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The map label for this gene is sbcD [H]

Identifier: 120611304

GI number: 120611304

Start: 2890332

End: 2891552

Strand: Direct

Name: sbcD [H]

Synonym: Aave_2636

Alternate gene names: 120611304

Gene position: 2890332-2891552 (Clockwise)

Preceding gene: 120611300

Following gene: 120611305

Centisome position: 54.0

GC content: 73.05

Gene sequence:

>1221_bases
TTGCGTCTGCTGCACACTTCCGACTGGCATCTGGGCCAGCATTTCATGGGCAAGAGCCGCCAGGCCGAGCACCGTGCGTT
CATCGACTGGCTGGCCGCGCAGGCGGCCGGCTGCCAGGCGGACGCCGTCCTGGTCGCCGGGGACGTGTTCGACACCTCCG
CCCCGCCCAGCCATGCGCGCGAACTCTACCACCGCGCCGTACTGGCCTTGCGAGAGGCGGGATCCGAGCTGGTGGTGCTG
GGCGGCAACCACGATTCGGTCGCAGTGCTCGGCGAAAGCCGGGCGCTGCTCGCGCAGCTCGGCACCCGGGTGGTTCCATG
CGCGGCCGACCACCTGGAAGAGCAGGTCCTGGTGCTGCGCAAGCGCACGGGCGGGCCGGGCGCGGTGCTCTGCGCCGTAC
CCTACCTGAGGGCCCGGGAGCTGCTATTGAGCCTGCCCGGCGAGAGCGCGCAGGACAAGCGGCAGGCCCTGCAGCAGGCC
ATCCGCGCCCACTACCACGCCCTGTTCGGCCTGGCGCGCGAGCGCAGCGAGTCGCTGGGCGGCCTGCCGATCGTGGCCAC
CGGGCATCTGGCGACCGTGGGCGCCTCGGGCGGCGAGGCCGTGCGGGAGATCTACGTGGGCACGCTGGAGGCCTTCCCGA
CCGACGCCTTTCCGCCGGCCGACTACATCGCCCTGGGGCACATCCACCAGCCGATGAAGGTGGGAGGCCAGGAGCACATC
CGCTATTGCGGCTCGCCCATCGCGCTGGGCTTCGACGAGGCCGGGCAGCGCAAGGAGGTGCTGCAGGTCGATTTCGACCT
GGCGGGCCTGCAGGCGGTCACCGCGCTGCCGGTGCCGTGCTTCCAGCCCATGGCGTCCCTGCGGGGGACCCTGCAGGAGC
TGGCCACGGCGCTGGGGCAGGCCGCCGCGGCGGGCACGGCCGAGATGCCCGTCTGGCTCGACGTGGAGGTGGCCGGGGAC
GATTACCTCGCCAGCCTGCAGGCGCGTATCGCCGCGATGGCCGAAGGCCTGCCCGTGGAAGTGCTGCGCGTGCGCCGGGC
ACGGGCGGGCGCGGCCCCGGCACTGGCTCCGGTGGCCCGCGAAACCCTCGATGAGCTCGATCCCGCCGAGGTGTTCCAGC
GCCGCCTGGGTACGGAATCGATCGACGAAGCGCTCCGGGAGCGGCTGGCGGCGCTGCACGGCCGGGTGCTGTCCGGGCTG
CGCGAGGAGGGCGCCGCATGA

Upstream 100 bases:

>100_bases
GCGACGCACTTTCCGCTTCGAAAAAGCCTACCATTATCGCATAACCGCGCAAAGAAGCGCCAGCCCCGGATGCGGGGCCT
TCCACGGGAACCCTTCCATC

Downstream 100 bases:

>100_bases
AGATCCTGGCACTGCGCCTCAAGAACCTCAACTCCCTCAAGGGCGAATGGCGCATCGATTTCACGGCGCCGCCTTTTTCC
GAAGGCGGGCTGTTCGCGAT

Product: exonuclease subunit SbcD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MRLLHTSDWHLGQHFMGKSRQAEHRAFIDWLAAQAAGCQADAVLVAGDVFDTSAPPSHARELYHRAVLALREAGSELVVL
GGNHDSVAVLGESRALLAQLGTRVVPCAADHLEEQVLVLRKRTGGPGAVLCAVPYLRARELLLSLPGESAQDKRQALQQA
IRAHYHALFGLARERSESLGGLPIVATGHLATVGASGGEAVREIYVGTLEAFPTDAFPPADYIALGHIHQPMKVGGQEHI
RYCGSPIALGFDEAGQRKEVLQVDFDLAGLQAVTALPVPCFQPMASLRGTLQELATALGQAAAAGTAEMPVWLDVEVAGD
DYLASLQARIAAMAEGLPVEVLRVRRARAGAAPALAPVARETLDELDPAEVFQRRLGTESIDEALRERLAALHGRVLSGL
REEGAA

Sequences:

>Translated_406_residues
MRLLHTSDWHLGQHFMGKSRQAEHRAFIDWLAAQAAGCQADAVLVAGDVFDTSAPPSHARELYHRAVLALREAGSELVVL
GGNHDSVAVLGESRALLAQLGTRVVPCAADHLEEQVLVLRKRTGGPGAVLCAVPYLRARELLLSLPGESAQDKRQALQQA
IRAHYHALFGLARERSESLGGLPIVATGHLATVGASGGEAVREIYVGTLEAFPTDAFPPADYIALGHIHQPMKVGGQEHI
RYCGSPIALGFDEAGQRKEVLQVDFDLAGLQAVTALPVPCFQPMASLRGTLQELATALGQAAAAGTAEMPVWLDVEVAGD
DYLASLQARIAAMAEGLPVEVLRVRRARAGAAPALAPVARETLDELDPAEVFQRRLGTESIDEALRERLAALHGRVLSGL
REEGAA
>Mature_406_residues
MRLLHTSDWHLGQHFMGKSRQAEHRAFIDWLAAQAAGCQADAVLVAGDVFDTSAPPSHARELYHRAVLALREAGSELVVL
GGNHDSVAVLGESRALLAQLGTRVVPCAADHLEEQVLVLRKRTGGPGAVLCAVPYLRARELLLSLPGESAQDKRQALQQA
IRAHYHALFGLARERSESLGGLPIVATGHLATVGASGGEAVREIYVGTLEAFPTDAFPPADYIALGHIHQPMKVGGQEHI
RYCGSPIALGFDEAGQRKEVLQVDFDLAGLQAVTALPVPCFQPMASLRGTLQELATALGQAAAAGTAEMPVWLDVEVAGD
DYLASLQARIAAMAEGLPVEVLRVRRARAGAAPALAPVARETLDELDPAEVFQRRLGTESIDEALRERLAALHGRVLSGL
REEGAA

Specific function: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sbcD family [H]

Homologues:

Organism=Escherichia coli, GI1786598, Length=407, Percent_Identity=51.8427518427518, Blast_Score=397, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR004593 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: 3.1.-.-

Molecular weight: Translated: 43181; Mature: 43181

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLHTSDWHLGQHFMGKSRQAEHRAFIDWLAAQAAGCQADAVLVAGDVFDTSAPPSHAR
CCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHH
ELYHRAVLALREAGSELVVLGGNHDSVAVLGESRALLAQLGTRVVPCAADHLEEQVLVLR
HHHHHHHHHHHHCCCCEEEEECCCCCEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
KRTGGPGAVLCAVPYLRARELLLSLPGESAQDKRQALQQAIRAHYHALFGLARERSESLG
HCCCCCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GLPIVATGHLATVGASGGEAVREIYVGTLEAFPTDAFPPADYIALGHIHQPMKVGGQEHI
CCCEEEECCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCHHHCCCHHHH
RYCGSPIALGFDEAGQRKEVLQVDFDLAGLQAVTALPVPCFQPMASLRGTLQELATALGQ
HHCCCCCEECCCCCCCCHHHHEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
AAAAGTAEMPVWLDVEVAGDDYLASLQARIAAMAEGLPVEVLRVRRARAGAAPALAPVAR
HHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHH
ETLDELDPAEVFQRRLGTESIDEALRERLAALHGRVLSGLREEGAA
HHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRLLHTSDWHLGQHFMGKSRQAEHRAFIDWLAAQAAGCQADAVLVAGDVFDTSAPPSHAR
CCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHH
ELYHRAVLALREAGSELVVLGGNHDSVAVLGESRALLAQLGTRVVPCAADHLEEQVLVLR
HHHHHHHHHHHHCCCCEEEEECCCCCEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
KRTGGPGAVLCAVPYLRARELLLSLPGESAQDKRQALQQAIRAHYHALFGLARERSESLG
HCCCCCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GLPIVATGHLATVGASGGEAVREIYVGTLEAFPTDAFPPADYIALGHIHQPMKVGGQEHI
CCCEEEECCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCHHHCCCHHHH
RYCGSPIALGFDEAGQRKEVLQVDFDLAGLQAVTALPVPCFQPMASLRGTLQELATALGQ
HHCCCCCEECCCCCCCCHHHHEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
AAAAGTAEMPVWLDVEVAGDDYLASLQARIAAMAEGLPVEVLRVRRARAGAAPALAPVAR
HHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHH
ETLDELDPAEVFQRRLGTESIDEALRERLAALHGRVLSGLREEGAA
HHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]