Click here to switch to the map view.

The map label for this gene is panB

Identifier: 120612493

GI number: 120612493

Start: 4279698

End: 4280588

Strand: Direct

Name: panB

Synonym: Aave_3852

Alternate gene names: 120612493

Gene position: 4279698-4280588 (Clockwise)

Preceding gene: 120612487

Following gene: 120612494

Centisome position: 79.95

GC content: 73.4

Gene sequence:

>891_bases
ATGACCGCGCCAACGCCGACCCCCGCCAACGCCGCCACGCCCTACGGCACCCTGCCTCCTGCCTCCCCGCTGCCGCAGCG
CCGCCCCGTGAGCCTGCCGCGCCTGGCGCAGATGCGCGAGGCCGGCGAGAAGATCACCATGCTGACGGCCTATGACGCCA
CCTTCGCCGCGGTGGCCGATGCGGCAGGCGTGGAATGCCTGCTCGTGGGCGATTCGCTGGGCATGGTCTGCCAGGGCCTG
CCCAGCACCGTCGGCGTGTCGCTGGACACCATGGCCTACCACACGGCCAGCGTGGCGCGGGGCCTGCACCGGGTGCAGGG
CACGGCCTGGCTGATCGCCGACCTGCCCTACGGCAGCTACGCGGAAGGTCCCGAACAGGCCATGCGCAGCGCCTGCACGC
TGATGCAGGCCGGCGCGCACATGGTCAAGCTCGAAGGCGGCGGCTGGACGGCGCCCACCGTCCGGTTCCTGGTCGAGCGC
GGCGTGCCGGTCTGCGCGCACCTGGGCCTGACCCCTCAGACGGTGCACGCCCTGGGCGGCTACCGCGTCCAGGGCCGCAG
CGACGAGGCCGCGCGCGCGCTGCGCAGCCAGGCCAACGAACTGCAGGACGCGGGCGCCGCCATGCTGGTGCTCGAGATGG
TGCCCGCCACCCTGGCGCGCGAGGTGACCGACGCCCTGCCGCGCTGCCACACCATCGGCATCGGCGCCGGCAGCGGCACG
GCCGGCCAGGTGCTGGTGCTGCACGACATGCTGGGCGTGAACCTCGGCAAGAACCCGAAGTTCGCGCACGATTTCATGGC
CCAGGCCGGCAGCGTGCGCGGCGCGATCGAAGCCTACGTGCAGGCCGTCAAGGCTGGGCGCTTCCCCGACGACGCGCTGC
ACGCCTGGTAG

Upstream 100 bases:

>100_bases
GCCGACGCGGGTGCCCCCCTGCCTCCGGGAGAACACTCCGGCGGGCCGGCCCCGACGCCGGCTTAGACTCGCGGCTCATT
CGCGTTTCCCGAGGATTGAT

Downstream 100 bases:

>100_bases
CGCCTCCTGCCCTCCCGCCGCTTCCGGCCGCCCTGCCGCCTTTCCAGCCGTTCCTTCATGCTCATCGCACACTCCATCGC
CGACCTGCGCTCCGCGCTCG

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTAPTPTPANAATPYGTLPPASPLPQRRPVSLPRLAQMREAGEKITMLTAYDATFAAVADAAGVECLLVGDSLGMVCQGL
PSTVGVSLDTMAYHTASVARGLHRVQGTAWLIADLPYGSYAEGPEQAMRSACTLMQAGAHMVKLEGGGWTAPTVRFLVER
GVPVCAHLGLTPQTVHALGGYRVQGRSDEAARALRSQANELQDAGAAMLVLEMVPATLAREVTDALPRCHTIGIGAGSGT
AGQVLVLHDMLGVNLGKNPKFAHDFMAQAGSVRGAIEAYVQAVKAGRFPDDALHAW

Sequences:

>Translated_296_residues
MTAPTPTPANAATPYGTLPPASPLPQRRPVSLPRLAQMREAGEKITMLTAYDATFAAVADAAGVECLLVGDSLGMVCQGL
PSTVGVSLDTMAYHTASVARGLHRVQGTAWLIADLPYGSYAEGPEQAMRSACTLMQAGAHMVKLEGGGWTAPTVRFLVER
GVPVCAHLGLTPQTVHALGGYRVQGRSDEAARALRSQANELQDAGAAMLVLEMVPATLAREVTDALPRCHTIGIGAGSGT
AGQVLVLHDMLGVNLGKNPKFAHDFMAQAGSVRGAIEAYVQAVKAGRFPDDALHAW
>Mature_295_residues
TAPTPTPANAATPYGTLPPASPLPQRRPVSLPRLAQMREAGEKITMLTAYDATFAAVADAAGVECLLVGDSLGMVCQGLP
STVGVSLDTMAYHTASVARGLHRVQGTAWLIADLPYGSYAEGPEQAMRSACTLMQAGAHMVKLEGGGWTAPTVRFLVERG
VPVCAHLGLTPQTVHALGGYRVQGRSDEAARALRSQANELQDAGAAMLVLEMVPATLAREVTDALPRCHTIGIGAGSGTA
GQVLVLHDMLGVNLGKNPKFAHDFMAQAGSVRGAIEAYVQAVKAGRFPDDALHAW

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family

Homologues:

Organism=Escherichia coli, GI1786326, Length=262, Percent_Identity=48.4732824427481, Blast_Score=244, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6319653, Length=263, Percent_Identity=37.2623574144487, Blast_Score=172, Evalue=7e-44,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PANB_ACIAC (A1TTV9)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_972171.1
- ProteinModelPortal:   A1TTV9
- SMR:   A1TTV9
- STRING:   A1TTV9
- GeneID:   4667381
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_3852
- eggNOG:   COG0413
- HOGENOM:   HBG299908
- OMA:   YATPEQT
- PhylomeDB:   A1TTV9
- ProtClustDB:   PRK00311
- BioCyc:   AAVE397945:AAVE_3852-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00156
- InterPro:   IPR003700
- InterPro:   IPR015813
- Gene3D:   G3DSA:3.20.20.60
- PANTHER:   PTHR20881
- PIRSF:   PIRSF000388
- TIGRFAMs:   TIGR00222

Pfam domain/function: PF02548 Pantoate_transf; SSF51621 Pyrv/PenolPyrv_Kinase_cat

EC number: =2.1.2.11

Molecular weight: Translated: 30858; Mature: 30727

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: ACT_SITE 212-212 BINDING 114-114 BINDING 143-143

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPTPTPANAATPYGTLPPASPLPQRRPVSLPRLAQMREAGEKITMLTAYDATFAAVAD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCHHHHHHHH
AAGVECLLVGDSLGMVCQGLPSTVGVSLDTMAYHTASVARGLHRVQGTAWLIADLPYGSY
CCCCEEEEECCCHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
AEGPEQAMRSACTLMQAGAHMVKLEGGGWTAPTVRFLVERGVPVCAHLGLTPQTVHALGG
CCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHCC
YRVQGRSDEAARALRSQANELQDAGAAMLVLEMVPATLAREVTDALPRCHTIGIGAGSGT
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
AGQVLVLHDMLGVNLGKNPKFAHDFMAQAGSVRGAIEAYVQAVKAGRFPDDALHAW
CCCEEEEEHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHCCC
>Mature Secondary Structure 
TAPTPTPANAATPYGTLPPASPLPQRRPVSLPRLAQMREAGEKITMLTAYDATFAAVAD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCHHHHHHHH
AAGVECLLVGDSLGMVCQGLPSTVGVSLDTMAYHTASVARGLHRVQGTAWLIADLPYGSY
CCCCEEEEECCCHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
AEGPEQAMRSACTLMQAGAHMVKLEGGGWTAPTVRFLVERGVPVCAHLGLTPQTVHALGG
CCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHCC
YRVQGRSDEAARALRSQANELQDAGAAMLVLEMVPATLAREVTDALPRCHTIGIGAGSGT
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
AGQVLVLHDMLGVNLGKNPKFAHDFMAQAGSVRGAIEAYVQAVKAGRFPDDALHAW
CCCEEEEEHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA