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The map label for this gene is mmsB [H]

Identifier: 120611268

GI number: 120611268

Start: 2847750

End: 2848649

Strand: Reverse

Name: mmsB [H]

Synonym: Aave_2600

Alternate gene names: 120611268

Gene position: 2848649-2847750 (Counterclockwise)

Preceding gene: 120611269

Following gene: 120611267

Centisome position: 53.22

GC content: 70.89

Gene sequence:

>900_bases
ATGAAGATCGCATTCATCGGCCTGGGCAACATGGGCGGCCCCATGGCCCTGAACCTGCACAAGGCCGGCCACGACGTCGG
CGCGTTCGACCTGTCCAGGCCCGCCTGCGACAGGCTGGCGGCCGACGGGGTGCGCATCGCCACCGACGCCAGCGCCTGCG
TGGCGGGTGCCGAGGTGGTCATCAGCATGCTGCCGGCCAGCCCGCATGTGGAGGCGCTTTTCCTGGGAGGCGGCCAACAG
CCCGGCCTGCTGCCCCAACTGGCCGCAGGCACGCTGGTGATCGACTGCTCGACCATCGCGGCGGCCACATCGCGCAAGGT
GGCCGATGCCGCGCGGGAGCGCGGCATCGCCTTCATCGACGCGCCTGTCTCCGGCGGCACGGGGGGCGCCGTCGCCGGCA
CGCTGACCTTCATGGTGGGCGGCGATGCGGCCGATCTGGAACGCGCGCGCCCGGTGCTGGAGAAGATGGGCGCCAACATC
TTCCACGCGGGCGGCGTGGGCGCGGGGCAGACCGCCAAGATCTGCAACAACATGCTGCTGGGCATCCTGATGGCCGGCAC
GAGCGAGGCCCTCGCCCTGGGCGCCGCCAACGGCCTGGATCCGGCAGTGCTCAGCGAGATCATGCGCCGCAGCTCGGGCG
GGAACTGGGCCCTGGAAAAATACAACCCCTGGCCGGGCGTCATGCCCCAGGCCCCGGCGAGCAAGGACTACGCGGGAGGC
TTCGGCACCGACCTGATGCTCAAGGACCTGGGGCTCGCGCAGGAGAACGCTGCTGCGGTGAAGGCGGCCACGCCCCTGGG
CGGACTCGCGCGCAGCCTGTACGCGGCGCACAGCCTCGCAGGCCATTGCGAGCTGGATTTTTCCAGCATCGTGCGCCTCG
TCCGCAAACCCGGTGCCTGA

Upstream 100 bases:

>100_bases
GAGCCCCACGGCGCCACAGCATTTTCGAGGCCGATGACTGAGGGGGACGCATCCCGTCCGCCGGCCTGCACACCGATTCA
CCACCCCAAGGAGACAACAC

Downstream 100 bases:

>100_bases
GCTCCCCACGGTACGTTGCCGGCAGCCGTTGCCGAAGGTCCACACTGGCGGCCTCCGGGCGGTTGTCCTACGCGACGGGC
AGGCATCGCGCCGCATGCTC

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKIAFIGLGNMGGPMALNLHKAGHDVGAFDLSRPACDRLAADGVRIATDASACVAGAEVVISMLPASPHVEALFLGGGQQ
PGLLPQLAAGTLVIDCSTIAAATSRKVADAARERGIAFIDAPVSGGTGGAVAGTLTFMVGGDAADLERARPVLEKMGANI
FHAGGVGAGQTAKICNNMLLGILMAGTSEALALGAANGLDPAVLSEIMRRSSGGNWALEKYNPWPGVMPQAPASKDYAGG
FGTDLMLKDLGLAQENAAAVKAATPLGGLARSLYAAHSLAGHCELDFSSIVRLVRKPGA

Sequences:

>Translated_299_residues
MKIAFIGLGNMGGPMALNLHKAGHDVGAFDLSRPACDRLAADGVRIATDASACVAGAEVVISMLPASPHVEALFLGGGQQ
PGLLPQLAAGTLVIDCSTIAAATSRKVADAARERGIAFIDAPVSGGTGGAVAGTLTFMVGGDAADLERARPVLEKMGANI
FHAGGVGAGQTAKICNNMLLGILMAGTSEALALGAANGLDPAVLSEIMRRSSGGNWALEKYNPWPGVMPQAPASKDYAGG
FGTDLMLKDLGLAQENAAAVKAATPLGGLARSLYAAHSLAGHCELDFSSIVRLVRKPGA
>Mature_299_residues
MKIAFIGLGNMGGPMALNLHKAGHDVGAFDLSRPACDRLAADGVRIATDASACVAGAEVVISMLPASPHVEALFLGGGQQ
PGLLPQLAAGTLVIDCSTIAAATSRKVADAARERGIAFIDAPVSGGTGGAVAGTLTFMVGGDAADLERARPVLEKMGANI
FHAGGVGAGQTAKICNNMLLGILMAGTSEALALGAANGLDPAVLSEIMRRSSGGNWALEKYNPWPGVMPQAPASKDYAGG
FGTDLMLKDLGLAQENAAAVKAATPLGGLARSLYAAHSLAGHCELDFSSIVRLVRKPGA

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=294, Percent_Identity=44.2176870748299, Blast_Score=246, Evalue=1e-65,
Organism=Homo sapiens, GI40556376, Length=291, Percent_Identity=26.8041237113402, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI145693186, Length=266, Percent_Identity=36.8421052631579, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1786719, Length=292, Percent_Identity=33.2191780821918, Blast_Score=150, Evalue=9e-38,
Organism=Escherichia coli, GI1790315, Length=293, Percent_Identity=34.4709897610922, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1789092, Length=304, Percent_Identity=29.6052631578947, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17557316, Length=297, Percent_Identity=43.0976430976431, Blast_Score=228, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24655230, Length=295, Percent_Identity=45.7627118644068, Blast_Score=240, Evalue=8e-64,
Organism=Drosophila melanogaster, GI19922568, Length=295, Percent_Identity=45.7627118644068, Blast_Score=240, Evalue=8e-64,
Organism=Drosophila melanogaster, GI24655240, Length=64, Percent_Identity=51.5625, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI28574115, Length=297, Percent_Identity=22.5589225589226, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 30094; Mature: 30094

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAFIGLGNMGGPMALNLHKAGHDVGAFDLSRPACDRLAADGVRIATDASACVAGAEVV
CEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCEEEEECCHHHHHHHHHH
ISMLPASPHVEALFLGGGQQPGLLPQLAAGTLVIDCSTIAAATSRKVADAARERGIAFID
HHHCCCCCCEEEEEECCCCCCCCCHHHCCCEEEEECHHHHHHHHHHHHHHHHHCCCEEEE
APVSGGTGGAVAGTLTFMVGGDAADLERARPVLEKMGANIFHAGGVGAGQTAKICNNMLL
CCCCCCCCCHHEEEEEEEECCCHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHH
GILMAGTSEALALGAANGLDPAVLSEIMRRSSGGNWALEKYNPWPGVMPQAPASKDYAGG
HHHHCCCCHHHEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCC
FGTDLMLKDLGLAQENAAAVKAATPLGGLARSLYAAHSLAGHCELDFSSIVRLVRKPGA
CCHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCEECHHHHHHHHHCCCC
>Mature Secondary Structure
MKIAFIGLGNMGGPMALNLHKAGHDVGAFDLSRPACDRLAADGVRIATDASACVAGAEVV
CEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCEEEEECCHHHHHHHHHH
ISMLPASPHVEALFLGGGQQPGLLPQLAAGTLVIDCSTIAAATSRKVADAARERGIAFID
HHHCCCCCCEEEEEECCCCCCCCCHHHCCCEEEEECHHHHHHHHHHHHHHHHHCCCEEEE
APVSGGTGGAVAGTLTFMVGGDAADLERARPVLEKMGANIFHAGGVGAGQTAKICNNMLL
CCCCCCCCCHHEEEEEEEECCCHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHH
GILMAGTSEALALGAANGLDPAVLSEIMRRSSGGNWALEKYNPWPGVMPQAPASKDYAGG
HHHHCCCCHHHEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCC
FGTDLMLKDLGLAQENAAAVKAATPLGGLARSLYAAHSLAGHCELDFSSIVRLVRKPGA
CCHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCEECHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]