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The map label for this gene is pqqL [C]

Identifier: 120612396

GI number: 120612396

Start: 4169986

End: 4171353

Strand: Direct

Name: pqqL [C]

Synonym: Aave_3753

Alternate gene names: 120612396

Gene position: 4169986-4171353 (Clockwise)

Preceding gene: 120612387

Following gene: 120612403

Centisome position: 77.9

GC content: 70.47

Gene sequence:

>1368_bases
ATGGCCCATCCCCCCACTCCCCTCCTCCACACCCTCCCCAACGGCGTCCGCCTCCTCGCCCTCCCCATGCCCCACGTGCA
GAGCGCCAGCGTCGGCGTGTTCCTGCGCGTGGGCTCGCGCGACGAGACGCCGGAGACCAACGGCATCAGCCACGTGCTGG
AGCACATGGCGTTCAAGGGAACGGCCACGCGTTCGGTGCAGGCGATCAACCTCGATGCGGAGCGGCTGGGCGCGGACGTG
AATGCCTACACGGGCAAGGACAGCACGGGCTATTTCATGACCGGGCTGGGGCAGCATGCGCTGCAGCTGCTGGGCATGAC
GGCGGACATCGTGCTGCACAGCACCTTCCCCGAGGCCGAGCTGCAGCGCGAGCTCGACGTTATTCGGCAGGAGGCGATCG
AGTACGACGAGGACCCGGAGGACAGTTCCAACGACCTGCTGGACCGCGCGCTGTGGGGCGACGATCCCATGGGCATGCCG
GTGATCGGCACGGTGGAGAACATCGAGGGCTTCACGCGCGATGACCTCGTGCGGCATGTGCAGCGGCACTACGTGGCCGG
CAAGACCATCGTCGCGGCCGCGGGGAATTTCGATGTCGGTGCGTGGATGCGGCGCGCGGAGGAATTGTTTGCTGCGATGC
CCGCGCCTGGGTCCGCATCCGGGCCGCAGGCCGGTGGCGCCGGGGTGCTGCCGCCCACGCCCGCTCCGCACGTCGGCCAG
GCCATGGCGCGCCGCTTCACGCAGGTGTCGCAGGTGTTCCTGAACATCGCCTATCCGCTGCCCGGTCCTGGCGCGCCGGA
GTGGCAGGGTGCCGGCACGGTGCAAGCCCTGCTGCCCCCGCGCTGGCGCCTGGCCGCGGCGCTCGCGGCCAACCTGTTCG
GCGGCGGCATGTCCTCGCCGCTGGTGGACACGGTGCGCGAGCGGCTGGGCCTGGCCTACAACACCGATGCCACGATCGAC
AGCGGTGACGCGTGGCTCAATTTCGTGGTGCATGCGGTGACCACGCCGGACAAGGTCGAGGCGCTGGTGCAGGCCACGGG
CGAATTGCTGCAGGCGCAGGCCTCCGCGATCGACCCGGTGCACCTGGAGCGCGCGAAGAACCAGCTCACCGTCTCCCGCG
TGCGGGCCAGCGAGCGGCCCTTCGCGACCATGGAGCGGGCCGTGGAGGAGGTGTTCGCGCACGGCACCGTGACGCCGCTG
GCCGAGACGATCGCGCTGATCGGCGACATCCGTGCGGACGAAGTGCAGCAGGTGTTCGCGCGCATGCTCGCCCATCCGCC
CGCGCTGTCGATCACGGGCAAGGGCGTGAGCGCGAAGTCCGCGCGGCTGCTGGCGGCATCGCTGGTCGCGAGCAGCAGCC
GGGCATAG

Upstream 100 bases:

>100_bases
GCACGGCCCGGCGACAATGCAGCATGCAGGCAGAGATCCATGGGACGATGCGCCGCGTCTGTCCGATAGAAGTCGCAAAG
ACTCCCTGCCCCAACCACCG

Downstream 100 bases:

>100_bases
TGCGGCGACGCCGCCGGGCGGGTGGCGTCCGCCGCGCTCAATGCATCGGTCGCCCGAGCCGCCGGCTCGCCCGCGAGATC
GCGTAGTTCACCAGGCAGTA

Product: peptidase M16 domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MAHPPTPLLHTLPNGVRLLALPMPHVQSASVGVFLRVGSRDETPETNGISHVLEHMAFKGTATRSVQAINLDAERLGADV
NAYTGKDSTGYFMTGLGQHALQLLGMTADIVLHSTFPEAELQRELDVIRQEAIEYDEDPEDSSNDLLDRALWGDDPMGMP
VIGTVENIEGFTRDDLVRHVQRHYVAGKTIVAAAGNFDVGAWMRRAEELFAAMPAPGSASGPQAGGAGVLPPTPAPHVGQ
AMARRFTQVSQVFLNIAYPLPGPGAPEWQGAGTVQALLPPRWRLAAALAANLFGGGMSSPLVDTVRERLGLAYNTDATID
SGDAWLNFVVHAVTTPDKVEALVQATGELLQAQASAIDPVHLERAKNQLTVSRVRASERPFATMERAVEEVFAHGTVTPL
AETIALIGDIRADEVQQVFARMLAHPPALSITGKGVSAKSARLLAASLVASSSRA

Sequences:

>Translated_455_residues
MAHPPTPLLHTLPNGVRLLALPMPHVQSASVGVFLRVGSRDETPETNGISHVLEHMAFKGTATRSVQAINLDAERLGADV
NAYTGKDSTGYFMTGLGQHALQLLGMTADIVLHSTFPEAELQRELDVIRQEAIEYDEDPEDSSNDLLDRALWGDDPMGMP
VIGTVENIEGFTRDDLVRHVQRHYVAGKTIVAAAGNFDVGAWMRRAEELFAAMPAPGSASGPQAGGAGVLPPTPAPHVGQ
AMARRFTQVSQVFLNIAYPLPGPGAPEWQGAGTVQALLPPRWRLAAALAANLFGGGMSSPLVDTVRERLGLAYNTDATID
SGDAWLNFVVHAVTTPDKVEALVQATGELLQAQASAIDPVHLERAKNQLTVSRVRASERPFATMERAVEEVFAHGTVTPL
AETIALIGDIRADEVQQVFARMLAHPPALSITGKGVSAKSARLLAASLVASSSRA
>Mature_454_residues
AHPPTPLLHTLPNGVRLLALPMPHVQSASVGVFLRVGSRDETPETNGISHVLEHMAFKGTATRSVQAINLDAERLGADVN
AYTGKDSTGYFMTGLGQHALQLLGMTADIVLHSTFPEAELQRELDVIRQEAIEYDEDPEDSSNDLLDRALWGDDPMGMPV
IGTVENIEGFTRDDLVRHVQRHYVAGKTIVAAAGNFDVGAWMRRAEELFAAMPAPGSASGPQAGGAGVLPPTPAPHVGQA
MARRFTQVSQVFLNIAYPLPGPGAPEWQGAGTVQALLPPRWRLAAALAANLFGGGMSSPLVDTVRERLGLAYNTDATIDS
GDAWLNFVVHAVTTPDKVEALVQATGELLQAQASAIDPVHLERAKNQLTVSRVRASERPFATMERAVEEVFAHGTVTPLA
ETIALIGDIRADEVQQVFARMLAHPPALSITGKGVSAKSARLLAASLVASSSRA

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=439, Percent_Identity=26.879271070615, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI46593007, Length=430, Percent_Identity=27.2093023255814, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI24308013, Length=443, Percent_Identity=25.2821670428894, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1787770, Length=219, Percent_Identity=25.1141552511416, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71999683, Length=434, Percent_Identity=25.3456221198157, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17553678, Length=195, Percent_Identity=27.1794871794872, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323192, Length=217, Percent_Identity=34.1013824884793, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6321813, Length=423, Percent_Identity=23.6406619385343, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21357875, Length=191, Percent_Identity=36.1256544502618, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24646943, Length=191, Percent_Identity=36.1256544502618, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI19921772, Length=431, Percent_Identity=22.5058004640371, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 48413; Mature: 48282

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHPPTPLLHTLPNGVRLLALPMPHVQSASVGVFLRVGSRDETPETNGISHVLEHMAFKG
CCCCCCCHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCC
TATRSVQAINLDAERLGADVNAYTGKDSTGYFMTGLGQHALQLLGMTADIVLHSTFPEAE
CCCCCEEEEECCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHEEEECCCCHHH
LQRELDVIRQEAIEYDEDPEDSSNDLLDRALWGDDPMGMPVIGTVENIEGFTRDDLVRHV
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEHHHCCCCCHHHHHHHH
QRHYVAGKTIVAAAGNFDVGAWMRRAEELFAAMPAPGSASGPQAGGAGVLPPTPAPHVGQ
HHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHH
AMARRFTQVSQVFLNIAYPLPGPGAPEWQGAGTVQALLPPRWRLAAALAANLFGGGMSSP
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCH
LVDTVRERLGLAYNTDATIDSGDAWLNFVVHAVTTPDKVEALVQATGELLQAQASAIDPV
HHHHHHHHHCCEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHH
HLERAKNQLTVSRVRASERPFATMERAVEEVFAHGTVTPLAETIALIGDIRADEVQQVFA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHH
RMLAHPPALSITGKGVSAKSARLLAASLVASSSRA
HHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AHPPTPLLHTLPNGVRLLALPMPHVQSASVGVFLRVGSRDETPETNGISHVLEHMAFKG
CCCCCCHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCC
TATRSVQAINLDAERLGADVNAYTGKDSTGYFMTGLGQHALQLLGMTADIVLHSTFPEAE
CCCCCEEEEECCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHEEEECCCCHHH
LQRELDVIRQEAIEYDEDPEDSSNDLLDRALWGDDPMGMPVIGTVENIEGFTRDDLVRHV
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEHHHCCCCCHHHHHHHH
QRHYVAGKTIVAAAGNFDVGAWMRRAEELFAAMPAPGSASGPQAGGAGVLPPTPAPHVGQ
HHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHH
AMARRFTQVSQVFLNIAYPLPGPGAPEWQGAGTVQALLPPRWRLAAALAANLFGGGMSSP
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCH
LVDTVRERLGLAYNTDATIDSGDAWLNFVVHAVTTPDKVEALVQATGELLQAQASAIDPV
HHHHHHHHHCCEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHH
HLERAKNQLTVSRVRASERPFATMERAVEEVFAHGTVTPLAETIALIGDIRADEVQQVFA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHH
RMLAHPPALSITGKGVSAKSARLLAASLVASSSRA
HHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA