Click here to switch to the map view.

The map label for this gene is dctA

Identifier: 120612152

GI number: 120612152

Start: 3870637

End: 3871992

Strand: Direct

Name: dctA

Synonym: Aave_3501

Alternate gene names: 120612152

Gene position: 3870637-3871992 (Clockwise)

Preceding gene: 120612144

Following gene: 120612153

Centisome position: 72.31

GC content: 64.75

Gene sequence:

>1356_bases
ATGACCGCGAACGCCCGCATTCCCGCCAGAAAACTCCCCCTCTACCGCTCGCTCTACGTGCAGGTGCTGTTCGCCGTCGT
CGTGGGCGTGCTGCTCGGGCACTTCTACCCCGAGATCGGCGAGAAGATGAAGCCCCTGGGCGATGGCTTCATCAAGCTCA
TCAAGATGATCATCGCGCCCATCATCTTCTGCACCGTGGTGGTGGGCATCGCGGGCATGGAGGACATGAAGAAGGTGGGC
CGCACCGGCGGCCTCGCCCTGCTCTACTTCGAGATCGTGAGCAGCGTCGCGCTGGTCATCGGCCTGATCGTCGTCAACGT
GCTCCAGCCCGGCGCGGGCATGAACGTCGATGCCTCGGCCATCGATACCAAGTCCATCGCCGCCTACACGGCGCCCGGCA
AGATGGGCACGACCACCGACTTCCTGATGAACATCATCCCCACCACCGTGGTGGATGCGTTCGCCAAGGGCGAGATCCTG
CAGGTGCTGCTCATCGCCGTGATGTTCGGCTTCGCGCTGCACCGCTTCGGCGGCCGCGGCACGCTGGTGTTCGACTTCAT
CGAGAAGACCTCGCACGTGCTGTTCACCATCGTGGGCTACATCATGAAGGTGGCCCCGATCGGCGCGTTCGGCGCCATGT
CCTTCACCATCGGCAAGTACGGCGTCGGCTCGCTGCTGTCGCTGGGCAAGCTGATGGGCTCGTTCTACCTGACCTGCCTG
CTGTTCGTCTTCGTCGTGCTCGGCCTGATCGCGCGCTTCCACGGCTTCTCGATCTGGAAGTTCGTGAAGTACATCAAGGA
AGAGCTGCTCATCGTGCTGGGTACCTCCTCCAGCGAATCGGTGCTGCCGCGCATGATGGAGAAGATGGAGAACCTGGGCG
CCAGGAAGACCACCGTGGGCCTGGTGATCCCCACCGGCTACTCCTTCAACCTGGACGGCACCTCCATCTACCTGACCATG
GCCGCCGTGTTCATCGCCCAGGCCACGAACACGCCGCTGGACATCACGCACCAGATCACCCTGTTGCTGGTGCTGCTGCT
CACCTCCAAGGGCGCCGCCGGCATCACCGGCAGCGGTTTCATCGTGCTGGCCGCCACGCTCTCGGCCGTGGGCCACGTGC
CCGTGGCGGGCCTCGCGCTGATCCTGGGCATCGACCGCTTCATGTCCGAGGCGCGCGCGCTCACCAACCTCGTGGGCAAC
GGCGTGGCCACCATCGTCGTCGCCAAGTGGACCGGCGACCTCGACACGGAACAGCTCAAGCAGCGCCTGGACAACCCCGA
CTGGGTGGCGGCGCAGGAGCCGGAAGCCATCCTGGACCACAAGACCGAGCGCATGGACGTGTCGGGCTCGCGCTGA

Upstream 100 bases:

>100_bases
ATTTGCGCGCGGCACAGCCTTACAGTGCGTCACCCGCGCGACGGCGGCCTGCGGACAGGCGCCTGGAACCCGCTCTTTTT
TGTTGACGCAAGAGGCCTGC

Downstream 100 bases:

>100_bases
TCGCCCGGTTCCTGCACCACGCACCGAGGCCGGCATATGCCGGCCTTTTTCTTTCCTCGGGAGGAACGCACCGTGCGACA
GGCGCGGCCGCTTGCTTCGC

Product: C4-dicarboxylate transporter DctA

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MTANARIPARKLPLYRSLYVQVLFAVVVGVLLGHFYPEIGEKMKPLGDGFIKLIKMIIAPIIFCTVVVGIAGMEDMKKVG
RTGGLALLYFEIVSSVALVIGLIVVNVLQPGAGMNVDASAIDTKSIAAYTAPGKMGTTTDFLMNIIPTTVVDAFAKGEIL
QVLLIAVMFGFALHRFGGRGTLVFDFIEKTSHVLFTIVGYIMKVAPIGAFGAMSFTIGKYGVGSLLSLGKLMGSFYLTCL
LFVFVVLGLIARFHGFSIWKFVKYIKEELLIVLGTSSSESVLPRMMEKMENLGARKTTVGLVIPTGYSFNLDGTSIYLTM
AAVFIAQATNTPLDITHQITLLLVLLLTSKGAAGITGSGFIVLAATLSAVGHVPVAGLALILGIDRFMSEARALTNLVGN
GVATIVVAKWTGDLDTEQLKQRLDNPDWVAAQEPEAILDHKTERMDVSGSR

Sequences:

>Translated_451_residues
MTANARIPARKLPLYRSLYVQVLFAVVVGVLLGHFYPEIGEKMKPLGDGFIKLIKMIIAPIIFCTVVVGIAGMEDMKKVG
RTGGLALLYFEIVSSVALVIGLIVVNVLQPGAGMNVDASAIDTKSIAAYTAPGKMGTTTDFLMNIIPTTVVDAFAKGEIL
QVLLIAVMFGFALHRFGGRGTLVFDFIEKTSHVLFTIVGYIMKVAPIGAFGAMSFTIGKYGVGSLLSLGKLMGSFYLTCL
LFVFVVLGLIARFHGFSIWKFVKYIKEELLIVLGTSSSESVLPRMMEKMENLGARKTTVGLVIPTGYSFNLDGTSIYLTM
AAVFIAQATNTPLDITHQITLLLVLLLTSKGAAGITGSGFIVLAATLSAVGHVPVAGLALILGIDRFMSEARALTNLVGN
GVATIVVAKWTGDLDTEQLKQRLDNPDWVAAQEPEAILDHKTERMDVSGSR
>Mature_450_residues
TANARIPARKLPLYRSLYVQVLFAVVVGVLLGHFYPEIGEKMKPLGDGFIKLIKMIIAPIIFCTVVVGIAGMEDMKKVGR
TGGLALLYFEIVSSVALVIGLIVVNVLQPGAGMNVDASAIDTKSIAAYTAPGKMGTTTDFLMNIIPTTVVDAFAKGEILQ
VLLIAVMFGFALHRFGGRGTLVFDFIEKTSHVLFTIVGYIMKVAPIGAFGAMSFTIGKYGVGSLLSLGKLMGSFYLTCLL
FVFVVLGLIARFHGFSIWKFVKYIKEELLIVLGTSSSESVLPRMMEKMENLGARKTTVGLVIPTGYSFNLDGTSIYLTMA
AVFIAQATNTPLDITHQITLLLVLLLTSKGAAGITGSGFIVLAATLSAVGHVPVAGLALILGIDRFMSEARALTNLVGNG
VATIVVAKWTGDLDTEQLKQRLDNPDWVAAQEPEAILDHKTERMDVSGSR

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family

Homologues:

Organism=Homo sapiens, GI5032093, Length=433, Percent_Identity=29.7921478060046, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI40254478, Length=470, Percent_Identity=25.531914893617, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI4827012, Length=448, Percent_Identity=24.3303571428571, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI21314632, Length=442, Percent_Identity=25.5656108597285, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI194239697, Length=511, Percent_Identity=24.853228962818, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI223468566, Length=300, Percent_Identity=32, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI223468564, Length=300, Percent_Identity=32, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI169790839, Length=487, Percent_Identity=24.6406570841889, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI66773030, Length=435, Percent_Identity=25.0574712643678, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI262359914, Length=428, Percent_Identity=23.5981308411215, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI301601644, Length=195, Percent_Identity=27.1794871794872, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1789947, Length=419, Percent_Identity=72.3150357995227, Blast_Score=620, Evalue=1e-179,
Organism=Escherichia coli, GI1790514, Length=421, Percent_Identity=42.0427553444181, Blast_Score=322, Evalue=3e-89,
Organism=Escherichia coli, GI1788024, Length=404, Percent_Identity=22.5247524752475, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1789473, Length=221, Percent_Identity=25.7918552036199, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17537407, Length=424, Percent_Identity=25.4716981132075, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71983099, Length=429, Percent_Identity=24.2424242424242, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71983106, Length=429, Percent_Identity=24.2424242424242, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71996953, Length=434, Percent_Identity=23.7327188940092, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI193206505, Length=484, Percent_Identity=23.7603305785124, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI193206654, Length=467, Percent_Identity=22.4839400428266, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17541374, Length=438, Percent_Identity=22.3744292237443, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24583025, Length=440, Percent_Identity=21.8181818181818, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17137668, Length=440, Percent_Identity=21.8181818181818, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24583023, Length=440, Percent_Identity=21.8181818181818, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI281360483, Length=456, Percent_Identity=22.8070175438596, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17137666, Length=456, Percent_Identity=22.8070175438596, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281360481, Length=456, Percent_Identity=22.8070175438596, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCTA_ACIAC (A1TSW8)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_971830.1
- ProteinModelPortal:   A1TSW8
- SMR:   A1TSW8
- STRING:   A1TSW8
- GeneID:   4665082
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_3501
- NMPDR:   fig|397945.5.peg.2993
- eggNOG:   COG1301
- HOGENOM:   HBG739804
- OMA:   ACFYITC
- PhylomeDB:   A1TSW8
- ProtClustDB:   PRK01663
- BioCyc:   AAVE397945:AAVE_3501-MONOMER
- HAMAP:   MF_01300
- InterPro:   IPR001991
- InterPro:   IPR018107
- PANTHER:   PTHR11958
- PRINTS:   PR00173

Pfam domain/function: PF00375 SDF

EC number: NA

Molecular weight: Translated: 48319; Mature: 48188

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x160cff44)-; HASH(0x16cace34)-; HASH(0x16ccca98)-; HASH(0x16cdc794)-; HASH(0x15d74884)-; HASH(0x138790b4)-; HASH(0x16cf6a74)-; HASH(0x1696ef70)-; HASH(0x16cdc8cc)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTANARIPARKLPLYRSLYVQVLFAVVVGVLLGHFYPEIGEKMKPLGDGFIKLIKMIIAP
CCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
IIFCTVVVGIAGMEDMKKVGRTGGLALLYFEIVSSVALVIGLIVVNVLQPGAGMNVDASA
HHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
IDTKSIAAYTAPGKMGTTTDFLMNIIPTTVVDAFAKGEILQVLLIAVMFGFALHRFGGRG
CCHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCC
TLVFDFIEKTSHVLFTIVGYIMKVAPIGAFGAMSFTIGKYGVGSLLSLGKLMGSFYLTCL
CEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LFVFVVLGLIARFHGFSIWKFVKYIKEELLIVLGTSSSESVLPRMMEKMENLGARKTTVG
HHHHHHHHHHHHHHCHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEE
LVIPTGYSFNLDGTSIYLTMAAVFIAQATNTPLDITHQITLLLVLLLTSKGAAGITGSGF
EEEECCEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCH
IVLAATLSAVGHVPVAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWTGDLDTEQLK
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHH
QRLDNPDWVAAQEPEAILDHKTERMDVSGSR
HHCCCCCCCCCCCCHHHHCCCHHHCCCCCCH
>Mature Secondary Structure 
TANARIPARKLPLYRSLYVQVLFAVVVGVLLGHFYPEIGEKMKPLGDGFIKLIKMIIAP
CCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH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HHCCCCCCCCCCCCHHHHCCCHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA