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The map label for this gene is pyrD

Identifier: 120611126

GI number: 120611126

Start: 2677587

End: 2678666

Strand: Reverse

Name: pyrD

Synonym: Aave_2455

Alternate gene names: 120611126

Gene position: 2678666-2677587 (Counterclockwise)

Preceding gene: 120611128

Following gene: 120611111

Centisome position: 50.04

GC content: 68.24

Gene sequence:

>1080_bases
ATGTCCCTGATCCCCTACGCCCTCACCCGCCCCTTCCTCTTCGGCATGGATGCCGAAGCTGCCCACGAACTCACCATGGA
CATGCTCGCGCGCGGCCAGCGCACGCCCCTGCAGTGGGCATGGAGCGGCGAGCAGGTGTCCGATCCCGTCCAGCTCGCGG
GCCTCACCTTTCCCAACCGCGTGGGCATGGCCGCAGGGCTGGACAAGAACGCGCGCTGCATCGACGCCCTGGGTGCCATG
GGATTCGGTTTCGTCGAAGTGGGCACCGTCACTCCGCGCGCCCAACCCGGCAACCCCAAGCCGCGAATGTTCCGTCTGCC
CGAAGCCAACGCCCTCATCAACCGCCTCGGCTTCAACAACGAAGGCCTGGACGCCTTCCTGCACAACGTGCGGCAGTCGA
ACCACCACGCACGCCCCGGCATGCGCCCCATGCTGCTGGGCCTCAACATCGGCAAGAACGCCACCACGCCGATCGAGGAC
GCCACGCGCGACTACCTGCTGTGCCTGGAAGGCGTGTACCCGCACGCCGACTACGTCACGGTCAACATCAGCTCCCCCAA
CACCCAGAACCTGCGCGCGCTGCAGAGCGACGCAGCCCTCGACGGATTGCTGGGCGCCATCGCCGAGCGGCGGGAATCGC
TGGCCCGGCAGCCTGAAAAAGCCACGGGGCGCCCTCGCCGCGTTCCCATCTTCGTGAAGATCGCCCCCGACCTGGCCGAG
GAGCAGGTGGCTGTCATCGCATCCACGCTGCAACGCCATGGCATGGACGGCGTCATCGCCACCAACACCACCATTTCGCG
CGATGCGGTGCAGGGGCTGCGGCATGCGGAGGAAACCGGTGGCCTGAGCGGCGCGCCGGTGCGGGAAGCCAGCAACCGCG
TCATCCGCCAGTTGCGCCATGCATTGGGCAAGGACTTCCCCATCATCGGAGTGGGCGGCATCCTCAGCGCCGAGGACGCG
GTCGAGAAGATCCGCGCGGGCGCCGACGTGGTACAGATCTACACCGGCCTCATCTACCGGGGCCCCGCGCTGGTTCCCCA
GGTCGCCAAGGCGCTGCGCGCCATGCCGCGCCCAGCCTGA

Upstream 100 bases:

>100_bases
TTTCAGCGCGGCCTGGCCCACCAGGGCTTTGAGTTCATCTTGGGAAAGGGGTGCGGGAGTGGTCATGGGAGAGAATCGGA
GTGAAGCCCGAATTATCCCC

Downstream 100 bases:

>100_bases
GCGCACGGAAACAGGCCGGCTGCGGCCGCGTAGCCCGCGGCCTGTCCCATCCGCAGACCGCGCGTGGCGAATAGCCAGCG
CCGCCGATCAACGCTTCATT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MSLIPYALTRPFLFGMDAEAAHELTMDMLARGQRTPLQWAWSGEQVSDPVQLAGLTFPNRVGMAAGLDKNARCIDALGAM
GFGFVEVGTVTPRAQPGNPKPRMFRLPEANALINRLGFNNEGLDAFLHNVRQSNHHARPGMRPMLLGLNIGKNATTPIED
ATRDYLLCLEGVYPHADYVTVNISSPNTQNLRALQSDAALDGLLGAIAERRESLARQPEKATGRPRRVPIFVKIAPDLAE
EQVAVIASTLQRHGMDGVIATNTTISRDAVQGLRHAEETGGLSGAPVREASNRVIRQLRHALGKDFPIIGVGGILSAEDA
VEKIRAGADVVQIYTGLIYRGPALVPQVAKALRAMPRPA

Sequences:

>Translated_359_residues
MSLIPYALTRPFLFGMDAEAAHELTMDMLARGQRTPLQWAWSGEQVSDPVQLAGLTFPNRVGMAAGLDKNARCIDALGAM
GFGFVEVGTVTPRAQPGNPKPRMFRLPEANALINRLGFNNEGLDAFLHNVRQSNHHARPGMRPMLLGLNIGKNATTPIED
ATRDYLLCLEGVYPHADYVTVNISSPNTQNLRALQSDAALDGLLGAIAERRESLARQPEKATGRPRRVPIFVKIAPDLAE
EQVAVIASTLQRHGMDGVIATNTTISRDAVQGLRHAEETGGLSGAPVREASNRVIRQLRHALGKDFPIIGVGGILSAEDA
VEKIRAGADVVQIYTGLIYRGPALVPQVAKALRAMPRPA
>Mature_358_residues
SLIPYALTRPFLFGMDAEAAHELTMDMLARGQRTPLQWAWSGEQVSDPVQLAGLTFPNRVGMAAGLDKNARCIDALGAMG
FGFVEVGTVTPRAQPGNPKPRMFRLPEANALINRLGFNNEGLDAFLHNVRQSNHHARPGMRPMLLGLNIGKNATTPIEDA
TRDYLLCLEGVYPHADYVTVNISSPNTQNLRALQSDAALDGLLGAIAERRESLARQPEKATGRPRRVPIFVKIAPDLAEE
QVAVIASTLQRHGMDGVIATNTTISRDAVQGLRHAEETGGLSGAPVREASNRVIRQLRHALGKDFPIIGVGGILSAEDAV
EKIRAGADVVQIYTGLIYRGPALVPQVAKALRAMPRPA

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=345, Percent_Identity=44.6376811594203, Blast_Score=257, Evalue=1e-68,
Organism=Escherichia coli, GI1787177, Length=344, Percent_Identity=50.2906976744186, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI87082059, Length=186, Percent_Identity=30.1075268817204, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17509475, Length=347, Percent_Identity=38.328530259366, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI281361352, Length=346, Percent_Identity=41.0404624277457, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI17137316, Length=346, Percent_Identity=41.0404624277457, Blast_Score=247, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_ACIAC (A1TPZ2)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_970804.1
- ProteinModelPortal:   A1TPZ2
- SMR:   A1TPZ2
- STRING:   A1TPZ2
- GeneID:   4669515
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_2455
- NMPDR:   fig|397945.5.peg.2100
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   SYVTVNI
- PhylomeDB:   A1TPZ2
- ProtClustDB:   PRK05286
- BioCyc:   AAVE397945:AAVE_2455-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 38732; Mature: 38601

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 185-185

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIPYALTRPFLFGMDAEAAHELTMDMLARGQRTPLQWAWSGEQVSDPVQLAGLTFPNR
CCCCCHHHHCCHHCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHCCCCCCC
VGMAAGLDKNARCIDALGAMGFGFVEVGTVTPRAQPGNPKPRMFRLPEANALINRLGFNN
CCHHCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEECCCHHHHHHHHCCCC
EGLDAFLHNVRQSNHHARPGMRPMLLGLNIGKNATTPIEDATRDYLLCLEGVYPHADYVT
CCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEE
VNISSPNTQNLRALQSDAALDGLLGAIAERRESLARQPEKATGRPRRVPIFVKIAPDLAE
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEEEECCCHHH
EQVAVIASTLQRHGMDGVIATNTTISRDAVQGLRHAEETGGLSGAPVREASNRVIRQLRH
HHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
ALGKDFPIIGVGGILSAEDAVEKIRAGADVVQIYTGLIYRGPALVPQVAKALRAMPRPA
HHCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SLIPYALTRPFLFGMDAEAAHELTMDMLARGQRTPLQWAWSGEQVSDPVQLAGLTFPNR
CCCCHHHHCCHHCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHCCCCCCC
VGMAAGLDKNARCIDALGAMGFGFVEVGTVTPRAQPGNPKPRMFRLPEANALINRLGFNN
CCHHCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEECCCHHHHHHHHCCCC
EGLDAFLHNVRQSNHHARPGMRPMLLGLNIGKNATTPIEDATRDYLLCLEGVYPHADYVT
CCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEE
VNISSPNTQNLRALQSDAALDGLLGAIAERRESLARQPEKATGRPRRVPIFVKIAPDLAE
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEEEECCCHHH
EQVAVIASTLQRHGMDGVIATNTTISRDAVQGLRHAEETGGLSGAPVREASNRVIRQLRH
HHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
ALGKDFPIIGVGGILSAEDAVEKIRAGADVVQIYTGLIYRGPALVPQVAKALRAMPRPA
HHCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA