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The map label for this gene is hrcA

Identifier: 120612240

GI number: 120612240

Start: 3963779

End: 3964783

Strand: Reverse

Name: hrcA

Synonym: Aave_3593

Alternate gene names: 120612240

Gene position: 3964783-3963779 (Counterclockwise)

Preceding gene: 120612241

Following gene: 120612237

Centisome position: 74.07

GC content: 65.87

Gene sequence:

>1005_bases
ATGCTCGATGACCGTGCCAAGTTGTTGCTCAAAGCGCTGATCGAGCGCTACATCGCCGACGGCCAGCCGGTGGGATCGCG
CACCCTGTCCAGGTCGTCGGGGCTGGATCTTTCGCCGGCGACCATCCGCAACGTCATGGCCGACCTGGAGGACATCGGGC
TGATCGCCAGCCCCCACACCTCGGCGGGCCGCATCCCCACGGCCAAAGGCTACCGTCTGTTCGTTGACACCATGTTGACG
GTGCAGCGCGGCGAGCTGTGCTCCCCCGAGCTCGCTCCCGACCAGCCGCAGAAGGTCATCGCGAACGCGGCGCAGCTGCT
GTCCAGCCTTTCGCAGTTCGTGGGCGTCGTCATGGCTCCGCGCCGGCCGTCGGTCTTTCGCCACATCGAGTTCCTCCGCC
TTTCGGAGCGGCGCCTGCTGGTCATCATCGTCTCGCCGGACGGCGACGTGCAGAACCGCGTGATCTTCACCGAAGTGGAC
CATTCCCAGTCCCAGCTGGCCGAGGCCGCCAACTTCCTCAACAGCCATTATTCCGGCCTGGGGATGGAAGAGGTGCGCGA
GCGGCTCAAGACCGAGGTGGACCAGTTGCGCGGAGAGATCGCTTCCCTCATGCAGGCCGCGGTGAACGTCGGCTCCGAGG
CCATGGCCGCCTCGCAGGAGGAGGTGGTCATCTCCGGCGAGCGCAACCTGCTGGCCCTGAGCGATTTCTCGAACGACATG
GGCAACCTGCGCAAGGCCTTCGACCTCTTCGAGCAGAAGACCCAGATACTGCGCCTGCTGGACGTCTCCAACCGGGCCGA
GGGGGTGCGCATCTTCATCGGGGGCGAAAGCCAGGTCGTGCCGTTCGAGGAGCTCTCGGTGGTCAGCGCCCCCTACGAGG
TGGACGGGCAGGTCGTGGGCACGCTGGGCGTCATCGGTCCTACGCGCATGCCCTACGACCGCATGATCCAGATCGTGGAC
ATCACCTCCAAGCTGGTGACCAACGCGCTGAGCCATCGCCGCTAG

Upstream 100 bases:

>100_bases
CATGTTGGGTGTGCCTGTCGGCACGTTGCGATACCACGTCCACCGCCATGAGGGTCGCGGCCGGCACGGCGCATGGAGCA
CAGATAAGTAAAATGATTCA

Downstream 100 bases:

>100_bases
GGTGCCCGATCCGGATGACGCGGCATGCGGCCATGGCGGACCGGAAAGCCGGGGGCGGACGGTTTACCGGCCGTCGCTCC
AGGTACCTGCCTTGATCACG

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MLDDRAKLLLKALIERYIADGQPVGSRTLSRSSGLDLSPATIRNVMADLEDIGLIASPHTSAGRIPTAKGYRLFVDTMLT
VQRGELCSPELAPDQPQKVIANAAQLLSSLSQFVGVVMAPRRPSVFRHIEFLRLSERRLLVIIVSPDGDVQNRVIFTEVD
HSQSQLAEAANFLNSHYSGLGMEEVRERLKTEVDQLRGEIASLMQAAVNVGSEAMAASQEEVVISGERNLLALSDFSNDM
GNLRKAFDLFEQKTQILRLLDVSNRAEGVRIFIGGESQVVPFEELSVVSAPYEVDGQVVGTLGVIGPTRMPYDRMIQIVD
ITSKLVTNALSHRR

Sequences:

>Translated_334_residues
MLDDRAKLLLKALIERYIADGQPVGSRTLSRSSGLDLSPATIRNVMADLEDIGLIASPHTSAGRIPTAKGYRLFVDTMLT
VQRGELCSPELAPDQPQKVIANAAQLLSSLSQFVGVVMAPRRPSVFRHIEFLRLSERRLLVIIVSPDGDVQNRVIFTEVD
HSQSQLAEAANFLNSHYSGLGMEEVRERLKTEVDQLRGEIASLMQAAVNVGSEAMAASQEEVVISGERNLLALSDFSNDM
GNLRKAFDLFEQKTQILRLLDVSNRAEGVRIFIGGESQVVPFEELSVVSAPYEVDGQVVGTLGVIGPTRMPYDRMIQIVD
ITSKLVTNALSHRR
>Mature_334_residues
MLDDRAKLLLKALIERYIADGQPVGSRTLSRSSGLDLSPATIRNVMADLEDIGLIASPHTSAGRIPTAKGYRLFVDTMLT
VQRGELCSPELAPDQPQKVIANAAQLLSSLSQFVGVVMAPRRPSVFRHIEFLRLSERRLLVIIVSPDGDVQNRVIFTEVD
HSQSQLAEAANFLNSHYSGLGMEEVRERLKTEVDQLRGEIASLMQAAVNVGSEAMAASQEEVVISGERNLLALSDFSNDM
GNLRKAFDLFEQKTQILRLLDVSNRAEGVRIFIGGESQVVPFEELSVVSAPYEVDGQVVGTLGVIGPTRMPYDRMIQIVD
ITSKLVTNALSHRR

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_ACIAC (A1TT56)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_971918.1
- ProteinModelPortal:   A1TT56
- SMR:   A1TT56
- STRING:   A1TT56
- GeneID:   4666977
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_3593
- NMPDR:   fig|397945.5.peg.3066
- eggNOG:   COG1420
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- BioCyc:   AAVE397945:AAVE_3593-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR005104
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF03444 DUF293; PF01628 HrcA

EC number: NA

Molecular weight: Translated: 36696; Mature: 36696

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDDRAKLLLKALIERYIADGQPVGSRTLSRSSGLDLSPATIRNVMADLEDIGLIASPHT
CCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCEEECCCC
SAGRIPTAKGYRLFVDTMLTVQRGELCSPELAPDQPQKVIANAAQLLSSLSQFVGVVMAP
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECC
RRPSVFRHIEFLRLSERRLLVIIVSPDGDVQNRVIFTEVDHSQSQLAEAANFLNSHYSGL
CCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCC
GMEEVRERLKTEVDQLRGEIASLMQAAVNVGSEAMAASQEEVVISGERNLLALSDFSNDM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEECCCCEEEEHHCCCHH
GNLRKAFDLFEQKTQILRLLDVSNRAEGVRIFIGGESQVVPFEELSVVSAPYEVDGQVVG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCEEEE
TLGVIGPTRMPYDRMIQIVDITSKLVTNALSHRR
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDDRAKLLLKALIERYIADGQPVGSRTLSRSSGLDLSPATIRNVMADLEDIGLIASPHT
CCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCEEECCCC
SAGRIPTAKGYRLFVDTMLTVQRGELCSPELAPDQPQKVIANAAQLLSSLSQFVGVVMAP
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECC
RRPSVFRHIEFLRLSERRLLVIIVSPDGDVQNRVIFTEVDHSQSQLAEAANFLNSHYSGL
CCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCC
GMEEVRERLKTEVDQLRGEIASLMQAAVNVGSEAMAASQEEVVISGERNLLALSDFSNDM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEECCCCEEEEHHCCCHH
GNLRKAFDLFEQKTQILRLLDVSNRAEGVRIFIGGESQVVPFEELSVVSAPYEVDGQVVG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCEEEE
TLGVIGPTRMPYDRMIQIVDITSKLVTNALSHRR
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA