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The map label for this gene is garD [H]

Identifier: 120611263

GI number: 120611263

Start: 2840977

End: 2842533

Strand: Direct

Name: garD [H]

Synonym: Aave_2595

Alternate gene names: 120611263

Gene position: 2840977-2842533 (Clockwise)

Preceding gene: 120611262

Following gene: 120611264

Centisome position: 53.07

GC content: 69.24

Gene sequence:

>1557_bases
ATGACCACGCCCCTGACCATCCGCATGCACGAGGCCGACAACGTGGCCATCGTGGCCAACGACGGCGGCCTGCCGGCCGG
CACGGCGCTGCCTTCGGGCATCACGCTGCGCGAGCACGTGCCCCAGGCCCACAAGGTGGCGCTGCAGGACATTGCCGAAG
GCGGTGCCGTGCGCCGCTACAACGTGCCCATCGGCTATGCCATCCGGCCGATCGCGGCCGGCAGCTGGGTGCACGAGAAG
CTGCTGCACATGCCCGACGCGCGCTCGCTCGAAGGCCTGCCCATCGCCACGGCTAGGCCGCCGGCCCTCCCGCCGCTGGA
GGGCTACACCTTCGAGGGCTACCGCAATGCCGACGGTTCGGTGGGTACGCGCAACATCCTGGCCATCACCGAAACCGTGC
AGTGCGTGGCCGGTGTGACCGAATTCGCCGTGCAGCGCATCAAGGCGGAACTGCTGCCGAAGTACCCGCACGTCGATGAC
GTGGTGGCCCTGGCCCACACCTACGGCTGCGGCGTGGCCATCGATGCGCCCGATGCGGTGATCCCGATCCGCACGCTGCG
CAACATCAGCCTCAACCCGAACTTCGGCGGCGAGGTGATGGTGGTCAGCCTGGGCTGCGAGAAGCTGCAGCCCGAGCGCC
TGCTGCCGCCCGGTGCCATACCGCTGGTGGACGAACGCACGCTGCAGGAGGATCCGCTCGACGTGGTCTGCCTGCAGGAC
GAGGCCCATGTGGGCTTCATGTCCATGGTCGGTTCGGTGATGCGCCAGGCAGAAGTTCATCTGGAGCGCCTCAATCGCCG
CCGCCGCGAGACCGTGCCGGCCAGCGAGCTGGTGGTCGGCGTGCAGTGCGGTGGCAGCGACGCCTTCAGCGGTGTCACCG
CCAACCCGGCCGTGGGGTTCTGCACCGACCTGCTGGTGCGCGCCGGGGCCACGGTGATGTTCAGCGAGGTGACCGAGGTG
CGCGACGGCATCGACCAGCTCACCTCCCGCGCGGCATCGCCCGAGGTGGCCGAGGCCATGATCCGCGAGATGGCCTGGTA
CGACGCCTACCTCAGCCAAGGCCGCGTGGACCGCAGTGCCAACACCACGCCGGGCAACAAGAAGGGGGGGCTGTCCAACA
TCGTCGAGAAGGCGATGGGCTCCATCGTCAAGAGCGGCAGCGCGCCCATCAGCGGCGTGGTGGCACCCGGCGAGAAGGCG
CGGCAGAAGGGGCTGCTCTATGCGGCCACGCCCGCCAGCGATTTCATCTGCGGCACGCTGCAGGTGGCCGCGGGCATGAA
CCTGCACGTCTTCACCACCGGCCGGGGCACGCCCTATGGCCTGGCCGAAGTGCCGGTCATCAAGGTGGCCACGCGCAGCG
ACCTGGCGCGGCGCTGGCACGACCTGATGGACGTGAACGCCGGCCGCATCGCCGACGGGGAGGCCACCATCGAGGAGATG
GGCTGGGAGATGTTCCGCCTGATGCTGGACGTGGCCAGTGGCCGCAGGAAGACCTGGGCCGAGCACTGGAAGCTCGCCAA
CGCGCTGGTACTGTTCAATCCCGCGCCCGTGACCTGA

Upstream 100 bases:

>100_bases
TTCGTGCCGTCGTTCTCGACCTGGCTGCCCAGCATGTTCATGGCGGTGCGCTGAGGCGCCGCCCGGCCCGCCCCGAAACC
ATGCGCCGAACGAACACTCC

Downstream 100 bases:

>100_bases
CTGCGCACGTGGCGCTTTCCATCATCACGAACAGGGAGAGAGAAACATGACGCCACGGCACCCAACCTTTCACTCCGGCG
GCCACCGCAGGGCCTTTCTC

Product: galactarate dehydratase

Products: NA

Alternate protein names: GalcD [H]

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MTTPLTIRMHEADNVAIVANDGGLPAGTALPSGITLREHVPQAHKVALQDIAEGGAVRRYNVPIGYAIRPIAAGSWVHEK
LLHMPDARSLEGLPIATARPPALPPLEGYTFEGYRNADGSVGTRNILAITETVQCVAGVTEFAVQRIKAELLPKYPHVDD
VVALAHTYGCGVAIDAPDAVIPIRTLRNISLNPNFGGEVMVVSLGCEKLQPERLLPPGAIPLVDERTLQEDPLDVVCLQD
EAHVGFMSMVGSVMRQAEVHLERLNRRRRETVPASELVVGVQCGGSDAFSGVTANPAVGFCTDLLVRAGATVMFSEVTEV
RDGIDQLTSRAASPEVAEAMIREMAWYDAYLSQGRVDRSANTTPGNKKGGLSNIVEKAMGSIVKSGSAPISGVVAPGEKA
RQKGLLYAATPASDFICGTLQVAAGMNLHVFTTGRGTPYGLAEVPVIKVATRSDLARRWHDLMDVNAGRIADGEATIEEM
GWEMFRLMLDVASGRRKTWAEHWKLANALVLFNPAPVT

Sequences:

>Translated_518_residues
MTTPLTIRMHEADNVAIVANDGGLPAGTALPSGITLREHVPQAHKVALQDIAEGGAVRRYNVPIGYAIRPIAAGSWVHEK
LLHMPDARSLEGLPIATARPPALPPLEGYTFEGYRNADGSVGTRNILAITETVQCVAGVTEFAVQRIKAELLPKYPHVDD
VVALAHTYGCGVAIDAPDAVIPIRTLRNISLNPNFGGEVMVVSLGCEKLQPERLLPPGAIPLVDERTLQEDPLDVVCLQD
EAHVGFMSMVGSVMRQAEVHLERLNRRRRETVPASELVVGVQCGGSDAFSGVTANPAVGFCTDLLVRAGATVMFSEVTEV
RDGIDQLTSRAASPEVAEAMIREMAWYDAYLSQGRVDRSANTTPGNKKGGLSNIVEKAMGSIVKSGSAPISGVVAPGEKA
RQKGLLYAATPASDFICGTLQVAAGMNLHVFTTGRGTPYGLAEVPVIKVATRSDLARRWHDLMDVNAGRIADGEATIEEM
GWEMFRLMLDVASGRRKTWAEHWKLANALVLFNPAPVT
>Mature_517_residues
TTPLTIRMHEADNVAIVANDGGLPAGTALPSGITLREHVPQAHKVALQDIAEGGAVRRYNVPIGYAIRPIAAGSWVHEKL
LHMPDARSLEGLPIATARPPALPPLEGYTFEGYRNADGSVGTRNILAITETVQCVAGVTEFAVQRIKAELLPKYPHVDDV
VALAHTYGCGVAIDAPDAVIPIRTLRNISLNPNFGGEVMVVSLGCEKLQPERLLPPGAIPLVDERTLQEDPLDVVCLQDE
AHVGFMSMVGSVMRQAEVHLERLNRRRRETVPASELVVGVQCGGSDAFSGVTANPAVGFCTDLLVRAGATVMFSEVTEVR
DGIDQLTSRAASPEVAEAMIREMAWYDAYLSQGRVDRSANTTPGNKKGGLSNIVEKAMGSIVKSGSAPISGVVAPGEKAR
QKGLLYAATPASDFICGTLQVAAGMNLHVFTTGRGTPYGLAEVPVIKVATRSDLARRWHDLMDVNAGRIADGEATIEEMG
WEMFRLMLDVASGRRKTWAEHWKLANALVLFNPAPVT

Specific function: D-galactarate metabolism; first step. [C]

COG id: COG2721

COG function: function code G; Altronate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uxaA family [H]

Homologues:

Organism=Escherichia coli, GI1789516, Length=516, Percent_Identity=63.1782945736434, Blast_Score=684, Evalue=0.0,
Organism=Escherichia coli, GI1789475, Length=503, Percent_Identity=32.4055666003976, Blast_Score=217, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007392
- InterPro:   IPR017654
- InterPro:   IPR013974 [H]

Pfam domain/function: PF04295 GD_AH_C; PF08666 SAF [H]

EC number: =4.2.1.42 [H]

Molecular weight: Translated: 55451; Mature: 55320

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPLTIRMHEADNVAIVANDGGLPAGTALPSGITLREHVPQAHKVALQDIAEGGAVRRY
CCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHCCCCEEEE
NVPIGYAIRPIAAGSWVHEKLLHMPDARSLEGLPIATARPPALPPLEGYTFEGYRNADGS
CCCCCCEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCC
VGTRNILAITETVQCVAGVTEFAVQRIKAELLPKYPHVDDVVALAHTYGCGVAIDAPDAV
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEECCCCCE
IPIRTLRNISLNPNFGGEVMVVSLGCEKLQPERLLPPGAIPLVDERTLQEDPLDVVCLQD
EEHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
EAHVGFMSMVGSVMRQAEVHLERLNRRRRETVPASELVVGVQCGGSDAFSGVTANPAVGF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCCCCCCCHHHH
CTDLLVRAGATVMFSEVTEVRDGIDQLTSRAASPEVAEAMIREMAWYDAYLSQGRVDRSA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
NTTPGNKKGGLSNIVEKAMGSIVKSGSAPISGVVAPGEKARQKGLLYAATPASDFICGTL
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHCCEEEEECCCCCHHHHHH
QVAAGMNLHVFTTGRGTPYGLAEVPVIKVATRSDLARRWHDLMDVNAGRIADGEATIEEM
HHHCCCEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
GWEMFRLMLDVASGRRKTWAEHWKLANALVLFNPAPVT
HHHHHHHHHHHHCCCHHHHHHHHHHHCEEEEECCCCCC
>Mature Secondary Structure 
TTPLTIRMHEADNVAIVANDGGLPAGTALPSGITLREHVPQAHKVALQDIAEGGAVRRY
CCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHCCCCEEEE
NVPIGYAIRPIAAGSWVHEKLLHMPDARSLEGLPIATARPPALPPLEGYTFEGYRNADGS
CCCCCCEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCC
VGTRNILAITETVQCVAGVTEFAVQRIKAELLPKYPHVDDVVALAHTYGCGVAIDAPDAV
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEECCCCCE
IPIRTLRNISLNPNFGGEVMVVSLGCEKLQPERLLPPGAIPLVDERTLQEDPLDVVCLQD
EEHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
EAHVGFMSMVGSVMRQAEVHLERLNRRRRETVPASELVVGVQCGGSDAFSGVTANPAVGF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCCCCCCCHHHH
CTDLLVRAGATVMFSEVTEVRDGIDQLTSRAASPEVAEAMIREMAWYDAYLSQGRVDRSA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
NTTPGNKKGGLSNIVEKAMGSIVKSGSAPISGVVAPGEKARQKGLLYAATPASDFICGTL
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHCCEEEEECCCCCHHHHHH
QVAAGMNLHVFTTGRGTPYGLAEVPVIKVATRSDLARRWHDLMDVNAGRIADGEATIEEM
HHHCCCEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
GWEMFRLMLDVASGRRKTWAEHWKLANALVLFNPAPVT
HHHHHHHHHHHHCCCHHHHHHHHHHHCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7704254; 9384377 [H]