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The map label for this gene is bioA [H]

Identifier: 120612482

GI number: 120612482

Start: 4268903

End: 4270270

Strand: Direct

Name: bioA [H]

Synonym: Aave_3841

Alternate gene names: 120612482

Gene position: 4268903-4270270 (Clockwise)

Preceding gene: 120612481

Following gene: 120612483

Centisome position: 79.75

GC content: 73.39

Gene sequence:

>1368_bases
ATGGTCCGAGACGACACTTCCTTCGCCGCCCGCAGCATCGCCAGCGTGTGGCATCCCTGCACCCAGATGAAGCGCCACGA
GGCCGATCCACCCGTGGCCATCGCCCGCGCGGCCGGCCCCTGGCTGGAGGGGGACGACGGCCGCCGCTACCTGGACGGCA
TCAGTTCGTGGTGGGTCAACCTTTTCGGCCACGGCCATCCGCACATCCGCGAAGCCATCGCCGACCAGCTGGCGCGGCTG
GACCACGTGATGCTCGCGGGCTTCACGCACGCGCCGGTGGTGGAGCTCTCCGAGCGCCTCTCCGCGCTCACCGGGCTCGG
ACATGCGTTCTACGGCAGCGACGGCTCGGCCGCCACGGAGATCGCGCTCAAGATGAGCGCGCATTTCTGGCGCAACCACG
GCCGGCCCGGGAAATGCCGGTTCATCGGCCTGGCAGGCGGCTACCACGGGGAGACCGTGGGCGCGCTCGCCGTGACCGAC
ATCGGCCTGTTCCGCGAAGCCTACGCGCCCCTCGTGCGCCTGGGCGCCACCGTGCCCAGCCCCGACGCGCGCGGCGCCGT
GGACGGAGAGGACGCCGCCGCCGTGGCGCGCCGCGCCGCCGCCGCGCTGCAGGCCTGGCTGGAGGAACACCACGCCACCA
CCGCCGCGCTCATCGTGGAGCCGCTGGTGCAGTGCGCCGCCGGCATGGCGATGCACGATGCCGAATACCTGCGGCAGGCC
CGCGCGCTGTGCGACCGCTACGGCGTGCACCTCGTCGTGGACGAGATCGCCACCGGCTTCGGCCGCACCGGCACGATGTT
CGCGCACCAGCAGGCGGGCATCCGTCCGGACTTCATCTGCCTCTCCAAGGGCCTGACGGGCGGCACCCTGCCGCTGTCGG
CCGTGCTCACCACCGATGCGGTGTATGCCGCGTTCTACGACGACGACGTGGCGCGCGGCTTCCTGCATTCGCACTCCTAC
ACCGGCAACCCGCTCGCCTGCCGCGCGGCGCTGGCCACGCTCGAGCTGTTCGCGCAGACCGATGCACTCGCGCGCAACGC
ACGGCGCGCGCCGCTGTTCCACGCGGCCTTCGCACCGCTTTCGGCGCACCCGCGCGTGCGGCACGCGCGCCACCTCGGCA
TGCTCTGGGCCTGGGACGTGGAAGGCACGGCGCCCGACTTCGCGCGCCGCTACCACCGCCACGCGATGGCGCGCGGCCTG
CTGCTGCGGCCCATCGGCTGCACCCTCTACGCCCTGCCGCCCTACGTGCTGGACGACGACGCCATCGCGCACCTGGGCCG
GCAGGCGCTCGCGGCGCTGGACGCCACGCTCGCCGAAGAGGACGGCGCGCCCGGCACGGCCGCGGCCACCGAAGGGAGCC
TGCCATGA

Upstream 100 bases:

>100_bases
CCGCGACTGGCCCGCCATGGCCGCGCCCGCGGCGCCCACCCTCCTCGTGCCGCCGGTCCGCTGACCGGCGCCGGCCCTTT
TTTTCCTTTCCTGCAGACGC

Downstream 100 bases:

>100_bases
CCGGCTGCTTCGTCACCGGCACCGACACCGGCGTGGGCAAGACCCTCGCCAGCGCCGGCCTGCTGCACGCGCTCGCGCGG
CACCATGCGCGCGTGGTCGG

Product: aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MVRDDTSFAARSIASVWHPCTQMKRHEADPPVAIARAAGPWLEGDDGRRYLDGISSWWVNLFGHGHPHIREAIADQLARL
DHVMLAGFTHAPVVELSERLSALTGLGHAFYGSDGSAATEIALKMSAHFWRNHGRPGKCRFIGLAGGYHGETVGALAVTD
IGLFREAYAPLVRLGATVPSPDARGAVDGEDAAAVARRAAAALQAWLEEHHATTAALIVEPLVQCAAGMAMHDAEYLRQA
RALCDRYGVHLVVDEIATGFGRTGTMFAHQQAGIRPDFICLSKGLTGGTLPLSAVLTTDAVYAAFYDDDVARGFLHSHSY
TGNPLACRAALATLELFAQTDALARNARRAPLFHAAFAPLSAHPRVRHARHLGMLWAWDVEGTAPDFARRYHRHAMARGL
LLRPIGCTLYALPPYVLDDDAIAHLGRQALAALDATLAEEDGAPGTAAATEGSLP

Sequences:

>Translated_455_residues
MVRDDTSFAARSIASVWHPCTQMKRHEADPPVAIARAAGPWLEGDDGRRYLDGISSWWVNLFGHGHPHIREAIADQLARL
DHVMLAGFTHAPVVELSERLSALTGLGHAFYGSDGSAATEIALKMSAHFWRNHGRPGKCRFIGLAGGYHGETVGALAVTD
IGLFREAYAPLVRLGATVPSPDARGAVDGEDAAAVARRAAAALQAWLEEHHATTAALIVEPLVQCAAGMAMHDAEYLRQA
RALCDRYGVHLVVDEIATGFGRTGTMFAHQQAGIRPDFICLSKGLTGGTLPLSAVLTTDAVYAAFYDDDVARGFLHSHSY
TGNPLACRAALATLELFAQTDALARNARRAPLFHAAFAPLSAHPRVRHARHLGMLWAWDVEGTAPDFARRYHRHAMARGL
LLRPIGCTLYALPPYVLDDDAIAHLGRQALAALDATLAEEDGAPGTAAATEGSLP
>Mature_455_residues
MVRDDTSFAARSIASVWHPCTQMKRHEADPPVAIARAAGPWLEGDDGRRYLDGISSWWVNLFGHGHPHIREAIADQLARL
DHVMLAGFTHAPVVELSERLSALTGLGHAFYGSDGSAATEIALKMSAHFWRNHGRPGKCRFIGLAGGYHGETVGALAVTD
IGLFREAYAPLVRLGATVPSPDARGAVDGEDAAAVARRAAAALQAWLEEHHATTAALIVEPLVQCAAGMAMHDAEYLRQA
RALCDRYGVHLVVDEIATGFGRTGTMFAHQQAGIRPDFICLSKGLTGGTLPLSAVLTTDAVYAAFYDDDVARGFLHSHSY
TGNPLACRAALATLELFAQTDALARNARRAPLFHAAFAPLSAHPRVRHARHLGMLWAWDVEGTAPDFARRYHRHAMARGL
LLRPIGCTLYALPPYVLDDDAIAHLGRQALAALDATLAEEDGAPGTAAATEGSLP

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=410, Percent_Identity=28.780487804878, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI37574042, Length=331, Percent_Identity=28.0966767371601, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI13994255, Length=341, Percent_Identity=27.5659824046921, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI284507298, Length=301, Percent_Identity=28.9036544850498, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI226442705, Length=363, Percent_Identity=25.8953168044077, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI226442709, Length=297, Percent_Identity=27.6094276094276, Blast_Score=93, Evalue=6e-19,
Organism=Escherichia coli, GI1786991, Length=423, Percent_Identity=38.2978723404255, Blast_Score=252, Evalue=5e-68,
Organism=Escherichia coli, GI145693181, Length=409, Percent_Identity=30.3178484107579, Blast_Score=168, Evalue=8e-43,
Organism=Escherichia coli, GI1788044, Length=410, Percent_Identity=26.5853658536585, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789759, Length=397, Percent_Identity=25.9445843828715, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789016, Length=415, Percent_Identity=30.6024096385542, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1787560, Length=379, Percent_Identity=29.5514511873351, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786349, Length=322, Percent_Identity=27.0186335403727, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25144271, Length=326, Percent_Identity=28.5276073619632, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI25144274, Length=135, Percent_Identity=39.2592592592593, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI32564660, Length=338, Percent_Identity=25.7396449704142, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71992977, Length=443, Percent_Identity=24.1534988713318, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324386, Length=462, Percent_Identity=27.4891774891775, Blast_Score=192, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6323470, Length=404, Percent_Identity=28.4653465346535, Blast_Score=136, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6324432, Length=406, Percent_Identity=24.6305418719212, Blast_Score=109, Evalue=9e-25,
Organism=Drosophila melanogaster, GI21357415, Length=396, Percent_Identity=27.020202020202, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI161085790, Length=340, Percent_Identity=28.5294117647059, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28574759, Length=340, Percent_Identity=28.5294117647059, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21356575, Length=322, Percent_Identity=27.3291925465839, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 48748; Mature: 48748

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRDDTSFAARSIASVWHPCTQMKRHEADPPVAIARAAGPWLEGDDGRRYLDGISSWWVN
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHH
LFGHGHPHIREAIADQLARLDHVMLAGFTHAPVVELSERLSALTGLGHAFYGSDGSAATE
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHEECCCCCHHHH
IALKMSAHFWRNHGRPGKCRFIGLAGGYHGETVGALAVTDIGLFREAYAPLVRLGATVPS
HHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PDARGAVDGEDAAAVARRAAAALQAWLEEHHATTAALIVEPLVQCAAGMAMHDAEYLRQA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
RALCDRYGVHLVVDEIATGFGRTGTMFAHQQAGIRPDFICLSKGLTGGTLPLSAVLTTDA
HHHHHHCCCEEEHHHHHHCCCCCCCEEHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHH
VYAAFYDDDVARGFLHSHSYTGNPLACRAALATLELFAQTDALARNARRAPLFHAAFAPL
HHEEHHCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCC
SAHPRVRHARHLGMLWAWDVEGTAPDFARRYHRHAMARGLLLRPIGCTLYALPPYVLDDD
CCCCHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEECCH
AIAHLGRQALAALDATLAEEDGAPGTAAATEGSLP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVRDDTSFAARSIASVWHPCTQMKRHEADPPVAIARAAGPWLEGDDGRRYLDGISSWWVN
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHH
LFGHGHPHIREAIADQLARLDHVMLAGFTHAPVVELSERLSALTGLGHAFYGSDGSAATE
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHEECCCCCHHHH
IALKMSAHFWRNHGRPGKCRFIGLAGGYHGETVGALAVTDIGLFREAYAPLVRLGATVPS
HHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PDARGAVDGEDAAAVARRAAAALQAWLEEHHATTAALIVEPLVQCAAGMAMHDAEYLRQA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
RALCDRYGVHLVVDEIATGFGRTGTMFAHQQAGIRPDFICLSKGLTGGTLPLSAVLTTDA
HHHHHHCCCEEEHHHHHHCCCCCCCEEHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHH
VYAAFYDDDVARGFLHSHSYTGNPLACRAALATLELFAQTDALARNARRAPLFHAAFAPL
HHEEHHCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCC
SAHPRVRHARHLGMLWAWDVEGTAPDFARRYHRHAMARGLLLRPIGCTLYALPPYVLDDD
CCCCHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEECCH
AIAHLGRQALAALDATLAEEDGAPGTAAATEGSLP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]