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The map label for this gene is gltA [H]

Identifier: 120610873

GI number: 120610873

Start: 2419508

End: 2420818

Strand: Reverse

Name: gltA [H]

Synonym: Aave_2199

Alternate gene names: 120610873

Gene position: 2420818-2419508 (Counterclockwise)

Preceding gene: 120610874

Following gene: 120610869

Centisome position: 45.23

GC content: 64.91

Gene sequence:

>1311_bases
ATGAAACTGGCAGACAACAAAGCAACGCTCTCGTTCAGCAATGGCAGCCCGAGCGTGGAATTGCCCGTGTACCACGGCAG
CGTGGGTCCGGACGTGGTGGACATCCGCAAGCTCTACGCCCAGACGGGCATGTTCACGTACGACCCGGGCTTCCTGTCCA
CGGCCGCCTGCCAGTCGTCGATCACCTACATCGACGGCGACAAGGGCGAACTGCTCTACCGCGGCTATCCCATCGAGCAG
CTGGCCACGAACTGCGACTACCTCGAGACCTGCTACCTGCTGCTCAAGGGCGAGCTGCCGAACGCCACCCAGAAGCAGGA
GTTCAGCGACAGCGTGACCAAGCACACGATGGTCAACGAGCAGATGCAGTTCTTCCTGCGCGGCTTCCGCCGCGACGCGC
ACCCGATGGCCGTGCTCACGGGCCTGGTGGGCGCCCTGTCGGCCTTCTACCACGACAGCACGGACATCAACAATCCGCAG
CACCGCGAGATCTCGGCCATCCGCCTGATCGCCAAGATGCCGACGCTGGTCGCCATGGCCTACAAGTACGGCGTGGGCCA
GCCGTACATGTACCCGCAGAACCACCTGAGCTATGCCGGCAACTTCCTGCGCATGATGTTCGGCACGCCCTGCGAGGAGT
ACAAGGTCAACCCCGTGCTCGAGCGCGCGCTGGACCGCATCTTCATCCTGCACGCCGACCACGAGCAGAACGCCTCCACC
TCCACCGTGCGCCTGTGCGGCTCGTCGGGCACCAACCCGTTCGCCGCCATCGCGGCCGGCGTGGCCTGCCTCTGGGGCCC
CGCACACGGCGGCGCCAACGAAGCGGCCCTGAACATGCTGCACGACATCCAGGCCCAGGGCGGCGTGGAGAAGATCGGCG
AGTTCATCAAGCAGGTCAAGGACAAGAACTCCGGCGTCAAGCTCATGGGCTTCGGCCACCGCGTGTACAAGAACTACGAC
CCGCGCGCCAAGCTCATGCAGGAAACCTGCAACGAGGTGCTGGCCGAGCTGGGCCTGGAAAAGGACCCGCTGTTCGCCCT
GGCCAAGGAACTGGAAAAGATCGCCCTGGAAGACGACTACTTCGTGCAGCGCAAGCTCTACCCGAACGTGGACTTCTACT
CCGGCATCGTGCAGCGCGCCATCGGCATCCCGGTGAACCTGTTCACCGGCATCTTCGCCCTGGCCCGCACCGTGGGCTGG
ATCGCCCAGCTCAACGAGATGATCGGCGACCCCGAGTACAAGATCGGCCGTCCGCGCCAGCTGTTCGTGGGCGCCGAGCC
CCGCACGGTGAAGCCGATCGCGCAGCGCTGA

Upstream 100 bases:

>100_bases
GATACCGCCGAGGTCAGGGACGTGCTCGAACTGCTGCGCCACCGCGCGCCGGCAACTCCTCCGCTTGCGGGCTAACCACT
ACCACCCAAGGAAACTCAGA

Downstream 100 bases:

>100_bases
CAGGGTGCCCAAGGCGCGGCCACCAGGTGGCCGCGCCGGCAAGGAACGAACCGCCGCGGGGCATGTCTCCGCGGCGGTTT
TTCATTGTTCGCCCTGATGG

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MKLADNKATLSFSNGSPSVELPVYHGSVGPDVVDIRKLYAQTGMFTYDPGFLSTAACQSSITYIDGDKGELLYRGYPIEQ
LATNCDYLETCYLLLKGELPNATQKQEFSDSVTKHTMVNEQMQFFLRGFRRDAHPMAVLTGLVGALSAFYHDSTDINNPQ
HREISAIRLIAKMPTLVAMAYKYGVGQPYMYPQNHLSYAGNFLRMMFGTPCEEYKVNPVLERALDRIFILHADHEQNAST
STVRLCGSSGTNPFAAIAAGVACLWGPAHGGANEAALNMLHDIQAQGGVEKIGEFIKQVKDKNSGVKLMGFGHRVYKNYD
PRAKLMQETCNEVLAELGLEKDPLFALAKELEKIALEDDYFVQRKLYPNVDFYSGIVQRAIGIPVNLFTGIFALARTVGW
IAQLNEMIGDPEYKIGRPRQLFVGAEPRTVKPIAQR

Sequences:

>Translated_436_residues
MKLADNKATLSFSNGSPSVELPVYHGSVGPDVVDIRKLYAQTGMFTYDPGFLSTAACQSSITYIDGDKGELLYRGYPIEQ
LATNCDYLETCYLLLKGELPNATQKQEFSDSVTKHTMVNEQMQFFLRGFRRDAHPMAVLTGLVGALSAFYHDSTDINNPQ
HREISAIRLIAKMPTLVAMAYKYGVGQPYMYPQNHLSYAGNFLRMMFGTPCEEYKVNPVLERALDRIFILHADHEQNAST
STVRLCGSSGTNPFAAIAAGVACLWGPAHGGANEAALNMLHDIQAQGGVEKIGEFIKQVKDKNSGVKLMGFGHRVYKNYD
PRAKLMQETCNEVLAELGLEKDPLFALAKELEKIALEDDYFVQRKLYPNVDFYSGIVQRAIGIPVNLFTGIFALARTVGW
IAQLNEMIGDPEYKIGRPRQLFVGAEPRTVKPIAQR
>Mature_436_residues
MKLADNKATLSFSNGSPSVELPVYHGSVGPDVVDIRKLYAQTGMFTYDPGFLSTAACQSSITYIDGDKGELLYRGYPIEQ
LATNCDYLETCYLLLKGELPNATQKQEFSDSVTKHTMVNEQMQFFLRGFRRDAHPMAVLTGLVGALSAFYHDSTDINNPQ
HREISAIRLIAKMPTLVAMAYKYGVGQPYMYPQNHLSYAGNFLRMMFGTPCEEYKVNPVLERALDRIFILHADHEQNAST
STVRLCGSSGTNPFAAIAAGVACLWGPAHGGANEAALNMLHDIQAQGGVEKIGEFIKQVKDKNSGVKLMGFGHRVYKNYD
PRAKLMQETCNEVLAELGLEKDPLFALAKELEKIALEDDYFVQRKLYPNVDFYSGIVQRAIGIPVNLFTGIFALARTVGW
IAQLNEMIGDPEYKIGRPRQLFVGAEPRTVKPIAQR

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=352, Percent_Identity=29.8295454545455, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI1786939, Length=434, Percent_Identity=63.594470046083, Blast_Score=586, Evalue=1e-168,
Organism=Escherichia coli, GI1786527, Length=383, Percent_Identity=28.4595300261097, Blast_Score=155, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17555174, Length=410, Percent_Identity=25.609756097561, Blast_Score=108, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6324328, Length=368, Percent_Identity=25.2717391304348, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6319850, Length=362, Percent_Identity=25.414364640884, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6325257, Length=370, Percent_Identity=25.9459459459459, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24640126, Length=411, Percent_Identity=28.7104622871046, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24640124, Length=411, Percent_Identity=28.7104622871046, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21356863, Length=397, Percent_Identity=28.2115869017632, Blast_Score=108, Evalue=7e-24,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48417; Mature: 48417

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLADNKATLSFSNGSPSVELPVYHGSVGPDVVDIRKLYAQTGMFTYDPGFLSTAACQSS
CCCCCCCEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEECCCHHHHHHHHCC
ITYIDGDKGELLYRGYPIEQLATNCDYLETCYLLLKGELPNATQKQEFSDSVTKHTMVNE
CEEEECCCCCEEECCCCHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
QMQFFLRGFRRDAHPMAVLTGLVGALSAFYHDSTDINNPQHREISAIRLIAKMPTLVAMA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YKYGVGQPYMYPQNHLSYAGNFLRMMFGTPCEEYKVNPVLERALDRIFILHADHEQNAST
HHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHEEEEECCCCCCCCC
STVRLCGSSGTNPFAAIAAGVACLWGPAHGGANEAALNMLHDIQAQGGVEKIGEFIKQVK
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
DKNSGVKLMGFGHRVYKNYDPRAKLMQETCNEVLAELGLEKDPLFALAKELEKIALEDDY
CCCCCEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCH
FVQRKLYPNVDFYSGIVQRAIGIPVNLFTGIFALARTVGWIAQLNEMIGDPEYKIGRPRQ
HHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
LFVGAEPRTVKPIAQR
EEECCCCCCCCHHCCC
>Mature Secondary Structure
MKLADNKATLSFSNGSPSVELPVYHGSVGPDVVDIRKLYAQTGMFTYDPGFLSTAACQSS
CCCCCCCEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEECCCHHHHHHHHCC
ITYIDGDKGELLYRGYPIEQLATNCDYLETCYLLLKGELPNATQKQEFSDSVTKHTMVNE
CEEEECCCCCEEECCCCHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
QMQFFLRGFRRDAHPMAVLTGLVGALSAFYHDSTDINNPQHREISAIRLIAKMPTLVAMA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YKYGVGQPYMYPQNHLSYAGNFLRMMFGTPCEEYKVNPVLERALDRIFILHADHEQNAST
HHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHEEEEECCCCCCCCC
STVRLCGSSGTNPFAAIAAGVACLWGPAHGGANEAALNMLHDIQAQGGVEKIGEFIKQVK
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
DKNSGVKLMGFGHRVYKNYDPRAKLMQETCNEVLAELGLEKDPLFALAKELEKIALEDDY
CCCCCEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCH
FVQRKLYPNVDFYSGIVQRAIGIPVNLFTGIFALARTVGWIAQLNEMIGDPEYKIGRPRQ
HHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
LFVGAEPRTVKPIAQR
EEECCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]