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The map label for this gene is gbsB [H]

Identifier: 120612071

GI number: 120612071

Start: 3774106

End: 3775242

Strand: Direct

Name: gbsB [H]

Synonym: Aave_3418

Alternate gene names: 120612071

Gene position: 3774106-3775242 (Clockwise)

Preceding gene: 120612067

Following gene: 120612075

Centisome position: 70.51

GC content: 71.94

Gene sequence:

>1137_bases
ATGGCCCTCATCCACTACATCACCCAGATCCAGATCGAATTCGGCGCAGTGCGGCTGCTCGCCCAGGAATGCGTGCGCGC
GGGCATCACGCGCCCGCTCGTGGTCACCGATCCCGGCGTCAAGGCCGCCGGCGTGCTGCAGCCTGCGCTGGACGCGCTCG
CCGGCCTGCCGGTGGCGGTGTTCGACCAGACGCCCGCCAACCCCACCGAAGCCGCCGTGCGCGCGGCCGTGGAGATCTAC
CGCGCCCATGGCTGCGACGGCCTGATCGCCGTCGGCGGCGGCTCGGCCATCGACTGCGCCAAGGGCATCGCCATCGCCGC
CACGCACGACGGGCCGCTCACGCACTACGCGACCATCGAAGGCGGCTCGCCCCGGATCACGGAGCGGGTGGCGCCCCTGA
TCGCCGTGCCCACCACGGCAGGCACGGGCAGCGAGGTGGCGCGCGGCGCCATCCTGATCGTGGACGACCACCGCAAGCTC
GGCTTCCACTCCTGGCACCTGGTGCCCAAGGCCGCCATCTGCGACCCGGCCCTGACACTGGGCCTGCCGCCCCACCTGAC
CGCCGCCACCGGCATGGACGCGATCGCGCACTGCATGGAAACCTTCATGTCCTCCGCCTTCAACCCGCCGGCCGACGGCA
TCGCGCTCGACGGCCTGGCCCGCGGCTGGGCCCACATCGAGCGCGCCACGCGCGACGGGCAGGACCGCGACGCACGGCTG
CACATGATGAGCGCGAGCATGCAGGGCGCCATGGCCTTCCAGAAGGGCCTGGGCTGCGTGCATTCGCTCAGCCACAGCCT
GGGCGGCATCAACCCGCGCCTGCACCACGGCACCCTGAATGCGGTCTTCCTGCCCGCGGTGGTGCGCTTCAATGCGCAGG
ACGAGGCCGTGCGCCGCGACCGCCGGCTGGAGCGCATGGCCCAGGCCATGGGCCTGGCCAGCGCGGACGACATTCCCGAT
GCGATCCGCGACATGAGCGCGCGCCTGGGACTGCCGACCGGGCTGGCCGCGATGGGGGTCGGAGAAGATGTGTGGGACGG
CGTGATCCGCGGCGCCATGGCCGACCACTGCCACAAGACCAATCCGCGCGAGGCCAGCGTGGACGACTACCGGGCCATGC
TGGAAGCGTCGATGTAG

Upstream 100 bases:

>100_bases
GGGTTTGCTGCAGGGCCATGGAAAGCTCCGGGGTTGTAGATTGGCGTGATCAGACCACCAATACGCCAGGGCGCGCATCC
TGGCAACCCCCATCACCACC

Downstream 100 bases:

>100_bases
CCGAAGCAGTCCTGGTGGAACCCGGCCTACAGCGGCTCCACGGCATCCGGGGGACAGCCCCGGGCGAGCCATTGCGCGAA
CTCGTCGGCCAGCTGGCGGC

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MALIHYITQIQIEFGAVRLLAQECVRAGITRPLVVTDPGVKAAGVLQPALDALAGLPVAVFDQTPANPTEAAVRAAVEIY
RAHGCDGLIAVGGGSAIDCAKGIAIAATHDGPLTHYATIEGGSPRITERVAPLIAVPTTAGTGSEVARGAILIVDDHRKL
GFHSWHLVPKAAICDPALTLGLPPHLTAATGMDAIAHCMETFMSSAFNPPADGIALDGLARGWAHIERATRDGQDRDARL
HMMSASMQGAMAFQKGLGCVHSLSHSLGGINPRLHHGTLNAVFLPAVVRFNAQDEAVRRDRRLERMAQAMGLASADDIPD
AIRDMSARLGLPTGLAAMGVGEDVWDGVIRGAMADHCHKTNPREASVDDYRAMLEASM

Sequences:

>Translated_378_residues
MALIHYITQIQIEFGAVRLLAQECVRAGITRPLVVTDPGVKAAGVLQPALDALAGLPVAVFDQTPANPTEAAVRAAVEIY
RAHGCDGLIAVGGGSAIDCAKGIAIAATHDGPLTHYATIEGGSPRITERVAPLIAVPTTAGTGSEVARGAILIVDDHRKL
GFHSWHLVPKAAICDPALTLGLPPHLTAATGMDAIAHCMETFMSSAFNPPADGIALDGLARGWAHIERATRDGQDRDARL
HMMSASMQGAMAFQKGLGCVHSLSHSLGGINPRLHHGTLNAVFLPAVVRFNAQDEAVRRDRRLERMAQAMGLASADDIPD
AIRDMSARLGLPTGLAAMGVGEDVWDGVIRGAMADHCHKTNPREASVDDYRAMLEASM
>Mature_377_residues
ALIHYITQIQIEFGAVRLLAQECVRAGITRPLVVTDPGVKAAGVLQPALDALAGLPVAVFDQTPANPTEAAVRAAVEIYR
AHGCDGLIAVGGGSAIDCAKGIAIAATHDGPLTHYATIEGGSPRITERVAPLIAVPTTAGTGSEVARGAILIVDDHRKLG
FHSWHLVPKAAICDPALTLGLPPHLTAATGMDAIAHCMETFMSSAFNPPADGIALDGLARGWAHIERATRDGQDRDARLH
MMSASMQGAMAFQKGLGCVHSLSHSLGGINPRLHHGTLNAVFLPAVVRFNAQDEAVRRDRRLERMAQAMGLASADDIPDA
IRDMSARLGLPTGLAAMGVGEDVWDGVIRGAMADHCHKTNPREASVDDYRAMLEASM

Specific function: Essential for the utilization of choline as a precursor [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=416, Percent_Identity=27.6442307692308, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI48994951, Length=366, Percent_Identity=36.0655737704918, Blast_Score=194, Evalue=9e-51,
Organism=Escherichia coli, GI87082107, Length=373, Percent_Identity=32.4396782841823, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1789163, Length=365, Percent_Identity=32.6027397260274, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1787493, Length=405, Percent_Identity=29.6296296296296, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1789386, Length=318, Percent_Identity=31.4465408805031, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17537053, Length=363, Percent_Identity=28.099173553719, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321181, Length=369, Percent_Identity=35.230352303523, Blast_Score=200, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24657991, Length=396, Percent_Identity=28.2828282828283, Blast_Score=104, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 39725; Mature: 39594

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIHYITQIQIEFGAVRLLAQECVRAGITRPLVVTDPGVKAAGVLQPALDALAGLPVAV
CHHEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEE
FDQTPANPTEAAVRAAVEIYRAHGCDGLIAVGGGSAIDCAKGIAIAATHDGPLTHYATIE
ECCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHCCEEEEEECCCCCEEEEEEC
GGSPRITERVAPLIAVPTTAGTGSEVARGAILIVDDHRKLGFHSWHLVPKAAICDPALTL
CCCCHHHHHHCCEEEECCCCCCCHHHHCCEEEEEECCCCCCCCCEECCCCHHHCCCHHHC
GLPPHLTAATGMDAIAHCMETFMSSAFNPPADGIALDGLARGWAHIERATRDGQDRDARL
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHH
HMMSASMQGAMAFQKGLGCVHSLSHSLGGINPRLHHGTLNAVFLPAVVRFNAQDEAVRRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHCCCCHHHHHHHH
RRLERMAQAMGLASADDIPDAIRDMSARLGLPTGLAAMGVGEDVWDGVIRGAMADHCHKT
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCC
NPREASVDDYRAMLEASM
CCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ALIHYITQIQIEFGAVRLLAQECVRAGITRPLVVTDPGVKAAGVLQPALDALAGLPVAV
HHEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEE
FDQTPANPTEAAVRAAVEIYRAHGCDGLIAVGGGSAIDCAKGIAIAATHDGPLTHYATIE
ECCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHCCEEEEEECCCCCEEEEEEC
GGSPRITERVAPLIAVPTTAGTGSEVARGAILIVDDHRKLGFHSWHLVPKAAICDPALTL
CCCCHHHHHHCCEEEECCCCCCCHHHHCCEEEEEECCCCCCCCCEECCCCHHHCCCHHHC
GLPPHLTAATGMDAIAHCMETFMSSAFNPPADGIALDGLARGWAHIERATRDGQDRDARL
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHH
HMMSASMQGAMAFQKGLGCVHSLSHSLGGINPRLHHGTLNAVFLPAVVRFNAQDEAVRRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHCCCCHHHHHHHH
RRLERMAQAMGLASADDIPDAIRDMSARLGLPTGLAAMGVGEDVWDGVIRGAMADHCHKT
HHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCC
NPREASVDDYRAMLEASM
CCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8752328; 9384377 [H]