGNVATEDVVYMLHGMGIETGIDLDALVDAGAYISDFLGRKPNSRAATALLNR
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHCCCCCCHHHHHHHHH
RAG
CCC
>Mature Secondary Structure 
SSLPTRAKIVDVGPRDGLQNEKSPVPASVKIGLVHRLQAAGLTEIEVTSYVSPKWVPQM
CCCCCCEEEEECCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCCEEEEECCCCCCCCCCC
ADNHEVMAGIERLPGVRYSVLTPNLKGYEAAVLDRPDEIVVFGSASEAFSQKNINCSIAE
CCCHHHHHHHHHCCCCEEEEECCCCCCCEEHEECCCCCEEEECCCHHHHHHCCCCCHHHH
SIERFAPVVEAARAAGIHVRGAMSCTVGCPYEGEVAPERVGYLAGLMKGIGVQHIGVADT
HHHHHHHHHHHHHHCCEEEEECEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHH
IGVGTPRKVQRAIEATLAHYAVDDVSGHFHDTYGQALANTLAALEMGIWQFDTSVAGLGG
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
CPYAKGATGNVATEDVVYMLHGMGIETGIDLDALVDAGAYISDFLGRKPNSRAATALLNR
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHCCCCCCHHHHHHHHH
RAG
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]