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The map label for this gene is norM [H]

Identifier: 120611301

GI number: 120611301

Start: 2886627

End: 2888003

Strand: Reverse

Name: norM [H]

Synonym: Aave_2633

Alternate gene names: 120611301

Gene position: 2888003-2886627 (Counterclockwise)

Preceding gene: 120611302

Following gene: 120611293

Centisome position: 53.95

GC content: 72.33

Gene sequence:

>1377_bases
ATGCCGTCCGAGCGCGCCCAGGTCGCGCGCCACGCGGCCACCGTCCTGGCGGGGCAACTCGCCGTGATGGCGTTCGGCGT
GACCGACACCATCGTCGCCGGCCGCCATGCGCCCTCCTCCCTGGCCGCGCTCTCGATCGGCTCCGCCGTCTATGTGAGCG
TCTATGTCGCCCTCATGGGCGTGCTGCAGGCGCTGCTGCCCATCTGGGCGGAACAGCGCGGCGCCGGACACACCACGGAG
ATCGGGCGCACGGTGCGCCAGGCGCTGTACCTTTGCGCCCTGGCGAGCCTGCTGGGCATGGTCGTGCTGCTGTCGCCCGG
GGCCATCCTGCGCTGGACGCAGGTGCCGGCCGAGCTGCGCGCGGAGGTGGGCCGCTACCTCACGGTGCTGGCCGCGGCGC
TGCCTCCGGCACTGGCCTTCCGGCTCTACACCACGCTCAACCAGGCCCTGGGGCGCCCCCAGCTGGTCACCTGGCTGCAA
TTGGGTTCGCTGGCCGTGAAGATCCCGCTGTCCATCGGCTTCACCTTCGGGTTCGCGGGCCTGCCCGCGCAGGGCGCCGT
CGGGTGCGCCTGGGCCACGCTCGTCGTGAACTACCTGCTGCTGGGCATCGCGCTGTGGCTGGTCCGCTCGTCGCCGGTGT
ATGCGCCGCTCTCGCTGTGGAAGCGCATGGAGCGCCCCGACCCCGCGCAGATCGGGCACTTCGCGCGGCTGGGCGTGCCT
GCGGGACTGGCCGTGATGGTGGAAGTCACCTCGTTCACGCTGATGGCGCTGTTCATCGCCCGGCAGGGAACGGTCGCCGC
CGCGGCGCACCAGATCGCCTCGAATCTCACCGCCGTGCTCTACATGGTCCCGCTCTCGCTGGCCATCGCCACCAGCGCCC
GGATCAGCTACTGGCGCGGCCGTGCCGACGAGGCCCTCGCCCGGCAGGTGGCGTGGATGGGGCTGCGCATGGCGGGCGCC
ACCGCCCTCGTCCTGTCGGGACTGGCCCTCGCGGCACGCGAAGGCCTGGCGGGCCTCTATACGTCCTCACCCGAGGTGCT
GGCGATGGCCCGCGGGCTGCTGGCCTGGGCCGCGGCCTACCACGTCGCCGATGCGCTGCAGACCTTCTGCGCATTCGCCC
TGCGCTGCTACCGGATCACCATCGCTCCGCTGGCCACTTACGGGGTACTGCTCTGGGGCGCCGGGCTGCCGGCGGGCTAT
GTACTGGCCTACGTGGGCTTCGCCGGACATCCGCCGCAGCAGTCGCCCGCCGCCTTCTGGATCGGCGGGGCGCTGGCGCT
GGGACTGACGGCCGCGCTGTTCATTGCGATGCTGGCGAGGGCCTTGCGGAAGGCCCGTTCATCGGGTCCGCGCCCCGCTC
CGGCAGGATGGGCTTAG

Upstream 100 bases:

>100_bases
GTGCCGGCTGGCGCCGCGCCGTGGTGCTGCCACGCCCGACCGACAAGAACGACCGGCTTCTGGTGCTGCGCCGCGAACCT
TCCGCGGCCGGGCGGCCCTG

Downstream 100 bases:

>100_bases
GGCCTGTCAACAGGCCTTTGCCGGTGCGCCGCGTACCGGGGCACTGCGTTGGATGCGGTGCGGCGGGAACGTGACGGAAA
ACACGGAACCCTTGCCCACG

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MPSERAQVARHAATVLAGQLAVMAFGVTDTIVAGRHAPSSLAALSIGSAVYVSVYVALMGVLQALLPIWAEQRGAGHTTE
IGRTVRQALYLCALASLLGMVVLLSPGAILRWTQVPAELRAEVGRYLTVLAAALPPALAFRLYTTLNQALGRPQLVTWLQ
LGSLAVKIPLSIGFTFGFAGLPAQGAVGCAWATLVVNYLLLGIALWLVRSSPVYAPLSLWKRMERPDPAQIGHFARLGVP
AGLAVMVEVTSFTLMALFIARQGTVAAAAHQIASNLTAVLYMVPLSLAIATSARISYWRGRADEALARQVAWMGLRMAGA
TALVLSGLALAAREGLAGLYTSSPEVLAMARGLLAWAAAYHVADALQTFCAFALRCYRITIAPLATYGVLLWGAGLPAGY
VLAYVGFAGHPPQQSPAAFWIGGALALGLTAALFIAMLARALRKARSSGPRPAPAGWA

Sequences:

>Translated_458_residues
MPSERAQVARHAATVLAGQLAVMAFGVTDTIVAGRHAPSSLAALSIGSAVYVSVYVALMGVLQALLPIWAEQRGAGHTTE
IGRTVRQALYLCALASLLGMVVLLSPGAILRWTQVPAELRAEVGRYLTVLAAALPPALAFRLYTTLNQALGRPQLVTWLQ
LGSLAVKIPLSIGFTFGFAGLPAQGAVGCAWATLVVNYLLLGIALWLVRSSPVYAPLSLWKRMERPDPAQIGHFARLGVP
AGLAVMVEVTSFTLMALFIARQGTVAAAAHQIASNLTAVLYMVPLSLAIATSARISYWRGRADEALARQVAWMGLRMAGA
TALVLSGLALAAREGLAGLYTSSPEVLAMARGLLAWAAAYHVADALQTFCAFALRCYRITIAPLATYGVLLWGAGLPAGY
VLAYVGFAGHPPQQSPAAFWIGGALALGLTAALFIAMLARALRKARSSGPRPAPAGWA
>Mature_457_residues
PSERAQVARHAATVLAGQLAVMAFGVTDTIVAGRHAPSSLAALSIGSAVYVSVYVALMGVLQALLPIWAEQRGAGHTTEI
GRTVRQALYLCALASLLGMVVLLSPGAILRWTQVPAELRAEVGRYLTVLAAALPPALAFRLYTTLNQALGRPQLVTWLQL
GSLAVKIPLSIGFTFGFAGLPAQGAVGCAWATLVVNYLLLGIALWLVRSSPVYAPLSLWKRMERPDPAQIGHFARLGVPA
GLAVMVEVTSFTLMALFIARQGTVAAAAHQIASNLTAVLYMVPLSLAIATSARISYWRGRADEALARQVAWMGLRMAGAT
ALVLSGLALAAREGLAGLYTSSPEVLAMARGLLAWAAAYHVADALQTFCAFALRCYRITIAPLATYGVLLWGAGLPAGYV
LAYVGFAGHPPQQSPAAFWIGGALALGLTAALFIAMLARALRKARSSGPRPAPAGWA

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI48994890, Length=429, Percent_Identity=32.1678321678322, Blast_Score=191, Evalue=7e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48011; Mature: 47880

Theoretical pI: Translated: 10.61; Mature: 10.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSERAQVARHAATVLAGQLAVMAFGVTDTIVAGRHAPSSLAALSIGSAVYVSVYVALMG
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHH
VLQALLPIWAEQRGAGHTTEIGRTVRQALYLCALASLLGMVVLLSPGAILRWTQVPAELR
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHH
AEVGRYLTVLAAALPPALAFRLYTTLNQALGRPQLVTWLQLGSLAVKIPLSIGFTFGFAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCEEEEEEHEECCCCCCCC
LPAQGAVGCAWATLVVNYLLLGIALWLVRSSPVYAPLSLWKRMERPDPAQIGHFARLGVP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHCCHHHHCCC
AGLAVMVEVTSFTLMALFIARQGTVAAAAHQIASNLTAVLYMVPLSLAIATSARISYWRG
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RADEALARQVAWMGLRMAGATALVLSGLALAAREGLAGLYTSSPEVLAMARGLLAWAAAY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHH
HVADALQTFCAFALRCYRITIAPLATYGVLLWGAGLPAGYVLAYVGFAGHPPQQSPAAFW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHH
IGGALALGLTAALFIAMLARALRKARSSGPRPAPAGWA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PSERAQVARHAATVLAGQLAVMAFGVTDTIVAGRHAPSSLAALSIGSAVYVSVYVALMG
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHH
VLQALLPIWAEQRGAGHTTEIGRTVRQALYLCALASLLGMVVLLSPGAILRWTQVPAELR
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHH
AEVGRYLTVLAAALPPALAFRLYTTLNQALGRPQLVTWLQLGSLAVKIPLSIGFTFGFAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCEEEEEEHEECCCCCCCC
LPAQGAVGCAWATLVVNYLLLGIALWLVRSSPVYAPLSLWKRMERPDPAQIGHFARLGVP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHCCHHHHCCC
AGLAVMVEVTSFTLMALFIARQGTVAAAAHQIASNLTAVLYMVPLSLAIATSARISYWRG
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RADEALARQVAWMGLRMAGATALVLSGLALAAREGLAGLYTSSPEVLAMARGLLAWAAAY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHH
HVADALQTFCAFALRCYRITIAPLATYGVLLWGAGLPAGYVLAYVGFAGHPPQQSPAAFW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHH
IGGALALGLTAALFIAMLARALRKARSSGPRPAPAGWA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA