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The map label for this gene is gyrA [H]

Identifier: 120611936

GI number: 120611936

Start: 3624352

End: 3627012

Strand: Direct

Name: gyrA [H]

Synonym: Aave_3280

Alternate gene names: 120611936

Gene position: 3624352-3627012 (Clockwise)

Preceding gene: 120611931

Following gene: 120611937

Centisome position: 67.71

GC content: 66.44

Gene sequence:

>2661_bases
ATGACCCAGTTCGCCAAAGAAACCCTGCCCATCAGCCTCGAAGAGGAGATGCGGCGCAGTTATCTCGATTACGCGATGAG
CGTGATCGTCGGCCGCGCGTTGCCGGATGCGCGGGACGGCCTCAAGCCGGTGCATCGCCGCGTGCTGTTCGCGATGCACG
AACTGAATAACGACTGGAACCGCCCTTACAAGAAGTCGGCCCGTATCGTCGGCGACGTCATCGGCAAGTACCACCCCCAC
GGAGACAGCGCCGTGTACGACACGATCGTGCGGATGGCGCAGGATTTCTCGCTGCGGCACATGCTGGTGGACGGCCAGGG
CAATTTCGGCTCCGTGGACGGCGACGGCGCGGCCGCCATGCGGTACACGGAAATCCGCCTGTCGAAGATCGCCCACGAGA
TGCTGGCCGACATCGACAAGGAAACCGTTGATTTCGGTCCCAACTACGACGGCAGCGAGAAGGAGCCGCTGGTGCTGCCC
AGCAAGCTGCCCAACCTGCTCGTGAACGGCTCGGCCGGCATCGCGGTGGGCATGGCGACGAACATTCCGCCGCACAACCT
GAACGAGGTGGTGGATGCCTGCCTGCACGTGCTGCGCCACCCGGACGCCACGGTGGACGAGATCATGGAGATCATCCCCG
CGCCGGACTTCCCGACCGCGGGCATCATCTACGGCATCAACGGCGTGAAGGAAGGCTACCGGACCGGCCGCGGCAAGGTG
GTCATGCGCGCGCGCTGCCACTTCGAGGACATCGACCGCGGCCAGCGCCAGGCCATCATCGTCGATGAGCTGCCCTACCA
GGTCAACAAGAAGACGCTCCAGGAGCGCATGGCCGAACTGGTGCACGAGAAGAAGATCGAGGGCATCAGCCACATCCAGG
ACGAGTCCGACAAATCGGGCATGCGCCTGGTGATCGAACTCAAGCGCGGCGAAGTGCCCGAGGTGGTGCTGAACAACCTC
TACAAGCAGACCCAGCTGCAGGATACCTTCGGCATCAACATGGTGGCGCTGGTGGACGGCCAGCCGCGCCTGTGCAACCT
GCGGGACCTGATCGTCGTGTTCCTGCAGCACCGCCGCGAGGTGGTGACGCGGCGCACGGTGTTCGAGCTGCGCAAGGCCC
GCGAGCGCGGCCACGTGCTGGAAGGCCTCGCCGTGGCGCTGGCCAACATCGACGAGTTCATCCGCATCATCCGCGAATCG
CCCACGCCGCCCATCGCCAAGACCGAGCTGATGAACCGCGCCTGGGACAGCCAGCTGGTGCGCGAGATGCTCACGCGCAC
CCGTGCGGACGGCGGCGTGGTCAATGCCGACGACTACCGCCCCGAGGGCCTGGAGCGCGAATACGGCATGGGGCAGGACG
GCCTGTACCGGCTCTCCGAAACGCAGGCCCAGGAAATCCTGCAGATGCGCCTGCAGCGCCTGACGGGCCTGGAGCAGGAC
AAGATCGTCGCGGAGTACAAGGACATCATGGCGGTCATCGAGGACCTGCTGGACATCCTGGCCAAGCCCGAGCGCGTCTC
GGTCATCATCGGCGACGAGCTCACCGCCATCAAGGCGGAGTTCGGCCAGCACAAGCTCGGCATGCGCCGCACCCTGGTCG
AGCACAGCGCGCAGGATCTCTCCACCGAGGACCTCATCACGCCCACCGACATGGTGGTGACCCTCTCGCACACGGGCTAC
ATCAAGAGCCAGCCGCTGTCCGAGTACCGCGCGCAGAAGCGCGGCGGGCGCGGCAAGCAGGCCACGGCGACCAAGGAAGA
CGACTGGATCGACCAGCTCTTCATCGCCAATACGCACGACTACATCCTCTGCTTCTCCAACCGCGGCCGGCTGTACTGGC
TCAAGGTCTGGGAAGTGCCGGCGGGCTCGCGCGGCTCCCGAGGCCGGCCGATCGTGAACATGTTCCCGCTGCAGGAAGGC
GAGAAGATCAACGTGGTGCTGCCGCTGACCGGCGACATGCGCACCTTCCCCGCCGACCGCTTCGTCTTCATGGCGACCAG
CATGGGCACGGTGAAGAAGACGGCGCTGGACGAGTTCAGCAACCCGCGCAAGGGCGGCATCATCGCCGTGAACCTGGACG
ACGGCGACTATCTGATCGGGGCTGCGCTCACCGACGGCCAGCACGACGTGATGCTCTTCTCGGACGGCGGCAAGGGCGTG
CGCTTCGACGAGAACGACGTGCGGCCGCTGGGCCGCGCCGCGCGCGGCGTGCGCGGCATGATGCTGGAGGACGGCCAGAG
CGTGATCGCCATGCTGGTGGCGGAGGACGAGACGCAGAGCGTGCTCACCGCCACCGAGAACGGCTACGGCAAGCGCACCA
GCATCGTCGAATACACGCGCCACGGCCGCGGGACCAAGGGGATGATCGCCATCCAGCAGAGCGAGCGCAACGGCAAGGTC
GTCGCCGCCACCCTGGTCCATGCGGAAGACGAGATCATGCTGATCACCGACAAGGGCGTGCTGGTGCGCACGCGCGTGGC
GGAGATCCGCGAGCTGGGCCGCGCCACGCAGGGCGTGACGCTGATCGCGCTGGACGAAGGCGCGAAACTGAGCGGGCTGC
AGCGCATCGTAGAGAACGACGCGAACCCGCCGGCCGCCGACACCACCGACGACGCTCCCCCTTCCGACGCGCAGGACGCG
GACGGGCCCTCGACCGAATGA

Upstream 100 bases:

>100_bases
GACAAAAGCGCTTTACCCCCCGATCTGTTGCGCACTTGCGACAAGGCGTTGCGCCTAGAATGTCCGACCTCCGCCGCCCT
GATCCCGCATCCCCGACCCC

Downstream 100 bases:

>100_bases
CGGTACGGTGCGCCGGCTCGACCGCGGGCGCACCGAGATGTTTACCCCCACGCCCCCCAGAAACGGCACGGCCTCCGACC
GCTTGAACCGATGAACCGCC

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 886; Mature: 885

Protein sequence:

>886_residues
MTQFAKETLPISLEEEMRRSYLDYAMSVIVGRALPDARDGLKPVHRRVLFAMHELNNDWNRPYKKSARIVGDVIGKYHPH
GDSAVYDTIVRMAQDFSLRHMLVDGQGNFGSVDGDGAAAMRYTEIRLSKIAHEMLADIDKETVDFGPNYDGSEKEPLVLP
SKLPNLLVNGSAGIAVGMATNIPPHNLNEVVDACLHVLRHPDATVDEIMEIIPAPDFPTAGIIYGINGVKEGYRTGRGKV
VMRARCHFEDIDRGQRQAIIVDELPYQVNKKTLQERMAELVHEKKIEGISHIQDESDKSGMRLVIELKRGEVPEVVLNNL
YKQTQLQDTFGINMVALVDGQPRLCNLRDLIVVFLQHRREVVTRRTVFELRKARERGHVLEGLAVALANIDEFIRIIRES
PTPPIAKTELMNRAWDSQLVREMLTRTRADGGVVNADDYRPEGLEREYGMGQDGLYRLSETQAQEILQMRLQRLTGLEQD
KIVAEYKDIMAVIEDLLDILAKPERVSVIIGDELTAIKAEFGQHKLGMRRTLVEHSAQDLSTEDLITPTDMVVTLSHTGY
IKSQPLSEYRAQKRGGRGKQATATKEDDWIDQLFIANTHDYILCFSNRGRLYWLKVWEVPAGSRGSRGRPIVNMFPLQEG
EKINVVLPLTGDMRTFPADRFVFMATSMGTVKKTALDEFSNPRKGGIIAVNLDDGDYLIGAALTDGQHDVMLFSDGGKGV
RFDENDVRPLGRAARGVRGMMLEDGQSVIAMLVAEDETQSVLTATENGYGKRTSIVEYTRHGRGTKGMIAIQQSERNGKV
VAATLVHAEDEIMLITDKGVLVRTRVAEIRELGRATQGVTLIALDEGAKLSGLQRIVENDANPPAADTTDDAPPSDAQDA
DGPSTE

Sequences:

>Translated_886_residues
MTQFAKETLPISLEEEMRRSYLDYAMSVIVGRALPDARDGLKPVHRRVLFAMHELNNDWNRPYKKSARIVGDVIGKYHPH
GDSAVYDTIVRMAQDFSLRHMLVDGQGNFGSVDGDGAAAMRYTEIRLSKIAHEMLADIDKETVDFGPNYDGSEKEPLVLP
SKLPNLLVNGSAGIAVGMATNIPPHNLNEVVDACLHVLRHPDATVDEIMEIIPAPDFPTAGIIYGINGVKEGYRTGRGKV
VMRARCHFEDIDRGQRQAIIVDELPYQVNKKTLQERMAELVHEKKIEGISHIQDESDKSGMRLVIELKRGEVPEVVLNNL
YKQTQLQDTFGINMVALVDGQPRLCNLRDLIVVFLQHRREVVTRRTVFELRKARERGHVLEGLAVALANIDEFIRIIRES
PTPPIAKTELMNRAWDSQLVREMLTRTRADGGVVNADDYRPEGLEREYGMGQDGLYRLSETQAQEILQMRLQRLTGLEQD
KIVAEYKDIMAVIEDLLDILAKPERVSVIIGDELTAIKAEFGQHKLGMRRTLVEHSAQDLSTEDLITPTDMVVTLSHTGY
IKSQPLSEYRAQKRGGRGKQATATKEDDWIDQLFIANTHDYILCFSNRGRLYWLKVWEVPAGSRGSRGRPIVNMFPLQEG
EKINVVLPLTGDMRTFPADRFVFMATSMGTVKKTALDEFSNPRKGGIIAVNLDDGDYLIGAALTDGQHDVMLFSDGGKGV
RFDENDVRPLGRAARGVRGMMLEDGQSVIAMLVAEDETQSVLTATENGYGKRTSIVEYTRHGRGTKGMIAIQQSERNGKV
VAATLVHAEDEIMLITDKGVLVRTRVAEIRELGRATQGVTLIALDEGAKLSGLQRIVENDANPPAADTTDDAPPSDAQDA
DGPSTE
>Mature_885_residues
TQFAKETLPISLEEEMRRSYLDYAMSVIVGRALPDARDGLKPVHRRVLFAMHELNNDWNRPYKKSARIVGDVIGKYHPHG
DSAVYDTIVRMAQDFSLRHMLVDGQGNFGSVDGDGAAAMRYTEIRLSKIAHEMLADIDKETVDFGPNYDGSEKEPLVLPS
KLPNLLVNGSAGIAVGMATNIPPHNLNEVVDACLHVLRHPDATVDEIMEIIPAPDFPTAGIIYGINGVKEGYRTGRGKVV
MRARCHFEDIDRGQRQAIIVDELPYQVNKKTLQERMAELVHEKKIEGISHIQDESDKSGMRLVIELKRGEVPEVVLNNLY
KQTQLQDTFGINMVALVDGQPRLCNLRDLIVVFLQHRREVVTRRTVFELRKARERGHVLEGLAVALANIDEFIRIIRESP
TPPIAKTELMNRAWDSQLVREMLTRTRADGGVVNADDYRPEGLEREYGMGQDGLYRLSETQAQEILQMRLQRLTGLEQDK
IVAEYKDIMAVIEDLLDILAKPERVSVIIGDELTAIKAEFGQHKLGMRRTLVEHSAQDLSTEDLITPTDMVVTLSHTGYI
KSQPLSEYRAQKRGGRGKQATATKEDDWIDQLFIANTHDYILCFSNRGRLYWLKVWEVPAGSRGSRGRPIVNMFPLQEGE
KINVVLPLTGDMRTFPADRFVFMATSMGTVKKTALDEFSNPRKGGIIAVNLDDGDYLIGAALTDGQHDVMLFSDGGKGVR
FDENDVRPLGRAARGVRGMMLEDGQSVIAMLVAEDETQSVLTATENGYGKRTSIVEYTRHGRGTKGMIAIQQSERNGKVV
AATLVHAEDEIMLITDKGVLVRTRVAEIRELGRATQGVTLIALDEGAKLSGLQRIVENDANPPAADTTDDAPPSDAQDAD
GPSTE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=513, Percent_Identity=23.5867446393762, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI19913406, Length=410, Percent_Identity=25.1219512195122, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788562, Length=858, Percent_Identity=59.6736596736597, Blast_Score=1021, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=777, Percent_Identity=33.4620334620335, Blast_Score=370, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17535065, Length=496, Percent_Identity=24.3951612903226, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=574, Percent_Identity=24.0418118466899, Blast_Score=76, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI212645845, Length=188, Percent_Identity=30.3191489361702, Blast_Score=69, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=171, Percent_Identity=30.9941520467836, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17136538, Length=352, Percent_Identity=25, Blast_Score=79, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 98628; Mature: 98497

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQFAKETLPISLEEEMRRSYLDYAMSVIVGRALPDARDGLKPVHRRVLFAMHELNNDWN
CCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCC
RPYKKSARIVGDVIGKYHPHGDSAVYDTIVRMAQDFSLRHMLVDGQGNFGSVDGDGAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCHHE
RYTEIRLSKIAHEMLADIDKETVDFGPNYDGSEKEPLVLPSKLPNLLVNGSAGIAVGMAT
EHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEECCCCCCCEEECCCCCEEEEEEC
NIPPHNLNEVVDACLHVLRHPDATVDEIMEIIPAPDFPTAGIIYGINGVKEGYRTGRGKV
CCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEECCCHHHHHHHCCCCCE
VMRARCHFEDIDRGQRQAIIVDELPYQVNKKTLQERMAELVHEKKIEGISHIQDESDKSG
EEEEECCHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
MRLVIELKRGEVPEVVLNNLYKQTQLQDTFGINMVALVDGQPRLCNLRDLIVVFLQHRRE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEECHHHHHHHHHHHHHH
VVTRRTVFELRKARERGHVLEGLAVALANIDEFIRIIRESPTPPIAKTELMNRAWDSQLV
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
REMLTRTRADGGVVNADDYRPEGLEREYGMGQDGLYRLSETQAQEILQMRLQRLTGLEQD
HHHHHHHCCCCCEECCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
KIVAEYKDIMAVIEDLLDILAKPERVSVIIGDELTAIKAEFGQHKLGMRRTLVEHSAQDL
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCHHHHHHHHHHHHHHHHCC
STEDLITPTDMVVTLSHTGYIKSQPLSEYRAQKRGGRGKQATATKEDDWIDQLFIANTHD
CCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHEEECCCC
YILCFSNRGRLYWLKVWEVPAGSRGSRGRPIVNMFPLQEGEKINVVLPLTGDMRTFPADR
EEEEECCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCC
FVFMATSMGTVKKTALDEFSNPRKGGIIAVNLDDGDYLIGAALTDGQHDVMLFSDGGKGV
EEEEEECCCHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEECCCCCCC
RFDENDVRPLGRAARGVRGMMLEDGQSVIAMLVAEDETQSVLTATENGYGKRTSIVEYTR
CCCCCCCCHHHHHHHCCCCCCHHCCCEEEEEEEECCCCHHHEEECCCCCCCCHHHHHHHH
HGRGTKGMIAIQQSERNGKVVAATLVHAEDEIMLITDKGVLVRTRVAEIRELGRATQGVT
CCCCCCCEEEEEECCCCCCEEEEEEEECCCCEEEEECCCEEEHHHHHHHHHHCCHHCCEE
LIALDEGAKLSGLQRIVENDANPPAADTTDDAPPSDAQDADGPSTE
EEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQFAKETLPISLEEEMRRSYLDYAMSVIVGRALPDARDGLKPVHRRVLFAMHELNNDWN
CCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCC
RPYKKSARIVGDVIGKYHPHGDSAVYDTIVRMAQDFSLRHMLVDGQGNFGSVDGDGAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCHHE
RYTEIRLSKIAHEMLADIDKETVDFGPNYDGSEKEPLVLPSKLPNLLVNGSAGIAVGMAT
EHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEECCCCCCCEEECCCCCEEEEEEC
NIPPHNLNEVVDACLHVLRHPDATVDEIMEIIPAPDFPTAGIIYGINGVKEGYRTGRGKV
CCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEECCCHHHHHHHCCCCCE
VMRARCHFEDIDRGQRQAIIVDELPYQVNKKTLQERMAELVHEKKIEGISHIQDESDKSG
EEEEECCHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
MRLVIELKRGEVPEVVLNNLYKQTQLQDTFGINMVALVDGQPRLCNLRDLIVVFLQHRRE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEECHHHHHHHHHHHHHH
VVTRRTVFELRKARERGHVLEGLAVALANIDEFIRIIRESPTPPIAKTELMNRAWDSQLV
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
REMLTRTRADGGVVNADDYRPEGLEREYGMGQDGLYRLSETQAQEILQMRLQRLTGLEQD
HHHHHHHCCCCCEECCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
KIVAEYKDIMAVIEDLLDILAKPERVSVIIGDELTAIKAEFGQHKLGMRRTLVEHSAQDL
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCHHHHHHHHHHHHHHHHCC
STEDLITPTDMVVTLSHTGYIKSQPLSEYRAQKRGGRGKQATATKEDDWIDQLFIANTHD
CCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHEEECCCC
YILCFSNRGRLYWLKVWEVPAGSRGSRGRPIVNMFPLQEGEKINVVLPLTGDMRTFPADR
EEEEECCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCC
FVFMATSMGTVKKTALDEFSNPRKGGIIAVNLDDGDYLIGAALTDGQHDVMLFSDGGKGV
EEEEEECCCHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEECCCCCCC
RFDENDVRPLGRAARGVRGMMLEDGQSVIAMLVAEDETQSVLTATENGYGKRTSIVEYTR
CCCCCCCCHHHHHHHCCCCCCHHCCCEEEEEEEECCCCHHHEEECCCCCCCCHHHHHHHH
HGRGTKGMIAIQQSERNGKVVAATLVHAEDEIMLITDKGVLVRTRVAEIRELGRATQGVT
CCCCCCCEEEEEECCCCCCEEEEEEEECCCCEEEEECCCEEEHHHHHHHHHHCCHHCCEE
LIALDEGAKLSGLQRIVENDANPPAADTTDDAPPSDAQDADGPSTE
EEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7811002; 10984043 [H]