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The map label for this gene is purD [H]

Identifier: 120611860

GI number: 120611860

Start: 3530304

End: 3531584

Strand: Reverse

Name: purD [H]

Synonym: Aave_3202

Alternate gene names: 120611860

Gene position: 3531584-3530304 (Counterclockwise)

Preceding gene: 120611861

Following gene: 120611859

Centisome position: 65.98

GC content: 69.48

Gene sequence:

>1281_bases
ATGAAAGTTCTTGTCATCGGAGGCGGCGGCCGTGAACACGCAATGGCCTGGAAACTCTCGCAGTCTCCCAAGGTCATCAA
GGTCTACGTGGCCCCCGGCAACGGCGGCACCGCCCTCAATTCCAAGCTCGAAAACATTCCCCTGACCGACGTGCGCGCGC
TGCGCGCCTGGGCGCAGGAGCAGAAGATCCAGCTTACCGTGGTCGGCCCCGAGGCGCCCCTGGCCGCCGGCGTGGTGGAC
GAGTTCCGCGCGCACGGCCTGCGCATCTTCGGCCCCACGAAGGCCGCCGCGCAGCTGGAAAGCTCCAAGGCCTTCTCCAA
GGCCTTCATGCGCCGCCACGGCATCCCCACGGCCGACTACGACACCTTCACCGACCCGGCGCTGGCCCATGCCTTCATCG
ACCGCCTGGGCGCGCCCATCGTGGTCAAGGCCGACGGCCTGGCCGCCGGCAAGGGCGTGGTCGTGGCCATGACCGCGCGG
GAGGCCCACGACGCGGTGGACTTCATGCTCGTGGACAACAAGTACGGCGTGAGCCACAACGAAGGCGGCGCGCGCGTGGT
GATCGAGCAGTTCCTCGAAGGCGAGGAAGCGAGCTTCATCGTGCTGTGCGACGGCAAGAACGTCGCCGCGCTGGCCACCA
GCCAGGACCACAAGCGCCTGAAGGACGGCGACCAGGGCCCCAACACGGGCGGCATGGGCGCGTACTCGCCCGCACCGGTG
GTCACGGCCGACGTGCATGCGCGCGCCATGCGCGAGATCATCCTGCCGACCATCCGCGGCATGGAAAAGGATGGCATCCC
CTACACCGGCTTCCTGTACGCCGGCCTGATGATCGACGCCAAGGGCCATCCCAAGACGCTGGAGTTCAACTGCCGCATGG
GCGACCCCGAGACCCAGCCCATCCTCATGCGCCTCAAGAGCGACCTGGTGGACGTGCTGGGCGCCGGCGTGGACGGCAAG
CTCGACCAGGTCGAGCTGCAGTGGGACCGCCGCCCCGCGCTGGGCGTCGTCATGGCCGCCCACGGCTACCCGGAAAGCCC
CCGCAAGGGCGACGCCATCACCGGCCTGCCGGCGGATGCCGACGACGCCATGGTGTTCCATGCCGGCACCGGGCTGCAGG
ACGGCGTGGTGCGCACCACCGGCGGCCGCGTGCTCTGCGTGACGGCGCTGGCCGACAGCGTGAAGCTGGCGCAGCAGCGC
GTCTATGACGTGGCGCGCGGCATCCACTTCGACGGCGCGCAGTACCGCCGCGACATCGGCCACCGGGCGGTGAAGAGCTG
A

Upstream 100 bases:

>100_bases
AGCGCATGCAGAAGCTCCTGGACGTGATCGAGGACCTCGACGACGTGCAGGAGGTTTATCACAACGCCGCGCTCTGACCG
ACGAGGCACCCGGACACCCC

Downstream 100 bases:

>100_bases
TGGCCACGGCTTCCGGACCGGGGCGCGCCCCGGGCGTTTCCGCGCCGCCGCCGGATGCGGCCGAGCGCGTGCGCGCCTAC
CTGGTGGACCTGCAGTCGCG

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MKVLVIGGGGREHAMAWKLSQSPKVIKVYVAPGNGGTALNSKLENIPLTDVRALRAWAQEQKIQLTVVGPEAPLAAGVVD
EFRAHGLRIFGPTKAAAQLESSKAFSKAFMRRHGIPTADYDTFTDPALAHAFIDRLGAPIVVKADGLAAGKGVVVAMTAR
EAHDAVDFMLVDNKYGVSHNEGGARVVIEQFLEGEEASFIVLCDGKNVAALATSQDHKRLKDGDQGPNTGGMGAYSPAPV
VTADVHARAMREIILPTIRGMEKDGIPYTGFLYAGLMIDAKGHPKTLEFNCRMGDPETQPILMRLKSDLVDVLGAGVDGK
LDQVELQWDRRPALGVVMAAHGYPESPRKGDAITGLPADADDAMVFHAGTGLQDGVVRTTGGRVLCVTALADSVKLAQQR
VYDVARGIHFDGAQYRRDIGHRAVKS

Sequences:

>Translated_426_residues
MKVLVIGGGGREHAMAWKLSQSPKVIKVYVAPGNGGTALNSKLENIPLTDVRALRAWAQEQKIQLTVVGPEAPLAAGVVD
EFRAHGLRIFGPTKAAAQLESSKAFSKAFMRRHGIPTADYDTFTDPALAHAFIDRLGAPIVVKADGLAAGKGVVVAMTAR
EAHDAVDFMLVDNKYGVSHNEGGARVVIEQFLEGEEASFIVLCDGKNVAALATSQDHKRLKDGDQGPNTGGMGAYSPAPV
VTADVHARAMREIILPTIRGMEKDGIPYTGFLYAGLMIDAKGHPKTLEFNCRMGDPETQPILMRLKSDLVDVLGAGVDGK
LDQVELQWDRRPALGVVMAAHGYPESPRKGDAITGLPADADDAMVFHAGTGLQDGVVRTTGGRVLCVTALADSVKLAQQR
VYDVARGIHFDGAQYRRDIGHRAVKS
>Mature_426_residues
MKVLVIGGGGREHAMAWKLSQSPKVIKVYVAPGNGGTALNSKLENIPLTDVRALRAWAQEQKIQLTVVGPEAPLAAGVVD
EFRAHGLRIFGPTKAAAQLESSKAFSKAFMRRHGIPTADYDTFTDPALAHAFIDRLGAPIVVKADGLAAGKGVVVAMTAR
EAHDAVDFMLVDNKYGVSHNEGGARVVIEQFLEGEEASFIVLCDGKNVAALATSQDHKRLKDGDQGPNTGGMGAYSPAPV
VTADVHARAMREIILPTIRGMEKDGIPYTGFLYAGLMIDAKGHPKTLEFNCRMGDPETQPILMRLKSDLVDVLGAGVDGK
LDQVELQWDRRPALGVVMAAHGYPESPRKGDAITGLPADADDAMVFHAGTGLQDGVVRTTGGRVLCVTALADSVKLAQQR
VYDVARGIHFDGAQYRRDIGHRAVKS

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=428, Percent_Identity=51.1682242990654, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI209869995, Length=428, Percent_Identity=51.1682242990654, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI209869993, Length=428, Percent_Identity=51.1682242990654, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI28416899, Length=428, Percent_Identity=51.1682242990654, Blast_Score=402, Evalue=1e-112,
Organism=Escherichia coli, GI1790438, Length=429, Percent_Identity=61.0722610722611, Blast_Score=506, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17567511, Length=426, Percent_Identity=43.1924882629108, Blast_Score=323, Evalue=1e-88,
Organism=Saccharomyces cerevisiae, GI6321203, Length=447, Percent_Identity=44.7427293064877, Blast_Score=352, Evalue=5e-98,
Organism=Drosophila melanogaster, GI62471619, Length=435, Percent_Identity=49.4252873563218, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24582400, Length=435, Percent_Identity=49.4252873563218, Blast_Score=364, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 45442; Mature: 45442

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVIGGGGREHAMAWKLSQSPKVIKVYVAPGNGGTALNSKLENIPLTDVRALRAWAQE
CEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCHHHCHHCCCCCHHHHHHHHHHHC
QKIQLTVVGPEAPLAAGVVDEFRAHGLRIFGPTKAAAQLESSKAFSKAFMRRHGIPTADY
CEEEEEEECCCCCCHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
DTFTDPALAHAFIDRLGAPIVVKADGLAAGKGVVVAMTAREAHDAVDFMLVDNKYGVSHN
CCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCC
EGGARVVIEQFLEGEEASFIVLCDGKNVAALATSQDHKRLKDGDQGPNTGGMGAYSPAPV
CCCHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCCCCCE
VTADVHARAMREIILPTIRGMEKDGIPYTGFLYAGLMIDAKGHPKTLEFNCRMGDPETQP
EEEHHHHHHHHHHHHHHHCCCCCCCCCEEHHEEEEEEEECCCCCCEEEEEEECCCCCCCH
ILMRLKSDLVDVLGAGVDGKLDQVELQWDRRPALGVVMAAHGYPESPRKGDAITGLPADA
HHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCCEECCCCCC
DDAMVFHAGTGLQDGVVRTTGGRVLCVTALADSVKLAQQRVYDVARGIHFDGAQYRRDIG
CCCEEEEECCCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
HRAVKS
HHHHCC
>Mature Secondary Structure
MKVLVIGGGGREHAMAWKLSQSPKVIKVYVAPGNGGTALNSKLENIPLTDVRALRAWAQE
CEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCHHHCHHCCCCCHHHHHHHHHHHC
QKIQLTVVGPEAPLAAGVVDEFRAHGLRIFGPTKAAAQLESSKAFSKAFMRRHGIPTADY
CEEEEEEECCCCCCHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
DTFTDPALAHAFIDRLGAPIVVKADGLAAGKGVVVAMTAREAHDAVDFMLVDNKYGVSHN
CCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCC
EGGARVVIEQFLEGEEASFIVLCDGKNVAALATSQDHKRLKDGDQGPNTGGMGAYSPAPV
CCCHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCCCCCE
VTADVHARAMREIILPTIRGMEKDGIPYTGFLYAGLMIDAKGHPKTLEFNCRMGDPETQP
EEEHHHHHHHHHHHHHHHCCCCCCCCCEEHHEEEEEEEECCCCCCEEEEEEECCCCCCCH
ILMRLKSDLVDVLGAGVDGKLDQVELQWDRRPALGVVMAAHGYPESPRKGDAITGLPADA
HHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCCEECCCCCC
DDAMVFHAGTGLQDGVVRTTGGRVLCVTALADSVKLAQQRVYDVARGIHFDGAQYRRDIG
CCCEEEEECCCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
HRAVKS
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]