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The map label for this gene is serC

Identifier: 120611937

GI number: 120611937

Start: 3627103

End: 3628212

Strand: Direct

Name: serC

Synonym: Aave_3281

Alternate gene names: 120611937

Gene position: 3627103-3628212 (Clockwise)

Preceding gene: 120611936

Following gene: 120611938

Centisome position: 67.76

GC content: 66.67

Gene sequence:

>1110_bases
ATGAACCGCCCGTACAACTTCTCCGCCGGCCCCGCCGCCATTCCCGCCGAAGTCCTCCAGCAGGCCGCCTCCGAAATGCT
GGACTGGCACGGCAGCGGCATGGGCGTGATGGAGATGAGCCACCGGGGCAAGGAGTTCATCTCGATCTACGAGCAGGCCG
AGGCGGACCTGCGCGAACTGCTCGCCGTTCCGCAGGATTTCAGGATCCTGTTCATGCAGGGTGGTGGCCTGGCCGAGAAC
GCGATCGTGCCGCTGAACCTCTCGCGCGCCGCTACGGTGGACATGGTGGTGACCGGCAGCTGGAGCCAGAAATCCCTGAA
GGAGGCGCGCAAGTACGCTTCCGAGGTCCACGTGGCCGCATCGGCGGAGGACAGCGGTTTCACCACCCTGCCCGACCCCG
CGAGCTGGCAGTTGAGTCGCGGCGCGAGCTACCTGCACCTGTGCAGCAACGAGACGATCCATGGCATCGAGTTCCACGAA
CTGCCGGACCTGCGCGCCCTGGGCAGCGATGCGCCGCTGGTGATCGACTTTTCGTCGCACGTGGCCTCCCGCCCGGTGGA
CTGGTCGCGCGTGGGCCTGGCATTCGGCGGCGCGCAGAAGAACCTCGGCCCCGCCGGGCTCACGCTGGTGGTGGTGCGCG
AGGACCTGCTGGGCCACGCGCTGCCGGCCTGCCCGAGCGCCTTCGACTACAAGGTGGTGGCGGAGAACCAGTCGATGTTC
AACACCCCTCCCACCTGGGGCATCTACATCGCGGGCCTGACCTTCCAGTGGCTCAAGCGCCAGCGCGAGGGCGATCTTTC
CGGCATCGCGGCCATGGAGCAGCGCAACATCGCCAAGGCCCGCCTGCTCTACAACTTCATCGACCAGTCGCAGTTCTACG
TGAACAAGGTGTCGCCGAACGCGCGGTCGCGCATGAACATCCCTTTCTTCCTGCGCGACGAAACGCGCAACGAGGCCTTC
CTGGCAGGCGCCAGGGAGCGGGGTCTGCTGCAGCTCAAGGGCCACAAGTCGGTGGGCGGCATGCGTGCGAGCCTCTACAA
CGCCATGCCGCTGGCAGGCGTGGAGGCGCTCGTGGCCTACATGCAAGAATTCGAACAGCGCAGCGCCTGA

Upstream 100 bases:

>100_bases
GACCGAATGACGGTACGGTGCGCCGGCTCGACCGCGGGCGCACCGAGATGTTTACCCCCACGCCCCCCAGAAACGGCACG
GCCTCCGACCGCTTGAACCG

Downstream 100 bases:

>100_bases
GACGGCGCGCCGCGCCCTATCGCCCGCTGCCCGCAGCCCCGACCGATCCATGTCCCAATCCCCTCAAGCGTCCCCCGATC
TCGCCAGCCTGCGGGTGCAG

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MNRPYNFSAGPAAIPAEVLQQAASEMLDWHGSGMGVMEMSHRGKEFISIYEQAEADLRELLAVPQDFRILFMQGGGLAEN
AIVPLNLSRAATVDMVVTGSWSQKSLKEARKYASEVHVAASAEDSGFTTLPDPASWQLSRGASYLHLCSNETIHGIEFHE
LPDLRALGSDAPLVIDFSSHVASRPVDWSRVGLAFGGAQKNLGPAGLTLVVVREDLLGHALPACPSAFDYKVVAENQSMF
NTPPTWGIYIAGLTFQWLKRQREGDLSGIAAMEQRNIAKARLLYNFIDQSQFYVNKVSPNARSRMNIPFFLRDETRNEAF
LAGARERGLLQLKGHKSVGGMRASLYNAMPLAGVEALVAYMQEFEQRSA

Sequences:

>Translated_369_residues
MNRPYNFSAGPAAIPAEVLQQAASEMLDWHGSGMGVMEMSHRGKEFISIYEQAEADLRELLAVPQDFRILFMQGGGLAEN
AIVPLNLSRAATVDMVVTGSWSQKSLKEARKYASEVHVAASAEDSGFTTLPDPASWQLSRGASYLHLCSNETIHGIEFHE
LPDLRALGSDAPLVIDFSSHVASRPVDWSRVGLAFGGAQKNLGPAGLTLVVVREDLLGHALPACPSAFDYKVVAENQSMF
NTPPTWGIYIAGLTFQWLKRQREGDLSGIAAMEQRNIAKARLLYNFIDQSQFYVNKVSPNARSRMNIPFFLRDETRNEAF
LAGARERGLLQLKGHKSVGGMRASLYNAMPLAGVEALVAYMQEFEQRSA
>Mature_369_residues
MNRPYNFSAGPAAIPAEVLQQAASEMLDWHGSGMGVMEMSHRGKEFISIYEQAEADLRELLAVPQDFRILFMQGGGLAEN
AIVPLNLSRAATVDMVVTGSWSQKSLKEARKYASEVHVAASAEDSGFTTLPDPASWQLSRGASYLHLCSNETIHGIEFHE
LPDLRALGSDAPLVIDFSSHVASRPVDWSRVGLAFGGAQKNLGPAGLTLVVVREDLLGHALPACPSAFDYKVVAENQSMF
NTPPTWGIYIAGLTFQWLKRQREGDLSGIAAMEQRNIAKARLLYNFIDQSQFYVNKVSPNARSRMNIPFFLRDETRNEAF
LAGARERGLLQLKGHKSVGGMRASLYNAMPLAGVEALVAYMQEFEQRSA

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=367, Percent_Identity=46.0490463215259, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI10863955, Length=363, Percent_Identity=41.3223140495868, Blast_Score=286, Evalue=3e-77,
Organism=Escherichia coli, GI1787136, Length=368, Percent_Identity=51.3586956521739, Blast_Score=377, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17506897, Length=371, Percent_Identity=43.1266846361186, Blast_Score=300, Evalue=7e-82,
Organism=Saccharomyces cerevisiae, GI6324758, Length=394, Percent_Identity=37.0558375634518, Blast_Score=271, Evalue=2e-73,
Organism=Drosophila melanogaster, GI21356589, Length=369, Percent_Identity=44.7154471544715, Blast_Score=328, Evalue=3e-90,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_ACIAC (A1TSA3)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_971615.1
- ProteinModelPortal:   A1TSA3
- SMR:   A1TSA3
- STRING:   A1TSA3
- GeneID:   4667688
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_3281
- NMPDR:   fig|397945.5.peg.2805
- eggNOG:   COG1932
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- PhylomeDB:   A1TSA3
- ProtClustDB:   PRK05355
- BioCyc:   AAVE397945:AAVE_3281-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 40522; Mature: 40522

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 42-42 BINDING 101-101 BINDING 152-152 BINDING 176-176 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRPYNFSAGPAAIPAEVLQQAASEMLDWHGSGMGVMEMSHRGKEFISIYEQAEADLREL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHH
LAVPQDFRILFMQGGGLAENAIVPLNLSRAATVDMVVTGSWSQKSLKEARKYASEVHVAA
HCCCCCEEEEEEECCCCCCCCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHEEEEE
SAEDSGFTTLPDPASWQLSRGASYLHLCSNETIHGIEFHELPDLRALGSDAPLVIDFSSH
CCCCCCCCCCCCCCCCCHHCCCCEEEECCCCCCCCEEHHCCCCHHHCCCCCCEEEEECHH
VASRPVDWSRVGLAFGGAQKNLGPAGLTLVVVREDLLGHALPACPSAFDYKVVAENQSMF
HHCCCCCHHHHCEEECCCCCCCCCCCEEEEEEEHHHHHHHCCCCCCCCCEEEEECCCCCC
NTPPTWGIYIAGLTFQWLKRQREGDLSGIAAMEQRNIAKARLLYNFIDQSQFYVNKVSPN
CCCCCCEEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
ARSRMNIPFFLRDETRNEAFLAGARERGLLQLKGHKSVGGMRASLYNAMPLAGVEALVAY
CCCCCCCCEEEECCCCCCEEEECCCCCCEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHH
MQEFEQRSA
HHHHHHHCC
>Mature Secondary Structure
MNRPYNFSAGPAAIPAEVLQQAASEMLDWHGSGMGVMEMSHRGKEFISIYEQAEADLREL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHH
LAVPQDFRILFMQGGGLAENAIVPLNLSRAATVDMVVTGSWSQKSLKEARKYASEVHVAA
HCCCCCEEEEEEECCCCCCCCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHEEEEE
SAEDSGFTTLPDPASWQLSRGASYLHLCSNETIHGIEFHELPDLRALGSDAPLVIDFSSH
CCCCCCCCCCCCCCCCCHHCCCCEEEECCCCCCCCEEHHCCCCHHHCCCCCCEEEEECHH
VASRPVDWSRVGLAFGGAQKNLGPAGLTLVVVREDLLGHALPACPSAFDYKVVAENQSMF
HHCCCCCHHHHCEEECCCCCCCCCCCEEEEEEEHHHHHHHCCCCCCCCCEEEEECCCCCC
NTPPTWGIYIAGLTFQWLKRQREGDLSGIAAMEQRNIAKARLLYNFIDQSQFYVNKVSPN
CCCCCCEEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
ARSRMNIPFFLRDETRNEAFLAGARERGLLQLKGHKSVGGMRASLYNAMPLAGVEALVAY
CCCCCCCCEEEECCCCCCEEEECCCCCCEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHH
MQEFEQRSA
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA