Click here to switch to the map view.

The map label for this gene is hemF [H]

Identifier: 120611859

GI number: 120611859

Start: 3529333

End: 3530304

Strand: Reverse

Name: hemF [H]

Synonym: Aave_3201

Alternate gene names: 120611859

Gene position: 3530304-3529333 (Counterclockwise)

Preceding gene: 120611860

Following gene: 120611858

Centisome position: 65.95

GC content: 71.5

Gene sequence:

>972_bases
ATGGCCACGGCTTCCGGACCGGGGCGCGCCCCGGGCGTTTCCGCGCCGCCGCCGGATGCGGCCGAGCGCGTGCGCGCCTA
CCTGGTGGACCTGCAGTCGCGCATCACCAACGCGGTCGAGAGCGTCGAGGGGCAGGGCGGTGCGCGCTTTCTCTCCGACG
CGTGGAGCAAGGCCCCGGGCGAGCCGCTGCAGGGCGACGGCGTCACCCGCATCCTCGAGGGCGGGCGCGTGTTCGAGCGC
GCGGGCTGCGGCTTCTCGCACGTGCGCGGCGCCGCGCTGCCGCCTTCGGCCACGCAGCACCGGCCCGAGCTGGCCGGCGC
GCCGTTCGAGGCCATGGGCGTGTCGCTGGTGTTCCACCCGGTCAACCCCTACGTGCCCACGGTGCACATGAACGTACGCA
TGATCGCCGCCGCGCGCGACGGGCAGCCGCCCGTGTGCTGGTTCGGCGGCGGCATGGACCTCACGCCCTACTACGGCTTC
GAGGAAGACGCGGTGCATTTCCACCGCAGCTGCCGCGACGCGGTCTATCCGTTCGGCGAAGGGCTCTACCTGCGCTTCAA
GCGCTGGTGCGACGAATACTTCTACCTCAAGCACCGCGACGAGCAGCGCGGCATCGGCGGCATCTTCTTCGACGACTTCT
CCGAGCTGGGTTTCGACCGCAGCCTGGCGATGATGCAGTCGGTGGGCGATGCGTTCCTGGGCGCCTACCTGCCGATCGTG
CAGCGGCGCCAGGGCATCTACTTCGGCGACCGCGAGCGCTCCTTCCAGTGCTACCGGCGCGGCCGCTACGTCGAGTTCAA
CCTCGTCTGGGACCGCGGCACGCATTTCGGGCTGCAGTCCGGCGGGCGCACCGAGTCGATCCTGCTGTCCATGCCGCCCC
TGGCGGGCTGGGCCTACCAGCGGCAGGACGCCCCGGGCACGCCCGAAGCCGAGCTGACGCGTCGCTTTCTCGTGCGGCGC
GACTGGCTGTGA

Upstream 100 bases:

>100_bases
TGAAGCTGGCGCAGCAGCGCGTCTATGACGTGGCGCGCGGCATCCACTTCGACGGCGCGCAGTACCGCCGCGACATCGGC
CACCGGGCGGTGAAGAGCTG

Downstream 100 bases:

>100_bases
GCCGCCGCCGCATGCCCCCGTGGAGGGCGCAAAGCTATAATTTCAATAGCTGCCTGCGTCCGCCTCGCCAAGGTACCCGG
CAGGAAACACCCTCCAACCC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MATASGPGRAPGVSAPPPDAAERVRAYLVDLQSRITNAVESVEGQGGARFLSDAWSKAPGEPLQGDGVTRILEGGRVFER
AGCGFSHVRGAALPPSATQHRPELAGAPFEAMGVSLVFHPVNPYVPTVHMNVRMIAAARDGQPPVCWFGGGMDLTPYYGF
EEDAVHFHRSCRDAVYPFGEGLYLRFKRWCDEYFYLKHRDEQRGIGGIFFDDFSELGFDRSLAMMQSVGDAFLGAYLPIV
QRRQGIYFGDRERSFQCYRRGRYVEFNLVWDRGTHFGLQSGGRTESILLSMPPLAGWAYQRQDAPGTPEAELTRRFLVRR
DWL

Sequences:

>Translated_323_residues
MATASGPGRAPGVSAPPPDAAERVRAYLVDLQSRITNAVESVEGQGGARFLSDAWSKAPGEPLQGDGVTRILEGGRVFER
AGCGFSHVRGAALPPSATQHRPELAGAPFEAMGVSLVFHPVNPYVPTVHMNVRMIAAARDGQPPVCWFGGGMDLTPYYGF
EEDAVHFHRSCRDAVYPFGEGLYLRFKRWCDEYFYLKHRDEQRGIGGIFFDDFSELGFDRSLAMMQSVGDAFLGAYLPIV
QRRQGIYFGDRERSFQCYRRGRYVEFNLVWDRGTHFGLQSGGRTESILLSMPPLAGWAYQRQDAPGTPEAELTRRFLVRR
DWL
>Mature_322_residues
ATASGPGRAPGVSAPPPDAAERVRAYLVDLQSRITNAVESVEGQGGARFLSDAWSKAPGEPLQGDGVTRILEGGRVFERA
GCGFSHVRGAALPPSATQHRPELAGAPFEAMGVSLVFHPVNPYVPTVHMNVRMIAAARDGQPPVCWFGGGMDLTPYYGFE
EDAVHFHRSCRDAVYPFGEGLYLRFKRWCDEYFYLKHRDEQRGIGGIFFDDFSELGFDRSLAMMQSVGDAFLGAYLPIVQ
RRQGIYFGDRERSFQCYRRGRYVEFNLVWDRGTHFGLQSGGRTESILLSMPPLAGWAYQRQDAPGTPEAELTRRFLVRRD
WL

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=315, Percent_Identity=40.9523809523809, Blast_Score=238, Evalue=7e-63,
Organism=Escherichia coli, GI1788777, Length=306, Percent_Identity=60.4575163398693, Blast_Score=375, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6320249, Length=320, Percent_Identity=41.875, Blast_Score=248, Evalue=7e-67,
Organism=Drosophila melanogaster, GI17864388, Length=309, Percent_Identity=41.747572815534, Blast_Score=242, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 36023; Mature: 35892

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATASGPGRAPGVSAPPPDAAERVRAYLVDLQSRITNAVESVEGQGGARFLSDAWSKAPG
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
EPLQGDGVTRILEGGRVFERAGCGFSHVRGAALPPSATQHRPELAGAPFEAMGVSLVFHP
CCCCCCCHHHHHHCCCHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHCCEEEEEEC
VNPYVPTVHMNVRMIAAARDGQPPVCWFGGGMDLTPYYGFEEDAVHFHRSCRDAVYPFGE
CCCCCCEEEEEEEEEEEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
GLYLRFKRWCDEYFYLKHRDEQRGIGGIFFDDFSELGFDRSLAMMQSVGDAFLGAYLPIV
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
QRRQGIYFGDRERSFQCYRRGRYVEFNLVWDRGTHFGLQSGGRTESILLSMPPLAGWAYQ
HHCCCCEECCCCCHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCC
RQDAPGTPEAELTRRFLVRRDWL
CCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATASGPGRAPGVSAPPPDAAERVRAYLVDLQSRITNAVESVEGQGGARFLSDAWSKAPG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
EPLQGDGVTRILEGGRVFERAGCGFSHVRGAALPPSATQHRPELAGAPFEAMGVSLVFHP
CCCCCCCHHHHHHCCCHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHCCEEEEEEC
VNPYVPTVHMNVRMIAAARDGQPPVCWFGGGMDLTPYYGFEEDAVHFHRSCRDAVYPFGE
CCCCCCEEEEEEEEEEEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
GLYLRFKRWCDEYFYLKHRDEQRGIGGIFFDDFSELGFDRSLAMMQSVGDAFLGAYLPIV
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
QRRQGIYFGDRERSFQCYRRGRYVEFNLVWDRGTHFGLQSGGRTESILLSMPPLAGWAYQ
HHCCCCEECCCCCHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCC
RQDAPGTPEAELTRRFLVRRDWL
CCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA