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The map label for this gene is nadB1 [H]

Identifier: 120612481

GI number: 120612481

Start: 4267277

End: 4268866

Strand: Direct

Name: nadB1 [H]

Synonym: Aave_3840

Alternate gene names: 120612481

Gene position: 4267277-4268866 (Clockwise)

Preceding gene: 120612480

Following gene: 120612482

Centisome position: 79.72

GC content: 73.08

Gene sequence:

>1590_bases
ATGGCCTCCTTCGATTACGACGTACTCATCATCGGCAGCGGCCTCGCGGGCCTGTCCACCGCGCTGCACCTCGCTCCCAC
GCACCGCGTGGCCGTGCTCACCAAGCGGGGGCTGGGCGACGGCGCCAGCGGCTGGGCCCAGGGCGGCATCGCCGCCGTGC
TGGCCGACGGCGACACGTTCGATGCCCACGTGCAGGACACGCTCGTGGCGGGCGCGGGGCTGTGCGACCTCGCCGCCACG
CGCGCCGTCGTCGAGGGCGCGCCGCAGGCCATCCGGTGGCTGCAGACCCTGGGCGTGCCGTTCTCGGAGGAAGCGCCGGG
CCGGCTGCACCTCACGCGCGAAGGCGGCCACGGCGCCCGGCGCATCGTGCATGCCACCGATGCCACCGGCGCGGCCGTGC
AGCGCACCCTGCTGGACACAGTGCGCGCGACGCCCGGCATCACCCTGCTGGAAGAGCACACGCTGGTGGACCTCATCACC
GCCCGCAAGCTCGGCCTGCCCGGCCCGCAGCGCTGCCTGGGCCTCTACGCGCTCGACGAGGCCACCGACACCGTGCACAC
CTTCCGCGCACCGCACACCGTGCTGGCGACGGGGGGCGCGGGCAAGGTGTACCTCTACACCAGCAACCCGGACACGGCCA
CGGGCGACGGCATCGCCGCCGCATGGCGCGCGGGCTGCCGGGTGCAGAACATGGAATTCATCCAGTTCCACCCCACCTGC
CTCTACCACCCCCAGGCCAAGTCGTTCCTGATCAGCGAAGCGGTGCGCGGCGAGGGCGGGCGCCTGCTGCGGCCCGATGG
CACGCGCTTCATGCCGGCGCACGACGAGCGCGCCGAACTCGCCCCGCGCGACGTGGTCGCGCGGGCCATCGACTTCGAGA
TGAAGACCCACGGGCTCGACTGCGTGCACCTGGACATCTCGCACCAGAGCCCGGAATTCCTGCAAGCGCACTTCCCGACC
ATCCTCGCGCGCTGCGCGGAACTGGGCATCGACATCACCCGCCAGCCCATTCCCGTGGTGCCCGCCGCCCACTACACCTG
CGGCGGCGTGCTCACCGACCTCGCGGGGCGCACCGACCTCGCGGGCCTGCACGCCATCGGCGAGACCGCCTGCACCGGCC
TGCACGGCGCCAACCGCCTGGCGAGCAACTCGCTGGTGGAGTGCATGGTGTTCGCGCGCGCCGCCGCCGGCGCCATCCTC
GCCGCGCCGCCTGCCGCCAGCGCGCCACCGGCCCTGCCCGCCTGGGACGACAGCCGCGTGACCGATGCCGACGAGCGCGT
GGTCATCTCGCACAACTGGGACGAGCTGCGCCGCTTCATGTGGGACTACGTGGGCATCGTGCGCACCGACAAGCGCCTGG
AGCGCGCAGCGCATCGCATCGCGCTGCTGCAGGCGGAGATCGCCGAGTTCTACGCGAACTTCCATGTCTGCCGCGACCTG
CTGGAGCTGCGCAACCTCGTGCAGGTGGCCGAGCTCATCGTGCGCTCGGCCCAGCAGCGGCGCGAAAGCCGCGGCCTGCA
CTACAGCCGCGACTGGCCCGCCATGGCCGCGCCCGCGGCGCCCACCCTCCTCGTGCCGCCGGTCCGCTGA

Upstream 100 bases:

>100_bases
TACGTGCGCCTGGCCTACACCCCGGTGTGAACCGCCGCCGCGGCACCGCCCTCCGGCGGACAGCGGCCCCTTCCGACTTC
TCTCTCCCCTTCCGAACCGC

Downstream 100 bases:

>100_bases
CCGGCGCCGGCCCTTTTTTTCCTTTCCTGCAGACGCATGGTCCGAGACGACACTTCCTTCGCCGCCCGCAGCATCGCCAG
CGTGTGGCATCCCTGCACCC

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO 1; Quinolinate synthase B 1 [H]

Number of amino acids: Translated: 529; Mature: 528

Protein sequence:

>529_residues
MASFDYDVLIIGSGLAGLSTALHLAPTHRVAVLTKRGLGDGASGWAQGGIAAVLADGDTFDAHVQDTLVAGAGLCDLAAT
RAVVEGAPQAIRWLQTLGVPFSEEAPGRLHLTREGGHGARRIVHATDATGAAVQRTLLDTVRATPGITLLEEHTLVDLIT
ARKLGLPGPQRCLGLYALDEATDTVHTFRAPHTVLATGGAGKVYLYTSNPDTATGDGIAAAWRAGCRVQNMEFIQFHPTC
LYHPQAKSFLISEAVRGEGGRLLRPDGTRFMPAHDERAELAPRDVVARAIDFEMKTHGLDCVHLDISHQSPEFLQAHFPT
ILARCAELGIDITRQPIPVVPAAHYTCGGVLTDLAGRTDLAGLHAIGETACTGLHGANRLASNSLVECMVFARAAAGAIL
AAPPAASAPPALPAWDDSRVTDADERVVISHNWDELRRFMWDYVGIVRTDKRLERAAHRIALLQAEIAEFYANFHVCRDL
LELRNLVQVAELIVRSAQQRRESRGLHYSRDWPAMAAPAAPTLLVPPVR

Sequences:

>Translated_529_residues
MASFDYDVLIIGSGLAGLSTALHLAPTHRVAVLTKRGLGDGASGWAQGGIAAVLADGDTFDAHVQDTLVAGAGLCDLAAT
RAVVEGAPQAIRWLQTLGVPFSEEAPGRLHLTREGGHGARRIVHATDATGAAVQRTLLDTVRATPGITLLEEHTLVDLIT
ARKLGLPGPQRCLGLYALDEATDTVHTFRAPHTVLATGGAGKVYLYTSNPDTATGDGIAAAWRAGCRVQNMEFIQFHPTC
LYHPQAKSFLISEAVRGEGGRLLRPDGTRFMPAHDERAELAPRDVVARAIDFEMKTHGLDCVHLDISHQSPEFLQAHFPT
ILARCAELGIDITRQPIPVVPAAHYTCGGVLTDLAGRTDLAGLHAIGETACTGLHGANRLASNSLVECMVFARAAAGAIL
AAPPAASAPPALPAWDDSRVTDADERVVISHNWDELRRFMWDYVGIVRTDKRLERAAHRIALLQAEIAEFYANFHVCRDL
LELRNLVQVAELIVRSAQQRRESRGLHYSRDWPAMAAPAAPTLLVPPVR
>Mature_528_residues
ASFDYDVLIIGSGLAGLSTALHLAPTHRVAVLTKRGLGDGASGWAQGGIAAVLADGDTFDAHVQDTLVAGAGLCDLAATR
AVVEGAPQAIRWLQTLGVPFSEEAPGRLHLTREGGHGARRIVHATDATGAAVQRTLLDTVRATPGITLLEEHTLVDLITA
RKLGLPGPQRCLGLYALDEATDTVHTFRAPHTVLATGGAGKVYLYTSNPDTATGDGIAAAWRAGCRVQNMEFIQFHPTCL
YHPQAKSFLISEAVRGEGGRLLRPDGTRFMPAHDERAELAPRDVVARAIDFEMKTHGLDCVHLDISHQSPEFLQAHFPTI
LARCAELGIDITRQPIPVVPAAHYTCGGVLTDLAGRTDLAGLHAIGETACTGLHGANRLASNSLVECMVFARAAAGAILA
APPAASAPPALPAWDDSRVTDADERVVISHNWDELRRFMWDYVGIVRTDKRLERAAHRIALLQAEIAEFYANFHVCRDLL
ELRNLVQVAELIVRSAQQRRESRGLHYSRDWPAMAAPAAPTLLVPPVR

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=508, Percent_Identity=33.0708661417323, Blast_Score=225, Evalue=8e-59,
Organism=Escherichia coli, GI1788928, Length=524, Percent_Identity=58.587786259542, Blast_Score=619, Evalue=1e-178,
Organism=Escherichia coli, GI1790597, Length=504, Percent_Identity=34.7222222222222, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1786942, Length=554, Percent_Identity=31.9494584837545, Blast_Score=197, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17505833, Length=530, Percent_Identity=32.6415094339623, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17550100, Length=528, Percent_Identity=32.3863636363636, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI71986328, Length=471, Percent_Identity=25.2653927813163, Blast_Score=80, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322416, Length=554, Percent_Identity=33.2129963898917, Blast_Score=233, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6322701, Length=551, Percent_Identity=32.6678765880218, Blast_Score=226, Evalue=8e-60,
Organism=Saccharomyces cerevisiae, GI6322511, Length=476, Percent_Identity=26.4705882352941, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320788, Length=489, Percent_Identity=26.5848670756646, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24663005, Length=509, Percent_Identity=32.0235756385069, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI17137288, Length=552, Percent_Identity=32.6086956521739, Blast_Score=221, Evalue=9e-58,
Organism=Drosophila melanogaster, GI24655642, Length=552, Percent_Identity=32.6086956521739, Blast_Score=221, Evalue=9e-58,
Organism=Drosophila melanogaster, GI24655647, Length=552, Percent_Identity=32.6086956521739, Blast_Score=221, Evalue=9e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 56787; Mature: 56656

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASFDYDVLIIGSGLAGLSTALHLAPTHRVAVLTKRGLGDGASGWAQGGIAAVLADGDTF
CCCCCEEEEEEECCCHHHHHHHEECCCCEEEEEEECCCCCCCCCHHCCCEEEEEECCCCC
DAHVQDTLVAGAGLCDLAATRAVVEGAPQAIRWLQTLGVPFSEEAPGRLHLTREGGHGAR
CHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCE
RIVHATDATGAAVQRTLLDTVRATPGITLLEEHTLVDLITARKLGLPGPQRCLGLYALDE
EEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCCCHHHHHEEEEECC
ATDTVHTFRAPHTVLATGGAGKVYLYTSNPDTATGDGIAAAWRAGCRVQNMEFIQFHPTC
CHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCCCHHHHHHCCCEECCCEEEEECCEE
LYHPQAKSFLISEAVRGEGGRLLRPDGTRFMPAHDERAELAPRDVVARAIDFEMKTHGLD
EECCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHCCCE
CVHLDISHQSPEFLQAHFPTILARCAELGIDITRQPIPVVPAAHYTCGGVLTDLAGRTDL
EEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
AGLHAIGETACTGLHGANRLASNSLVECMVFARAAAGAILAAPPAASAPPALPAWDDSRV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCC
TDADERVVISHNWDELRRFMWDYVGIVRTDKRLERAAHRIALLQAEIAEFYANFHVCRDL
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LELRNLVQVAELIVRSAQQRRESRGLHYSRDWPAMAAPAAPTLLVPPVR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCC
>Mature Secondary Structure 
ASFDYDVLIIGSGLAGLSTALHLAPTHRVAVLTKRGLGDGASGWAQGGIAAVLADGDTF
CCCCEEEEEEECCCHHHHHHHEECCCCEEEEEEECCCCCCCCCHHCCCEEEEEECCCCC
DAHVQDTLVAGAGLCDLAATRAVVEGAPQAIRWLQTLGVPFSEEAPGRLHLTREGGHGAR
CHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCE
RIVHATDATGAAVQRTLLDTVRATPGITLLEEHTLVDLITARKLGLPGPQRCLGLYALDE
EEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCCCHHHHHEEEEECC
ATDTVHTFRAPHTVLATGGAGKVYLYTSNPDTATGDGIAAAWRAGCRVQNMEFIQFHPTC
CHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCCCHHHHHHCCCEECCCEEEEECCEE
LYHPQAKSFLISEAVRGEGGRLLRPDGTRFMPAHDERAELAPRDVVARAIDFEMKTHGLD
EECCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHCCCE
CVHLDISHQSPEFLQAHFPTILARCAELGIDITRQPIPVVPAAHYTCGGVLTDLAGRTDL
EEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
AGLHAIGETACTGLHGANRLASNSLVECMVFARAAAGAILAAPPAASAPPALPAWDDSRV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCC
TDADERVVISHNWDELRRFMWDYVGIVRTDKRLERAAHRIALLQAEIAEFYANFHVCRDL
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LELRNLVQVAELIVRSAQQRRESRGLHYSRDWPAMAAPAAPTLLVPPVR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]