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The map label for this gene is ilvD [H]

Identifier: 120612402

GI number: 120612402

Start: 4175553

End: 4177328

Strand: Reverse

Name: ilvD [H]

Synonym: Aave_3759

Alternate gene names: 120612402

Gene position: 4177328-4175553 (Counterclockwise)

Preceding gene: 120612406

Following gene: 120612401

Centisome position: 78.04

GC content: 67.79

Gene sequence:

>1776_bases
GTGAATTCTTCAAGCAGCCCCGAGAAGAACCGTATCGGAACGCGCCCGCTGCGCAGCGCACGGTGGTTCCAGAAAAACGA
CCTGCCCGGATTCATCCATCGTTCCACGCTGGCGGCGGATGGATGGACGCGAGAAGACCTGATGGAGCGCCCGATCGTCG
GGATACTCAACACCTGGTCCGATCTCAATCCATGCAACAGCAACCTGCGATCGCTGGCCGGGAAGGTCCGGGAAGGGGTG
CTGGAGGCAGGCGGCATTCCGTTCGAACTGCCGCTGCTGTCGATCAGCGAGAACCTGATCAAGCCGAGCGCGTTCCCGTT
CCGCAATCTGCTTGCCATGGCGGCGGAGGAAAGCATCCGGGGCTATCCGCTGGATTCGGTGGTCCTGCTGGGCGGTTGTG
ACAAGACCCAGCCGGGTCTGCTGATGGGGGCCGCGAGCGCGAACGTTCCGGCCATCGTCCTCAACAGTGGGCCGGGTACT
CCGCGATCGGCCACGGGCGGTCCGCTGGCGACCGCCAATGGCGTCTGGCGATTCGTCGATCAACTGCGCGCCGGCAGTGT
TTCGATCAAGGCATTCGAGGACTTCGAGCGCGGAGTCATGGGGACGCCGGGGCACTGCAGCGAGATGGGCACTGCGTCCA
CCATGTCCGTGCTGAGCGAGGCGCTGGGCATGGCGCTGCCAGGCAGCAGCCTCGTCCCGTCGAGCGACGGCCGGCGGATT
CAATACGCGAAGGAGGTGGGGCGCCGCGCCGTCGCGATGACCGCCATCGAGCGCATGTCGCCGTCGAGCATCCTGAGTGC
CCAGGCTTTCGACAACGCGATCACGCTGCTCTGCGCGGTGGGGGGCTCGACCAATGCCGTCATCCACCTTCTGGCGCTTG
CGGGGCGGGTGGGCGTGCCGTTGTCCCTCGGCCGTTTCGATGAAATCGCCCGCCAGGTGCCGCTCATCGCCAACGTCCAG
CCTTCGGGGCAACACCTGACGGAACGCCTGATGAGCGCTGGCGGAGTGCCGGGCCTCCTGCGGGCGCTGCGGCCGATGCT
GCACCTCGATGCGCCGACCGTCGATGGCCGCACCATCGGCCAGATCGCGGACGAGGCGCACATCGGTGATCCGGACGTGA
TACGCCCTCTGGACGGGCCGGTGAAGCCCGGGGCCAGCCTGGTGGTGGTCAAGGGCAGCCTGGCGCCGGACGGTGCCGTC
ATCAAGACGTGCGCTGCCTCGCCCGCCCTGTTCCGCCATCGCGGGCCAGCGGTCGTTTTCGAGGATGTCCAGAGCATCGC
GGACCGCATCGACGATCCCGGGCTGGATATCGGCGCCGACAGCGTCCTCGTCCTGCGCAATGTCGGGCCGGTGGGAGCGG
CCATGCCCGAATGGGGCATGCTGCCGATCCCGCGCCGGCTGATGGAATCCGGAGTGACCGACATGCTGAGGATCTCCGAC
GCGCGCATGAGCGGCACCGCCTACGGTACGGCGGTCCTTCATGTTTCGCCCGAGGCGGCTGTGGGAGGGCCGCTCGCGCT
GGTGCGCACCGGCGACATCATCGAACTCGATGTCGAGGCGCGCCGCCTCGACTTGCTGGTTTCCGAAGAGGAGTTGCAGC
GCCGTCGCGCCGAACTTCCCCGGCCGCCGGCACCGGCCCGTGCCCGGGGCTACCGGCAGCTCTACGCGGAAAAAGTGGAG
CAGGCGCATCTGGGCTGCGACTTCGGATTCCTGCGAGGCGCCGACGGCGAAACGCTCCCCGACGGGCTGTTCGACGGCTG
GGTCGGGGGCTGGTGA

Upstream 100 bases:

>100_bases
GGTGTTTTCAGTATTTTCTCGTGCTTCGGCGCGGGACAACCGCAGATCATTTTGCCGCGCCTTCAATACACTTTTCGGAC
CAGCACGTCAGAAAGCGTAT

Downstream 100 bases:

>100_bases
TACGGAGGCGCGACACACCATGGCTGTCCTCTACCGTCCCGACGTCTCCCGTGGCCCCGCATGGCGCAAGCTGTTCGCCG
AGCAGGCACCCGACATCGAT

Product: dihydroxyacid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MNSSSSPEKNRIGTRPLRSARWFQKNDLPGFIHRSTLAADGWTREDLMERPIVGILNTWSDLNPCNSNLRSLAGKVREGV
LEAGGIPFELPLLSISENLIKPSAFPFRNLLAMAAEESIRGYPLDSVVLLGGCDKTQPGLLMGAASANVPAIVLNSGPGT
PRSATGGPLATANGVWRFVDQLRAGSVSIKAFEDFERGVMGTPGHCSEMGTASTMSVLSEALGMALPGSSLVPSSDGRRI
QYAKEVGRRAVAMTAIERMSPSSILSAQAFDNAITLLCAVGGSTNAVIHLLALAGRVGVPLSLGRFDEIARQVPLIANVQ
PSGQHLTERLMSAGGVPGLLRALRPMLHLDAPTVDGRTIGQIADEAHIGDPDVIRPLDGPVKPGASLVVVKGSLAPDGAV
IKTCAASPALFRHRGPAVVFEDVQSIADRIDDPGLDIGADSVLVLRNVGPVGAAMPEWGMLPIPRRLMESGVTDMLRISD
ARMSGTAYGTAVLHVSPEAAVGGPLALVRTGDIIELDVEARRLDLLVSEEELQRRRAELPRPPAPARARGYRQLYAEKVE
QAHLGCDFGFLRGADGETLPDGLFDGWVGGW

Sequences:

>Translated_591_residues
MNSSSSPEKNRIGTRPLRSARWFQKNDLPGFIHRSTLAADGWTREDLMERPIVGILNTWSDLNPCNSNLRSLAGKVREGV
LEAGGIPFELPLLSISENLIKPSAFPFRNLLAMAAEESIRGYPLDSVVLLGGCDKTQPGLLMGAASANVPAIVLNSGPGT
PRSATGGPLATANGVWRFVDQLRAGSVSIKAFEDFERGVMGTPGHCSEMGTASTMSVLSEALGMALPGSSLVPSSDGRRI
QYAKEVGRRAVAMTAIERMSPSSILSAQAFDNAITLLCAVGGSTNAVIHLLALAGRVGVPLSLGRFDEIARQVPLIANVQ
PSGQHLTERLMSAGGVPGLLRALRPMLHLDAPTVDGRTIGQIADEAHIGDPDVIRPLDGPVKPGASLVVVKGSLAPDGAV
IKTCAASPALFRHRGPAVVFEDVQSIADRIDDPGLDIGADSVLVLRNVGPVGAAMPEWGMLPIPRRLMESGVTDMLRISD
ARMSGTAYGTAVLHVSPEAAVGGPLALVRTGDIIELDVEARRLDLLVSEEELQRRRAELPRPPAPARARGYRQLYAEKVE
QAHLGCDFGFLRGADGETLPDGLFDGWVGGW
>Mature_591_residues
MNSSSSPEKNRIGTRPLRSARWFQKNDLPGFIHRSTLAADGWTREDLMERPIVGILNTWSDLNPCNSNLRSLAGKVREGV
LEAGGIPFELPLLSISENLIKPSAFPFRNLLAMAAEESIRGYPLDSVVLLGGCDKTQPGLLMGAASANVPAIVLNSGPGT
PRSATGGPLATANGVWRFVDQLRAGSVSIKAFEDFERGVMGTPGHCSEMGTASTMSVLSEALGMALPGSSLVPSSDGRRI
QYAKEVGRRAVAMTAIERMSPSSILSAQAFDNAITLLCAVGGSTNAVIHLLALAGRVGVPLSLGRFDEIARQVPLIANVQ
PSGQHLTERLMSAGGVPGLLRALRPMLHLDAPTVDGRTIGQIADEAHIGDPDVIRPLDGPVKPGASLVVVKGSLAPDGAV
IKTCAASPALFRHRGPAVVFEDVQSIADRIDDPGLDIGADSVLVLRNVGPVGAAMPEWGMLPIPRRLMESGVTDMLRISD
ARMSGTAYGTAVLHVSPEAAVGGPLALVRTGDIIELDVEARRLDLLVSEEELQRRRAELPRPPAPARARGYRQLYAEKVE
QAHLGCDFGFLRGADGETLPDGLFDGWVGGW

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=578, Percent_Identity=29.9307958477509, Blast_Score=216, Evalue=4e-57,
Organism=Escherichia coli, GI1788157, Length=577, Percent_Identity=30.6759098786828, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI2367371, Length=460, Percent_Identity=31.0869565217391, Blast_Score=168, Evalue=1e-42,
Organism=Escherichia coli, GI1786464, Length=458, Percent_Identity=31.8777292576419, Blast_Score=161, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322476, Length=553, Percent_Identity=32.7305605786618, Blast_Score=263, Evalue=5e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 62514; Mature: 62514

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSSSSPEKNRIGTRPLRSARWFQKNDLPGFIHRSTLAADGWTREDLMERPIVGILNTWS
CCCCCCCHHHCCCCCCCHHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHCCHHHHHHCCC
DLNPCNSNLRSLAGKVREGVLEAGGIPFELPLLSISENLIKPSAFPFRNLLAMAAEESIR
CCCHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC
GYPLDSVVLLGGCDKTQPGLLMGAASANVPAIVLNSGPGTPRSATGGPLATANGVWRFVD
CCCCCCEEEEECCCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHH
QLRAGSVSIKAFEDFERGVMGTPGHCSEMGTASTMSVLSEALGMALPGSSLVPSSDGRRI
HHHCCCEEEEEHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEE
QYAKEVGRRAVAMTAIERMSPSSILSAQAFDNAITLLCAVGGSTNAVIHLLALAGRVGVP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHCCCCCC
LSLGRFDEIARQVPLIANVQPSGQHLTERLMSAGGVPGLLRALRPMLHLDAPTVDGRTIG
CCCCHHHHHHHHCCEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHH
QIADEAHIGDPDVIRPLDGPVKPGASLVVVKGSLAPDGAVIKTCAASPALFRHRGPAVVF
HHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHCCCCHHHHCCCCCHHH
EDVQSIADRIDDPGLDIGADSVLVLRNVGPVGAAMPEWGMLPIPRRLMESGVTDMLRISD
HHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHH
ARMSGTAYGTAVLHVSPEAAVGGPLALVRTGDIIELDVEARRLDLLVSEEELQRRRAELP
HHCCCCEEEEEEEEECCCCCCCCCEEEEECCCEEEEECCHHHHHHEECHHHHHHHHHCCC
RPPAPARARGYRQLYAEKVEQAHLGCDFGFLRGADGETLPDGLFDGWVGGW
CCCCCHHHHHHHHHHHHHHHHHHCCCCCHHEECCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MNSSSSPEKNRIGTRPLRSARWFQKNDLPGFIHRSTLAADGWTREDLMERPIVGILNTWS
CCCCCCCHHHCCCCCCCHHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHCCHHHHHHCCC
DLNPCNSNLRSLAGKVREGVLEAGGIPFELPLLSISENLIKPSAFPFRNLLAMAAEESIR
CCCHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC
GYPLDSVVLLGGCDKTQPGLLMGAASANVPAIVLNSGPGTPRSATGGPLATANGVWRFVD
CCCCCCEEEEECCCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHH
QLRAGSVSIKAFEDFERGVMGTPGHCSEMGTASTMSVLSEALGMALPGSSLVPSSDGRRI
HHHCCCEEEEEHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEE
QYAKEVGRRAVAMTAIERMSPSSILSAQAFDNAITLLCAVGGSTNAVIHLLALAGRVGVP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHCCCCCC
LSLGRFDEIARQVPLIANVQPSGQHLTERLMSAGGVPGLLRALRPMLHLDAPTVDGRTIG
CCCCHHHHHHHHCCEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHH
QIADEAHIGDPDVIRPLDGPVKPGASLVVVKGSLAPDGAVIKTCAASPALFRHRGPAVVF
HHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHCCCCHHHHCCCCCHHH
EDVQSIADRIDDPGLDIGADSVLVLRNVGPVGAAMPEWGMLPIPRRLMESGVTDMLRISD
HHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHH
ARMSGTAYGTAVLHVSPEAAVGGPLALVRTGDIIELDVEARRLDLLVSEEELQRRRAELP
HHCCCCEEEEEEEEECCCCCCCCCEEEEECCCEEEEECCHHHHHHEECHHHHHHHHHCCC
RPPAPARARGYRQLYAEKVEQAHLGCDFGFLRGADGETLPDGLFDGWVGGW
CCCCCHHHHHHHHHHHHHHHHHHCCCCCHHEECCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA