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The map label for this gene is ghrA [H]

Identifier: 120612401

GI number: 120612401

Start: 4174607

End: 4175533

Strand: Reverse

Name: ghrA [H]

Synonym: Aave_3758

Alternate gene names: 120612401

Gene position: 4175533-4174607 (Counterclockwise)

Preceding gene: 120612402

Following gene: 120612400

Centisome position: 78.01

GC content: 67.85

Gene sequence:

>927_bases
ATGGCTGTCCTCTACCGTCCCGACGTCTCCCGTGGCCCCGCATGGCGCAAGCTGTTCGCCGAGCAGGCACCCGACATCGA
TTTCAGAGTGTGGCCCGACGCGGGCAACCTCGACGAGATCGAATACCTGATCGCCTGGCAGGCTCCCGCCGCGTTCCTCG
CTTCCCTGTCCAACCTCAAGGTGCTTTTCTCTTCCGGCGCGGGCGTGGACCACATCGACCTGACCGCCGTACCTGCGCAT
GTCGATATCGTGCGGATGGTGGAGCCCGGCATCATCAACGGCATGGTCGAGTATGTGACGATGGCGGTGCTCGCACAGCA
CCGCCACCTCTTCGACTACCAGGCGTCGCAGCGCGCGAGGCGCTGGGAGCCCCTCGAAGAGCTTCCGCCGTCCACCTGCT
CCGTCGGCGTCATGGGCCTGGGGGTGCTGGGACAGGCGGTTCTCGACCGCCTCGGCCTGTTCGGGTTCGAGCGATCGGGC
TGGAACCGATCGCCCAGGGACCTTCCGGGGGTTCGGTGCTTCGCGGGCACCGATTCGCTCGGCGAATTCCTGGGACAGGT
GGATGTGCTGGTCTGCCTGCTTCCGCTCACCGATGCCACGCGGCACATCCTCGATGCCCGCCTTTTCGCGCGCATGCGTG
ACGGCAGTGCGCTGGTCAATGTGGGCCGCGGAGGCCACCTGGACCAGCAGGCGCTCCTGCAGGCGCTCGACAGCGGGCGC
CTGAGCCGGGCGATCCTGGACGTCACCGATCCGGAGCCGCTGCCCGCCGAGAGTCCCCTGTGGTCCCATCCCCGCGTCGT
GCTCACCCCGCATATCGCGAGCATGACGCAGCCGGAAACGGCCGTGCCGATCCTGATCCGGAACCTGCGCCGCCATGGCA
GGGGGCAGCCACTGCCCGATCTGATCGATCGCCGCGCCGGCTACTGA

Upstream 100 bases:

>100_bases
TGCGACTTCGGATTCCTGCGAGGCGCCGACGGCGAAACGCTCCCCGACGGGCTGTTCGACGGCTGGGTCGGGGGCTGGTG
ATACGGAGGCGCGACACACC

Downstream 100 bases:

>100_bases
CCCTTTCCCTTCCGCGTTCCTGTCACTCCACCACAAAGGCTCCAATGACCGCCGTTTTCAAACCCAAGTACATCAGCTTC
GACTGCTACGGAACCCTGAC

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MAVLYRPDVSRGPAWRKLFAEQAPDIDFRVWPDAGNLDEIEYLIAWQAPAAFLASLSNLKVLFSSGAGVDHIDLTAVPAH
VDIVRMVEPGIINGMVEYVTMAVLAQHRHLFDYQASQRARRWEPLEELPPSTCSVGVMGLGVLGQAVLDRLGLFGFERSG
WNRSPRDLPGVRCFAGTDSLGEFLGQVDVLVCLLPLTDATRHILDARLFARMRDGSALVNVGRGGHLDQQALLQALDSGR
LSRAILDVTDPEPLPAESPLWSHPRVVLTPHIASMTQPETAVPILIRNLRRHGRGQPLPDLIDRRAGY

Sequences:

>Translated_308_residues
MAVLYRPDVSRGPAWRKLFAEQAPDIDFRVWPDAGNLDEIEYLIAWQAPAAFLASLSNLKVLFSSGAGVDHIDLTAVPAH
VDIVRMVEPGIINGMVEYVTMAVLAQHRHLFDYQASQRARRWEPLEELPPSTCSVGVMGLGVLGQAVLDRLGLFGFERSG
WNRSPRDLPGVRCFAGTDSLGEFLGQVDVLVCLLPLTDATRHILDARLFARMRDGSALVNVGRGGHLDQQALLQALDSGR
LSRAILDVTDPEPLPAESPLWSHPRVVLTPHIASMTQPETAVPILIRNLRRHGRGQPLPDLIDRRAGY
>Mature_307_residues
AVLYRPDVSRGPAWRKLFAEQAPDIDFRVWPDAGNLDEIEYLIAWQAPAAFLASLSNLKVLFSSGAGVDHIDLTAVPAHV
DIVRMVEPGIINGMVEYVTMAVLAQHRHLFDYQASQRARRWEPLEELPPSTCSVGVMGLGVLGQAVLDRLGLFGFERSGW
NRSPRDLPGVRCFAGTDSLGEFLGQVDVLVCLLPLTDATRHILDARLFARMRDGSALVNVGRGGHLDQQALLQALDSGRL
SRAILDVTDPEPLPAESPLWSHPRVVLTPHIASMTQPETAVPILIRNLRRHGRGQPLPDLIDRRAGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=257, Percent_Identity=32.295719844358, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI23308577, Length=250, Percent_Identity=30.4, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI145580578, Length=234, Percent_Identity=28.6324786324786, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI4557499, Length=234, Percent_Identity=28.6324786324786, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI145580575, Length=234, Percent_Identity=28.6324786324786, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI61743967, Length=273, Percent_Identity=26.7399267399267, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4557497, Length=273, Percent_Identity=26.7399267399267, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI87081824, Length=301, Percent_Identity=37.8737541528239, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI87082289, Length=238, Percent_Identity=31.5126050420168, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1789279, Length=175, Percent_Identity=29.1428571428571, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=229, Percent_Identity=27.5109170305677, Blast_Score=91, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6324055, Length=149, Percent_Identity=34.8993288590604, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324964, Length=250, Percent_Identity=24.8, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24585516, Length=280, Percent_Identity=27.8571428571429, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI28574286, Length=171, Percent_Identity=36.2573099415205, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19921140, Length=230, Percent_Identity=30.8695652173913, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24585514, Length=252, Percent_Identity=29.3650793650794, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28574282, Length=252, Percent_Identity=29.3650793650794, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45552429, Length=252, Percent_Identity=29.3650793650794, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28574284, Length=252, Percent_Identity=29.3650793650794, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45551003, Length=252, Percent_Identity=29.3650793650794, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28571528, Length=225, Percent_Identity=32, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24646446, Length=272, Percent_Identity=25.3676470588235, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646448, Length=272, Percent_Identity=25.3676470588235, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646452, Length=272, Percent_Identity=25.3676470588235, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646450, Length=272, Percent_Identity=25.3676470588235, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI62472511, Length=272, Percent_Identity=25.3676470588235, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 33919; Mature: 33788

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVLYRPDVSRGPAWRKLFAEQAPDIDFRVWPDAGNLDEIEYLIAWQAPAAFLASLSNLK
CEEEECCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCEEEEEEECCHHHHHHHHHHHH
VLFSSGAGVDHIDLTAVPAHVDIVRMVEPGIINGMVEYVTMAVLAQHRHLFDYQASQRAR
EEEECCCCCCEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RWEPLEELPPSTCSVGVMGLGVLGQAVLDRLGLFGFERSGWNRSPRDLPGVRCFAGTDSL
CCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCHH
GEFLGQVDVLVCLLPLTDATRHILDARLFARMRDGSALVNVGRGGHLDQQALLQALDSGR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHCCC
LSRAILDVTDPEPLPAESPLWSHPRVVLTPHIASMTQPETAVPILIRNLRRHGRGQPLPD
HHHHEEECCCCCCCCCCCCCCCCCEEEECCCHHHCCCCCHHHHHHHHHHHHHCCCCCCHH
LIDRRAGY
HHHHCCCC
>Mature Secondary Structure 
AVLYRPDVSRGPAWRKLFAEQAPDIDFRVWPDAGNLDEIEYLIAWQAPAAFLASLSNLK
EEEECCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCEEEEEEECCHHHHHHHHHHHH
VLFSSGAGVDHIDLTAVPAHVDIVRMVEPGIINGMVEYVTMAVLAQHRHLFDYQASQRAR
EEEECCCCCCEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RWEPLEELPPSTCSVGVMGLGVLGQAVLDRLGLFGFERSGWNRSPRDLPGVRCFAGTDSL
CCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCHH
GEFLGQVDVLVCLLPLTDATRHILDARLFARMRDGSALVNVGRGGHLDQQALLQALDSGR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHCCC
LSRAILDVTDPEPLPAESPLWSHPRVVLTPHIASMTQPETAVPILIRNLRRHGRGQPLPD
HHHHEEECCCCCCCCCCCCCCCCCEEEECCCHHHCCCCCHHHHHHHHHHHHHCCCCCCHH
LIDRRAGY
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA