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The map label for this gene is phoP [H]

Identifier: 120612912

GI number: 120612912

Start: 4738252

End: 4738962

Strand: Direct

Name: phoP [H]

Synonym: Aave_4276

Alternate gene names: 120612912

Gene position: 4738252-4738962 (Clockwise)

Preceding gene: 120612911

Following gene: 120612914

Centisome position: 88.52

GC content: 65.12

Gene sequence:

>711_bases
ATGCGCATTGCAGTCCTCGACGACGACCTGATCCTTATCGAACTCATACAGGCAACGGCCGCCCGTGCCGGGCATTCCTG
CTACCTCTACCAGGAAGGCAAGGAGTTCCTGAAGGCGCTGCGCACGGAAACCTTCGACCTGATGGTGGTGGACTGGCACT
TGCCCGACATGGAGGGCCTGGAGGTGATCCGCACCGTGCGCGCGGCATCGATGTCCGTGCCCATCCTGTTCATCACCCGC
CGCAATGCCGAGCAGGACCTGGTGGAGGCGCTGGCCAGCGGGGCCGACGATTTCATGACCAAGCCGCTGCGCATGGGTGA
ATTCATCGCGCGCTGCAGCGCCCTGCTGCGCCGCGCCTATCCGCAGGTGGTTTCCGGCACGCTGATGTTCGGGCGCTACC
GGTTCGATCCGGACAAGCGCAGCCTGCTGGTGGACGACGTGCCGGTGGAGCTGAAGAACAAGGAATACGAGCTGGCGCTG
TTCATGTTCCAGAACGCGGGACGGCTGCTGTCGCGCGAGCACCTGCGCGAGGCGATATGGGGCGGCATCCACGACGCACC
CTCGCGTTCTCTGGACACGCACATATCCCGCCTGCGCGCCAAGCTGGCGCTGGCGCCGGACCATGGCTACGTGATCACGG
CGGTGTACGGGGTGGGTTATCGGCTGGAAATAGCGGCACCCCCTGAGTCGCCTTCGGCGCCTTCCCCCTGA

Upstream 100 bases:

>100_bases
ACGCCTGGCGCACGCGGGACGTTAGTTTTGAACGCTTCGTATTTCCGCGAAGCGCTGCGGCCGGCCTGCGCGGCCGCGCC
GTCGCTCCGCTCCCGTTTCC

Downstream 100 bases:

>100_bases
AGGGGGACGACGCCAGTGGCCCGGAACATGTTGCCCCCCTGTGTCGCCTTCGGCGCCTTCCCCCGAGGGGGACGACGCCA
GTGGCCCGGCGGAGCCGGTT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MRIAVLDDDLILIELIQATAARAGHSCYLYQEGKEFLKALRTETFDLMVVDWHLPDMEGLEVIRTVRAASMSVPILFITR
RNAEQDLVEALASGADDFMTKPLRMGEFIARCSALLRRAYPQVVSGTLMFGRYRFDPDKRSLLVDDVPVELKNKEYELAL
FMFQNAGRLLSREHLREAIWGGIHDAPSRSLDTHISRLRAKLALAPDHGYVITAVYGVGYRLEIAAPPESPSAPSP

Sequences:

>Translated_236_residues
MRIAVLDDDLILIELIQATAARAGHSCYLYQEGKEFLKALRTETFDLMVVDWHLPDMEGLEVIRTVRAASMSVPILFITR
RNAEQDLVEALASGADDFMTKPLRMGEFIARCSALLRRAYPQVVSGTLMFGRYRFDPDKRSLLVDDVPVELKNKEYELAL
FMFQNAGRLLSREHLREAIWGGIHDAPSRSLDTHISRLRAKLALAPDHGYVITAVYGVGYRLEIAAPPESPSAPSP
>Mature_236_residues
MRIAVLDDDLILIELIQATAARAGHSCYLYQEGKEFLKALRTETFDLMVVDWHLPDMEGLEVIRTVRAASMSVPILFITR
RNAEQDLVEALASGADDFMTKPLRMGEFIARCSALLRRAYPQVVSGTLMFGRYRFDPDKRSLLVDDVPVELKNKEYELAL
FMFQNAGRLLSREHLREAIWGGIHDAPSRSLDTHISRLRAKLALAPDHGYVITAVYGVGYRLEIAAPPESPSAPSP

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=33.3333333333333, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=30.8035714285714, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=31.1111111111111, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790860, Length=203, Percent_Identity=33.0049261083744, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=29.0909090909091, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=27.7533039647577, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788394, Length=231, Percent_Identity=31.1688311688312, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1787229, Length=217, Percent_Identity=29.9539170506912, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=30.1801801801802, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1786911, Length=182, Percent_Identity=32.4175824175824, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=27.6315789473684, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=28.3185840707965, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=27.3913043478261, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1790437, Length=101, Percent_Identity=31.6831683168317, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=28.7037037037037, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26501; Mature: 26501

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAVLDDDLILIELIQATAARAGHSCYLYQEGKEFLKALRTETFDLMVVDWHLPDMEGL
CEEEEECCCHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHCCCEEEEEEEECCCCHHHH
EVIRTVRAASMSVPILFITRRNAEQDLVEALASGADDFMTKPLRMGEFIARCSALLRRAY
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHH
PQVVSGTLMFGRYRFDPDKRSLLVDDVPVELKNKEYELALFMFQNAGRLLSREHLREAIW
HHHHCCEEEEEEEEECCCCCCEEECCCCCEECCCCEEEEEEEECCCCHHHHHHHHHHHHH
GGIHDAPSRSLDTHISRLRAKLALAPDHGYVITAVYGVGYRLEIAAPPESPSAPSP
CCCCCCCCCHHHHHHHHHHHHHEECCCCCEEEEEEECCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MRIAVLDDDLILIELIQATAARAGHSCYLYQEGKEFLKALRTETFDLMVVDWHLPDMEGL
CEEEEECCCHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHCCCEEEEEEEECCCCHHHH
EVIRTVRAASMSVPILFITRRNAEQDLVEALASGADDFMTKPLRMGEFIARCSALLRRAY
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHH
PQVVSGTLMFGRYRFDPDKRSLLVDDVPVELKNKEYELALFMFQNAGRLLSREHLREAIW
HHHHCCEEEEEEEEECCCCCCEEECCCCCEECCCCEEEEEEEECCCCHHHHHHHHHHHHH
GGIHDAPSRSLDTHISRLRAKLALAPDHGYVITAVYGVGYRLEIAAPPESPSAPSP
CCCCCCCCCHHHHHHHHHHHHHEECCCCCEEEEEEECCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]