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The map label for this gene is ybhO [H]

Identifier: 120612935

GI number: 120612935

Start: 4773865

End: 4775247

Strand: Direct

Name: ybhO [H]

Synonym: Aave_4299

Alternate gene names: 120612935

Gene position: 4773865-4775247 (Clockwise)

Preceding gene: 120612934

Following gene: 120612936

Centisome position: 89.18

GC content: 72.52

Gene sequence:

>1383_bases
ATGACACGGCCGGGCCGCTCCTCGCGCTGGGTACCGGGCAACCGCTTCGAGCTGCTGGAAAACGGCGAGGCCTTCTTCCC
GCGCGTGTTCGAGGCGATCGCGGCGGCGAAGCGCGAAGTGCTGCTGGAGACCTTCATCCTGTTCGACGACAAGATCGGCC
GGGGCCTGCACGCCGCGCTGCTGCAGGCCGCGCGCAACGGCGCCGAAGTGCACGTGCTCGTGGACGGCTTCGGCTCGCCC
GACCTCTCCGATGCCTTCGTCGGCCCGCTCGTGGCCGCGGGCGTGCGGTTCCGCATCTTCGATCCGGGCGGACTGCGCAT
CTTCGGCCAGCGGCTGAACCTGCTGCGCCGCATGCACCGCAAGATCGTCGTGGTCGATGGCGAGGTCGGCTTCATCGGCG
GCATCAACTACTCGGCCGACCACGTGGCGGATTTCGGGCCCGAGGCCAAGCAGGACTATTCCGTCGAGGTGCGCGGCCCC
ATCGTGGCGCAGATGCGCGCCTTCGCACGCAGCGTCGTGGACAAGGGCGCCAGGAAGGACGGCCGGCGCGCGAACCCGCA
GGCCACCTCCAGCGCCGAGCCGGAAGCCGGGGCAGGCACGGCACGCGCCGGCGGCGCGGCCCGGGCCCCGTTGCCCGCGG
GCACGCCGGCAGACGGTCCGCGCGCCGCGGCCGAGCGGCGCCGGTGGCCCTTCGGCGCCCGCGCCGCCGTGGAGCGGCAC
CCCGCGGCCGGCCACGCGGACGCCATCTTCGTCACGCGCGACAACCATGCCCACACCAACGACATCGAGCGCCACTACCG
CGTCGCGCTGCGCGCGGCGCGCGAGCGCGTGGTGATCGCCAATGCGTATTTCTTCCCGGGCTACCGCTTCATCCGCGAGA
TGCGGCGGGCCGCGCGCCGCGGGGTGGACGTGCGCCTGATCCTGCAGGGCCAACCCGACATGCCGATCGTGCGCGTGGCC
GCGAGCATGCTCTACGACCACCTCATCCGCGGCGGCGTGCGCATCTACGAATACTGCGACCGCCCCCTGCACGGCAAGGT
CGCGCTGGTGGACGGCGAGTGGTCCACGGTGGGATCGAGCAACCTCGACCCCCTGAGCCTGTCGCTGAACCTGGAGGCCA
ACGTCGTCATCCGCGACCGGGAGTTCAACGCCACGCTGCACGGGCGCCTCGCGCACCTGATGGAGCACAGCTGCCGACAG
GTCGAACCGACGCCGCCGGGCCGCTGGGACGGGCTGCGGCTGCTGCGCAGCTACTGCCTGTTCCACCTGATGCGCTGGTT
CCCCGCGTGGGCCGGCTGGCTGCCCCGGCACGAGCCGGAGATCTCGCTGGTGCAGCCCGACGCGCATGGCGGCGACCACG
GCCACCGGCCGTCCACCACCTGA

Upstream 100 bases:

>100_bases
TCTACGTGCGCAACGCGTCGGTGCATGCCCCCGTGGTGCTGCCGCGCAAGCCCTGGCACAAGCTGTCGGACCACGCGCCG
CTGGCGGCGGAGATCGCGCT

Downstream 100 bases:

>100_bases
GCGCGCGGCGCCCGATCGGTCTTCCATGCCTGCGGCCTCGCCCACGCCCGCCCTGCCCCAGGACCACGCCGACGGCGCGG
GCAGCTCCGGCGAGAAGAAG

Product: cardiolipin synthase 2

Products: cardiolipin; glycerol [C]

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MTRPGRSSRWVPGNRFELLENGEAFFPRVFEAIAAAKREVLLETFILFDDKIGRGLHAALLQAARNGAEVHVLVDGFGSP
DLSDAFVGPLVAAGVRFRIFDPGGLRIFGQRLNLLRRMHRKIVVVDGEVGFIGGINYSADHVADFGPEAKQDYSVEVRGP
IVAQMRAFARSVVDKGARKDGRRANPQATSSAEPEAGAGTARAGGAARAPLPAGTPADGPRAAAERRRWPFGARAAVERH
PAAGHADAIFVTRDNHAHTNDIERHYRVALRAARERVVIANAYFFPGYRFIREMRRAARRGVDVRLILQGQPDMPIVRVA
ASMLYDHLIRGGVRIYEYCDRPLHGKVALVDGEWSTVGSSNLDPLSLSLNLEANVVIRDREFNATLHGRLAHLMEHSCRQ
VEPTPPGRWDGLRLLRSYCLFHLMRWFPAWAGWLPRHEPEISLVQPDAHGGDHGHRPSTT

Sequences:

>Translated_460_residues
MTRPGRSSRWVPGNRFELLENGEAFFPRVFEAIAAAKREVLLETFILFDDKIGRGLHAALLQAARNGAEVHVLVDGFGSP
DLSDAFVGPLVAAGVRFRIFDPGGLRIFGQRLNLLRRMHRKIVVVDGEVGFIGGINYSADHVADFGPEAKQDYSVEVRGP
IVAQMRAFARSVVDKGARKDGRRANPQATSSAEPEAGAGTARAGGAARAPLPAGTPADGPRAAAERRRWPFGARAAVERH
PAAGHADAIFVTRDNHAHTNDIERHYRVALRAARERVVIANAYFFPGYRFIREMRRAARRGVDVRLILQGQPDMPIVRVA
ASMLYDHLIRGGVRIYEYCDRPLHGKVALVDGEWSTVGSSNLDPLSLSLNLEANVVIRDREFNATLHGRLAHLMEHSCRQ
VEPTPPGRWDGLRLLRSYCLFHLMRWFPAWAGWLPRHEPEISLVQPDAHGGDHGHRPSTT
>Mature_459_residues
TRPGRSSRWVPGNRFELLENGEAFFPRVFEAIAAAKREVLLETFILFDDKIGRGLHAALLQAARNGAEVHVLVDGFGSPD
LSDAFVGPLVAAGVRFRIFDPGGLRIFGQRLNLLRRMHRKIVVVDGEVGFIGGINYSADHVADFGPEAKQDYSVEVRGPI
VAQMRAFARSVVDKGARKDGRRANPQATSSAEPEAGAGTARAGGAARAPLPAGTPADGPRAAAERRRWPFGARAAVERHP
AAGHADAIFVTRDNHAHTNDIERHYRVALRAARERVVIANAYFFPGYRFIREMRRAARRGVDVRLILQGQPDMPIVRVAA
SMLYDHLIRGGVRIYEYCDRPLHGKVALVDGEWSTVGSSNLDPLSLSLNLEANVVIRDREFNATLHGRLAHLMEHSCRQV
EPTPPGRWDGLRLLRSYCLFHLMRWFPAWAGWLPRHEPEISLVQPDAHGGDHGHRPSTT

Specific function: Catalyzes, in vitro, the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787007, Length=440, Percent_Identity=49.3181818181818, Blast_Score=410, Evalue=1e-115,
Organism=Escherichia coli, GI1787502, Length=385, Percent_Identity=25.974025974026, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 50901; Mature: 50769

Theoretical pI: Translated: 10.36; Mature: 10.36

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPGRSSRWVPGNRFELLENGEAFFPRVFEAIAAAKREVLLETFILFDDKIGRGLHAAL
CCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LQAARNGAEVHVLVDGFGSPDLSDAFVGPLVAAGVRFRIFDPGGLRIFGQRLNLLRRMHR
HHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHCC
KIVVVDGEVGFIGGINYSADHVADFGPEAKQDYSVEVRGPIVAQMRAFARSVVDKGARKD
EEEEEECCEEEEECCCCCHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCC
GRRANPQATSSAEPEAGAGTARAGGAARAPLPAGTPADGPRAAAERRRWPFGARAAVERH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHCC
PAAGHADAIFVTRDNHAHTNDIERHYRVALRAARERVVIANAYFFPGYRFIREMRRAARR
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCEEEEEEEEECCCHHHHHHHHHHHHC
GVDVRLILQGQPDMPIVRVAASMLYDHLIRGGVRIYEYCDRPLHGKVALVDGEWSTVGSS
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEECCCCCCCCCC
NLDPLSLSLNLEANVVIRDREFNATLHGRLAHLMEHSCRQVEPTPPGRWDGLRLLRSYCL
CCCCEEEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
FHLMRWFPAWAGWLPRHEPEISLVQPDAHGGDHGHRPSTT
HHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TRPGRSSRWVPGNRFELLENGEAFFPRVFEAIAAAKREVLLETFILFDDKIGRGLHAAL
CCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LQAARNGAEVHVLVDGFGSPDLSDAFVGPLVAAGVRFRIFDPGGLRIFGQRLNLLRRMHR
HHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHCC
KIVVVDGEVGFIGGINYSADHVADFGPEAKQDYSVEVRGPIVAQMRAFARSVVDKGARKD
EEEEEECCEEEEECCCCCHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCC
GRRANPQATSSAEPEAGAGTARAGGAARAPLPAGTPADGPRAAAERRRWPFGARAAVERH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHCC
PAAGHADAIFVTRDNHAHTNDIERHYRVALRAARERVVIANAYFFPGYRFIREMRRAARR
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCEEEEEEEEECCCHHHHHHHHHHHHC
GVDVRLILQGQPDMPIVRVAASMLYDHLIRGGVRIYEYCDRPLHGKVALVDGEWSTVGSS
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEECCCCCCCCCC
NLDPLSLSLNLEANVVIRDREFNATLHGRLAHLMEHSCRQVEPTPPGRWDGLRLLRSYCL
CCCCEEEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
FHLMRWFPAWAGWLPRHEPEISLVQPDAHGGDHGHRPSTT
HHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 L-1-phosphatidyl-glycerol [C]

Specific reaction: 2 L-1-phosphatidyl-glycerol = cardiolipin + glycerol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]