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The map label for this gene is cyoB [H]

Identifier: 120610896

GI number: 120610896

Start: 2441918

End: 2443921

Strand: Reverse

Name: cyoB [H]

Synonym: Aave_2222

Alternate gene names: 120610896

Gene position: 2443921-2441918 (Counterclockwise)

Preceding gene: 120610897

Following gene: 120610895

Centisome position: 45.66

GC content: 64.47

Gene sequence:

>2004_bases
ATGTCCTCCGAACAAATTACCGCGTCCCACTGGGCCCTGGGACGGCTCACCTGGGACTCCGTGCCGATGGCGCACGAACC
CATCGTGCTGTGGACCTTCATCGCCGTGATGCTGGGCGGCATCGCCGTGCTGGCCGCGGTCACGCGCTTCCGCCTCTGGG
GCCCGCTGTGGCGTGACTGGGTCTGCAGCATCGACCACAAGAAGATCGGGATCATGTACATGATCCTCGGCCTGGTGATG
CTGCTGCGCGGCTTCGCAGACGCTGTGATGATGCGCCTGCAGCAGGCCGTCGCCTTCGGCGACAACATGGGCTACCTGCC
GCCGCACCACTACGACCAGATCTTCACCGCCCACGGCGTGATCATGATCTTCTTCGTGGCGATGCCGCTGGTCACCGGCC
TCATGAACTACGTCGTACCGCTGCAGATCGGCGCGCGCGACGTGGCGTTCCCGTTCCTGAACAACTTCAGCTTCTGGATG
ACCACGGCCGGCGCCATCCTGGTGATGATCTCGCTGTTCCTCGGCGAGTTCTCCACCTCCGGCTGGCTGGCCCTCTCCAA
CCTGGGCGCGCAGAACCCGGGAACGGGGCTGGACTACTACATATGGGCGCTGCAGGTCGCGGGGGTCGGCACCACGCTCT
CGGGCATCAACCTGATCGTCACGATCATCAAGATGCGCGCACCCGGCATGAACCTGATGAAGATGCCCATCTTCACCTGG
ACGTCCCTGTGCACCAACGCCCTGATCGTGGCCTCCTTCCCGGTGCTGACGGCCGCCCTGGTGCTGATGTCGCTGGACCG
CTACGTCGGCACGAACTTCTTCACGAACGACTTCGGCGGCAACCCGATGCTGTACGTGAACCTGATCTGGATCTGGGGCC
ACCCCGAGGTGTACATCCTGATCCTGCCCGCCTTCGGCATCTTCTCCGAGGTGGTCGCCACGTTCTGCCGCAAGCGCCTG
TTCGGCTACACCTCCATGGTCTACGCCACGGTGGTGATCACCATCCTGTCGTACCTGGTCTGGCTGCACCACTTCTTCAC
GATGGGCTCCGGCGCCAGCGTGAACACGTTCTTCGGCATCACGACGATGATCATCTCGATCCCGACGGGCGCGAAGATCT
TCAACTGGCTGTTCACCATGTACAAAGGCCGCATCCGCTTCGAGCTGCCCATGATGTGGACCGTGGCGTTCATGGCCACC
TTCGCCATCGGCGGCATGACCGGCGTGCTGCTGGCCGTGCCCCCGGCCGACTTCGTGCTGCACAACAGCCTGTTCCTGAT
CGCCCACTTCCACAACGTGATCATCGGCGGCGTGCTGTTCGGCCTGTTCGCCGGCATCAACTACTGGTTCCCCAAGGCCT
TCGGCTACAAGCTGGACCGCACCTGGGGCGTGCGCTCCTTCTGGCTGTGGGTGGTGGGCTTCTGGGTGGCGTTCGCTCCC
CTGTACGTCCTGGGCCTGCTGGGCGTGACGCGCCGCGTCAACCACTTCGAGGACCCGTCCCTGCAGATCTGGTTCGTGAT
CGCCGCCATCGGCGCGGGCCTCATCGCCCTGGGCATCGCCTGCTTCCTGATCCAGCTCGCGGTGAGCTACCTCAAGCGCG
ACCAGCTGCGCGACTTCACGGGCGACCCGTGGGATGCGCGCACGCTGGAGTGGGCCACTTCCTCGCCCCCGCCCCAGTAC
AACTTCGCGTTCACGCCCCGCGTGCACGAGATCGACGCCTGGTGGGACATGAAGAAGCACGGCTACAAGCGTCCCCTGGC
CGGCTTCCAGCCGATCCACATGCCGGCCAACACCGGCGCGGGTGCAGTGATCTCCGGACTCTCGCTGGTGCTCGGCTTCG
CCCTGATCTGGCACATGTGGCTGCTCGCGGGCGTGTCGTTCGCCGGCATCGTGCTGGCCGCGATCATCCACACGTTCAAC
TACAAGCGCGACTTCTACATCCCCGCCGATGAAGTCGGCACGACCGAAGAAGCCCGCACTCTCCAACTCGCCCGCCATGT
CTGA

Upstream 100 bases:

>100_bases
TGGAAACGACGCGCGAGACCGCGTCCGCCACCACCCCGCAATGACCCTGCAGGGCCGGCGCCGCGCGAGCGGAGCCGGCC
CCCACCAGAAGAAACCCGAT

Downstream 100 bases:

>100_bases
TATCCGATACCAAGCCGGCGCCGCAGGCGCCCTGGCTTCCCGCGACTACCACCTCGCGGAGGAGCCCCATCCAGAGAACG
GCACCGCCCTGGGCTTCTGG

Product: cytochrome-c oxidase

Products: NA

Alternate protein names: Cytochrome o subunit 1; Cytochrome o ubiquinol oxidase subunit 1; Oxidase BO(3) subunit 1; Ubiquinol oxidase chain A; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 667; Mature: 666

Protein sequence:

>667_residues
MSSEQITASHWALGRLTWDSVPMAHEPIVLWTFIAVMLGGIAVLAAVTRFRLWGPLWRDWVCSIDHKKIGIMYMILGLVM
LLRGFADAVMMRLQQAVAFGDNMGYLPPHHYDQIFTAHGVIMIFFVAMPLVTGLMNYVVPLQIGARDVAFPFLNNFSFWM
TTAGAILVMISLFLGEFSTSGWLALSNLGAQNPGTGLDYYIWALQVAGVGTTLSGINLIVTIIKMRAPGMNLMKMPIFTW
TSLCTNALIVASFPVLTAALVLMSLDRYVGTNFFTNDFGGNPMLYVNLIWIWGHPEVYILILPAFGIFSEVVATFCRKRL
FGYTSMVYATVVITILSYLVWLHHFFTMGSGASVNTFFGITTMIISIPTGAKIFNWLFTMYKGRIRFELPMMWTVAFMAT
FAIGGMTGVLLAVPPADFVLHNSLFLIAHFHNVIIGGVLFGLFAGINYWFPKAFGYKLDRTWGVRSFWLWVVGFWVAFAP
LYVLGLLGVTRRVNHFEDPSLQIWFVIAAIGAGLIALGIACFLIQLAVSYLKRDQLRDFTGDPWDARTLEWATSSPPPQY
NFAFTPRVHEIDAWWDMKKHGYKRPLAGFQPIHMPANTGAGAVISGLSLVLGFALIWHMWLLAGVSFAGIVLAAIIHTFN
YKRDFYIPADEVGTTEEARTLQLARHV

Sequences:

>Translated_667_residues
MSSEQITASHWALGRLTWDSVPMAHEPIVLWTFIAVMLGGIAVLAAVTRFRLWGPLWRDWVCSIDHKKIGIMYMILGLVM
LLRGFADAVMMRLQQAVAFGDNMGYLPPHHYDQIFTAHGVIMIFFVAMPLVTGLMNYVVPLQIGARDVAFPFLNNFSFWM
TTAGAILVMISLFLGEFSTSGWLALSNLGAQNPGTGLDYYIWALQVAGVGTTLSGINLIVTIIKMRAPGMNLMKMPIFTW
TSLCTNALIVASFPVLTAALVLMSLDRYVGTNFFTNDFGGNPMLYVNLIWIWGHPEVYILILPAFGIFSEVVATFCRKRL
FGYTSMVYATVVITILSYLVWLHHFFTMGSGASVNTFFGITTMIISIPTGAKIFNWLFTMYKGRIRFELPMMWTVAFMAT
FAIGGMTGVLLAVPPADFVLHNSLFLIAHFHNVIIGGVLFGLFAGINYWFPKAFGYKLDRTWGVRSFWLWVVGFWVAFAP
LYVLGLLGVTRRVNHFEDPSLQIWFVIAAIGAGLIALGIACFLIQLAVSYLKRDQLRDFTGDPWDARTLEWATSSPPPQY
NFAFTPRVHEIDAWWDMKKHGYKRPLAGFQPIHMPANTGAGAVISGLSLVLGFALIWHMWLLAGVSFAGIVLAAIIHTFN
YKRDFYIPADEVGTTEEARTLQLARHV
>Mature_666_residues
SSEQITASHWALGRLTWDSVPMAHEPIVLWTFIAVMLGGIAVLAAVTRFRLWGPLWRDWVCSIDHKKIGIMYMILGLVML
LRGFADAVMMRLQQAVAFGDNMGYLPPHHYDQIFTAHGVIMIFFVAMPLVTGLMNYVVPLQIGARDVAFPFLNNFSFWMT
TAGAILVMISLFLGEFSTSGWLALSNLGAQNPGTGLDYYIWALQVAGVGTTLSGINLIVTIIKMRAPGMNLMKMPIFTWT
SLCTNALIVASFPVLTAALVLMSLDRYVGTNFFTNDFGGNPMLYVNLIWIWGHPEVYILILPAFGIFSEVVATFCRKRLF
GYTSMVYATVVITILSYLVWLHHFFTMGSGASVNTFFGITTMIISIPTGAKIFNWLFTMYKGRIRFELPMMWTVAFMATF
AIGGMTGVLLAVPPADFVLHNSLFLIAHFHNVIIGGVLFGLFAGINYWFPKAFGYKLDRTWGVRSFWLWVVGFWVAFAPL
YVLGLLGVTRRVNHFEDPSLQIWFVIAAIGAGLIALGIACFLIQLAVSYLKRDQLRDFTGDPWDARTLEWATSSPPPQYN
FAFTPRVHEIDAWWDMKKHGYKRPLAGFQPIHMPANTGAGAVISGLSLVLGFALIWHMWLLAGVSFAGIVLAAIIHTFNY
KRDFYIPADEVGTTEEARTLQLARHV

Specific function: Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=509, Percent_Identity=36.9351669941061, Blast_Score=315, Evalue=1e-85,
Organism=Escherichia coli, GI1786634, Length=656, Percent_Identity=64.0243902439024, Blast_Score=876, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=536, Percent_Identity=36.5671641791045, Blast_Score=324, Evalue=4e-89,
Organism=Saccharomyces cerevisiae, GI6226524, Length=324, Percent_Identity=40.7407407407407, Blast_Score=226, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6226523, Length=250, Percent_Identity=34, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 74561; Mature: 74430

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEQITASHWALGRLTWDSVPMAHEPIVLWTFIAVMLGGIAVLAAVTRFRLWGPLWRDW
CCCCCEEHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
VCSIDHKKIGIMYMILGLVMLLRGFADAVMMRLQQAVAFGDNMGYLPPHHYDQIFTAHGV
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
IMIFFVAMPLVTGLMNYVVPLQIGARDVAFPFLNNFSFWMTTAGAILVMISLFLGEFSTS
HHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
GWLALSNLGAQNPGTGLDYYIWALQVAGVGTTLSGINLIVTIIKMRAPGMNLMKMPIFTW
CCEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
TSLCTNALIVASFPVLTAALVLMSLDRYVGTNFFTNDFGGNPMLYVNLIWIWGHPEVYIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCEEEE
ILPAFGIFSEVVATFCRKRLFGYTSMVYATVVITILSYLVWLHHFFTMGSGASVNTFFGI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
TTMIISIPTGAKIFNWLFTMYKGRIRFELPMMWTVAFMATFAIGGMTGVLLAVPPADFVL
HHHHHCCCCCHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHCCHHCEEEEECCHHHHH
HNSLFLIAHFHNVIIGGVLFGLFAGINYWFPKAFGYKLDRTWGVRSFWLWVVGFWVAFAP
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
LYVLGLLGVTRRVNHFEDPSLQIWFVIAAIGAGLIALGIACFLIQLAVSYLKRDQLRDFT
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GDPWDARTLEWATSSPPPQYNFAFTPRVHEIDAWWDMKKHGYKRPLAGFQPIHMPANTGA
CCCCCCCEEEECCCCCCCCCCEEECCCCEEHHHHHHHHHCCCCCCCCCCCCEECCCCCCC
GAVISGLSLVLGFALIWHMWLLAGVSFAGIVLAAIIHTFNYKRDFYIPADEVGTTEEART
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHH
LQLARHV
HHHHHCC
>Mature Secondary Structure 
SSEQITASHWALGRLTWDSVPMAHEPIVLWTFIAVMLGGIAVLAAVTRFRLWGPLWRDW
CCCCEEHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
VCSIDHKKIGIMYMILGLVMLLRGFADAVMMRLQQAVAFGDNMGYLPPHHYDQIFTAHGV
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
IMIFFVAMPLVTGLMNYVVPLQIGARDVAFPFLNNFSFWMTTAGAILVMISLFLGEFSTS
HHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
GWLALSNLGAQNPGTGLDYYIWALQVAGVGTTLSGINLIVTIIKMRAPGMNLMKMPIFTW
CCEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
TSLCTNALIVASFPVLTAALVLMSLDRYVGTNFFTNDFGGNPMLYVNLIWIWGHPEVYIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCEEEE
ILPAFGIFSEVVATFCRKRLFGYTSMVYATVVITILSYLVWLHHFFTMGSGASVNTFFGI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
TTMIISIPTGAKIFNWLFTMYKGRIRFELPMMWTVAFMATFAIGGMTGVLLAVPPADFVL
HHHHHCCCCCHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHCCHHCEEEEECCHHHHH
HNSLFLIAHFHNVIIGGVLFGLFAGINYWFPKAFGYKLDRTWGVRSFWLWVVGFWVAFAP
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
LYVLGLLGVTRRVNHFEDPSLQIWFVIAAIGAGLIALGIACFLIQLAVSYLKRDQLRDFT
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GDPWDARTLEWATSSPPPQYNFAFTPRVHEIDAWWDMKKHGYKRPLAGFQPIHMPANTGA
CCCCCCCEEEECCCCCCCCCCEEECCCCEEHHHHHHHHHCCCCCCCCCCCCEECCCCCCC
GAVISGLSLVLGFALIWHMWLLAGVSFAGIVLAAIIHTFNYKRDFYIPADEVGTTEEART
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHH
LQLARHV
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]