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The map label for this gene is panC

Identifier: 120612494

GI number: 120612494

Start: 4280646

End: 4281494

Strand: Direct

Name: panC

Synonym: Aave_3853

Alternate gene names: 120612494

Gene position: 4280646-4281494 (Clockwise)

Preceding gene: 120612493

Following gene: 120612499

Centisome position: 79.97

GC content: 70.79

Gene sequence:

>849_bases
ATGCTCATCGCACACTCCATCGCCGACCTGCGCTCCGCGCTCGCCAGCCGGGGCCGCCCGGCCTTCGTCCCCACCATGGG
CAACCTGCACGAAGGACACCTGTCCCTGGTGCGGCAGGCCCGCACGCTCGGCGACGTCACCGTCGCCAGCATCTTCGTCA
ACCGCCTGCAGTTCCTGCCCCACGAGGATTTCGACAGCTATCCCCGCACCTGGGAGGCCGACCGCGCGCAACTGGAGGTC
GCGGGCTGCGACATCCTCTTCGCCCCGCGCGAGGCGGACCTCTACCCGCAGGCACAGACCTTCAAGGTCCAGCCCGATCC
GCTGCTGGCCGACCTGCTCGAAGGGCATTTCCGCCCCGGCTTCTTCACGGGTGTCTGCACCGTGGTCATGAAACTGTTCT
CCGCCGTTTTCGGCACGACCGGCGGCGGAACGGCCCTTTTCGGCAAGAAGGACTACCAGCAGCTGATGGTGATCCGCCGC
ATGGTGGAGCAGTTCGCCCTGCCGGTGGACATCGTGGCGGGGGATACCTGCCGCGCCCCGGACGGGCTCGCCCTCAGCTC
GCGCAACGGCTACCTGGGGCCGGCCGAACGCACCAAGGCGGTGGAGCTGGCGCGCGCCCTGCGGACCCTGTCGGATGCCG
CACTCTCGCGCCCCGTCGCCGACTGGCCCGGGCTGGAGGCCGCGGCGAGCGACGCGCTGCGCGGCCAGGGCTGGCAGCCC
GACTATCTCGTGGTGCGTCGCAGGGCCGACCTGCAGCGCCCCGATACCGCACCGCGGCCGGGCACGCTGGTGGCCCTGGG
CGCGGCCCGGCTGGGCTCGACACGGCTCATCGACAACTTCGAATTCTGA

Upstream 100 bases:

>100_bases
CAAGGCTGGGCGCTTCCCCGACGACGCGCTGCACGCCTGGTAGCGCCTCCTGCCCTCCCGCCGCTTCCGGCCGCCCTGCC
GCCTTTCCAGCCGTTCCTTC

Downstream 100 bases:

>100_bases
GCAGCTCGACACGAGATATCCCGCGCGGCGGGAAGGTGCGCACCTACGCCGGCAGGTGCCCCGTGCGCACAATCCACAGG
GCATGCGGGTCTTAAGGTAG

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MLIAHSIADLRSALASRGRPAFVPTMGNLHEGHLSLVRQARTLGDVTVASIFVNRLQFLPHEDFDSYPRTWEADRAQLEV
AGCDILFAPREADLYPQAQTFKVQPDPLLADLLEGHFRPGFFTGVCTVVMKLFSAVFGTTGGGTALFGKKDYQQLMVIRR
MVEQFALPVDIVAGDTCRAPDGLALSSRNGYLGPAERTKAVELARALRTLSDAALSRPVADWPGLEAAASDALRGQGWQP
DYLVVRRRADLQRPDTAPRPGTLVALGAARLGSTRLIDNFEF

Sequences:

>Translated_282_residues
MLIAHSIADLRSALASRGRPAFVPTMGNLHEGHLSLVRQARTLGDVTVASIFVNRLQFLPHEDFDSYPRTWEADRAQLEV
AGCDILFAPREADLYPQAQTFKVQPDPLLADLLEGHFRPGFFTGVCTVVMKLFSAVFGTTGGGTALFGKKDYQQLMVIRR
MVEQFALPVDIVAGDTCRAPDGLALSSRNGYLGPAERTKAVELARALRTLSDAALSRPVADWPGLEAAASDALRGQGWQP
DYLVVRRRADLQRPDTAPRPGTLVALGAARLGSTRLIDNFEF
>Mature_282_residues
MLIAHSIADLRSALASRGRPAFVPTMGNLHEGHLSLVRQARTLGDVTVASIFVNRLQFLPHEDFDSYPRTWEADRAQLEV
AGCDILFAPREADLYPQAQTFKVQPDPLLADLLEGHFRPGFFTGVCTVVMKLFSAVFGTTGGGTALFGKKDYQQLMVIRR
MVEQFALPVDIVAGDTCRAPDGLALSSRNGYLGPAERTKAVELARALRTLSDAALSRPVADWPGLEAAASDALRGQGWQP
DYLVVRRRADLQRPDTAPRPGTLVALGAARLGSTRLIDNFEF

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=286, Percent_Identity=41.2587412587413, Blast_Score=176, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6322046, Length=204, Percent_Identity=42.6470588235294, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_ACIAC (A1TTW0)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_972172.1
- ProteinModelPortal:   A1TTW0
- SMR:   A1TTW0
- STRING:   A1TTW0
- GeneID:   4667368
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_3853
- NMPDR:   fig|397945.5.peg.3287
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- ProtClustDB:   PRK00380
- BioCyc:   AAVE397945:AAVE_3853-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 30774; Mature: 30774

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: NA

Important sites: ACT_SITE 33-33 BINDING 57-57 BINDING 57-57 BINDING 154-154

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIAHSIADLRSALASRGRPAFVPTMGNLHEGHLSLVRQARTLGDVTVASIFVNRLQFLP
CCCHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HEDFDSYPRTWEADRAQLEVAGCDILFAPREADLYPQAQTFKVQPDPLLADLLEGHFRPG
CCCCCCCCCCCCCCHHEEEEECCEEEECCCCCCCCCCCCEEEECCCHHHHHHHHCCCCCC
FFTGVCTVVMKLFSAVFGTTGGGTALFGKKDYQQLMVIRRMVEQFALPVDIVAGDTCRAP
HHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
DGLALSSRNGYLGPAERTKAVELARALRTLSDAALSRPVADWPGLEAAASDALRGQGWQP
CCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCC
DYLVVRRRADLQRPDTAPRPGTLVALGAARLGSTRLIDNFEF
CHHHHHHHHCCCCCCCCCCCCCEEEECHHHCCCCCCCCCCCC
>Mature Secondary Structure
MLIAHSIADLRSALASRGRPAFVPTMGNLHEGHLSLVRQARTLGDVTVASIFVNRLQFLP
CCCHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
HEDFDSYPRTWEADRAQLEVAGCDILFAPREADLYPQAQTFKVQPDPLLADLLEGHFRPG
CCCCCCCCCCCCCCHHEEEEECCEEEECCCCCCCCCCCCEEEECCCHHHHHHHHCCCCCC
FFTGVCTVVMKLFSAVFGTTGGGTALFGKKDYQQLMVIRRMVEQFALPVDIVAGDTCRAP
HHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
DGLALSSRNGYLGPAERTKAVELARALRTLSDAALSRPVADWPGLEAAASDALRGQGWQP
CCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCC
DYLVVRRRADLQRPDTAPRPGTLVALGAARLGSTRLIDNFEF
CHHHHHHHHCCCCCCCCCCCCCEEEECHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA