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The map label for this gene is cysK [H]

Identifier: 120612933

GI number: 120612933

Start: 4771840

End: 4772805

Strand: Direct

Name: cysK [H]

Synonym: Aave_4297

Alternate gene names: 120612933

Gene position: 4771840-4772805 (Clockwise)

Preceding gene: 120612930

Following gene: 120612934

Centisome position: 89.15

GC content: 69.98

Gene sequence:

>966_bases
ATGGCCCGTTCCCGTTCCTCAGGAACCCTTTTCCACCGTGGAGACGCCATGAAGATCGACAATATCCTGCAGTCCATCGG
CAGCACGCCGCACGTGCGCATCCACCGGCTCTTCGGGGCCGGGACGAATGTCTGGGTCAAGTCCGAGCGCAGCAACCCGG
GCGGCTCCATCAAGGACCGCATCGCGCTGGCCATGGTCGAGGACGCCGAACGCTCCGGCGCGCTGCAGCCCGGCGGCACC
ATCATCGAGCCCACCTCGGGCAACACCGGCATCGGCCTGGCGCTGGTCGCCGCGGTGAAGGGCTACCGGCTCATCCTGGT
GATGCCCGAGAGCATGAGCATCGAGCGCCGCCGCCTGATGCTCGCCTATGGCGCGCAGTTCGACCTCACCCCGCGCGAAA
AGGGCATGAAGGGCGCCATCGCCCGCGCGCAGGAGCTGGCCGCGCAGACGCCCGGCGCCTGGGTGCCCCAGCAGTTCGAA
AATCCCGCCAACATCGACGTGCACGTGCGCACCACGGCGCAGGAGATCCTGGCCGACTTCCCCGAAGGCATCGATGCGCT
CATCACCGGCGTGGGCACCGGCGGCCACATCACGGGCGTGGCGCGCGTGCTCAAGCCGAAATTCCCCCAGCTCAAGGTGT
TCGCCGTGGAGCCCGTGGCGTCGCCGGTGATCTCCGGCGGCCAGCCGGCGCCCCACCCGATCCAGGGCATCGGCGCGGGC
TTCGTGCCGAAGAACCTGGACACCAGCCTGCTGGACGGCGTGATCCAGGTCGATGCCGAGCCCGCGCGCGAATACGCCCG
CCGCGCCGCCCGCGAGGAAGGCCTGCTCGTGGGGATATCCTCCGGCGCCACGCTCGCGGCCATCGCCCAGAAGCTGCCCG
AGCTGCCGCAGGGCGCGCGCGTGCTGGGCTTCAACTACGACACGGGCGAGCGCTACCTGTCGGTCGAGGGCTTCCTGCCC
TCGTGA

Upstream 100 bases:

>100_bases
GAATATCTTTCATAAATTTAATTTTTAGAATGGCCGGGGTGCCTGGTGCGGGGGACGGCGGCATATCCATATGCGGGCCG
TATCGTTGGAGTGGTCCACA

Downstream 100 bases:

>100_bases
GTACATCCCCCTGAGGCGCTGCGCGCCTTCCCCCTTCTCTCGCCGTGCTGCGCACGGCGGGAAGGGGAACGACGCCGGTG
GCCGGGCCAAGCCCGTTCCA

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MARSRSSGTLFHRGDAMKIDNILQSIGSTPHVRIHRLFGAGTNVWVKSERSNPGGSIKDRIALAMVEDAERSGALQPGGT
IIEPTSGNTGIGLALVAAVKGYRLILVMPESMSIERRRLMLAYGAQFDLTPREKGMKGAIARAQELAAQTPGAWVPQQFE
NPANIDVHVRTTAQEILADFPEGIDALITGVGTGGHITGVARVLKPKFPQLKVFAVEPVASPVISGGQPAPHPIQGIGAG
FVPKNLDTSLLDGVIQVDAEPAREYARRAAREEGLLVGISSGATLAAIAQKLPELPQGARVLGFNYDTGERYLSVEGFLP
S

Sequences:

>Translated_321_residues
MARSRSSGTLFHRGDAMKIDNILQSIGSTPHVRIHRLFGAGTNVWVKSERSNPGGSIKDRIALAMVEDAERSGALQPGGT
IIEPTSGNTGIGLALVAAVKGYRLILVMPESMSIERRRLMLAYGAQFDLTPREKGMKGAIARAQELAAQTPGAWVPQQFE
NPANIDVHVRTTAQEILADFPEGIDALITGVGTGGHITGVARVLKPKFPQLKVFAVEPVASPVISGGQPAPHPIQGIGAG
FVPKNLDTSLLDGVIQVDAEPAREYARRAAREEGLLVGISSGATLAAIAQKLPELPQGARVLGFNYDTGERYLSVEGFLP
S
>Mature_320_residues
ARSRSSGTLFHRGDAMKIDNILQSIGSTPHVRIHRLFGAGTNVWVKSERSNPGGSIKDRIALAMVEDAERSGALQPGGTI
IEPTSGNTGIGLALVAAVKGYRLILVMPESMSIERRRLMLAYGAQFDLTPREKGMKGAIARAQELAAQTPGAWVPQQFEN
PANIDVHVRTTAQEILADFPEGIDALITGVGTGGHITGVARVLKPKFPQLKVFAVEPVASPVISGGQPAPHPIQGIGAGF
VPKNLDTSLLDGVIQVDAEPAREYARRAAREEGLLVGISSGATLAAIAQKLPELPQGARVLGFNYDTGERYLSVEGFLPS

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=319, Percent_Identity=41.3793103448276, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI295821200, Length=319, Percent_Identity=41.3793103448276, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI4557415, Length=319, Percent_Identity=41.3793103448276, Blast_Score=224, Evalue=1e-58,
Organism=Escherichia coli, GI1788754, Length=310, Percent_Identity=49.6774193548387, Blast_Score=229, Evalue=1e-61,
Organism=Escherichia coli, GI2367138, Length=301, Percent_Identity=38.2059800664452, Blast_Score=192, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17535051, Length=293, Percent_Identity=45.3924914675768, Blast_Score=237, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI115535073, Length=299, Percent_Identity=49.8327759197324, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17562970, Length=299, Percent_Identity=41.8060200668896, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI32566674, Length=294, Percent_Identity=42.5170068027211, Blast_Score=219, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17561720, Length=299, Percent_Identity=42.1404682274247, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI17534315, Length=325, Percent_Identity=38.7692307692308, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI25147552, Length=313, Percent_Identity=38.3386581469649, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=40.3755868544601, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17561716, Length=119, Percent_Identity=41.1764705882353, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=36.624203821656, Blast_Score=192, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6321449, Length=321, Percent_Identity=34.5794392523364, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24643623, Length=321, Percent_Identity=37.6947040498442, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI20129101, Length=321, Percent_Identity=37.6947040498442, Blast_Score=179, Evalue=2e-45,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34007; Mature: 33876

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARSRSSGTLFHRGDAMKIDNILQSIGSTPHVRIHRLFGAGTNVWVKSERSNPGGSIKDR
CCCCCCCCCEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCCCHHHH
IALAMVEDAERSGALQPGGTIIEPTSGNTGIGLALVAAVKGYRLILVMPESMSIERRRLM
EEEEEEHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHEE
LAYGAQFDLTPREKGMKGAIARAQELAAQTPGAWVPQQFENPANIDVHVRTTAQEILADF
EEECCEECCCHHHCCCHHHHHHHHHHHHCCCCCCCCHHCCCCCCEEEEEECCHHHHHHHC
PEGIDALITGVGTGGHITGVARVLKPKFPQLKVFAVEPVASPVISGGQPAPHPIQGIGAG
CCCHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEECCHHHHHHCCCCCCCCCHHHCCCC
FVPKNLDTSLLDGVIQVDAEPAREYARRAAREEGLLVGISSGATLAAIAQKLPELPQGAR
CCCCCCCHHHHCCEEEECCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCCCCCE
VLGFNYDTGERYLSVEGFLPS
EEEEECCCCCEEEEECCCCCC
>Mature Secondary Structure 
ARSRSSGTLFHRGDAMKIDNILQSIGSTPHVRIHRLFGAGTNVWVKSERSNPGGSIKDR
CCCCCCCCEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCCCHHHH
IALAMVEDAERSGALQPGGTIIEPTSGNTGIGLALVAAVKGYRLILVMPESMSIERRRLM
EEEEEEHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHEE
LAYGAQFDLTPREKGMKGAIARAQELAAQTPGAWVPQQFENPANIDVHVRTTAQEILADF
EEECCEECCCHHHCCCHHHHHHHHHHHHCCCCCCCCHHCCCCCCEEEEEECCHHHHHHHC
PEGIDALITGVGTGGHITGVARVLKPKFPQLKVFAVEPVASPVISGGQPAPHPIQGIGAG
CCCHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEECCHHHHHHCCCCCCCCCHHHCCCC
FVPKNLDTSLLDGVIQVDAEPAREYARRAAREEGLLVGISSGATLAAIAQKLPELPQGAR
CCCCCCCHHHHCCEEEECCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCCCCCE
VLGFNYDTGERYLSVEGFLPS
EEEEECCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8867384 [H]