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The map label for this gene is ppx [H]

Identifier: 120611293

GI number: 120611293

Start: 2878062

End: 2879582

Strand: Reverse

Name: ppx [H]

Synonym: Aave_2625

Alternate gene names: 120611293

Gene position: 2879582-2878062 (Counterclockwise)

Preceding gene: 120611301

Following gene: 120611292

Centisome position: 53.8

GC content: 70.55

Gene sequence:

>1521_bases
ATGCTGCGCCGCCAGAAAAACCAGCGCGCAAGGCGCGACAACATGCACGACGGAACATTGCTCGCCGCGGTGGATCTCGG
ATCCAACAGCTTTCGCCTCGAAATCGGACGCTTCGAGCACGGGCTGATACGCAGGATCGAATACCTCAAGGAAACCGTCC
GCCAGGGCAACGGCCTGGACGAAGACCGCAACCTCACGCCCGACGCCATGCAGCGCGGCTGGGACTGCCTCGCGCGTTTC
GCCGAGCGCCTCAAGGGTTTTCCGGCCGAGAGGGTGCGCGCCGTCGCCACCCAGACACTGCGCGAAGCGCGCAACCGCGA
CGCCTTCCTGCAGCGCGGCAGCGCCCTGCTCGGCCACCCGATCGACGTCGTCTCCGGCCCCGAAGAGGCCCGCCTGATCT
ACCAGGGCGTGGCCCACCTGCTGCCCCAGTCGGACGAGCGCCGGCTGGTGGTGGACATCGGCGGCCGCTCCACGGAGCTG
ATCCTGGGCCATGGCTTCTCGGCCGACACGGTGGCCTCGTTCCGCGTGGGCAGCGTAGCCTGGTCCAGCCGCTACTTCCC
GGAGGGCGCCTTCACCCCGGAGTCTTTCCGCACCGCCGAGATCGCGGCCCAGGCCGTGCTGGACGAGGCGCTCAACACCT
ACCGGCCCCAGGCCTGGGACGTGGCCTATGGATCCTCCGGCACCGCCGGCGCGATCGGCGACATCCTGGCCGTGCTGGGC
GGCCCGCCCGGCCTCATCACCCGGTCCGGGCTGGACTGGCTGCGGGAGCAACTGCTTCGCGCCCGCACGGTGGACAAGGT
GCGGCTGGAGGGCCTGAAGGAAGACCGCCGGCCGGTGATCGGCGGCGGCCTCAGCGTGCTGCGCGCCGTGTTCGACCTGC
TGGACATCCGCGAGATGCAGGTGGCCCAGGGCGCATTGCGCCAGGGCGTCCTGTACGACCTGCTCGACCGCGAACTGCAT
GCCGACGACCTGCGCTCCTCCACGGTGCTCGGACTGATGGAGCGGTTCCGCGTAGATGTCCGGCATGCCGAGCGCGTAGC
CCGCACGGCCGCCCTGCTCCACCAGCAGGCCTGTCCCGGCGTCGCCGAGCAAAGCCACAGGGAACTCGTCTGGGCCGCGC
GACTGCACGAGATCGGCTGCATCGTCTCCCATGGCGATCACCACCACCATGGCGCCTACCTCCTGGACCACACCGACGCG
GCGGGTTTTTCCGTGTCGGAGCTGCGCCACCTCGGCCGGCTCGTGCAGGGCCACCGGGGCAAGGTGCGCAAGCTCGAGGC
CGACATCGACGATCCGCGGCTGGCCCACCAGCTCGCCTGCCTGCGCATGGCGGTCGCCCTGTGCCATGCCCGCCGGGACC
CGGACCTGGAAGGTGTGGCCCTGGTGCGCGACGGGCACCGCTTCGTCGCCTCGGCCCGCCCGGGCTGGGCCGCGGCGTAT
CCGCAATCGGCCCACCTGCTGCGCGAGGAAGGCACCGCATGGCAGAGAACCGCCTGGGAGTTCGTGGCCGAATTGACCTG
A

Upstream 100 bases:

>100_bases
CGGCCCGCGCCACCCGTTCGCGCGGCACGGCCGATCACCCCGGCGGAACACCGCCGGCGGGCCTGCGCCTGTTTTGCACG
GGCACCGAAAAGGGAGTGCT

Downstream 100 bases:

>100_bases
CGGCACGGCGGTGCAAAAGCCGCAAAAACATGCGGACTCATCCATAACGGTATAAACTGTTTATACCGTTTTACCTTCGA
TGATCCGCCATGCCCGATAC

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MLRRQKNQRARRDNMHDGTLLAAVDLGSNSFRLEIGRFEHGLIRRIEYLKETVRQGNGLDEDRNLTPDAMQRGWDCLARF
AERLKGFPAERVRAVATQTLREARNRDAFLQRGSALLGHPIDVVSGPEEARLIYQGVAHLLPQSDERRLVVDIGGRSTEL
ILGHGFSADTVASFRVGSVAWSSRYFPEGAFTPESFRTAEIAAQAVLDEALNTYRPQAWDVAYGSSGTAGAIGDILAVLG
GPPGLITRSGLDWLREQLLRARTVDKVRLEGLKEDRRPVIGGGLSVLRAVFDLLDIREMQVAQGALRQGVLYDLLDRELH
ADDLRSSTVLGLMERFRVDVRHAERVARTAALLHQQACPGVAEQSHRELVWAARLHEIGCIVSHGDHHHHGAYLLDHTDA
AGFSVSELRHLGRLVQGHRGKVRKLEADIDDPRLAHQLACLRMAVALCHARRDPDLEGVALVRDGHRFVASARPGWAAAY
PQSAHLLREEGTAWQRTAWEFVAELT

Sequences:

>Translated_506_residues
MLRRQKNQRARRDNMHDGTLLAAVDLGSNSFRLEIGRFEHGLIRRIEYLKETVRQGNGLDEDRNLTPDAMQRGWDCLARF
AERLKGFPAERVRAVATQTLREARNRDAFLQRGSALLGHPIDVVSGPEEARLIYQGVAHLLPQSDERRLVVDIGGRSTEL
ILGHGFSADTVASFRVGSVAWSSRYFPEGAFTPESFRTAEIAAQAVLDEALNTYRPQAWDVAYGSSGTAGAIGDILAVLG
GPPGLITRSGLDWLREQLLRARTVDKVRLEGLKEDRRPVIGGGLSVLRAVFDLLDIREMQVAQGALRQGVLYDLLDRELH
ADDLRSSTVLGLMERFRVDVRHAERVARTAALLHQQACPGVAEQSHRELVWAARLHEIGCIVSHGDHHHHGAYLLDHTDA
AGFSVSELRHLGRLVQGHRGKVRKLEADIDDPRLAHQLACLRMAVALCHARRDPDLEGVALVRDGHRFVASARPGWAAAY
PQSAHLLREEGTAWQRTAWEFVAELT
>Mature_506_residues
MLRRQKNQRARRDNMHDGTLLAAVDLGSNSFRLEIGRFEHGLIRRIEYLKETVRQGNGLDEDRNLTPDAMQRGWDCLARF
AERLKGFPAERVRAVATQTLREARNRDAFLQRGSALLGHPIDVVSGPEEARLIYQGVAHLLPQSDERRLVVDIGGRSTEL
ILGHGFSADTVASFRVGSVAWSSRYFPEGAFTPESFRTAEIAAQAVLDEALNTYRPQAWDVAYGSSGTAGAIGDILAVLG
GPPGLITRSGLDWLREQLLRARTVDKVRLEGLKEDRRPVIGGGLSVLRAVFDLLDIREMQVAQGALRQGVLYDLLDRELH
ADDLRSSTVLGLMERFRVDVRHAERVARTAALLHQQACPGVAEQSHRELVWAARLHEIGCIVSHGDHHHHGAYLLDHTDA
AGFSVSELRHLGRLVQGHRGKVRKLEADIDDPRLAHQLACLRMAVALCHARRDPDLEGVALVRDGHRFVASARPGWAAAY
PQSAHLLREEGTAWQRTAWEFVAELT

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=407, Percent_Identity=40.7862407862408, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI48994966, Length=489, Percent_Identity=36.8098159509202, Blast_Score=279, Evalue=3e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 56278; Mature: 56278

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRRQKNQRARRDNMHDGTLLAAVDLGSNSFRLEIGRFEHGLIRRIEYLKETVRQGNGLD
CCCCCHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCC
EDRNLTPDAMQRGWDCLARFAERLKGFPAERVRAVATQTLREARNRDAFLQRGSALLGHP
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHHHCCCHHHCCC
IDVVSGPEEARLIYQGVAHLLPQSDERRLVVDIGGRSTELILGHGFSADTVASFRVGSVA
HHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCCCCHHHHHEECCCH
WSSRYFPEGAFTPESFRTAEIAAQAVLDEALNTYRPQAWDVAYGSSGTAGAIGDILAVLG
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHC
GPPGLITRSGLDWLREQLLRARTVDKVRLEGLKEDRRPVIGGGLSVLRAVFDLLDIREMQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHHHHH
VAQGALRQGVLYDLLDRELHADDLRSSTVLGLMERFRVDVRHAERVARTAALLHQQACPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VAEQSHRELVWAARLHEIGCIVSHGDHHHHGAYLLDHTDAAGFSVSELRHLGRLVQGHRG
HHHHHHHHHHHHHHHHHHCEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCC
KVRKLEADIDDPRLAHQLACLRMAVALCHARRDPDLEGVALVRDGHRFVASARPGWAAAY
CCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHEECCCCCCCCCC
PQSAHLLREEGTAWQRTAWEFVAELT
CCHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLRRQKNQRARRDNMHDGTLLAAVDLGSNSFRLEIGRFEHGLIRRIEYLKETVRQGNGLD
CCCCCHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCC
EDRNLTPDAMQRGWDCLARFAERLKGFPAERVRAVATQTLREARNRDAFLQRGSALLGHP
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHHHHHHCCCHHHCCC
IDVVSGPEEARLIYQGVAHLLPQSDERRLVVDIGGRSTELILGHGFSADTVASFRVGSVA
HHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCCCCHHHHHEECCCH
WSSRYFPEGAFTPESFRTAEIAAQAVLDEALNTYRPQAWDVAYGSSGTAGAIGDILAVLG
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHC
GPPGLITRSGLDWLREQLLRARTVDKVRLEGLKEDRRPVIGGGLSVLRAVFDLLDIREMQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHHHHH
VAQGALRQGVLYDLLDRELHADDLRSSTVLGLMERFRVDVRHAERVARTAALLHQQACPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VAEQSHRELVWAARLHEIGCIVSHGDHHHHGAYLLDHTDAAGFSVSELRHLGRLVQGHRG
HHHHHHHHHHHHHHHHHHCEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCC
KVRKLEADIDDPRLAHQLACLRMAVALCHARRDPDLEGVALVRDGHRFVASARPGWAAAY
CCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHEECCCCCCCCCC
PQSAHLLREEGTAWQRTAWEFVAELT
CCHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]