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The map label for this gene is paaF [H]

Identifier: 120612947

GI number: 120612947

Start: 4787797

End: 4788606

Strand: Reverse

Name: paaF [H]

Synonym: Aave_4311

Alternate gene names: 120612947

Gene position: 4788606-4787797 (Counterclockwise)

Preceding gene: 120612948

Following gene: 120612946

Centisome position: 89.46

GC content: 73.7

Gene sequence:

>810_bases
ATGGTTGACGCGACCGCGCCCCTGCTGCAGCGCCGCGAGGGCGCCGTGCTGGTGCTCAGCAACAACAACACCGCCGCGCG
CAACGCCCTGTCGCCCGCGTTCTATGCCGCGCTGACCGCCGCACTGGCCGCCGCGCAGGACGATCCCGCGGTGGGCGCCA
TCGTGCTCACCGGCGAAGGCGGCCACTTCTGCGCGGGCGGCGACCTGCGCCAATTGGCGAAGCGGCGCGAGCTGCCCGTC
GAAGAGCGCCGCGCCAAGCTGGAAGGCCTGCACGATCTGGTCCGTGCGGTGCGCGGCAGCGGCAAGCCGGTGATCGCGGC
CGTGGAGGGTGCGGCGGCCGGCGCGGGCCTGTCGCTGGCGCTGGCCTGCGACATGCTGGTGGCGGCGCGCGATGCCGTCT
TCTCGGTGGCCTATGTGAAGGTGGGCCTCACGCCCGATGGCGGCGCGACGGCCTTCCTGGCCGAATTCGTCTCGCGCCAG
GTGCTGACGGAGCTGTGCCTGACAGGCGAGCGGATTTCGGGCGAGCGCCTGCATGCACTCGGCGCCGTCAACCGCCTGGC
CGAGCCGGGCGAGGCGCTGGCGGGCGCGCTGGCGCTGGCCGCCAGCGTGGCGAACGGGCCGCAGCAGGCCATGGCGCGCA
TCAAGGCGCTGTGCCTGGCGGCGCCCCAGGCCACGCTCGAAGAGCAGTTGGAGAGCGAGGCGCAGAGCATGGTGCTGTCG
CAGGCGACCGAAGAGTCGCGCGAGGGCATCGCCGCCTTCCTGGAAAAGCGCGCGCCCGATTACGTGCGCCTGCGCGGCCC
GGCGGGCTGA

Upstream 100 bases:

>100_bases
CGGCCCTTGCTCGGCTGCCGCTGGGCTGGGCCGCGCCGGTTTCAAGGGACTTGGGTGGCGCATAGCGCCATGAACAACTG
AAATGGAAAAAGGAGCCGCC

Downstream 100 bases:

>100_bases
CGCGCTCCCGGTGCCGGGTCGCGAAGGGGGCAGCGGCCACGCCGCCCGCCGCATCACAATGAACGAATGACTGGAGACAA
GACATTGAATGCCACCACTT

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MVDATAPLLQRREGAVLVLSNNNTAARNALSPAFYAALTAALAAAQDDPAVGAIVLTGEGGHFCAGGDLRQLAKRRELPV
EERRAKLEGLHDLVRAVRGSGKPVIAAVEGAAAGAGLSLALACDMLVAARDAVFSVAYVKVGLTPDGGATAFLAEFVSRQ
VLTELCLTGERISGERLHALGAVNRLAEPGEALAGALALAASVANGPQQAMARIKALCLAAPQATLEEQLESEAQSMVLS
QATEESREGIAAFLEKRAPDYVRLRGPAG

Sequences:

>Translated_269_residues
MVDATAPLLQRREGAVLVLSNNNTAARNALSPAFYAALTAALAAAQDDPAVGAIVLTGEGGHFCAGGDLRQLAKRRELPV
EERRAKLEGLHDLVRAVRGSGKPVIAAVEGAAAGAGLSLALACDMLVAARDAVFSVAYVKVGLTPDGGATAFLAEFVSRQ
VLTELCLTGERISGERLHALGAVNRLAEPGEALAGALALAASVANGPQQAMARIKALCLAAPQATLEEQLESEAQSMVLS
QATEESREGIAAFLEKRAPDYVRLRGPAG
>Mature_269_residues
MVDATAPLLQRREGAVLVLSNNNTAARNALSPAFYAALTAALAAAQDDPAVGAIVLTGEGGHFCAGGDLRQLAKRRELPV
EERRAKLEGLHDLVRAVRGSGKPVIAAVEGAAAGAGLSLALACDMLVAARDAVFSVAYVKVGLTPDGGATAFLAEFVSRQ
VLTELCLTGERISGERLHALGAVNRLAEPGEALAGALALAASVANGPQQAMARIKALCLAAPQATLEEQLESEAQSMVLS
QATEESREGIAAFLEKRAPDYVRLRGPAG

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=251, Percent_Identity=32.2709163346614, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI31542718, Length=247, Percent_Identity=29.5546558704453, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI221136756, Length=256, Percent_Identity=22.65625, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI221136753, Length=256, Percent_Identity=22.65625, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI221307494, Length=256, Percent_Identity=22.65625, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI70995211, Length=253, Percent_Identity=30.4347826086957, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI116235487, Length=256, Percent_Identity=24.21875, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI4502327, Length=260, Percent_Identity=30.3846153846154, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI37594469, Length=193, Percent_Identity=28.4974093264249, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI37594471, Length=193, Percent_Identity=28.4974093264249, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4757968, Length=258, Percent_Identity=21.3178294573643, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI49355787, Length=258, Percent_Identity=21.3178294573643, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI20127408, Length=181, Percent_Identity=27.6243093922652, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI68989263, Length=183, Percent_Identity=27.8688524590164, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI25453481, Length=258, Percent_Identity=21.3178294573643, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI51538573, Length=258, Percent_Identity=21.3178294573643, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4757966, Length=225, Percent_Identity=24.4444444444444, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI51538581, Length=225, Percent_Identity=24.4444444444444, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787659, Length=255, Percent_Identity=34.1176470588235, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1787660, Length=256, Percent_Identity=33.59375, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI221142681, Length=256, Percent_Identity=30.078125, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788597, Length=250, Percent_Identity=28.4, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI87082183, Length=253, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25145438, Length=249, Percent_Identity=32.1285140562249, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17554946, Length=246, Percent_Identity=30.4878048780488, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17560910, Length=261, Percent_Identity=28.735632183908, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17540714, Length=178, Percent_Identity=31.4606741573034, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17540306, Length=239, Percent_Identity=28.8702928870293, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17535521, Length=250, Percent_Identity=24.4, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17558304, Length=191, Percent_Identity=30.8900523560209, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17536985, Length=196, Percent_Identity=26.530612244898, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17508953, Length=253, Percent_Identity=29.6442687747036, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508951, Length=253, Percent_Identity=29.6442687747036, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25144276, Length=253, Percent_Identity=29.6442687747036, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17534483, Length=199, Percent_Identity=29.1457286432161, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI20129971, Length=250, Percent_Identity=29.6, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653477, Length=250, Percent_Identity=29.6, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653139, Length=271, Percent_Identity=32.8413284132841, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI19920382, Length=251, Percent_Identity=29.8804780876494, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24654903, Length=184, Percent_Identity=27.1739130434783, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21357171, Length=258, Percent_Identity=27.5193798449612, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI19922422, Length=262, Percent_Identity=25.1908396946565, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24650670, Length=211, Percent_Identity=30.8056872037915, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 27669; Mature: 27669

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDATAPLLQRREGAVLVLSNNNTAARNALSPAFYAALTAALAAAQDDPAVGAIVLTGEG
CCCCHHHHHHCCCCCEEEEECCCHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEEECCC
GHFCAGGDLRQLAKRRELPVEERRAKLEGLHDLVRAVRGSGKPVIAAVEGAAAGAGLSLA
CCEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHH
LACDMLVAARDAVFSVAYVKVGLTPDGGATAFLAEFVSRQVLTELCLTGERISGERLHAL
HHHHHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
GAVNRLAEPGEALAGALALAASVANGPQQAMARIKALCLAAPQATLEEQLESEAQSMVLS
HHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
QATEESREGIAAFLEKRAPDYVRLRGPAG
HHHHHHHHHHHHHHHHCCCCEEEECCCCC
>Mature Secondary Structure
MVDATAPLLQRREGAVLVLSNNNTAARNALSPAFYAALTAALAAAQDDPAVGAIVLTGEG
CCCCHHHHHHCCCCCEEEEECCCHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEEECCC
GHFCAGGDLRQLAKRRELPVEERRAKLEGLHDLVRAVRGSGKPVIAAVEGAAAGAGLSLA
CCEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHH
LACDMLVAARDAVFSVAYVKVGLTPDGGATAFLAEFVSRQVLTELCLTGERISGERLHAL
HHHHHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
GAVNRLAEPGEALAGALALAASVANGPQQAMARIKALCLAAPQATLEEQLESEAQSMVLS
HHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
QATEESREGIAAFLEKRAPDYVRLRGPAG
HHHHHHHHHHHHHHHHCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]