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The map label for this gene is rnhA

Identifier: 120611321

GI number: 120611321

Start: 2914934

End: 2915383

Strand: Direct

Name: rnhA

Synonym: Aave_2653

Alternate gene names: 120611321

Gene position: 2914934-2915383 (Clockwise)

Preceding gene: 120611320

Following gene: 120611330

Centisome position: 54.46

GC content: 66.22

Gene sequence:

>450_bases
TTGAATCAGGTTGTGATCTATACCGACGGGGCCTGCAAGGGCAATCCGGGTCCCGGCGGCTGGGGGGTGGTACTGCGTTC
GGGCGCGCTGGAAAAGGAATTGTTCGGGGGGGAGCTGGGCACCACCAACAACCGCATGGAACTGCTGGCCGTGATCGAGG
CCCTGGGCGCGCTCAAGCGCCCGTGCGCGGTCACGCTCTATCTCGACAGCCAGTACGTGCGCAAGGGCATCACGGAGTGG
ATCCAGGGATGGAAGAAAAAGGGCTGGCGCACGGCATCCGGCCAGCCGGTGAAGAACGTGGAGCTGTGGAAGCGGCTCGA
TGACCTCGTGGCCGGGGGCGGCCACGTGATCGACTGGCGCTGGGTGAAGGGCCATGCGGGCGATCCCGGCAATGAACGCG
CGGATGCGCTCGCCAACAAGGGCGTTGACAAGGCCCTGGGCCGGGCCTAG

Upstream 100 bases:

>100_bases
GCGCAGCGCGCCGGGCCGGAGCCCGGCGGCGCGCCACGGCGGCGGGGCGGCCGATGAAGAAGCGGAAGCTATGAATGACG
ACAAAGGAAGCGAGCGAGTT

Downstream 100 bases:

>100_bases
GTGTTGAGTCTCACGAGGTTGTTCACACCCGGAATGCGTGTGATGGGAGGCTGATGGCCGAGCGCGGAGTGTGGCCGGCA
CCAGTTGTAGCCGTCAATGA

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MNQVVIYTDGACKGNPGPGGWGVVLRSGALEKELFGGELGTTNNRMELLAVIEALGALKRPCAVTLYLDSQYVRKGITEW
IQGWKKKGWRTASGQPVKNVELWKRLDDLVAGGGHVIDWRWVKGHAGDPGNERADALANKGVDKALGRA

Sequences:

>Translated_149_residues
MNQVVIYTDGACKGNPGPGGWGVVLRSGALEKELFGGELGTTNNRMELLAVIEALGALKRPCAVTLYLDSQYVRKGITEW
IQGWKKKGWRTASGQPVKNVELWKRLDDLVAGGGHVIDWRWVKGHAGDPGNERADALANKGVDKALGRA
>Mature_149_residues
MNQVVIYTDGACKGNPGPGGWGVVLRSGALEKELFGGELGTTNNRMELLAVIEALGALKRPCAVTLYLDSQYVRKGITEW
IQGWKKKGWRTASGQPVKNVELWKRLDDLVAGGGHVIDWRWVKGHAGDPGNERADALANKGVDKALGRA

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain

Homologues:

Organism=Homo sapiens, GI21359816, Length=153, Percent_Identity=39.2156862745098, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI1786408, Length=138, Percent_Identity=61.5942028985507, Blast_Score=173, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI115532542, Length=154, Percent_Identity=38.961038961039, Blast_Score=90, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45552509, Length=146, Percent_Identity=37.6712328767123, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17137476, Length=146, Percent_Identity=37.6712328767123, Blast_Score=90, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNH_ACIAC (A1TQI7)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_970999.1
- ProteinModelPortal:   A1TQI7
- SMR:   A1TQI7
- STRING:   A1TQI7
- GeneID:   4665830
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_2653
- NMPDR:   fig|397945.5.peg.2279
- eggNOG:   COG0328
- HOGENOM:   HBG742437
- OMA:   NGWRTAD
- PhylomeDB:   A1TQI7
- ProtClustDB:   PRK00203
- BioCyc:   AAVE397945:AAVE_2653-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00042
- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156

Pfam domain/function: PF00075 RnaseH; SSF53098 RNaseH_fold

EC number: =3.1.26.4

Molecular weight: Translated: 16123; Mature: 16123

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQVVIYTDGACKGNPGPGGWGVVLRSGALEKELFGGELGTTNNRMELLAVIEALGALKR
CCEEEEEECCCCCCCCCCCCCEEEEECCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCC
PCAVTLYLDSQYVRKGITEWIQGWKKKGWRTASGQPVKNVELWKRLDDLVAGGGHVIDWR
CEEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEE
WVKGHAGDPGNERADALANKGVDKALGRA
EEECCCCCCCCHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure
MNQVVIYTDGACKGNPGPGGWGVVLRSGALEKELFGGELGTTNNRMELLAVIEALGALKR
CCEEEEEECCCCCCCCCCCCCEEEEECCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCC
PCAVTLYLDSQYVRKGITEWIQGWKKKGWRTASGQPVKNVELWKRLDDLVAGGGHVIDWR
CEEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEE
WVKGHAGDPGNERADALANKGVDKALGRA
EEECCCCCCCCHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA