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The map label for this gene is guaB [H]

Identifier: 120612024

GI number: 120612024

Start: 3725639

End: 3727108

Strand: Reverse

Name: guaB [H]

Synonym: Aave_3370

Alternate gene names: 120612024

Gene position: 3727108-3725639 (Counterclockwise)

Preceding gene: 120612026

Following gene: 120612023

Centisome position: 69.63

GC content: 67.69

Gene sequence:

>1470_bases
ATGCGCCTTCTAGGAAAAGCGCTCACCTTCGACGATGTGTTGCTGGTGCCGGCGTACTCCCAGGTCCTGCCCAAGGACAC
GTCCCTCGCGACGCGACTCTCCCGCAATATCTCCCTGAACCTTCCCCTCGTGTCCGCCGCCATGGACACCGTCACCGAGG
CGCGCCTGGCCATCGCCATCGCGCAGGAGGGCGGCATCGGCATCGTGCACAAGAACCTCACGGCGCAGGAGCAGGCGGCC
CATGTCGCCAAGGTCAAGCGCTATGAATCCGGCGTGGTGCGCGACCCCGTCGTCATCACCCCCGAGCACACGGTGCTGCA
GGTGCTCCAGCTGTCCGAGCAGCTCGGCATCTCGGGCTTCCCGGTGTGCGACGCGGGCAAGGTGGTCGGCATCGTCACCG
GCCGCGACCTGCGCTTCGAGACCCGCTACGACGTCAAGGTGCGCGACATCATGACGCCGCGCGAGAAGCTCATCACGGTG
AAGGAGGGCGCGACCGCCTCCGAGGCCAAGGCGCTGCTCAACAAGCACAAGCTCGAGCGCCTGCTCGTTATCAACGACGC
CTTCGAGCTCAAGGGCCTGATCACCGTCAAGGACATCACCAAGCAGACCAGCTTCCCCAACGCGGCGCGCGACAGCAACG
GCCGCCTGCGCGTGGGCGCGGCCGTCGGCGTGGGCGAGGGCACCGAGGAGCGTGTCGAGGCGCTGGTGAAGGCCGGCGTC
GATGCGATCGTGGTGGACACGGCCCACGGCCACAGCAAGGGCGTGATCGACCGCGTGCGCTGGGTCAAGCAGAACTACCC
GCAGGTGGACGTGATCGGCGGCAACATCGCCACCGGCGCGGCGGCGCTCGCGCTGGTCGAGGCCGGTGCCGACGGCGTCA
AGGTCGGCATCGGCCCCGGCTCCATCTGCACCACCCGCATCGTCGCGGGCGTGGGCGTGCCGCAGATCATGGCCATCGAC
AGCGTGGCCACGGCCCTCCAGGGCACGGGCGTGCCGCTGATCGCCGACGGCGGCATCCGCTATTCGGGCGACATCGCCAA
GGCGCTGGCCGCGGGCGCGAGCACCGTGATGATGGGCGGCATGTTCGCCGGCACCGAAGAGGCGCCAGGCGAGGTCATCC
TGTTCCAGGGCCGCAGCTACAAGAGCTACCGCGGCATGGGCTCCATCGGTGCCATGCAGCAGGGCTCGGCCGACCGCTAC
TTCCAGGAATCCAGCACCGGCAATCCGAACGCCGACAAGCTGGTGCCCGAAGGTATCGAAGGCCGCGTGCCCTACAAGGG
CTCGATGGTCTCGATCGTGTTCCAGATGGCCGGCGGCGTGCGTGCTTCCATGGGCTACTGCGGCTGCGCCACCATCGAGG
AGATGAACAACAAGGCGGAGTTCGTCGAGATCACCACGGCCGGCATCCGCGAAAGCCACGTGCACGACGTGCAGATCACC
AAGGAAGCGCCGAACTACCGGGCTGATTAA

Upstream 100 bases:

>100_bases
GTGTAGCGCCCGCCCCCCGGCCGCGCCATGGGACCGGCAAGACCCGGCGCGGCGGTGGAAGCGGCCCGGCGGGTACAATC
GTTTTTTTGGAGCGAATCTC

Downstream 100 bases:

>100_bases
GTACAACCCCTGAGGCGCTGACGCAGCCGGTGCGGCGGGGCGGCCCTTGCACGGCTGCCTGCGCATGGGGCCGCGGGGGC
TTTGGGCGCCATGACGAATT

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MRLLGKALTFDDVLLVPAYSQVLPKDTSLATRLSRNISLNLPLVSAAMDTVTEARLAIAIAQEGGIGIVHKNLTAQEQAA
HVAKVKRYESGVVRDPVVITPEHTVLQVLQLSEQLGISGFPVCDAGKVVGIVTGRDLRFETRYDVKVRDIMTPREKLITV
KEGATASEAKALLNKHKLERLLVINDAFELKGLITVKDITKQTSFPNAARDSNGRLRVGAAVGVGEGTEERVEALVKAGV
DAIVVDTAHGHSKGVIDRVRWVKQNYPQVDVIGGNIATGAAALALVEAGADGVKVGIGPGSICTTRIVAGVGVPQIMAID
SVATALQGTGVPLIADGGIRYSGDIAKALAAGASTVMMGGMFAGTEEAPGEVILFQGRSYKSYRGMGSIGAMQQGSADRY
FQESSTGNPNADKLVPEGIEGRVPYKGSMVSIVFQMAGGVRASMGYCGCATIEEMNNKAEFVEITTAGIRESHVHDVQIT
KEAPNYRAD

Sequences:

>Translated_489_residues
MRLLGKALTFDDVLLVPAYSQVLPKDTSLATRLSRNISLNLPLVSAAMDTVTEARLAIAIAQEGGIGIVHKNLTAQEQAA
HVAKVKRYESGVVRDPVVITPEHTVLQVLQLSEQLGISGFPVCDAGKVVGIVTGRDLRFETRYDVKVRDIMTPREKLITV
KEGATASEAKALLNKHKLERLLVINDAFELKGLITVKDITKQTSFPNAARDSNGRLRVGAAVGVGEGTEERVEALVKAGV
DAIVVDTAHGHSKGVIDRVRWVKQNYPQVDVIGGNIATGAAALALVEAGADGVKVGIGPGSICTTRIVAGVGVPQIMAID
SVATALQGTGVPLIADGGIRYSGDIAKALAAGASTVMMGGMFAGTEEAPGEVILFQGRSYKSYRGMGSIGAMQQGSADRY
FQESSTGNPNADKLVPEGIEGRVPYKGSMVSIVFQMAGGVRASMGYCGCATIEEMNNKAEFVEITTAGIRESHVHDVQIT
KEAPNYRAD
>Mature_489_residues
MRLLGKALTFDDVLLVPAYSQVLPKDTSLATRLSRNISLNLPLVSAAMDTVTEARLAIAIAQEGGIGIVHKNLTAQEQAA
HVAKVKRYESGVVRDPVVITPEHTVLQVLQLSEQLGISGFPVCDAGKVVGIVTGRDLRFETRYDVKVRDIMTPREKLITV
KEGATASEAKALLNKHKLERLLVINDAFELKGLITVKDITKQTSFPNAARDSNGRLRVGAAVGVGEGTEERVEALVKAGV
DAIVVDTAHGHSKGVIDRVRWVKQNYPQVDVIGGNIATGAAALALVEAGADGVKVGIGPGSICTTRIVAGVGVPQIMAID
SVATALQGTGVPLIADGGIRYSGDIAKALAAGASTVMMGGMFAGTEEAPGEVILFQGRSYKSYRGMGSIGAMQQGSADRY
FQESSTGNPNADKLVPEGIEGRVPYKGSMVSIVFQMAGGVRASMGYCGCATIEEMNNKAEFVEITTAGIRESHVHDVQIT
KEAPNYRAD

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=454, Percent_Identity=42.9515418502203, Blast_Score=351, Evalue=7e-97,
Organism=Homo sapiens, GI34328928, Length=454, Percent_Identity=42.9515418502203, Blast_Score=351, Evalue=1e-96,
Organism=Homo sapiens, GI156616279, Length=454, Percent_Identity=42.9515418502203, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI34328930, Length=454, Percent_Identity=42.9515418502203, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI66933016, Length=488, Percent_Identity=39.9590163934426, Blast_Score=347, Evalue=2e-95,
Organism=Homo sapiens, GI217035152, Length=450, Percent_Identity=42.8888888888889, Blast_Score=345, Evalue=6e-95,
Organism=Homo sapiens, GI217035148, Length=454, Percent_Identity=42.0704845814978, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI217035150, Length=454, Percent_Identity=40.0881057268723, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI156104880, Length=250, Percent_Identity=36, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI50541954, Length=260, Percent_Identity=35.7692307692308, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI50541952, Length=260, Percent_Identity=35.7692307692308, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI50541948, Length=260, Percent_Identity=35.7692307692308, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI50541956, Length=260, Percent_Identity=35.7692307692308, Blast_Score=163, Evalue=3e-40,
Organism=Escherichia coli, GI1788855, Length=488, Percent_Identity=59.8360655737705, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI1786293, Length=227, Percent_Identity=33.4801762114537, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71994385, Length=482, Percent_Identity=36.3070539419087, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=38.8625592417062, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17560440, Length=320, Percent_Identity=31.25, Blast_Score=159, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6322012, Length=487, Percent_Identity=39.6303901437372, Blast_Score=351, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6323585, Length=487, Percent_Identity=38.8090349075975, Blast_Score=341, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6323464, Length=487, Percent_Identity=39.2197125256673, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=38.4615384615385, Blast_Score=258, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6319353, Length=114, Percent_Identity=44.7368421052632, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24641071, Length=487, Percent_Identity=40.6570841889117, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24641073, Length=487, Percent_Identity=40.6570841889117, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI28571163, Length=444, Percent_Identity=41.4414414414414, Blast_Score=319, Evalue=2e-87,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51576; Mature: 51576

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLGKALTFDDVLLVPAYSQVLPKDTSLATRLSRNISLNLPLVSAAMDTVTEARLAIAI
CCCCCCCCCCCCEEEECCHHHHCCCCHHHHHHHHCCEEECCCHHHHHHHHHHHCEEEEEE
AQEGGIGIVHKNLTAQEQAAHVAKVKRYESGVVRDPVVITPEHTVLQVLQLSEQLGISGF
ECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCCC
PVCDAGKVVGIVTGRDLRFETRYDVKVRDIMTPREKLITVKEGATASEAKALLNKHKLER
CCCCCCCEEEEEECCCEEEEEECCEEEECCCCCHHHEEEEECCCCHHHHHHHHHHHHHCE
LLVINDAFELKGLITVKDITKQTSFPNAARDSNGRLRVGAAVGVGEGTEERVEALVKAGV
EEEEECCHHHCEEEEEHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCC
DAIVVDTAHGHSKGVIDRVRWVKQNYPQVDVIGGNIATGAAALALVEAGADGVKVGIGPG
CEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCC
SICTTRIVAGVGVPQIMAIDSVATALQGTGVPLIADGGIRYSGDIAKALAAGASTVMMGG
CHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCEEECCHHHHHHHCCCHHHHCCC
MFAGTEEAPGEVILFQGRSYKSYRGMGSIGAMQQGSADRYFQESSTGNPNADKLVPEGIE
EECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCC
GRVPYKGSMVSIVFQMAGGVRASMGYCGCATIEEMNNKAEFVEITTAGIRESHVHDVQIT
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCEEEEEEEECCCCCCCCEEEEEE
KEAPNYRAD
CCCCCCCCC
>Mature Secondary Structure
MRLLGKALTFDDVLLVPAYSQVLPKDTSLATRLSRNISLNLPLVSAAMDTVTEARLAIAI
CCCCCCCCCCCCEEEECCHHHHCCCCHHHHHHHHCCEEECCCHHHHHHHHHHHCEEEEEE
AQEGGIGIVHKNLTAQEQAAHVAKVKRYESGVVRDPVVITPEHTVLQVLQLSEQLGISGF
ECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCCC
PVCDAGKVVGIVTGRDLRFETRYDVKVRDIMTPREKLITVKEGATASEAKALLNKHKLER
CCCCCCCEEEEEECCCEEEEEECCEEEECCCCCHHHEEEEECCCCHHHHHHHHHHHHHCE
LLVINDAFELKGLITVKDITKQTSFPNAARDSNGRLRVGAAVGVGEGTEERVEALVKAGV
EEEEECCHHHCEEEEEHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCC
DAIVVDTAHGHSKGVIDRVRWVKQNYPQVDVIGGNIATGAAALALVEAGADGVKVGIGPG
CEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCC
SICTTRIVAGVGVPQIMAIDSVATALQGTGVPLIADGGIRYSGDIAKALAAGASTVMMGG
CHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECCCEEECCHHHHHHHCCCHHHHCCC
MFAGTEEAPGEVILFQGRSYKSYRGMGSIGAMQQGSADRYFQESSTGNPNADKLVPEGIE
EECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCC
GRVPYKGSMVSIVFQMAGGVRASMGYCGCATIEEMNNKAEFVEITTAGIRESHVHDVQIT
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCEEEEEEEECCCCCCCCEEEEEE
KEAPNYRAD
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA