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The map label for this gene is hemA

Identifier: 120612307

GI number: 120612307

Start: 4039448

End: 4040746

Strand: Direct

Name: hemA

Synonym: Aave_3663

Alternate gene names: 120612307

Gene position: 4039448-4040746 (Clockwise)

Preceding gene: 120612303

Following gene: 120612308

Centisome position: 75.46

GC content: 70.05

Gene sequence:

>1299_bases
ATGGCAGTCTGGGCCCTCGGCATCAACCACACGACCGCGCCGCTCGATCTGCGCGGCCGTTTTGCGTTCGCCATCGACCA
GATCGCGCCCACGCTGCAGGGCCTGCGCCAGTCGCTGGGCGGCGCCACGCGCCATCCGCAGGTGGAAACCGCCATCCTCT
CCACCTGCAACCGCACCGAGATCTACTGCGCCGGCCAGCAGCCGGCACTGGACCACACGCTCGACTGGCTCGCCCACAGC
GGCGGCGTGAGCCCCTCGCTGCTGCGCTCGCACTCCTATACGCTCGAAGAAAGCCTCGTCGCGCGCCATGCGTTCCGCGT
GGCCAGCGGGCTCGATTCGATGGTGCTGGGCGAGGCCCAGATCCTCGGCCAGATGAAGGATGCCGTGCGCGCGGCAGAGA
CGGCCGGCGCGCTCGGCACCACGCTCAACCAGCTCTTCCAGCGCAGCTTCGCCGTCGCCAAGGAAGTGCGCACCAGCACC
GAGATCGGCGCCCACAGCATCAGCATGGCCGCCGCCGCCGTGCGCCTGGCCGGGCAGCTGTTCGAAGACCTGACGGAGAT
CCGCATCCTCTTCGTGGGCGCGGGCGAGATGATCGAGCTCGCCGCCACCCACTTCGCGGCGAAGAACCCCAAGAGCCTCG
CCATCGCCAACCGCACGCTGGAGCGTGGCGAGAAGCTCGCCTCCCGCTTCGGCGGCGAGGTCATGCGGCTGGCCGACCTG
CCCGACCGCCTGCACGAGTTCGACGCCGTGGTCAGCTGCACGGCCAGCAGCCTGCCCATCATCGGCCTGGGCGCTGTCGA
GCGCGCGCTGAAGAAACGCCGCCACCGCCCCATGTTCATGGTCGATCTGGCCGTGCCGCGCGACATCGAGCCCGAGGTGA
AGGCGCTGGAAGACATCTACCTCTACACCGTGGACGACCTCGCCAGCGTCGTGCAGACCGCGCAGGCCAGCCGGCAGGCG
GCTGTCGCGCAGGCCGAGGCCATCATCGATGCGGGCGTGCAGAGCTTCATGCACTGGATGGACCAGCGCAGCCCCGTGGG
CGGCGTGGTGCCGCTCATCCAGCAGATCCACGCCCAGGCCGACGAATGGCGCGCGCTGGAGATCGCACGCGCCAAGAAGC
TCATCGCCAGGGGCGAGGACATGGATGCCGTGCTGGAAGCGCTCTCGCGCGGCCTCACGCAGAAGATGCTGCACGGCACC
CTGGCCGAGCTGCGCGCGGGCGATGCCGACACGCGCGCCCAGACGGCCCAGACCGTCTCCCGCCTGTTCCTGCGCTCGCA
GTCCAGGAGCGGCCTGTAG

Upstream 100 bases:

>100_bases
GCGGCGGCAGTCGGGTCCATAGCGCAAAGGCATGACGCAGATCAAGACCCTTGTGCTGCGGGGAGCACACGGGCGGGATG
GAAATTTTATAATCCGGGGT

Downstream 100 bases:

>100_bases
CGGCGCCCGCCGCCCTGCCGCCAGGCCTCTTCTGCCCTCTCCGGCCTCCCGCATCCGCGCACGGATGCCCAGGCTGCGAA
CCACCGCCGCAGCCACCCTT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MAVWALGINHTTAPLDLRGRFAFAIDQIAPTLQGLRQSLGGATRHPQVETAILSTCNRTEIYCAGQQPALDHTLDWLAHS
GGVSPSLLRSHSYTLEESLVARHAFRVASGLDSMVLGEAQILGQMKDAVRAAETAGALGTTLNQLFQRSFAVAKEVRTST
EIGAHSISMAAAAVRLAGQLFEDLTEIRILFVGAGEMIELAATHFAAKNPKSLAIANRTLERGEKLASRFGGEVMRLADL
PDRLHEFDAVVSCTASSLPIIGLGAVERALKKRRHRPMFMVDLAVPRDIEPEVKALEDIYLYTVDDLASVVQTAQASRQA
AVAQAEAIIDAGVQSFMHWMDQRSPVGGVVPLIQQIHAQADEWRALEIARAKKLIARGEDMDAVLEALSRGLTQKMLHGT
LAELRAGDADTRAQTAQTVSRLFLRSQSRSGL

Sequences:

>Translated_432_residues
MAVWALGINHTTAPLDLRGRFAFAIDQIAPTLQGLRQSLGGATRHPQVETAILSTCNRTEIYCAGQQPALDHTLDWLAHS
GGVSPSLLRSHSYTLEESLVARHAFRVASGLDSMVLGEAQILGQMKDAVRAAETAGALGTTLNQLFQRSFAVAKEVRTST
EIGAHSISMAAAAVRLAGQLFEDLTEIRILFVGAGEMIELAATHFAAKNPKSLAIANRTLERGEKLASRFGGEVMRLADL
PDRLHEFDAVVSCTASSLPIIGLGAVERALKKRRHRPMFMVDLAVPRDIEPEVKALEDIYLYTVDDLASVVQTAQASRQA
AVAQAEAIIDAGVQSFMHWMDQRSPVGGVVPLIQQIHAQADEWRALEIARAKKLIARGEDMDAVLEALSRGLTQKMLHGT
LAELRAGDADTRAQTAQTVSRLFLRSQSRSGL
>Mature_431_residues
AVWALGINHTTAPLDLRGRFAFAIDQIAPTLQGLRQSLGGATRHPQVETAILSTCNRTEIYCAGQQPALDHTLDWLAHSG
GVSPSLLRSHSYTLEESLVARHAFRVASGLDSMVLGEAQILGQMKDAVRAAETAGALGTTLNQLFQRSFAVAKEVRTSTE
IGAHSISMAAAAVRLAGQLFEDLTEIRILFVGAGEMIELAATHFAAKNPKSLAIANRTLERGEKLASRFGGEVMRLADLP
DRLHEFDAVVSCTASSLPIIGLGAVERALKKRRHRPMFMVDLAVPRDIEPEVKALEDIYLYTVDDLASVVQTAQASRQAA
VAQAEAIIDAGVQSFMHWMDQRSPVGGVVPLIQQIHAQADEWRALEIARAKKLIARGEDMDAVLEALSRGLTQKMLHGTL
AELRAGDADTRAQTAQTVSRLFLRSQSRSGL

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=416, Percent_Identity=43.0288461538462, Blast_Score=300, Evalue=1e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_ACIAC (A1TTC3)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_971985.1
- ProteinModelPortal:   A1TTC3
- SMR:   A1TTC3
- STRING:   A1TTC3
- GeneID:   4665154
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_3663
- NMPDR:   fig|397945.5.peg.3129
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   A1TTC3
- ProtClustDB:   PRK00045
- BioCyc:   AAVE397945:AAVE_3663-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 46734; Mature: 46603

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00747 GLUTR; PS00012 PHOSPHOPANTETHEINE

Important sites: ACT_SITE 56-56 BINDING 113-113 BINDING 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVWALGINHTTAPLDLRGRFAFAIDQIAPTLQGLRQSLGGATRHPQVETAILSTCNRTE
CEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCE
IYCAGQQPALDHTLDWLAHSGGVSPSLLRSHSYTLEESLVARHAFRVASGLDSMVLGEAQ
EEECCCCCCHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
ILGQMKDAVRAAETAGALGTTLNQLFQRSFAVAKEVRTSTEIGAHSISMAAAAVRLAGQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
FEDLTEIRILFVGAGEMIELAATHFAAKNPKSLAIANRTLERGEKLASRFGGEVMRLADL
HHHHHHHEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHC
PDRLHEFDAVVSCTASSLPIIGLGAVERALKKRRHRPMFMVDLAVPRDIEPEVKALEDIY
HHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHH
LYTVDDLASVVQTAQASRQAAVAQAEAIIDAGVQSFMHWMDQRSPVGGVVPLIQQIHAQA
HEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
DEWRALEIARAKKLIARGEDMDAVLEALSRGLTQKMLHGTLAELRAGDADTRAQTAQTVS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RLFLRSQSRSGL
HHHHHHHCCCCC
>Mature Secondary Structure 
AVWALGINHTTAPLDLRGRFAFAIDQIAPTLQGLRQSLGGATRHPQVETAILSTCNRTE
EEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCE
IYCAGQQPALDHTLDWLAHSGGVSPSLLRSHSYTLEESLVARHAFRVASGLDSMVLGEAQ
EEECCCCCCHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
ILGQMKDAVRAAETAGALGTTLNQLFQRSFAVAKEVRTSTEIGAHSISMAAAAVRLAGQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
FEDLTEIRILFVGAGEMIELAATHFAAKNPKSLAIANRTLERGEKLASRFGGEVMRLADL
HHHHHHHEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHC
PDRLHEFDAVVSCTASSLPIIGLGAVERALKKRRHRPMFMVDLAVPRDIEPEVKALEDIY
HHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHH
LYTVDDLASVVQTAQASRQAAVAQAEAIIDAGVQSFMHWMDQRSPVGGVVPLIQQIHAQA
HEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
DEWRALEIARAKKLIARGEDMDAVLEALSRGLTQKMLHGTLAELRAGDADTRAQTAQTVS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RLFLRSQSRSGL
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA