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The map label for this gene is 120612144

Identifier: 120612144

GI number: 120612144

Start: 3861080

End: 3861793

Strand: Direct

Name: 120612144

Synonym: Aave_3493

Alternate gene names: NA

Gene position: 3861080-3861793 (Clockwise)

Preceding gene: 120612142

Following gene: 120612152

Centisome position: 72.13

GC content: 72.83

Gene sequence:

>714_bases
ATGAACGACGCCTTCCCCGACGTACGCCTGCTGGTCTTCGACATCTTCGGCACCGTGGTGGACTGGCACGGCAGCATCGT
GCGCGAAATGCAGGCGCTGCACCCCCAGGTGGACGCCGACGCCTTCGCCCTCGCCTGGCGCGAGGGCTACCAGCCCGCCA
TGCAGCGGGTGCGCAGCGGGGAGCTCGGCTGGACGCGCATCGACGAGTTGCACCGGACCATTCTCGACGGCCTGCTGCCC
CGCTTCGGCCTGGCGCACCTGTCCGAGCCGGAGCGCCGGCACCTGAACCGCGCGTGGCACCGGCTCGCGGCCTGGCCCGA
CAGCGTGGCCGGGCTGCAGCGGCTCAGGCGCCGCCGCACCATCGCCACGCTCTCCAACGGCAACATCGGCCTGCTCGCCA
ACATGGCCAAGGGGGCCGGCCTGCCCTGGGACTGCATCCTGAGCGCCGAGGTGTTCCGGGCCTACAAACCCGATCCGGCG
GTGTACCTGGGCGCCGCCCGCGTCTTCGACCTGGAGCCCGCGCAGGTGATGATGGTGGCCGCGCACCACGAGGACCTGGA
GGCCGCGCGGGCCTGCGGCCTGCGGACGGCGTATGTGGAAAGGCCGCACGAATTCGGCGCGGCCCGCGCGAAGGACGTCT
CGCCCCGGCCGGGCAACGACCTGCACTGCACGGACCTGGGCGCGCTCGCGGACATGCTCGCGGGCCCGGGCTGA

Upstream 100 bases:

>100_bases
GGTTTTGCGACCATTGCCGTATGCTGGACGGCACGCGGCATCCGCCACACCGGCAGGGCCGCGCCCTCCCCATCCCCCTC
TTCTTCCCCGGAAGCTGCCC

Downstream 100 bases:

>100_bases
AACGCCCGCGCCGGCCGCTTCAGCGCCAGCTTCAGGCAGGCAGGGCCGCGCGCAGGCCATGGCCGTGCGGCGAGCACAGC
CAGCCGAGCGCCGCGGCATG

Product: haloacid dehalogenase

Products: NA

Alternate protein names: 2-haloalkanoic acid dehalogenase I; DEHCI; Halocarboxylic acid halidohydrolase I; L-2-haloacid dehalogenase I [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MNDAFPDVRLLVFDIFGTVVDWHGSIVREMQALHPQVDADAFALAWREGYQPAMQRVRSGELGWTRIDELHRTILDGLLP
RFGLAHLSEPERRHLNRAWHRLAAWPDSVAGLQRLRRRRTIATLSNGNIGLLANMAKGAGLPWDCILSAEVFRAYKPDPA
VYLGAARVFDLEPAQVMMVAAHHEDLEAARACGLRTAYVERPHEFGAARAKDVSPRPGNDLHCTDLGALADMLAGPG

Sequences:

>Translated_237_residues
MNDAFPDVRLLVFDIFGTVVDWHGSIVREMQALHPQVDADAFALAWREGYQPAMQRVRSGELGWTRIDELHRTILDGLLP
RFGLAHLSEPERRHLNRAWHRLAAWPDSVAGLQRLRRRRTIATLSNGNIGLLANMAKGAGLPWDCILSAEVFRAYKPDPA
VYLGAARVFDLEPAQVMMVAAHHEDLEAARACGLRTAYVERPHEFGAARAKDVSPRPGNDLHCTDLGALADMLAGPG
>Mature_237_residues
MNDAFPDVRLLVFDIFGTVVDWHGSIVREMQALHPQVDADAFALAWREGYQPAMQRVRSGELGWTRIDELHRTILDGLLP
RFGLAHLSEPERRHLNRAWHRLAAWPDSVAGLQRLRRRRTIATLSNGNIGLLANMAKGAGLPWDCILSAEVFRAYKPDPA
VYLGAARVFDLEPAQVMMVAAHHEDLEAARACGLRTAYVERPHEFGAARAKDVSPRPGNDLHCTDLGALADMLAGPG

Specific function: Catalyzes the hydrolytic dehalogenation of small (S)-2- haloalkanoic acids to yield the corresponding (R)-2- hydroxyalkanoic acids. Acts on acids of short chain lengths, C(2) to C(4), with inversion of configuration at C-2 [H]

COG id: COG1011

COG function: function code R; Predicted hydrolase (HAD superfamily)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. S-2- haloalkanoic acid dehalogenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006388
- InterPro:   IPR006328
- InterPro:   IPR005833 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.8.1.2 [H]

Molecular weight: Translated: 26282; Mature: 26282

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDAFPDVRLLVFDIFGTVVDWHGSIVREMQALHPQVDADAFALAWREGYQPAMQRVRSG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHCC
ELGWTRIDELHRTILDGLLPRFGLAHLSEPERRHLNRAWHRLAAWPDSVAGLQRLRRRRT
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
IATLSNGNIGLLANMAKGAGLPWDCILSAEVFRAYKPDPAVYLGAARVFDLEPAQVMMVA
HHEECCCCEEEEEEHHHCCCCCHHHHHHHHHHHHCCCCCCEEECCHHEECCCCHHHEEHH
AHHEDLEAARACGLRTAYVERPHEFGAARAKDVSPRPGNDLHCTDLGALADMLAGPG
HHHHHHHHHHHCCCHHHHHHCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNDAFPDVRLLVFDIFGTVVDWHGSIVREMQALHPQVDADAFALAWREGYQPAMQRVRSG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHCC
ELGWTRIDELHRTILDGLLPRFGLAHLSEPERRHLNRAWHRLAAWPDSVAGLQRLRRRRT
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
IATLSNGNIGLLANMAKGAGLPWDCILSAEVFRAYKPDPAVYLGAARVFDLEPAQVMMVA
HHEECCCCEEEEEEHHHCCCCCHHHHHHHHHHHHCCCCCCEEECCHHEECCCCHHHEEHH
AHHEDLEAARACGLRTAYVERPHEFGAARAKDVSPRPGNDLHCTDLGALADMLAGPG
HHHHHHHHHHHCCCHHHHHHCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1995594 [H]