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The map label for this gene is fdh [H]

Identifier: 120612654

GI number: 120612654

Start: 4465483

End: 4466631

Strand: Direct

Name: fdh [H]

Synonym: Aave_4017

Alternate gene names: 120612654

Gene position: 4465483-4466631 (Clockwise)

Preceding gene: 120612653

Following gene: 120612655

Centisome position: 83.42

GC content: 68.67

Gene sequence:

>1149_bases
ATGCTGGCAATGAACTACCGCGGCCCCTACCGCGTGCGCGCGTCGCACAAGGCCGAGCCCGACATCGAACATCCCAACGA
TGCCATCGTGCGCGTCACGCGCGCGTGCATCTGCGGCTCGGACCTGCACCTCTACCACGGCCTCGTACCCGACACGCGCG
TGGGCACCACCTTCGGCCACGAGTTCACCGGCGTGGTCGAAGCCGTCGGCCCCTCGGTGCGCAACCTGAAACCCGGCGAC
CACGTGCTGGTGCCCTTCAACATCTTCTGCGGATCGTGCTACTTCTGCCAGAAGGAGCTCTACAGCAACTGCCACAACAC
CAACCCCGAGGCCACGGCCGTGGGCGGCATCTACGGCTACTCGCACACCACCGGCGGCTACGACGGCGGCCAGGCCGAGT
ACGTGCGCGTCCCCCTGGCGGACGTCGGCCCGCAGGTCATCCCCTCCGACATCGACCTGGACGACGCCGTGCTGCTCACC
GACGCGCTGCCCACCGGCTACCAGGCCGCGGAGATGGGCGACATCCAGGAGGGCGACACCGTCGTGGTGTTCGGCGCGGG
GCCCGTGGGCATCTTCGCGGCGCGCAGCGCCTGGCTGCTCGGCGCCGGGCGCGTGATCGTGGTGGACCACGTGGAATACC
GGCTCGACTTCGTGCGCCAGTACGCGCCCTGCGAAACCGTGGACTTCAAGAGCGTGCGCGACATGGCCGTGCACCTCAAG
CGCATGACCGACGGCCTGGGGCCCGACGTCTGCATCGATGCCGTGGGCTGCGAGGCCGCGGGATCGTTCGCGCAATCCCT
GACGGGCGTGCGCCTGAAACTGCAGGGCGGCGCGGCCACGGTGCTGCACTGGTGCATCAACTCCGTGCGCAAGGGCGGCA
CCGTATCGATCGTCGGCGTGTACGGCCCCACCTTCAACGCCGTGCCCATCGGCAATGCCGTGAACAAGGGACTGACGCTG
CGCATGAACCAGGCGAGCGTGAAGCGCCACCTGCCCCGGCTCATCGAGCACATCCAGGCCGGGCGCCTCAAGCCCCGCGA
GATCATCACCCACCGCTTCGCGCTGGAGGACATCGCCGAGGCCTACCACACCTTCTCGAGCAAGCTGGACGGCTGCATCA
AGCCCGTGATCGTGCCCTCCGCCGCCTGA

Upstream 100 bases:

>100_bases
GTGCGCCCGTCCTACACCACCGCCGCGCACGCGCTCCGGAAGATGCACCGGAGCGCGGATTTTTTTCGCGCCGCCGACTT
CGCGAAAGGCAGACCCCTCC

Downstream 100 bases:

>100_bases
GCTCGCCCTCCGAAGCCGCTACCCCGAAAGGACACCCGCATGACCACCGCCACCATCCACATAGATGCCACCCCGCCGGG
ACCGCGCGCCCGCGCCGATG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MLAMNYRGPYRVRASHKAEPDIEHPNDAIVRVTRACICGSDLHLYHGLVPDTRVGTTFGHEFTGVVEAVGPSVRNLKPGD
HVLVPFNIFCGSCYFCQKELYSNCHNTNPEATAVGGIYGYSHTTGGYDGGQAEYVRVPLADVGPQVIPSDIDLDDAVLLT
DALPTGYQAAEMGDIQEGDTVVVFGAGPVGIFAARSAWLLGAGRVIVVDHVEYRLDFVRQYAPCETVDFKSVRDMAVHLK
RMTDGLGPDVCIDAVGCEAAGSFAQSLTGVRLKLQGGAATVLHWCINSVRKGGTVSIVGVYGPTFNAVPIGNAVNKGLTL
RMNQASVKRHLPRLIEHIQAGRLKPREIITHRFALEDIAEAYHTFSSKLDGCIKPVIVPSAA

Sequences:

>Translated_382_residues
MLAMNYRGPYRVRASHKAEPDIEHPNDAIVRVTRACICGSDLHLYHGLVPDTRVGTTFGHEFTGVVEAVGPSVRNLKPGD
HVLVPFNIFCGSCYFCQKELYSNCHNTNPEATAVGGIYGYSHTTGGYDGGQAEYVRVPLADVGPQVIPSDIDLDDAVLLT
DALPTGYQAAEMGDIQEGDTVVVFGAGPVGIFAARSAWLLGAGRVIVVDHVEYRLDFVRQYAPCETVDFKSVRDMAVHLK
RMTDGLGPDVCIDAVGCEAAGSFAQSLTGVRLKLQGGAATVLHWCINSVRKGGTVSIVGVYGPTFNAVPIGNAVNKGLTL
RMNQASVKRHLPRLIEHIQAGRLKPREIITHRFALEDIAEAYHTFSSKLDGCIKPVIVPSAA
>Mature_382_residues
MLAMNYRGPYRVRASHKAEPDIEHPNDAIVRVTRACICGSDLHLYHGLVPDTRVGTTFGHEFTGVVEAVGPSVRNLKPGD
HVLVPFNIFCGSCYFCQKELYSNCHNTNPEATAVGGIYGYSHTTGGYDGGQAEYVRVPLADVGPQVIPSDIDLDDAVLLT
DALPTGYQAAEMGDIQEGDTVVVFGAGPVGIFAARSAWLLGAGRVIVVDHVEYRLDFVRQYAPCETVDFKSVRDMAVHLK
RMTDGLGPDVCIDAVGCEAAGSFAQSLTGVRLKLQGGAATVLHWCINSVRKGGTVSIVGVYGPTFNAVPIGNAVNKGLTL
RMNQASVKRHLPRLIEHIQAGRLKPREIITHRFALEDIAEAYHTFSSKLDGCIKPVIVPSAA

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=377, Percent_Identity=26.2599469496021, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI156523966, Length=387, Percent_Identity=23.7726098191214, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4501939, Length=376, Percent_Identity=23.6702127659574, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI4501929, Length=381, Percent_Identity=25.7217847769029, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI4501933, Length=386, Percent_Identity=25.9067357512953, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI34577061, Length=384, Percent_Identity=26.3020833333333, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI71565154, Length=355, Percent_Identity=24.7887323943662, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI71565152, Length=362, Percent_Identity=24.3093922651934, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786825, Length=391, Percent_Identity=42.4552429667519, Blast_Score=312, Evalue=2e-86,
Organism=Escherichia coli, GI1788073, Length=364, Percent_Identity=25, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87082125, Length=350, Percent_Identity=27.7142857142857, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1790045, Length=360, Percent_Identity=26.3888888888889, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787863, Length=351, Percent_Identity=26.2108262108262, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788407, Length=225, Percent_Identity=28.4444444444444, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI226510992, Length=345, Percent_Identity=24.0579710144928, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788075, Length=356, Percent_Identity=25.2808988764045, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786552, Length=370, Percent_Identity=23.7837837837838, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87081918, Length=372, Percent_Identity=25.2688172043011, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=347, Percent_Identity=27.0893371757925, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI25146526, Length=381, Percent_Identity=23.6220472440945, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=381, Percent_Identity=23.6220472440945, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=240, Percent_Identity=27.9166666666667, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=352, Percent_Identity=24.4318181818182, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323099, Length=374, Percent_Identity=27.5401069518717, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6320033, Length=367, Percent_Identity=27.5204359673025, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319258, Length=220, Percent_Identity=27.7272727272727, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=244, Percent_Identity=29.5081967213115, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=332, Percent_Identity=25, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=331, Percent_Identity=25.0755287009063, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=415, Percent_Identity=24.578313253012, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319621, Length=225, Percent_Identity=28.8888888888889, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137530, Length=375, Percent_Identity=26.4, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17737897, Length=378, Percent_Identity=25.9259259259259, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17737895, Length=361, Percent_Identity=26.0387811634349, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI221457811, Length=364, Percent_Identity=24.4505494505494, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45551930, Length=366, Percent_Identity=24.0437158469945, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45550770, Length=366, Percent_Identity=24.0437158469945, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 41097; Mature: 41097

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAMNYRGPYRVRASHKAEPDIEHPNDAIVRVTRACICGSDLHLYHGLVPDTRVGTTFGH
CEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCC
EFTGVVEAVGPSVRNLKPGDHVLVPFNIFCGSCYFCQKELYSNCHNTNPEATAVGGIYGY
HHHHHHHHCCCHHHCCCCCCEEEEEHHHHHCCHHHHHHHHHHHCCCCCCCCEEECCEECC
SHTTGGYDGGQAEYVRVPLADVGPQVIPSDIDLDDAVLLTDALPTGYQAAEMGDIQEGDT
CCCCCCCCCCCCEEEEEEHHHCCCCCCCCCCCCCCEEEEECCCCCCCCHHHCCCCCCCCE
VVVFGAGPVGIFAARSAWLLGAGRVIVVDHVEYRLDFVRQYAPCETVDFKSVRDMAVHLK
EEEECCCCHHHHHHHHHEEEECCCEEEEECHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
RMTDGLGPDVCIDAVGCEAAGSFAQSLTGVRLKLQGGAATVLHWCINSVRKGGTVSIVGV
HHHCCCCCCCEEECCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEE
YGPTFNAVPIGNAVNKGLTLRMNQASVKRHLPRLIEHIQAGRLKPREIITHRFALEDIAE
ECCCCCCEECCHHHCCCEEEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AYHTFSSKLDGCIKPVIVPSAA
HHHHHHHHHHHCCCCEEECCCC
>Mature Secondary Structure
MLAMNYRGPYRVRASHKAEPDIEHPNDAIVRVTRACICGSDLHLYHGLVPDTRVGTTFGH
CEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCC
EFTGVVEAVGPSVRNLKPGDHVLVPFNIFCGSCYFCQKELYSNCHNTNPEATAVGGIYGY
HHHHHHHHCCCHHHCCCCCCEEEEEHHHHHCCHHHHHHHHHHHCCCCCCCCEEECCEECC
SHTTGGYDGGQAEYVRVPLADVGPQVIPSDIDLDDAVLLTDALPTGYQAAEMGDIQEGDT
CCCCCCCCCCCCEEEEEEHHHCCCCCCCCCCCCCCEEEEECCCCCCCCHHHCCCCCCCCE
VVVFGAGPVGIFAARSAWLLGAGRVIVVDHVEYRLDFVRQYAPCETVDFKSVRDMAVHLK
EEEECCCCHHHHHHHHHEEEECCCEEEEECHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
RMTDGLGPDVCIDAVGCEAAGSFAQSLTGVRLKLQGGAATVLHWCINSVRKGGTVSIVGV
HHHCCCCCCCEEECCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEE
YGPTFNAVPIGNAVNKGLTLRMNQASVKRHLPRLIEHIQAGRLKPREIITHRFALEDIAE
ECCCCCCEECCHHHCCCEEEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AYHTFSSKLDGCIKPVIVPSAA
HHHHHHHHHHHCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]