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The map label for this gene is phoR [H]

Identifier: 120611300

GI number: 120611300

Start: 2885256

End: 2886620

Strand: Direct

Name: phoR [H]

Synonym: Aave_2632

Alternate gene names: 120611300

Gene position: 2885256-2886620 (Clockwise)

Preceding gene: 120611299

Following gene: 120611304

Centisome position: 53.9

GC content: 69.89

Gene sequence:

>1365_bases
ATGGTTTCGCGTTGCATCTTCTTCCTGTCCTTCCAGGTCGTCGGCCTCCTGCTCGGCTGGCTCTGGGGGGGCTTCCACGG
CGCGGTGGCGACCGTTTTCGCGGGCGTCTGGCTCTGGTTCCTCTGGGACCTCTGGCGCGGTTCCCGCGTACTGCGCTGGC
TGCGCGACGGCGACCTCGCCAGCTCTCCCTCGCTCAGGGGGCTCTGGGGCGAGGCCGCCGACAGGTTCCGCCGCCTGCTG
CGCCAGAACCAGGCCGACATCGCCGCGAGCGATGCGCGGCTGCAGGAGATCCTCGCGGCCCTGCAGGCGACGCCCAATGG
CGTGGTGCTGCTCGACGCCGAGGGACACATCGAGTGGTGCAACCAGATCGCGGTGACGCAGTTCGGTCTGGATGCCGCGC
GCGACATGGGCCAGTCGATCGGCAACCTGCTGCGCGACCCCGAGTTCAGCGCCTACTACGCCGCCCAGGATTTCTCCAGG
GATGTCGTCCTGCAAGGACGCGAGAGCACGCCCTCCCGGCCGGTGCGCATTTCCGTGCACCTGCATCCTTACGGCGACGG
CCGCAAGCTGCTGCTCTCGCGGGACGTGACGGCGCTGGAGCAGGCCGAGGCCATGCGCCGCGATTTCGTGGCCAACGTAT
CGCACGAGATCCGCACTCCGCTCACGGTCCTCATGGGGTTCGTGGAAACCCTGCAGACGCTGCCTCTGTCGTCCGAGGAG
CGCGCGCGCTACCTGAACATGATGTCGCAGCAGGCCGGCCGGATGCAAAGCGTGGTGCAGGACCTGCTGACCCTGTCGCG
CCTGGAGGGCAGCCCCCCGCCCGGGCTGACCGAATGCACGCCGGTGGATGCGCTGCTGCGCCGCTGCGAGGACGAGGCGC
GCGGCCTGTCCGCGCTGCTCACCCGCAGCCAGTCGGCGGGCCATGTGCTGGAGTTTCCGCCGGCCGAGGCGCTGCAGGGC
GCCGGCCAACTGATCGGGGTGACGGCCGAGCTGCAGAGTGCGCTCGCCAACCTGATCGGCAATGCAGTGCGCTATACGCC
CGCCGGCGGCCGGATCACGGTGGCGTGGGAGACGCTGGCCGACGGCAGTGCCCGGTTCTCGGTGAGGGATACGGGCCCCG
GCATCGAGTCCGTGCACATTCCGCGGCTGACCGAACGCTTCTACCGCGTGGACCGCAGCCGCTCCCGCGACACCGGCGGC
ACCGGGCTGGGCCTGGCCATCGTCAAGCACGTGGTGCAGCGCCATTCGGCGTCGCTGGGCATCGAGAGCACCGTGGGCAA
GGGTTCCGTGTTTTCCGTCACGTTCCCGCCGCACCGCATCCAACGCAGTGCCCCGGTACGCGGCGCACCGGCAAAGGCCT
GTTGA

Upstream 100 bases:

>100_bases
GTCGAGCGGGCCGCCCGCGGGCGGCCTTCCTTTTCGTTATCTGACAACAAGGCAGCGGAGCGCGGACGGGGAGGGGCCCC
GCGGAGCCCTCCCGGATTCC

Downstream 100 bases:

>100_bases
CAGGCCCTAAGCCCATCCTGCCGGAGCGGGGCGCGGACCCGATGAACGGGCCTTCCGCAAGGCCCTCGCCAGCATCGCAA
TGAACAGCGCGGCCGTCAGT

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MVSRCIFFLSFQVVGLLLGWLWGGFHGAVATVFAGVWLWFLWDLWRGSRVLRWLRDGDLASSPSLRGLWGEAADRFRRLL
RQNQADIAASDARLQEILAALQATPNGVVLLDAEGHIEWCNQIAVTQFGLDAARDMGQSIGNLLRDPEFSAYYAAQDFSR
DVVLQGRESTPSRPVRISVHLHPYGDGRKLLLSRDVTALEQAEAMRRDFVANVSHEIRTPLTVLMGFVETLQTLPLSSEE
RARYLNMMSQQAGRMQSVVQDLLTLSRLEGSPPPGLTECTPVDALLRRCEDEARGLSALLTRSQSAGHVLEFPPAEALQG
AGQLIGVTAELQSALANLIGNAVRYTPAGGRITVAWETLADGSARFSVRDTGPGIESVHIPRLTERFYRVDRSRSRDTGG
TGLGLAIVKHVVQRHSASLGIESTVGKGSVFSVTFPPHRIQRSAPVRGAPAKAC

Sequences:

>Translated_454_residues
MVSRCIFFLSFQVVGLLLGWLWGGFHGAVATVFAGVWLWFLWDLWRGSRVLRWLRDGDLASSPSLRGLWGEAADRFRRLL
RQNQADIAASDARLQEILAALQATPNGVVLLDAEGHIEWCNQIAVTQFGLDAARDMGQSIGNLLRDPEFSAYYAAQDFSR
DVVLQGRESTPSRPVRISVHLHPYGDGRKLLLSRDVTALEQAEAMRRDFVANVSHEIRTPLTVLMGFVETLQTLPLSSEE
RARYLNMMSQQAGRMQSVVQDLLTLSRLEGSPPPGLTECTPVDALLRRCEDEARGLSALLTRSQSAGHVLEFPPAEALQG
AGQLIGVTAELQSALANLIGNAVRYTPAGGRITVAWETLADGSARFSVRDTGPGIESVHIPRLTERFYRVDRSRSRDTGG
TGLGLAIVKHVVQRHSASLGIESTVGKGSVFSVTFPPHRIQRSAPVRGAPAKAC
>Mature_454_residues
MVSRCIFFLSFQVVGLLLGWLWGGFHGAVATVFAGVWLWFLWDLWRGSRVLRWLRDGDLASSPSLRGLWGEAADRFRRLL
RQNQADIAASDARLQEILAALQATPNGVVLLDAEGHIEWCNQIAVTQFGLDAARDMGQSIGNLLRDPEFSAYYAAQDFSR
DVVLQGRESTPSRPVRISVHLHPYGDGRKLLLSRDVTALEQAEAMRRDFVANVSHEIRTPLTVLMGFVETLQTLPLSSEE
RARYLNMMSQQAGRMQSVVQDLLTLSRLEGSPPPGLTECTPVDALLRRCEDEARGLSALLTRSQSAGHVLEFPPAEALQG
AGQLIGVTAELQSALANLIGNAVRYTPAGGRITVAWETLADGSARFSVRDTGPGIESVHIPRLTERFYRVDRSRSRDTGG
TGLGLAIVKHVVQRHSASLGIESTVGKGSVFSVTFPPHRIQRSAPVRGAPAKAC

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=433, Percent_Identity=39.9538106235566, Blast_Score=286, Evalue=1e-78,
Organism=Escherichia coli, GI1786783, Length=238, Percent_Identity=31.5126050420168, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788393, Length=253, Percent_Identity=33.201581027668, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1789149, Length=235, Percent_Identity=31.9148936170213, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790346, Length=244, Percent_Identity=31.1475409836066, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI145693157, Length=263, Percent_Identity=29.277566539924, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI48994928, Length=252, Percent_Identity=29.3650793650794, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790861, Length=233, Percent_Identity=32.1888412017167, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788713, Length=251, Percent_Identity=25.0996015936255, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788549, Length=356, Percent_Identity=24.1573033707865, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789403, Length=213, Percent_Identity=29.5774647887324, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1786912, Length=251, Percent_Identity=29.4820717131474, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790551, Length=236, Percent_Identity=31.3559322033898, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1790436, Length=265, Percent_Identity=26.0377358490566, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87081816, Length=241, Percent_Identity=26.5560165975104, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49681; Mature: 49681

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSRCIFFLSFQVVGLLLGWLWGGFHGAVATVFAGVWLWFLWDLWRGSRVLRWLRDGDLA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SSPSLRGLWGEAADRFRRLLRQNQADIAASDARLQEILAALQATPNGVVLLDAEGHIEWC
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHH
NQIAVTQFGLDAARDMGQSIGNLLRDPEFSAYYAAQDFSRDVVLQGRESTPSRPVRISVH
HHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCEEHHHHCCCCCEEECCCCCCCCCEEEEEE
LHPYGDGRKLLLSRDVTALEQAEAMRRDFVANVSHEIRTPLTVLMGFVETLQTLPLSSEE
EEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
RARYLNMMSQQAGRMQSVVQDLLTLSRLEGSPPPGLTECTPVDALLRRCEDEARGLSALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TRSQSAGHVLEFPPAEALQGAGQLIGVTAELQSALANLIGNAVRYTPAGGRITVAWETLA
HCCCCCCCEEECCCHHHHHCCCCEEEHHHHHHHHHHHHHCCCEEECCCCCEEEEEEEECC
DGSARFSVRDTGPGIESVHIPRLTERFYRVDRSRSRDTGGTGLGLAIVKHVVQRHSASLG
CCCCEEEEECCCCCCCCEECHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
IESTVGKGSVFSVTFPPHRIQRSAPVRGAPAKAC
CCCCCCCCCEEEEECCHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MVSRCIFFLSFQVVGLLLGWLWGGFHGAVATVFAGVWLWFLWDLWRGSRVLRWLRDGDLA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SSPSLRGLWGEAADRFRRLLRQNQADIAASDARLQEILAALQATPNGVVLLDAEGHIEWC
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHH
NQIAVTQFGLDAARDMGQSIGNLLRDPEFSAYYAAQDFSRDVVLQGRESTPSRPVRISVH
HHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCEEHHHHCCCCCEEECCCCCCCCCEEEEEE
LHPYGDGRKLLLSRDVTALEQAEAMRRDFVANVSHEIRTPLTVLMGFVETLQTLPLSSEE
EEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
RARYLNMMSQQAGRMQSVVQDLLTLSRLEGSPPPGLTECTPVDALLRRCEDEARGLSALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TRSQSAGHVLEFPPAEALQGAGQLIGVTAELQSALANLIGNAVRYTPAGGRITVAWETLA
HCCCCCCCEEECCCHHHHHCCCCEEEHHHHHHHHHHHHHCCCEEECCCCCEEEEEEEECC
DGSARFSVRDTGPGIESVHIPRLTERFYRVDRSRSRDTGGTGLGLAIVKHVVQRHSASLG
CCCCEEEEECCCCCCCCEECHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCC
IESTVGKGSVFSVTFPPHRIQRSAPVRGAPAKAC
CCCCCCCCCEEEEECCHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043; 2115874 [H]