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The map label for this gene is tbpA [C]

Identifier: 120612531

GI number: 120612531

Start: 4315703

End: 4316686

Strand: Reverse

Name: tbpA [C]

Synonym: Aave_3891

Alternate gene names: 120612531

Gene position: 4316686-4315703 (Counterclockwise)

Preceding gene: 120612537

Following gene: 120612530

Centisome position: 80.64

GC content: 66.87

Gene sequence:

>984_bases
ATGCTCGGAACCATGTCAAAACTATGTGCTGTACTCATCGTGGGCGCAGCAATGCATCTGTCCGCCATGGCCGGGACGGT
GGTGCTCTATTCGTCCAACAATGTGGAAACGGTGAACGGCGTGGTGGACCAGTTCACCAAGGAGAACCCGGACATCAAGG
TGTCGGTCGTGCGCGCCGGAACCGGGGCCCTGATGCAGCGCATCAAGGCGGAAGCGGCCAATCCGCTGGGCGACATCTTC
TGGAGCGGCGGGCTGTCGACGATCGCCGAATTCCGCGAGCTGCTGGCGCCCTATGTGTCTCCGCAGGCGGGCGCCGTGCC
GGAGAAGTACCGCGGACCGGACGGCCTCTGGCTGGGCACCAATACGCATGTGACGGTGCTGATGACCCATCTGCGCCAGG
TGCCCGGGGGGCAGCCCCCGAAGGCCTGGGCAGACCTCGCCGCACCGCAGTGGAAGGGCAAGATCGTCATCCCCGATCCC
GAACGCAGCAGTGCCTCCTTCGTCGCGCTCTATGGCCTGCGCACGCTGCTGGGCCAGGAGATGCTGGACCGCATAGCCCG
CAACGCGGTCATCGTCGGCACGACCTCCGCCGCCTACGAGGGTGTCGCCAAGGGGGAGTTCGCGGTGGCGGTCACGATGG
AATACGCCGCCTACGAGTACGTCGCCGGCGGCATGAAGGACATCCGCATCGTGTACCCGGCGGAAGGCACCTTCCTGTCC
CCCGAGGGCATGGCCCTGATCAAGGGAGGGAAGAACCCTGCGGAAGCCCGCCGGCTCTACGAGTTCCTGGCATCCAGGGG
CGTGCAGACGAAGGTGTTCCAGTCCGCCTACCGGCGCCCGCTGCGGGAGGACATCGACGTCAGCCGGCTGTCCGGGCTGC
CGGCGCTGTCCAGCATCCAGGTCGTTCCGCTGGACGACGCCCGGATGGCCGCGGAGCGCGCGGCCTTCATCGCGCAATGG
CGGCAAACCATCAGCGCGCGCTGA

Upstream 100 bases:

>100_bases
GTCCAGCGAACAAGAATACTGTCACACAGCGTGCATTGATCCCGGCGTCTTGACTGGAAACAATGAATCTCGTCGTTGTA
CTTCATCGGGATGCAGATCC

Downstream 100 bases:

>100_bases
TGCCGCTCCCCACGATCTCCAGGGCGTCCCCATGAAAGTAACGTTCCAGGCCATCGCGCAGAGCTATGGCGGCCAGCGGC
TGTTCGAGCAGCTGGACCTC

Product: extracellular solute-binding protein

Products: ADP; phosphate; thiamine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MLGTMSKLCAVLIVGAAMHLSAMAGTVVLYSSNNVETVNGVVDQFTKENPDIKVSVVRAGTGALMQRIKAEAANPLGDIF
WSGGLSTIAEFRELLAPYVSPQAGAVPEKYRGPDGLWLGTNTHVTVLMTHLRQVPGGQPPKAWADLAAPQWKGKIVIPDP
ERSSASFVALYGLRTLLGQEMLDRIARNAVIVGTTSAAYEGVAKGEFAVAVTMEYAAYEYVAGGMKDIRIVYPAEGTFLS
PEGMALIKGGKNPAEARRLYEFLASRGVQTKVFQSAYRRPLREDIDVSRLSGLPALSSIQVVPLDDARMAAERAAFIAQW
RQTISAR

Sequences:

>Translated_327_residues
MLGTMSKLCAVLIVGAAMHLSAMAGTVVLYSSNNVETVNGVVDQFTKENPDIKVSVVRAGTGALMQRIKAEAANPLGDIF
WSGGLSTIAEFRELLAPYVSPQAGAVPEKYRGPDGLWLGTNTHVTVLMTHLRQVPGGQPPKAWADLAAPQWKGKIVIPDP
ERSSASFVALYGLRTLLGQEMLDRIARNAVIVGTTSAAYEGVAKGEFAVAVTMEYAAYEYVAGGMKDIRIVYPAEGTFLS
PEGMALIKGGKNPAEARRLYEFLASRGVQTKVFQSAYRRPLREDIDVSRLSGLPALSSIQVVPLDDARMAAERAAFIAQW
RQTISAR
>Mature_327_residues
MLGTMSKLCAVLIVGAAMHLSAMAGTVVLYSSNNVETVNGVVDQFTKENPDIKVSVVRAGTGALMQRIKAEAANPLGDIF
WSGGLSTIAEFRELLAPYVSPQAGAVPEKYRGPDGLWLGTNTHVTVLMTHLRQVPGGQPPKAWADLAAPQWKGKIVIPDP
ERSSASFVALYGLRTLLGQEMLDRIARNAVIVGTTSAAYEGVAKGEFAVAVTMEYAAYEYVAGGMKDIRIVYPAEGTFLS
PEGMALIKGGKNPAEARRLYEFLASRGVQTKVFQSAYRRPLREDIDVSRLSGLPALSSIQVVPLDDARMAAERAAFIAQW
RQTISAR

Specific function: Part Of The Binding-Protein-Dependent Transport System Tbpa-Thipq For Thiamine And Tpp. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006059 [H]

Pfam domain/function: PF01547 SBP_bac_1 [H]

EC number: NA

Molecular weight: Translated: 35185; Mature: 35185

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGTMSKLCAVLIVGAAMHLSAMAGTVVLYSSNNVETVNGVVDQFTKENPDIKVSVVRAG
CCCCHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEECC
TGALMQRIKAEAANPLGDIFWSGGLSTIAEFRELLAPYVSPQAGAVPEKYRGPDGLWLGT
HHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCEEECC
NTHVTVLMTHLRQVPGGQPPKAWADLAAPQWKGKIVIPDPERSSASFVALYGLRTLLGQE
CCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHH
MLDRIARNAVIVGTTSAAYEGVAKGEFAVAVTMEYAAYEYVAGGMKDIRIVYPAEGTFLS
HHHHHHCCEEEEECCHHHHCCCCCCCEEEEEEEHHHHHHHHHCCCCCEEEEECCCCCEEC
PEGMALIKGGKNPAEARRLYEFLASRGVQTKVFQSAYRRPLREDIDVSRLSGLPALSSIQ
CCCEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHCCCHHHHCCCCCCCCEE
VVPLDDARMAAERAAFIAQWRQTISAR
EEECCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLGTMSKLCAVLIVGAAMHLSAMAGTVVLYSSNNVETVNGVVDQFTKENPDIKVSVVRAG
CCCCHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEECC
TGALMQRIKAEAANPLGDIFWSGGLSTIAEFRELLAPYVSPQAGAVPEKYRGPDGLWLGT
HHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCEEECC
NTHVTVLMTHLRQVPGGQPPKAWADLAAPQWKGKIVIPDPERSSASFVALYGLRTLLGQE
CCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHH
MLDRIARNAVIVGTTSAAYEGVAKGEFAVAVTMEYAAYEYVAGGMKDIRIVYPAEGTFLS
HHHHHHCCEEEEECCHHHHCCCCCCCEEEEEEEHHHHHHHHHCCCCCEEEEECCCCCEEC
PEGMALIKGGKNPAEARRLYEFLASRGVQTKVFQSAYRRPLREDIDVSRLSGLPALSSIQ
CCCEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHCCCHHHHCCCCCCCCEE
VVPLDDARMAAERAAFIAQWRQTISAR
EEECCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; thiamine [Periplasm]; H2O [C]

Specific reaction: ATP + thiamine [Periplasm] + H2O = ADP + phosphate + thiamine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]